Coronary in Biological News

Single gene defect can cause stroke, other artery diseases

... aneurysms and dissections as well as early onset coronary artery disease, ischemic stroke and Moyamoya ... Muscle Alpha-Actin (ACTA2) Cause Early Onset coronary Artery Disease, Stroke and Moyamoya Disease, ... for 76 mutation carriers, while 26 had premature coronary artery disease, 15 had ischemic stroke, including ...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

... studies in 10 week old mice subjected to coronary occlusion. Controls and PAI-1 overexpressing ... of PAI-1 in plasma in the latter. 6 weeks after coronary occlusion the PAI-1 overexpressing mice exhibited ... led to increased expression of PAI-1 late after coronary occlusion accompanied by increased fibrosis and ...

Genetic variation may lead to early cardiovascular disease

... gene that increases susceptibility to early coronary artery disease. For years, scientists have known ... study, a region on chromosome 7 was linked to coronary artery disease (CAD). More recently, the ... between the NPY genetic variants associated with coronary disease. The genetic results were even ...

12-month ATLANTA trial data show sustained benefit of Catania Stent

... (76 lesions) treated with the CATANIA™ coronary Stent System with NanoThin Polyzene®-F ... due to de novo, obstructive lesions of native coronary arteries. The trial was sponsored by CeloNova ... death, myocardial infarction, stroke, or coronary artery bypass graft. Target lesion ...

Mental stress reduces blood flow to the heart in patients with gene variation

... have involved populations of patients who had coronary disease and positive exercise stress tests. But ... shown that as many as two-thirds of patients with coronary artery disease who experience exercise-related ... Yet less oxygen is supplied, in part because coronary arteries constrict, impeding blood flow. Doctors ...

Power of molecular imaging reveals secrets of the heart

... study. Following the recanalization of blocked coronary arteries (the surgical reopening or formation of ... group, normalization of glucose metabolism and coronary blood flow was seen in nearly 50 percent of the ... and blood flow, he said. Subsequent early coronary recanalization and CPC administration may lead to ...

The Lancet publishes first clinical trial data of a fully bioabsorbable drug eluting stent

... drug eluting stent for the treatment of coronary artery disease, demonstrated no stent thrombosis, ... clinical safety out to one year in patients with coronary artery disease," said Patrick W. Serruys, M.D., ... company with a fully bioabsorbable drug eluting coronary stent in clinical trials. Abbotts bioabsorbable ...

Study locates cholesterol genes; finds surprises about good, bad cholesterol

... were associated with decreased risk of coronary artery disease. Perhaps that result will lead us ... to heart disease," Abecasis said. coronary artery disease, a condition where plaque accumulates on the walls of coronary arteries, is the most common type of heart ...

New genetic variants associated with lipid levels, risk for coronary artery disease

... fat, or lipid levels, important risk factors for coronary artery disease (CAD). While there is some ... were associated with decreased risk of coronary artery disease. Perhaps that result will lead us ... among genes influencing lipid levels and risk for coronary heart disease is a first step in a long path to ...

Mutant gene identified as villain in hardening of the arteries

... expands lesions in the aorta and promotes coronary atherosclerosis, more commonly known as hardening ... to their littermates. And, surprisingly, their coronary lesions were similar to humans, say the ... Akt1 aggravates atherosclerotic lesions, promotes coronary atherosclerosis, and may be a model of ...

People who skip meals: are they better off?

... registry comprised of patients who had undergone coronary angiography, an X-ray examination of the blood ... age 64, could clearly be diagnosed either with coronary artery disease (CAD) which is at least 70 ... 515 patients (average age 64) who underwent coronary angiography between 2004 and 2006, completed a ...

New CPR promises better results by compressing abdomen, not Chest

... flows in the wrong direction, which means the coronary blood flow goes backward, bringing de-oxygenated ... backward flow. The Purdue researchers compared coronary artery blood flow during standard ... the heart muscle without retrograde flow in the coronary arteries. The researchers followed the ...

Trans fats hinder multiple steps in blood flow regulation pathways

... describing the two main causes of heart disease sudden blood clots in the coronary arteries, and atherosclerosis, the buildup of plaque in the arteries to ... Heart Association, each year more than 330,000 people in the U.S. die from coronary heart disease before reaching a hospital or while in an emergency room. ...

American Chemical Society's weekly PressPac -- May 27, 2009

... and other anti-platelet agents used widely to prevent blood clots in coronary artery disease, heart attack and stroke. Their study, scheduled for the ... and antiplatelet which together can have unique utilities, for example in coronary stents." ARTICLE #2 FOR IMMEDIATE RELEASE "Characterization of ...

Chemical found in medical devices impairs heart function

... plastics manufacturing. In addition to loss of taste and memory, coronary bypass patients often complain of swelling and fatigue. These side effects ... troubling and sometimes hinder recovery. His personal experience with coronary bypass surgery propelled his search for a root cause for the loss of taste ...

A missing enzyme conveys major heart protection in pre-clinical work

... of the study. Chronic ischemia usually occurs in people with severe coronary blockages, and who are at risk for heart attacks, he said. "A therapy that can increase blood vessel growth in a person with only mild coronary artery narrowing would potentially decrease the amount of heart damage if ...

American Chemical Society's Weekly PressPac -- Jan. 28, 2009

... are reporting an advance toward the first urine test for diagnosing coronary artery disease (CAD), the condition responsible for most of the 1.5 ... of Urine Proteome Pattern Analysis for Its Potential To Reflect coronary Artery Atherosclerosis in Symptomatic Patients" DOWNLOAD FULL TEXT ...

The genetic heart of the lipids

... been associated with both LDL and triglyceride levels, associated with coronary heart disease. The results are part of an emerging portrait of genes ... lipid levels: a major aim is to predict more efficiently those at risk of coronary heart disease. The profiles developed using the new genetic variants are ...

A little wine boosts omega-3 in the body: Researchers find a novel mechanism for a healthier heart

... acids, mainly derived from fish, are considered as protective against coronary heart disease and sudden cardiac death, thus their high blood ... alcohol consumption, including wine, is associated with protection against coronary heart disease and ischemic stroke - says Romina di Giuseppe, lead author ...

New cardiology research presented at CHEST 2008

... Published reports have shown that Asian-Indians have a higher rate of coronary heart disease than other ethnic groups, and their small arteries may be to ... Medical Center in New York explored the differences in the sizes of coronary arteries between Asian-Indians, Caucasians, and African-Americans (n=273). ...

Syntermed licenses Emory ERTb software for enhanced cardiac imaging

... and physiologic processes that may signal the early progression of coronary artery disease. ERTb, which can be used on any standalone PC, is ... 13. "SPECT studies are a critical part of diagnosis and prognosis of coronary artery disease," says Garcia, who is a professor of radiology at Emory ...

Eating fish may explain very low levels of heart disease in Japan

... in Japan among developed countries has been puzzling. Death rates from coronary heart disease in Japan have been less than half of that in the U.S. This ... and despite the fact that among these same men, risk factors for coronary heart disease (serum levels of total cholesterol, blood pressure and rates ...

LSUHSC awarded $10M+ COBRE grant

... project will help to explain why diabetics who have stents placed in their coronary arteries are at increased risk for re-stenosis or reclosure of the ... more types of cardiovascular disease. These include high blood pressure, coronary heart disease, heart failure, stroke, and congenital cardiovascular ...

Findings released from 1 of the largest percutaneous coronary intervention trials ever

... in patients experiencing STEMI and undergoing primary percutaneous coronary intervention (PCI). Only 7.2 percent of patients in the bivalirudin group ... mortality in patients undergoing angioplasty and in those with acute coronary syndromes, he said. ...

Saliva can help diagnose heart attack, study shows

... for 32 proteins associated with atherosclerosis, thrombosis and acute coronary syndrome. They found these proteins were in higher concentrations in ... the United States. In 2008, an estimated 770,000 Americans will have a new coronary attack, and about 430,000 will have a recurrent attack. There is ...

Genetic variants of USF1 are associated with the increased risk for cardiovascular disease

... familial combined hyperlipidemia, a common dyslipidemia predisposing to coronary heart disease. The gene encodes a ubiquitously expressed transcription ... this risk allele has a direct impact on the atherosclerotic lesions of the coronary arteries and abdominal aorta, Kristansson used two study samples of ...

Expecting an afternoon nap can reduce blood pressure

... in Greece, those who regularly took siestas showed a 37% reduction in coronary mortality compared to those who never nap, while individuals who ... afternoon nap to see if this period may also pose an increased danger of coronary mortality. ...

Cardiologists and heart surgeons meet for 'Controversies and Advances' conference

... of Staff at Cedars-Sinai. Sessions on Thursday, Oct. 4, will address coronary artery disease (part 1), mitral valve and carotid artery disease, ... fibrillation, and the future and new techniques. Fridays sessions look at coronary artery disease (part 2), aortic valve disease, congenital heart disease, ...

New DNA and RNA aptamers offer unique therapeutic advantages

... time in the bloodstream. Aptamer therapeutics presently in clinical development target diseases and applications such as macular degeneration, coronary artery bypass graft surgery, and various types of cancer. Kristina W. Thiel, PhD and Paloma H. Giangrande, PhD, from the University of Iowa, ...

The sound of light: Innovative technology shatters the barriers of modern light microscopy

... genetic expression within live fly larvae and fish by "listening to light". In the future this technology may facilitate the examination of tumors or coronary vessels in humans. Since the dawn of the microscope scientists have been using light to scrutinize thin sections of tissue to ascertain whether ...

Pre-pregnancy depressed mood may heighten risk for premature birth

... larger longitudinal investigation looking at the risks for cardiovascular disease among more than 5,000 young adults in four metropolitan areas. The coronary Artery Risk Development in Young Adults Study also collected information about mental health and pregnancy outcomes. Between 1990 and 1996, 555 ...

Hypertension among lower-status employees lingers well into retirement

... of people thought to have job-related hypertension may be considerably larger than previously assumed. One study estimated that 12 percent of all coronary heart disease deaths can be attributed to occupation. When this estimate is applied to seniors, there could be an additional 2.1 million people in ...

Genetic factors may predict depression in heart disease patients

... States. The current study focused on 977 patients with cardiovascular disease who had either a 50 percent or higher blockage in at least one major coronary artery or a documented heart attack. Of these patients, 21 percent were female and the average age was 59 years. Symptoms of depression were measured ...

Eating fatty fish once a week reduces men's risk of heart failure

... needs, heart failure (also known as congestive heart failure) is usually caused by existing cardiac conditions, including high blood pressure and coronary artery disease. Heart failure is the leading cause of hospitalization among patients 65 and older, and is characterized by such symptoms as fatigue ...

Team identifies a molecular switch linking infectious disease and depression

... symptoms in some cases of chronic inflammation. Doctors have known for decades that patients with chronic inflammation, such as that linked to coronary heart disease or rheumatoid arthritis, are more likely than others to become depressed. Some pro-inflammatory drugs, such as interferon-alpha, which ...

Quails get super fit by simply eating omega-3 diet

... to Jean-Michel Weber from the University of Ottawa, omega-3 fatty acids have some rather astonishing effects. In humans they reduce the risk of coronary heart disease and alleviate depression. But it was not their potential medicinal properties that intrigued Weber; it was their ability to increase ...

Inhaling a heart attack: How air pollution can cause heart disease

... people who seem to be most susceptible to environmental pollutants are the people who are already vulnerable, including the elderly and people with coronary artery disease. There is also some evidence that diabetics, women and people who are obese may be at greater risk. Identifying harmful pollutants ...

Promising 3-year data: Saving limbs with drug-eluting stents

... infrapopliteal drug-eluting stents in critical limb ischemia treatment," he added. In the United States, drug-eluting stents are FDA-approved for the coronary arteries but not for infrapopliteal arteries. In Europe, drug-eluting stents have CE Mark approval for below-the-knee use. ...

Simple test helps predict heart attack risk

... risk factors (those not traditionally considered in the Framingham Risk Score) are abnormal in up to 45 percent of those not considered high risk for coronary heart events. "This is significant news that can profoundly impact public health. If novel risk factors are shown to improve risk prediction, ...

High-fat diets inflame fat tissue around blood vessels, contribute to heart disease

... of the American Heart Association journal Circulation Research . Neal Weintraub, MD, and colleagues examined adipose tissueor fatsurrounding the coronary arteries of humans. The researchers found these fat cells to be highly inflamed, suggesting that they could trigger inflammation of the blood ...