Congenital in Biological News

Sticky protein helps reinforce fragile muscle membranes

... mechanism is disrupted, which occurs in certain congenital and limb-girdle muscular dystrophies. ... are caused by abnormal dystroglycan." These congenital muscular dystrophies include Fukuyama congenital Muscular Dystrophy, Walker-Warburg Syndrome and ...

Brain malformations significantly associated with preterm birth, Wake Forest research shows

... found that there is a strong association between congenital brain defects and preterm birth, leading ... born preterm for infants who have a variety of congenital brain defects. "The most important thing ... looked at 1,168 autopsy files that contained congenital brain defects as well as information on the ...

Embryology study offers clues to birth defects

... limb development and provides new insights into congenital limb defects. The study was published online in ... but was needed for forelimb (arm) budding." congenital birth defects of the arms, legs, hands or feet ... therapeutic or preventative measures to combat congenital limb defects, such as Holt-Oram syndrome, a birth ...

Folic acid to prevent congenital heart defects

... of researchers from the McGill Adult Unit for congenital Heart Disease (MAUDE Unit), the Research ... that folic acid also decreases the incidence of congenital heart defects by more than 6%. According to ... factors associated with a higher prevalence of congenital heart defects, so without the fortification we ...

Cats' eye diseases genetically linked to diseases in humans

... mutations in two groups of cats; one with a congenital form of RP and another with a late-onset form and ... found in humans with Joubert syndrome and Leber's congenital amaurosis. In both of these diseases, the genetic ... are approximately 2 years old. The cats with the congenital form of the disease are blind from birth with ...

Potential therapy for congenital muscular dystrophy

... capacity in a mouse model for alpha 7 integrin congenital myopathy," appears in the January 2009 issue of ... no treatment or cure for alpha 7 integrin congenital myopathy. Interactions of alpha 7 integrin ... novel therapy for patients with alpha 7 integrin congenital myopathy and other muscle diseases." Dr. ...

Jupiter's shrinking red spot

... 7) MODELING EMBRYONIC HEART DEVELOPMENT congenital heart diseases affect one percent of newborn ... may allow doctors to detect the beginnings of congenital heart disease. "The ultimate goal of the ... and ultrasounds for the early detection of congenital heart disease. It may also be possible to use ...

Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25

... . 6) MODELING EMBRYONIC HEART DEVELOPMENT congenital heart diseases affect one percent of newborn ... may allow doctors to detect the beginnings of congenital heart disease. "The ultimate goal of the ... and ultrasounds for the early detection of congenital heart disease. It may also be possible to use ...

OSA's ISP launches with research on breathing disorders and congenital heart defects

... deaths in the first year of life than any other congenital problem. Some are caused by genetic defects, but ... can better understand and develop treatments for congenital heart disease in humans, says Davis. Understanding how congenital heart defects arise would be a boon for humanity, ...

Monitoring outcomes of suicide attempts in pregnancy can better assess drug dangers

... the Hungarian researchers reasoned that if no congenital abnormalities occur in children born to women who ... normal. The researchers recorded occurances of congenital abnormalities, retardation in fetal growth (the ... went on to deliver live babies, 15 of whom had congenital abnormalities. However, according to the ...

Virus weaves itself into the DNA transferred from parents to babies

... to subsequent generations. This unique mode of congenital infection may be occurring in as many as 1 of ... breaks, the child may briefly develop a rash. A congenital infection of HHV-6 or one that is present at ... developmental or immune system problems. Some congenital infections can cause serious problems in fetuses. ...

Treatment corrects severe insulin imbalance in animal studies

... become an innovative medicine for children with congenital hyperinsulinism, a rare but potentially ... for children with the most common type of congenital hyperinsulinism," said study leader Diva D. De ... Hospital of Philadelphia. "This type of congenital hyperinsulinism is caused by mutations in genes ...

Latest advances in interventional cardiology for congenital heart disease presented

... burgeoning field of interventional therapies for congenital and structural heart disease will gather in Las ... Ziyad M. Hijazi, director of the Rush Center for congenital and Structural Heart Disease, will perform ... in the field of interventional therapies for congenital and structural heart disease in children and ...

Children born from frozen embryos weigh more and do better than those born after fresh transfer

... the children did not show an increased risk of congenital malformations, said Dr. Anja Pinborg, from the ... Data on the children's outcomes, including congenital malformations, were obtained from Danish national ... Most encouragingly, we found no increased risk of congenital malformations in the FER group; the rate in this ...

Stowers Institute researchers identify gene linked to vertebral defects in patient populations

... play an important role in human patients with congenital vertebral abnormalities. The discovery was ... at Boston Childrens Hospital with various congenital vertebral defects, the team sequenced five genes ... to collect more samples from patients with congenital vertebral abnormalities and sequence more genes ...

New book gives a human face to children with congenital heart disease

... COLD SPRING HARBOR, N.Y. Despite the fact that congenital heart disease (CHD) is the most common birth ... children and young adults who are growing up with congenital heart defects, explains Mona Barmash, President of the congenital Heart Information Network. The hauntingly ...

Jingle bells not merry for tone-deaf individuals

... sheds light on the neurological basis for congenital amusia. Music, at all times of the year, but ... music is less pleasure and more cacophony. congenital amusia, or tone-deafness is a life-long disorder ... Overall, behavioral evidence indicates that congenital amusia is due to a severe deficit in the ...

Botched production of insulin molecule may lead to diabetes

... mutations in the proinsulin gene of people with congenital diabetes, and to understand how these mutations ... the second most common genetic cause of congenital diabetes, which is a relatively rare genetic illness. congenital diabetes differs from Type 1 diabetes ...

Bone deformities linked to inbreeding in Isle Royale wolves

... History and Michael P. Nelson at Michigan State University, report on the congenital bone deformities in the latest issue of the journal Biological ... scientists found that 58 percent of the wolves on Isle Royale exhibit a congenital malformation in the lumbosacral region or lower back, and 33 percent ...

Researchers apply systems biology and glycomics to study human inflammatory diseases

... diseases, including certain cardiovascular diseases and a cluster of congenital diseases termed congenital Disorders of Glycosylation. The paper demonstrates experimental ...

Aberrations in region of chromosome 1q21.1 associated with broad range of disorders in children

... retardation, learning disabilities, seizures, autism, heart defects, other congenital abnormalities, cataracts, small head size, unusual facial features, hand ... in groups of patients with unexplained mental retardation, autism, or congenital abnormalities, and compared their findings with similar testing of a group ...

USC researchers identify alternate pathway that leads to palate development

... that leads to palate formation. Cleft palate is one of the most common congenital birth defects, occurring in one out of every 700 live births. Clefts are ... Chai says. Further study could have big implications not only on congenital oral birth defects like cleft palate but also on malformations and ...

Embryo biopsy does not affect early growth and risk of congenital malformations in PGD/PGS babies

... the procedure does not adversely affect their early growth and risk of congenital malformations. The lead researcher, Professor Maryse Bonduelle, told ... frequently after caesarean section than ICSI children, but had no more congenital malformations, hospital admissions or surgical interventions than did the ...

How and where fat is stored predicts disease risk better than weight

... fat levels in their liver, heart and pancreas. Individuals with congenital generalized lipodystrophy a genetic condition in which people are born ... fat was stored in other tissues, mimicking what happens in people with congenital generalized lipodystrophy. Recognition of this should encourage ...

Bacterial infections in premature babies more common than previously realized

... College of Medicine found that genital mycoplasmas are a frequent cause of congenital fetal infection. 23% of neonates born between 23 and 32 weeks of gestation ... Irvine, comment that the article provides compelling evidence that congenital fetal infection is more frequent than previously realized. The detection ...

Pourquié lab links beta-catenin gradient to process of somite formation

... give rise to the vertebral column, which is malformed in people born with congenital scoliosis. It is believed that some cases of congenital scoliosis are caused by mutations related to the segmentation clock. ...

A step toward tissue-engineered heart structures for children

... hearts right ventricle into the pulmonary artery, are often malformed in congenital heart disease, putting an extra burden on the heart. The heart valve ... pulmonary artery an area that often needs augmentation in patients with congenital heart disease. Eventually, Sales hopes to use tissue-engineering ...

New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis

... suggest that the use of this technique will improve IVF success rates for poor prognosis patients. It is also likely to achieve a reduction in congenital abnormalities such as Down's syndrome, as well as a reduction in the frequency of spontaneous miscarriage." The incidence of chromosomal ...

ICSI or IVF: Babies born from frozen embryos do just as well

... multiple IVF pregnancies and 21.1% multiple ICSI pregnancies. Outcomes at the time of birth for Apgar scores, gestational ages, birth weights and congenital malformations were similar for both IVF and ICSI singleton babies. When she grouped the babies according to whether they came from medicated or ...

DuoCort: New chronotherapy for adrenal insufficiency

... are different types of adrenal insufficiency: primary adrenal insufficiency also called Addisons disease, secondary adrenal insufficiency and CAH- congenital adrenal hyperplasia. About chronotherapy Coordinating biological rhythms (chronobiology) with medical treatment is called chronotherapy . It takes ...

Complications early in pregnancy or in previous pregnancies adversely affect existing or subsequent pregnancies

... conditions; in addition, it increased the risk of placenta praevia (where the placenta partially or completely blocks the cervix) six-fold and congenital malformations nearly two-fold. If a previous pregnancy had to be terminated for any reason, this increased the risk of premature rupture of the ...

3-D kidney atlas created for researchers and physicians

... develops as a consequence of hypertension and diabetes. However, renal disease is a condition that also affects children, who are often born with congenital renal anomalies. In particular, the increase in the incidence of type 2 diabetes has caused a rise in the number of renal patients. Loss of ...

UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants

... has extensive experience in stem cell research, and Simeon Boyd, an associate professor of pediatrics, who is an internationally recognized expert on congenital anomalies of the head and face. ...

March of Dimes awards $250,000 prize to scientists unraveling the causes of muscular dystrophy

... muscular dystrophy and limb girdle muscular dystrophy, as well as childhood conditions such as Duchenne and Becker muscular dystrophies and congenital muscular dystrophy. The March of Dimes Prize is a $250,000 cash award and a silver medal in the design of the Roosevelt dime, in honor of ...

Mouse model provides a new tool for investigators of human developmental disorder

... how structural defects might contribute to WHS symptoms, as is the case in the heart defects and swallowing difficulties. The report, "Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice" was written by Catarina Catela, Daniel Bilbao-Cortes, Esfir ...

Case Western Reserve University receives $1.66m grant from NIH for otoprotection research

... on inner ear dysfunction in Ushers syndrome. Usher Syndrome (USH) is a clinically and genetically heterogeneous disorder characterized by congenital deafness and retinitis pigmentosa. It is the most common cause of deafness accompanied by blindness. *There are about 10-15,000 people with Usher ...

Hebrew University professor's work leads to FDA approval for product

... potentially life-threatening to the patient due to inadvertent vascular or cardiac injury. In the U.S., there are 350,000 to 400,000 children with congenital cardiac abnormalities. Many neonatal and infant patients must undergo multiple surgeries before their defect is corrected, while other children ...

Common gene variants influence risk factor for sudden cardiac death

... side effect of scores of medications in widespread use and has been a major barrier to the development of novel drugs. From studies of families with congenital long-QT syndrome, we know that rare mutations with strong effects on ion channel function lead to QT prolongation and sudden death. But the common ...

Pulmonary hypertension in children may result from reduced activity of gene regulator

... of Health grants and co-investigator on a third with Dr. Fineman to help dissect the dysregulation. In a surgically created animal model of a congenital heart defect that causes too much pulmonary blood flow, they have already shown PPARs peroxisome proliferator-activated receptors are down ...

Scientists discover why teeth form in a single row

... permanent teeth when lost are lost for good. U.S. adults aged 20 years and older are missing an average of four teeth due to gum disease, trauma or congenital defects. Tooth loss makes chewing difficult, causes speech problems, accelerates oral disease, and disfigures the face. Current treatments for ...