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Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
...cular, someone who was a low-birth-weight baby can compound the risk of developing diabetes by becoming overweight," she added. "The stage is set in two ways: low insulin production coupled with resistance to insulin -- a double whammy." Other researchers involved in the Joslin study included co-authors Jose...Controversial drug shown to act on brain protein to cut alcohol use
...ity ofCalifornia in San Diego identified a natural compound able to blockalcohol addiction in rodents. We can only hope that anti-alcoholismpatchs or gum will be available in a close future; it would help fix aproblem that we've been struggling with for ages. A naturally occurring hallucinogen advocated by so...Anti-bacterial additive widespread in U.S. waterways
... essentially no idea of whatexactly happens to the compound after we flush it down the drain," saidthe study's lead author, Rolf U. Halden, PhD, PE, assistant professorin the School's Department of Environmental Health Sciences andfounding member of its Center for Water and Health.The nationwide assessment of...Inflammatory molecules released by pollen trigger allergies
...s allergic reactions. They went on to identify the compound in the pollen extracts that caused the inhibitory ...ore sensitive to the effects of the pollen-derived compound than those from non-allergic individuals. A better understanding of these molecules and how they wor......antibiotic streptomycin -- also produces a natural compound called migrastatin, which appears to inhibit cell migration. Natural migrastatin's effect is relatively weak, but Dr. Huang suspected the molecule might be manipulated into something more potent. In collaboration with the laboratory of Dr. Samuel Da...Newly Discovered Compound Blocks Known Cancer-Causing Protein
...the first steps of drug development by testing the compound in animal models of cancer. The research was supp...ists to believe they had discovered a new chemical compound with a unique biological function. When the scientists tested the compound's ability to inhibit Ras...... different types of surfactant (a soluble chemical compound that reduces the surface tension between liquids). One surfactant acts as the template for mesoporous structure, while the other is used to limit the growth of the particles to nanometer dimensions. This method can be used to create a variety of nan...Chemists identify key gene in development of type 1 diabetes
...t diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. If human studies prove the effectiveness of ISO-1, the compound or its derivatives could ultimately save lives, reduce health care costs and help prediabetic people...Towards precise classification of cancers based on robust gene functional expression profiles
...t diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. If human studies prove the effectiveness of ISO-1, the compound or its derivatives could ultimately save lives, reduce health care costs and help prediabetic people...Children's taste sensitivity and food choices influenced by taste gene
...tegorized three concentrations of a bitter-tasting compound (propylthiouracil; PROP) as tasting either "like water" or "bitter or yucky." Having a bitter-sensitive allele (P) on the TAS2R38 receptor gene predicted sensitivity to the bitter taste of PROP in both children and mothers. While 70% of children and...Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
... "What we're doing is testing a novel adjuvant, a compound that stimulates the immunological response to a vaccine, which is essentially tricking the immune system into thinking the vaccine is a bacterial infection," says lead author Dr. Daniel Speiser from the LICR Lausanne Branch. "The immune system mounts...Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
...s now demonstrate that lanosterol--an intermediate compound in the synthetic pathway--mediates feedback control over the rate of cholesterol production by stimulating the degradation of cholesterol-building reductase. The availability of reductase, which functions early in the synthetic process, largely deter...New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
...you don’t do a lot of other experiments to study a compound that later will be dropped ?that alone saves a lot of money.?/p> UF researchers say they will continue to apply the screening approach to other drugs in various situations and also will seek to develop better ways of determining how frequently an...Products containing specific probes for detecting alternative splice forms protected
...patent, including drug discovery, diagnostics, and compound screenings for efficacy or toxicity as well as screening patients for potential efficacy of therapeutics. Alternative RNA Splicing is a critical step in the expression of most genes, which can result in the expression of several mRNAs encoding prote...New drug shows promise as powerful anticancer agent
...this study have led to clinical evaluation of this compound in phase I clinical trials. Plk1 is a molecule th...tant to commonly used chemotherapeutic agents. The compound significantly inhibited a wide variety of human tumors, including liver, breast, and pancreatic canc...Defenseless plants arm themselves with metals
... A molecule called salicylic acid - a common plant compound and the active ingredient in pharmaceuticals like aspirin and acne medications - governs this pathway. When faced with a fungus or bacteria, most plants turn up their production of salicylic acid, which then interacts with other molecules in the pla...Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
... in multiple cell-signaling pathways. This means a compound may affect several different targets, rather than just one." In essence, Enigmols may act like a multi-drug combination therapy, the investigators speculate. Enigmols are also being tested in combination with other cancer chemotherapeutic drugs usi...Compounds in plastic packaging act as environmental estrogens altering breast genes
...ur aim was to determine what effects, if any, each compound had on mammary gene expression during at different ages," said Moral. "Our results showed that exposure to BPA changes the gene expression profile of mammary tissues as a function of age. That is, there was a significant increase in protein producti...Activation of thermoreceptors mediates raw garlic's burning pungency
...be ascribed largely to the effects of a particular compound and its ability to activate specific protein therm.... The researchers went on to identify the sulfide compound allicin, an unstable chemical found in bruised, cut, or crushed garlic, as the chemical responsible ...Could microbes solve Russia's chemical weapons conundrum?
... the mustard RM consists of derivatives of a toxic compound called 1,4-perhydrothiazine (PHT). Ermakova's research team grew P putida in cultures containing mustard RM. They then moni-tored the levels of PHT derivatives in the cultures until the bacteria stopped growing, using monoethanolamine (MEA) and ethy...Man-made wetland's effectiveness similar to natural marsh
...n't quite the same with nitrates ?a nitrogen-based compound found in fertilizer. "As a wetland gets older, it gets better at handling and storing nitrogen," Mitsch said. "The idea is not to overload wetlands in the first place." The three-acre wetland in the study was roughly the size of three football fiel...Molecular thermometers on skin cells detect heat and camphor
...ured keratinocyte cells, TRPV3 is activated by the compound camphor, which is one of the main ingredients in many warming rubs. TRPV3 is the first known receptor for camphor. Significantly, when Patapoutian and his colleagues discovered TRPV3 a few years ago, they were intrigued to discover that it is unique...Future diabetes drugs may target new protein interaction
...however. In 2003, other scientists reported that a compound found in red wine activated yeast's sirtuin1-equivalent and extended the organism's lifespan. Moving up the food chain, decades of reports have shown that drinking moderate amounts of red wine is associated with a longer life for people. But at this......however. In 2003, other scientists reported that a compound found in red wine activated yeast's sirtuin1-equivalent and extended the organism's lifespan. Moving up the food chain, decades of reports have shown that drinking moderate amounts of red wine is associated with a longer life for people. But at this...Computational verification of protein-protein interactions by orthologous co-expression
...however. In 2003, other scientists reported that a compound found in red wine activated yeast's sirtuin1-equivalent and extended the organism's lifespan. Moving up the food chain, decades of reports have shown that drinking moderate amounts of red wine is associated with a longer life for people. But at this...Eliminate Data Analysis Bottlenecks in Drug Discovery
...however. In 2003, other scientists reported that a compound found in red wine activated yeast's sirtuin1-equivalent and extended the organism's lifespan. Moving up the food chain, decades of reports have shown that drinking moderate amounts of red wine is associated with a longer life for people. But at this...At the molecular level, the predator is the prey
...some T. sirtalis garter snakes. TTX is a defensive compound found in some puffer fish, octopuses and primitive chordates. It is used in low concentrations to treat morphine and heroine addicts. It's also the "zombie" drug used by Haitian voodoo ritualists. Despite its action at the molecular level, the evolu...While on trail of dioxin, scientists pinpoint cancer target of green tea
... protective effects, and that could help us find a compound that is much more potent." Palermo, Gasiewicz, and current undergraduate Claire Westlake discovered that a chaperone protein known as HSP90 is involved in conferring green tea's protective effects. Other researchers have shown that many cancer cells...Innovative coating could give medical implants a longer life
...to the body's enzymes. In contrast, the molecular compound developed at Northwestern, which sticks securely to a surface and prevents cell and protein buildup, works for a long period of time. In laboratory studies, the new coating provided effective fouling resistance for more than five months, which Philli...Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
...lgorithm that predicts the precise effects a given compound will have on a cell’s molecular components or chemical processes. Using this tool, drug developers can design compounds that will act on only desired gene and protein targets, eliciting therapeutic responses free of unwanted side effects. The resear...Protein synthesis can be controlled by light, opening way for new scientific, medical applications
...tivates the bioactive molecule. Exposing the caged compound to light releases the effector in its active form.... molecule." The team developed a caged anisomycin compound that can be activated by exposure to ultraviolet light or an infrared laser beam. (Anisomycin is an ...Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
...ew Jersey is acquiring the licensing rights to the compound from USF through its merger with Greenwich Therapeutics Inc. and is planning clinical trials with Moffitt. The trials are expected to start within six to eight months. Patients will be selected for the trials based on whether their tumors have hypera...Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
...ny-stimulating factor (G-CSF) to create a new oral compound that is capable of surviving the journey through the gastrointestinal (GI) tract and then able to cross over into the bloodstream to be used by the body, according to research from the University of Southern California School of Pharmacy. This techn...Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief
... of the body's naturally occurring cannabinoids, a compound known as 2-AG, has anything to do with pain regula...rsity of California-Irvine, is the discoverer of a compound that blocks the breakdown of this marijuana-like compound called 2-AG, and it is that blocking compo...Newly discovered genetic disease sheds light on body's water balance
...MD, Gitelman administered urea, a natural nitrogen compound that encourages urination by acting as an osmotic agent. As water flowed out of their bodies and sodium concentrations returned to normal, both babies recovered. They continue to be followed by the UCSF team. Next Gitelman, Rosenthal and Feldman too...Environmental chemical cocktail may sabotage sperm
...ans are likely to be exposed to more than one such compound at any given time and, secondly, our results show that human sperm are even more sensitive to these compounds than mouse sperm." Prof Fraser and her team tested combinations of three chemicals: genistein, 8-prenylnaringenin which is found in hops, a...Novel compounds show promise as safer, more potent insecticides
...ch scientist at Nihon Nohyaku. In early tests, the compound showed high activity against the tobacco budworm (... tobacco and other crops, the researchers say. The compound did not have any measurable effect on mammalian ryanodine receptors, according to Peter Lümmen, Ph.D...Anthrax inhibitors identified by Burnham team
... working on refining the chemical structure of the compound with the goal of achieving an even more potent and selective drug that should exhibit a higher degree of protection against anthrax." This research was supported by grants from the National Institute of Allergy and Infectious Diseases, from the Nati......oe crab (Limulus polyphemus): The horseshoe crab's compound eye and the (easily accessible) optic nerve that connects the eye to the brain are both relatively large, making this organism a great model for the study of vision. MBL scientists have also made significant research breakthroughs related to the hor...Compound might defeat African sleeping sickness, clinical trial beginning this month
... terrible re-emerging disease," Tidwell said. "The compound DB289 will be the first new drug for early stage (blood stage) African sleeping sickness in 50 years, and the only oral drug that's ever been specifically developed for it." Oral administration is important for treating the disease which occurs in v...Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure
...le, all the chemistry associated with the original compound changes,?said Noel. He explained that the addition of a prenyl group, also known as prenylation, produces a relatively large change in the chemical’s biological properties. “The molecule becomes a little bit more greasy, and so the kinds of targets t...Stem cell training program to make its Stanford debut
...le, all the chemistry associated with the original compound changes,?said Noel. He explained that the addition of a prenyl group, also known as prenylation, produces a relatively large change in the chemical’s biological properties. “The molecule becomes a little bit more greasy, and so the kinds of targets t...Compound from Chinese medicine shows promise in head and neck cancer
A compound derived from cottonseed could help improve the eff...ehensive Cancer Center, discovered (-)-gossypol, a compound derived from a component of Chinese medicine. Gossypol comes from cottonseed and was once used in C...Slipping past the blood brain barrier: Research shows potential treatment for brain cancer
A compound that kills cancer can sneak past the blood brain b...f Medicine and a member of the research team. The compound - JV-1-36 - is an antagonist of the hypothalamic growth hormone- releasing hormone, which has been f...Structures of marine toxins provide insight into their effectiveness as cancer drugs
...er drug, it is a good idea to know how the natural compound works," he says. "Scientists who study natural products take their cues from what nature has already done. We're adding deep biochemical meaning to this area." He adds that synthetic chemists hope that actin-based drugs might one day rival the suc...Seaweed could make junk food healthier
...y to produce the extract, alginate, a carbohydrate compound which is a tasteless and odourless off-white colou...r and it's unlikely to taste any different. "This compound can also be added to any number of foods, such as synthetic creams and yoghurts. With pork pies, on...Discovery of T-cell 'traffic control' boosts new drug promise
...e traffic control system -- composed of a fat-like compound called S1P and its receptor on T cells -- usually prevents T cells from launching harmful reactions. But when the S1P traffic cop reacts incorrectly, T cells can swamp healthy tissue. The new research explains how a promising experimental drug treats...Molecular miners find pain relief drugs from the sea
...rofessor Khalil. ACV1 is not the only therapeutic compound that cone snail venom has to offer. In fact, the venom is a cocktail of thousands of biologically active compounds of which only a few hundred have been identified. Associate Professor Gayler says the team, by using genes as the starting point, are ......to be 1,000 times more effective than the original compound in inhibiting 3CLpro. However, Johnson, said, the...in the proteases to put them out of business." "A compound that blocks all these sites, rather than just a few, and that conforms tightly to the pockets, is ul...Clear rules needed to govern deep sea bioprospecting: UNU
...ucts: US$ 100 billion; * Annual profits from a compound derived from a sea sponge to treat herpes: US$ 50 ...vatives of a sponge while a sponge-derived steroid compound completed phase one US trials as an asthma drug in 2000. Other research in progress includes treatme...A Father’s Day Gift: Free DNA Paternity Testing
...ucts: US$ 100 billion; * Annual profits from a compound derived from a sea sponge to treat herpes: US$ 50 ...vatives of a sponge while a sponge-derived steroid compound completed phase one US trials as an asthma drug in 2000. Other research in progress includes treatme...Ants, not evil spirits, create devil's gardens in the Amazon rainforest, study finds
... notes. Chemical analysis revealed that the only compound produced by the ants' poison glands is formic acid, a toxin that is common in many ant species and, in fact, got its name from formica, which is Latin for ant. "Treatment of leaves with formic acid induced leaf necrosis on all the plants we tested," ...Protein structure key for AIDS, cell function
...rnell researchers identified a peptide, an organic compound composed of amino acids, that they believe may play a role in interrupting the interface between CD4 and HIV-AIDS. The findings, published in the journal Structure (Vol. 13, Sept. 2005), mark a major step toward designing drugs that could inhibit p...Environmental lessons from tsunami as world's coastal population doubles
...coastal cities ?many these being Asian cities. To compound this, many weather-related disasters are becoming more destructive and intense due to climate change. The report is based on two case studies ?the Asian tsunami in 2004 and the impact of severe storms in the Caribbean over the past twenty years. Th...... to start from conventional chemistry and make the compound in the lab, then try to find the simplest structur...s five percent of the animal may be made up of one compound -- a big investment of energy and resources. Chemical ecology is the field of research that explore...Tiny avalanche photodiodes target bioterrorism agents
...devices, based on aluminum gallium nitride (AlGaN) compound semiconductors, have a photocurrent gain of more t...of solar-blind APDs is based on wide bandgap AlGaN compound semiconductors. To date, no semiconductor-based solar-blind APDs have been reported. This is due to ...Vaginal gel may provide a new approach to HIV prevention
...ny pharmaceutical company has licensed an anti-HIV compound for development as a microbicide when the class of drugs is so early in development. Women make up nearly half of all people living with HIV worldwide, and 80 percent of new cases of HIV infection in women result from heterosexual intercourse. A vag...Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease
...colleague Katherine Whartenby used an experimental compound called CEP-701, already known to block actions of the growth-promoting FLT3 gene, on human dendritic cells and in mice engineered to mimic multiple sclerosis, a disease that causes T-cells to destroy the myelin protein sheath around nerves in the cen...UT Southwestern researchers develop screening test for cells that activate immune system
...to. Previously, scientists would have to test each compound individually, a time-consuming process. Their research already has led to the discovery of several compounds that turn on dendritic cells, which are found throughout the body from skin to blood. They continuously scan the body at the cellular level ......up to its target compound. But delivering a larger compound required an auxiliary "spring" to ensure it would reach the target. So, he said, "chemical thinking" helped resolve the problematic enzymatic reaction. "By demonstrating the transfer of carbon chains as long as 4 to 5 units, we provide proof of pri...Other ContentsfetusfetusfetusfetusfetusfibroblastfibroblastfibroblastfibroblastfibroblastfibulafilialfishfishfishfishfishfishflameflameflankingflankingflankingOther TagskilledgamegamegamegameashashashashashashashmommommommomwingwingwingwingwingpaypayOther Tagsscourge 2paradigm 2paradigm 3century 2century 3century 4century 5past 2past 3past 4past 5past 6past 7past 8past 9past 10improvement 2improvement 3improvement 4improvement 5improvement 6improvement 7improvement 8needs 2needs 3needs 4needs 5needs 6needs 7needs 8needs 9needs 10fragile 2fragile 3
(Date:8/19/2008)...g up boring bran flakes; it can also preserve impo...ional Institute of Standards and Technology (NIST)...method for evaluating the sugars pharmaceutical co... at room temperature. The group presented their fi...ional Meeting and Exposition. , Protein-based dr...
(Date:8/19/2008)...ted can block the lung,s natural protective respon... at National Jewish Health. The findings, recently...ctober issue of Infection and Immunity, suggest ...ronic obstructive pulmonary disease. , "Although...ructive pulmonary disease (COPD), only 20 percent ...
(Date:8/19/2008)...attacks of 2001, the Bureau of Reclamation (BOR), ... and power to millions of people, has invested sig...to protect its facilities and personnel, says a ne...ver, BOR needs better communication among security...law enforcement personnel; security plans that are...
(Date:8/19/2008)...n the online early edition of the Proceedings of ... burning, primarily in North America and Europe, c...man health and ecosystems in and around Earth,s po...eaves Toxic Heavy Metal Legacy in the Arctic," was... Reno, Nev. and partially funded by the National S...
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(Date:8/20/2008)...cently enacted Medicare Improvement Law immediatel...re Advantage insurance companies .../PRNewswire/ -- When the House and Senate,overrode...gislation,protecting Medicare beneficiaries, they ...e Advantage plans during one of the busiest months...
(Date:8/20/2008)...T CREEK, Calif., Aug. 20 /PRNewswire-FirstCall/ --... reported preliminary income from,continuing opera...f $27.5,million, or $0.76 per diluted share, inclu...er diluted share, related to provisions for store,... a 6.8 percent increase,compared with income from ...
(Date:8/20/2008)...FIELD, Mich., Aug. 20 /PRNewswire/ -- WXYZ- TV/Cha...llness Promotion will give thousands of,Detroit me...ALTHY LIVING,FOR KIDS" program. This year the prog....m. to 5 p.m. at the Charles H. Wright Museum of A...77, "Healthy Living for Kids",has provided free im...
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