Clotting in Biological News

Where optics meets medicine

... lining the blood vessels, triggering natural clotting mechanisms and leading to the formation of an occlusion. The clotting process, as well as the subsequent changes in the ... Alzheimer's disease, they have already shown that clotting a microvessel triggers the formation of new ...

UCSB chemistry professor receives top military award for life-saving gauze

... brand hemostatic agent, which promotes instant clotting and sealing of the wound until the injured can be ... of QuikClot that also maintains the product's clotting power. Stucky's team also created a QuikClot formulation with silver ions that provides enhanced clotting as well as antimicrobial properties to fight ...

NIH stimulus funding supports Emory biomedical scientists

... on a mouse model of prostate cancer. Understanding hemophilia and other clotting disorders: If your blood has trouble clotting, you might have hemophilia. ... hemophilia and cardiovascular disease. This study looks at one particular clotting protein, factor VIII. Biomarkers for Alzheimer's via magnetic ...

Likely cause of postpartum blues and depression identified

... commonly associated with depression. But platelets that enable blood clotting also secrete serotonin which prompts platelets to aggregate and the ... know the gene plays an important role in the crosstalk that forestalls clotting until after birth. When the fetus and placenta are gone, blood ...

American Chemical Society's Weekly PressPac -- July 2, 2008

... right after transplantation in an inflammatory reaction triggered by blood clotting on the surface of the cells, the researchers say. To address this ... laboratory studies, the researchers showed that the coatings delayed the clotting long enough to prevent the destruction that otherwise would occur ...

Genetic factors may predict depression in heart disease patients

... gene that appears to have a significant association. vWF is a protein produced by the endothelium that is critical to the initial stages of blood clotting by helping platelets stick to damaged blood vessels. When elevated in concentration, VWF is a strong predictor of endothelial dysfunction and a risk ...

Komodo even more deadly than thought: Research

... finding that the toxin was similar to that of the Gila monster and many snakes. The venom causes a severe loss in blood pressure by preventing blood clotting and widening blood vessels, thus inducing shock in a victim. The researchers also examined fossils of the giant extinct dragon relative Varanus ...

Penn medicine draws road map for elimination of central line-associated bloodstream infections

... that can kill bacteria before they gain access to the bloodstream. When the staff learned that a special cap that had been used to keep blood from clotting inside the lines was associated with increased bloodstream infections, its use was eliminated, leading to another drop in CLABSI rates. The ...

Lancet study supports new, highly effective treatment for blood disorder

... NEW YORK (March 20, 2009) -- Patients suffering from a blood disorder that prevents proper clotting have the option of a new medication that may dramatically improve their health. There are estimated to be between 50,000 and 100,000 individuals in ...

Oh baby, interventional radiology makes childbirth safer

... vessels, controlling hemorrhage. Interventional radiologists guide a catheter up a uterine artery using X-ray imaging. Once at the site of bleeding, clotting agents, such as tiny sponge-like gelfoam particles (the size of sand) or little metal coils, are released to block an injured vessel and stop the ...

For old or young dialysis patients, AV fistulas remain pure gold

... second needle returns the cleansed blood. Interventional radiologists monitor AV fistulas to avoid complications such as infection, blockage from clotting and poor blood flow. Interventional radiologists also keep AV fistulas or other accesses open or unclogged through minimally invasive techniques such ...

Duke team finds compounds that prevent nerve damage

... an enzyme called tissue transglutaminase (TGM2). TGM2 may damage cells by forming strong bonds between proteins. Such bonding is beneficial for blood clotting which happens outside of cells, but if this type of bonding occurs inside cells, it can be harmful, Greenberg said. The study appears in the ...

MIT-led teams unravel heparin death mystery

... shortness of breath, and abdominal pain. The researchers found that the contaminant activates two inflammatory pathways: one that initiates blood clotting and dilation of the blood vessels, and one that produces anaphylactic toxins. The first leads to a dangerous decrease in blood pressure, the second a ...

New horizons in modelling surface processes

... arteries for heart surgery have been hampered by the fact that the body perceives them as foreign and triggers an injury response to start blood clotting in the implants. Now, a UCL team led by Professor Alexander Seifalian has created a new generation of nanocomposite materials known as UCL-NanoTM ...

NHLBI issues first US von Willebrand Disease clinical practice guidelines

... low or absent levels of a blood protein called von Willebrand factor affect the bloods ability to clot. Von Willebrand factor also carries with it clotting factor VIII, another important protein that helps blood clot. VWD is typically milder but more common than another bleeding disorder, hemophilia. ...

New study shows low-fat diets more likely to reduce risk of heart disease than low-carb diets

... The reduced production from the endothelium of nitric oxide, a specific chemical, puts the vessel at higher risk of abnormal thickening, greater clotting potential, and cholesterol deposition, all part of the atherosclerosis process, says Dr. Gutterman. Over a six-week period, the researchers found ...

Herpes virus link to complications in pregnancy

... research group has already demonstrated a link between viral infection in pregnancy, genetic mutations in genes controlling inflammatory and blood clotting processes, and the development of cerebral palsy. The group has also found an association between several hereditary gene mutations with changes ...

Fine print: New technique allows fast printing of microscopic electronics

... use a liquid that solidifies into a fiber for making precise three-dimensional lattices. Such a product could be used as a scaffold to promote blood clotting in wounds and in other medical devices. Princeton University has filed for a patent on the discovery and has licensed rights to Vorbeck Materials ...

Proposal to step up cardiovascular disease research

... inflammatory disease of the arteries in which atherosclerotic plaques develop, leading ultimately to a variety of complications including blood clotting and loss of blood supply to organs. The EVBI aims both to block progress of atherosclerosis through drug therapies and vaccination, and also to ...

Blood clotting protein linked to rheumatoid arthritis

... CINCINNATI Researchers at Cincinnati Childrens have issued the first study showing that a protein normally involved in blood clotting (fibrin), also plays an important role in the inflammatory response and development of rheumatoid arthritis. Inflammatory joint disease appears to be ...

OHSU turns innovations into commercial opportunities at record pace

... (vascular grafts). These advances will address the unmet medical need to prevent vascular graft failure that currently results from localized blood clotting and abnormal tissue ingrowth within such grafts. The company is perfecting a proprietary method of local drug delivery at the blood-graft interface ...

Chemistry turns killer gas into potential cure

... Although the gas is lethal in large doses, small amounts can reduce inflammation, widen blood vessels, increase blood flow, prevent unwanted blood clotting and even suppress the activity of cells and macrophages* which attack transplanted organs. The researchers have developed innovative water-soluble ...

Bleeding, not inflammation, is major cause of early lung infection death

... activator 1 (PAI-1). Against the pro-clotting influence of PAI-1 is balanced the action of another protein, cylindromatosis (CYLD), which blocks the clotting pathway just enough to keep blood flowing under normal circumstances. What Li and colleagues found is that the S. pneumoniae bacteria release a ...

Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor

... the sample loss that typically occurs during the bottom-up approach. Our results are a first step toward our ultimate goal to identify a virus, clotting factor or any type of large biological molecule by just weighing it or its gas-phase-generated fragments, said Bier. This would provide a rapid ...

Genetic variation alters response to common anti-clotting drug

... anticoagulant drug warfarin to prevent harmful clotting after a heart attack, stroke, or major surgery. ... that variations in a gene involved in blood clotting may explain why certain people require a lower or ... which makes a protein that helps control clotting and is the key target of warfarin. The ...

Promising therapies for haemophilia & heart disease

... intravenous infusion of recombinant Factor VIII clotting protein. Professor Denisa Wagner and her ... protein called P-selectin is important for blood clotting and altering its levels in the bloodstream by ... affordable and more effective means of achieving clotting to stop bleeding incidents in haemophiliacs. ...

Redesigned protein accelerates blood clotting

... reactions," Fay said. Study Details Blood clotting involves more than a dozen clotting factors, many named with roman numerals. They ... In patients with hemophilia, however, enhanced clotting is desirable." ...

Inhibiting blood to save the brain

... neglected as a therapeutic target, but this research shows that a blood clotting factor is an important player in MS." MS is an inflammatory ... blocks fibrin's interaction with microglia, but not with platelets, so clotting wouldn't be impacted," said Akassoglou, adding that this potential MS ...

Therapeutic prospects beyond Vioxx

... by removing its receptor all had the same effect ?a predisposition to clotting and an elevation of blood pressure. "This provides compelling evidence in ... of the inhibitors. Surprisingly, this appeared to reduce not only the clotting response, but also the rise in blood pressure caused by drugs like ...

Polymer aids in blood clotting, pointing way to new treatment

... lead to a new treatment strategy for injuries or illnesses in which blood clotting is paramount to survival. In a paper to be published in the Proceedings ... Georgia report that a linear polymer known as polyphosphate speeds blood clotting and helps clots last longer. The paper appears online this week (Jan. ...

Clot-dissolving agent may be beneficial in treatment of severe frostbite

... The researchers suspect tPA helps reduce the injury caused when frozen skin is warmed again. Inflammation during thawing typically stimulates clotting that blocks small blood vessels, leading to cell death. Because tPA reverses this clotting, blood flow is restored before permanent damage is done. ...

Scientists use nanoparticle to discover disease-causing proteins

... of proteins similar to some found in human blood, Tao said. The proteins apparently are part of the biochemical process that affects blood clotting or hemorrhage. Understanding how the proteins behave could help determine predisposition to heart disease and cancer and also be useful in diagnosis ...

Surgeons develop simpler way to cure atrial fibrillation

... from stroke and have up to a two-fold higher risk of death. For some patients, medications can control the abnormal heart rhythms and the risk of clotting associated with atrial fibrillation, but unlike the Cox-maze procedure, the drugs do not cure the disorder. Damiano says their most recent study ...

MIT material stops bleeding in seconds

... is unclear at this time," Ellis-Behnke said. The researchers are confident, however, that the material does not work by inducing blood clotting. clotting generally takes at least 90 seconds to start, and the researchers found no platelet aggregation, a telltale sign of clotting. Other MIT ...

Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes

... the researchers fed serum containing the antibodies to mosquitoes carrying Plasmodium falciparum. (Serum is the fluid from which blood cells and clotting factors have been removed.) Microscopic examination of the mosquito digestive tracts revealed that the antibodies were capable of completely ...

A transplant in time

... spleen transplantation at 42 days. Hemophiliac mice with spleen tissue transplanted from pig embryos at this time experienced completely normal blood clotting within a month or two of implantation. Although a number of problems would need to be surmounted before researchers could begin to think of ...

Blood-compatible nanoscale materials possible using heparin

... pores, and then demonstrated the materials' high compatibility with blood. Heparin is a common therapeutic used to maintain blood flow or prevent clotting during medical procedures and treatments. The researchers demonstrated the composite heparin membrane with nanopores could work as an artificial ...

Ultra low-dose estrogen shown safe for post-menopausal women

... reach the bloodstream," explains Yaffe. "It's thought that estrogen in pill form might stimulate the liver to produce substances that can lead to clotting or other adverse side effects. With a patch, you bypass the liver and go straight to the blood." Yaffe notes that since the WHI results were ...

Bones hold the key to blood renewal

... Only when they leave the niches do they morph into specialized blood cells, possibly becoming immune cells for fighting infection or cells for blood clotting and healing after injury. They can even respond to calls for help from organs such as the liver, migrating through the bloodstream to assist in ...