Trans fats hinder multiple steps in blood flow regulation pathways
... two main causes of heart disease sudden blood clots
in the coronary arteries, and atherosclerosis, ... (which regulates the formation of blood clots
needed for wound healing). While some in the food ... needed to keep blood flowing. Thus blood clots
may more easily develop, and sudden death is ...
Where optics meets medicine
... dementia often don't have the worst plaques, and clots
and hemorrhages in small blood vessels have also ... scientists to directly look at the effect of clots
in the brain's microvasculature on the ... tightly focused femtosecond lasers to introduce clots
in the microvasculature in the brains of rodents. ...
Pivotal national trial uses newest interventional radiology treatment to bust blood clots in legs
... treatments canunlike standard DVT therapyremove clots
and have strong potential to prevent PTS. The ... preventable if we are able to dissolve the clots
early, before permanent damage to the vein ... which remains in the leg. While many patients' clots
will slowly dissolve over time, often the vein ...
American Chemical Society's weekly PressPac -- May 27, 2009
Silver nanoparticles show "immense potential" in prevention of blood clots
Scientists are reporting discovery of a potential new ... ReoPro, and other anti-platelet agents used widely to prevent blood clots
in coronary artery disease, heart attack and stroke. Their study, ...
Nature study demonstrates that bacterial clotting depends on clustering
... known that bacteria can pass the coagulation threshold and cause blood clots
to form. Once they form, the clots
can grow and propagate. Although this may help prevent the dissemination ...
Chronic exposure to estrogen impairs some cognitive functions
... women was stopped because of an increased risk of stroke and blood clots
in women taking estrogen alone, and a higher than average incidence of breast cancer, cardiovascular disease, blood clots
and stroke in women taking estrogen and progesterone.
Studies of ...
Stroke study reveals key target for improving treatment and suggests that Gleevec may help
... barrier appears to be unrelated to tPA's main job, which is to break down clots
that have lodged in the brain's blood vessels, cutting off blood supply to the area and starving brain tissue until it begins to die.
cause 80 percent of the 15 million strokes that occur each year worldwide. ...
Bleeding, not inflammation, is major cause of early lung infection death
... likely to leak bleed out of vessels) or thicker (more likely form blood clots
that choke off blood flow through blood vessels). Blood clots
can represent either a dangerous blockage of blood flow, or a protective ...
NIH stimulus funding supports Emory biomedical scientists
... of prostate cancer.
Understanding hemophilia and other clotting disorders:
If your blood has trouble clotting, you might have hemophilia. If it clots
too easily, embolisms, heart attacks or strokes can occur. Understanding blood-clotting proteins can improve treatments for inherited hemophilia and ...
Study explains potential failure of oral contraceptives with obese women
... actually prescribe lower-dose oral contraceptives to obese patients in an effort to decrease their risk of venous thrombosis. These are blood clots
in the legs or elsewhere that can increase the risk of stroke and heart attacks.
The study was done with 20 women of ages 18 to 35, all of them ...
Brain malformations significantly associated with preterm birth, Wake Forest research shows
... could be a key element," he added. "In placental conditions such as preclampsia, which is strongly associated with preterm birth, there may be blood clots
coming from the placenta, causing brain damage and malformations in the brain and then, perhaps, the malformed fetus induces its own preterm birth or ...
New device detects heart disease using less than one drop of blood
... of blood, the device's design also provides researchers with a new model to study the effects that blood flow in the body has on cell binding (like clots
form in arteries).
"Most immediately, this is could be a new tool to assess cardiovascular health that cuts the amount of blood needed down to a ...
Older men more likely than women to die after pneumonia
... They found patterns in these biomarkers that suggest men generate a stronger inflammatory and coagulation response and, perhaps, break up blood clots
more quickly than women in response to infection. "These differences in inflammatory, coagulation and fibrinolysis biomarkers among men may explain ...
Blood test predicts chance of dementia
... defect occurs, cause a hereditable form of FTD. In 1998, defects were found in the gene for the tau protein, a substance that appears in the protein clots
in the brains of FTD and Alzheimer's patients. In 2006, Christine Van Broeckhoven's team discovered hereditable defects in the gene for the ...
Decreasing insulin resistance prevents obesity-related cardiovascular damage
... at the Vascular Biology Center and senior investigator on the grant. Blood vessels stop dilating as they should, walls become inflamed and thick and clots
can form. "You start adding up cardiovascular problems," says Dr. Fulton, associate professor in the MCG Schools of Medicine and Graduate Studies.
Inflammation worsens danger due to atherosclerosis
Atherosclerotic plaques consist of lipid cores covered by collagen fiber caps. These plaques can suddenly rupture, resulting in blood clots
that completely block blood flow and lead to heart attack or stroke in otherwise healthy individuals. One potential cause of plaque rupture is the ...
UNC scientists teach enzyme to make synthetic heparin in more varieties
... after procedures such as kidney dialysis, heart bypass surgery, stent implantation, indwelling catheters, and knee and hip replacements to prevent clots
from blocking or restricting the flow of blood. The annual worldwide sales of heparin are estimated at $3 billion.
The drug was in the spotlight ...
Friend or foe? How the body's clot-busting system speeds up atherosclerosis
... friends from foes, biologically speaking. Naturally produced in the body, urokinase plasminogen activator and plasminogen interact to break up blood clots
and recruit clean-up cells to clear away debris related to inflammation. In fact, urokinase manufactured as a drug effectively clears clogged ...
NIH's Genes, Environment and Health Initiative adds 6 studies
... Scan of Prostate Cancer.
John Heit, M.D., Mayo Clinic, Rochester, Minn.; $1.1 million. Genome-Wide Association of Venous Thrombosis (Blood clots
Braxton Mitchell, Ph.D., University of Maryland School of Medicine, Baltimore; $1.1 million. Genetic Risk to Stroke in Smokers and ...
Prosthetic vein valve designed to direct blood flow shows promising pre-clinical results
... results were described in the June 2007 issue of the Journal of Medical Devices.
Next, Farrell developed a laboratory method to test whether blood clots
would form inside the prosthetic valve. Results showed that the new generation of valves remained open with no clot formation after 120 minutes of ...
Researchers tap into a new and potentially better source of platelets for transfusion
... already committed to becoming platelets.
Another problem with making platelets from stem cells is that the resulting platelets often fail to form clots
properly. This defect can be caused by the presence of enzymes that shear adhesive proteins from the cells' surface, preventing them from sticking to ...
Radiation, nanotechnology, health care and more
... not a routine procedure used during pregnancies, a CT exam helps to detect possible life-threatening conditions such as bleeding in the brain, blood clots
in the lungs or appendicitis. To accurately assess the dose to mother and the fetus from CT exams, we developed a virtual CT scanner and used the ...
Quest for better treatment for effects of menopause
... is beneficial, but it also reduces antioxidant activity of the serum, which means an adverse effect on the endothelial function (which avoids blood clots
forming) and on the balance necessary between oxidant and antioxidant substances.
Genetic factors determining response to treatment
On the ...
Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf
... major and thalassemia intermediate found that the rate of thrombolytic events was 1.75 percent.
Surgical technique has played a role in developing clots
(thrombosis). A recent study found that patients who underwent open splenectomy had a 19 percent chance of developing life-threatening clots, whereas ...
Hyperviscous fluids: Better treatment for severe blood loss
... of isotonic fluids given after several studies demonstrated that sudden increases in blood pressure (without immediate bleeding control) would "pop" clots
that the body forms to control bleeding.
Over several decades, studies involving humans and animals have evaluated hypertonic saline (up to 7.5 ...
NHLBI issues first US von Willebrand Disease clinical practice guidelines
... may be prescribed to replace von Willebrand factor, or increase the release of it into the bloodstream (desmopressin), to prevent the breakdown of clots
(antifibrinolytics) or to control heavy menstrual bleeding in women (oral contraceptives).
According to the guidelines, it is important for people ...
Ireland Cancer Center researchers advance stem cell gene therapy
... to rescue the damaged cells.
Dr. Keith McCrae and colleagues presented that 2 glycoprotein is a cofactor in the process that dissolves blood clots
through the use of the medical agent tPA.
Protein controls blood vessel formation, offers new drug target
... in 1997. It was originally found in blood platelets. CIB1 keeps blood platelets from sticking together, acting as a natural anti-coagulant to prevent clots
that might lead to heart attacks or strokes. But further research showed CIB1 appears in almost every cell type in the body, Parise said. For ...
Blood clotting protein linked to rheumatoid arthritis
... and bleeding within joints. Dr. Degen and his colleagues explained that in arthritic joints, the mesh-like matrices formed by fibrin to create blood clots
may control local activity of inflammatory cells as well as support inappropriate tissue reorganization.
$22 million gift from Alfred Taubman launches new biomedical research institute
... DeJong Professor of Neurology.
David Pinsky, M.D., a cardiologist and scientist who studies proteins involved in preventing the formation of clots
inside blood vessels, which could lead to a new class of drugs to prevent strokes and heart attacks. Dr. Pinsky is also chief of the Division of ...
How cancer spreads by aggregating platelets
... it from attaching to platelet cells. The scientists are also investigating the role of the podoplanin-CLEC-2 interaction in the formation of blood clots
and the development of lymphatic vessels. ...
Genetics determine optimal drug dose of common anticoagulant
... with genetic testing to predict the therapeutic warfarin dose. Since warfarin is often prescribed after major orthopedic surgery to prevent blood clots
in the legs, the study followed 92 adults undergoing either total hip or knee replacement at the Washington University Medical Center, who had never ...
Exploring the molecular origin of blood clot flexibility
... How do blood clots
maintain that precise balance of stiffness for ... as a molecular spring, explaining one way that clots
may stretch and bend under such physical stresses ... healing, stroke, and cardiovascular disease.
are a three-dimensional network of fibers, made ...
Newer imaging techniques may lead to over-treatment
... in the lungs, including detecting small blood clots
not previously seen, but seeing more may have ... throughout the lungs, and to detect small clots
in those arteries, said J. David Prologo, MD, ... he said. "It is possible that we missed small clots
in the patients that had a single-detector CT ...
Polymers with copper show promise for implanted sensors
... measure blood chemistry. In the bloodstream, clots
form on the surface of implanted sensors or blood ... in the accuracy of the sensors and fewer clots
on the sensor surfaces when we use nitric ... if these materials are as effective at preventing clots
as the nitric oxide-releasing polymers they ...
UW launches study testing adult stem cells for heart damage repair
... or blocked by plaque deposits and blood clots. Poor blood flow and blood clots
"starve" and injure the heart muscle.
The American Heart Association ... that they limit the flow of blood to the heart and send small blood clots
downstream, blocking the small blood vessels in the heart.
Jefferson scientists find high glucose before surgery raises risk of dangerous complications
... a pulmonary embolism, a life-threatening condition in which blood clots
travel to the lungs, after surgery, a rate that is 6.2 times greater than ... before and during surgery could actually result in a lower risk of blood clots
and pulmonary embolism. He also would like to explore some of the ...
Polymer aids in blood clotting, pointing way to new treatment
... a linear polymer known as polyphosphate speeds blood clotting and helps clots
last longer. The paper appears online this week (Jan. 9-14) on the PNAS ... bleeding.
"The net effect is accelerating the rate at which blood clots
form and then prolonging how long they last," Morrissey said.
Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
... the previous 12 months, as well as patients with a prior history of blood clots
or who were on blood thinners. Serious bleeding and blood clots
were rare in this study. Patients receiving the combination of paclitaxel ...