Clones in Biological News

Carnegie donates landmark clones to biology

... on in the nucleus. They just donated 2010 of the clones for genes that function in the cell's interaction ... and prevent toxicity. "The newly donated 2010 clones will now be used to see how common such ... the importance and the potential that the new clones have for understanding a spectrum of problems ...

Texas-sized tract of single-celled clones

... report of a large, natural colony of amoebae clones -- a Texas-sized expanse measuring at least 12 ... clonal colonies. For example, one colony of aspen clones in Utah contains more than 40,000 trees that ... In contrast, the short-lived patch of amoeba clones contained millions of genetically identical ...

Human clones: New U.N. analysis lays out world's choices

... program to ensure that the wider society treats clones with respect and ensure they are protected ... about underdeveloped technologies producing clones with serious deformities or degenerative ... event is not far off, most experts agree. clones have been achieved with mice, sheep, pigs, cows ...

Study finds role for parasites in evolution of sex

... and the rates of parasite infection for both. The team found that clones that were plentiful at the beginning of the study became more susceptible ... parasites over time. As parasite infections increased, the once plentiful clones dwindled dramatically in number. Some clonal types disappeared entirely. ...

P[acman]-generated fruit fly gene 'library': A new research tool

... researchers led by Baylor College of Medicine has established a library of clones that cover most of the genome of Drosophila melanogaster (fruit fly) and ... so that a researcher can choose a gene and find the corresponding clones in the library that cover that gene. Their collaborators at Lawrence ...

Animal eggs not suitable substitutes to produce stem cells

... not produce the same results. Although the human-bovine and human-rabbit clones looked similar to the human-human embryos, the human-animal hybrids did not exhibit the changes in gene expression seen in the human-human clones and normal embryos. Specifically, they did not achieve up-regulation of ...

Tips on how to build a better home for biological parts

... database but also the collection of publicly available DNA sequences or clones (BioBricks) that are used to make the biological devices and systems. The analysis of the Registry database and the associated DNA clones identified several key needs where improvements could be made. These ...

Cancer-causing protein can also help fight the tumors it causes

... the membranes of the cells temporarily fuse together. What is certain, however, is that once t-cells acquire mutated Ras, they are able to generate clones with the ability to respond against this specific threat. "When immune cells scan their targets they bind to their targets," he says. "When ...

Uncultured bacteria found in amniotic fluids of women who experience preterm births

... of events." In addition to the bacteria identified by cultures by using a new detection process which amplifies the 16SrRNA bacterial gene and clones it in order to identify its sequence, the researchers were able to identify a number of harmful bacteria not detected by cultures of which some have ...

ETH Zurich study on salmonella self-destruction

... whether an individual salmonella bacterium cell self-sacrifices, or whether it will wait and benefit from the sacrifice of others? The two groups are clones of the same genotype, so genetic differences do not play a role. Rather, the difference between the two groups is a result of random molecular ...

NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use

... Huang, Ph.D., University of California, San Diego, La Jolla $2.5 million (4 years) Genome Sequencing by Natural DNA Synthesis on Amplified DNA clones Building on recent advances in sequencing by synthesis in several laboratories, and this lab's advances in preparing very large numbers of ...

UCSF researchers identify virus behind mysterious parrot disease

... "This provides a very compelling lead in the long-standing search for a viral cause of PDD," Ganem said. "With the development of molecular clones and diagnostic tests for ABV, we can now begin to explore both the epidemiology of the virus and how it is linked to the disease state." ...

New antibiotic beats superbugs at their own game

... 2008 issue of the journal Antimicrobial Agents and Chemotherapy and available online now, looked at how well Ceftobiprole worked against bacterial clones that had already developed resistance to other drugs. In every case, Ceftobiprole won. "It just knocked out the cells 100 percent," says the study's ...

Drought tolerance in potatoes

... 2000 genes that were differentially regulated under drought conditions. Many of these genes contribute to the increased drought tolerance of the two clones under investigation. Up-regulated genes included transcription factors and cell signaling-related genes such as kinases and phosphatases, which ...

Sand dollar larvae use cloning to 'make change,' confound predators

... in a way exchanging a dollar for a couple of dimes. University of Washington biologists have found that 4-day-old sand dollar larvae created clones of themselves within 24 hours of being exposed to fish mucous, a cue that predators are near. In each case, the cloning process resulted in a small ...

Is hybridoma production about to take a quantum leap forward?

... they found that the cloneability of cells from a semi-stable clone is also enhanced in NPD-based media. The researchers noted that hybridoma clones grown on NPD-based media secreted more monoclonal antibodies into their environment. However, they also observed that Some cells grow faster in ...

Study proposes new theory of how viruses may contribute to cancer

... We believe a separate mechanism may be at play in which a cellular insult, such as infection with a virus, selects a few pre-existing mutated clones of cells, promotes their further growth and multiplication, eventually leading to the emergence of fully cancerous cells. Consequently, similar to ...

Smithsonian scientists working to save microscopic threatened species

... already know, coral can be easily reared in captivitynew colonies can grow from broken fragments of parent colonies. Those new colonies, however, are clones with the same genetic makeup as the parent coral. For this reason, the National Zoos work with the artificial insemination and captive breeding ...

Clones on task serve greater good, evolutionary study shows

... that produce scads of genetically identical offspring like microbes, plants or water fleas. These creatures provide a chance to wonder about the clones raised in near-identical environments that turn out differently than their kin. In this weeks Proceedings of the National Academy of Sciences, a ...

Cloned mice created from fully differentiated cells, a milestone in cloning research

... Previous attempts by scientists to produce animal clones directly from fully differentiated B cells, T ... have countered these are not bona fide clones because they possess chromosomes that are not ... cloning's limited success to a theory that clones must be derived from adult stem cells, which ...

Protein structure initiative launches new resources for the scientific community

... and function. Researchers will be able to order clones for a minimal fee to cover processing, handling, and shipping. "Producing clones is an essential--and often time-consuming--step ... the current centers to produce a total of 20,000 clones annually. Knowledgebase In fall 2007, ...

Caterpillars tell us how bacteria cause disease

... covers most of the genome. They then inject the clones into Tobacco Hawkmoth Caterpillars to study the effects. Their work has shown that clones containing harmless genetic material are ... by the caterpillar's immune system while clones which contain genes which encode for virulence ...

Exploring the dark matter of the genome

... genes were assembled by comparing numerous copies with unique or sufficiently distinctive sequences. The assembly was checked by matching it to clones of longer sequences. With the painstaking manual assembly taken as far as practical, the researchers mapped the sequences to their physical locations ...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

... to clone copies of the RPL8 antigen from a melanoma. The scientists then showed that a peptide of RPL8 could stimulate a response in helper T cell clones and lymphocytes in four out of nine melanoma patients. The antigen created no response in cells taken from healthy donors. The study also showed ...

Lab research may one day lead to cancer treatment using patient's own immune cells

... set of immune cells, called T cells, to fight skin cancer (melanoma) and breast cancer. The research project is called "Molecular studies of T cell clones for adoptive therapy." The pre-clinical trial, which means it will be used only in human tissues in the laboratory at this stage, will focus on ...

No sex for 40 million years? No problem

... wet habitats including ponds, rivers, soils, and on mosses and lichens. These tiny asexual creatures multiply by producing eggs that are genetic clones of the mother ?there are no males. Fossil records and molecular data show that bdelloid rotifers have been around for over 40 million years without ...

Study of planarians offers insight into germ cell development

... to get at the mechanisms that tell a cell: ‘You’re going to be a germ cell.?" S. mediterranea also has the ability to reproduce asexually: It clones itself by means of fission. In looking at nanos in asexual individuals of this species, the researchers made the surprising discovery that these ...

The power of one: A simpler, cheaper method for cell fusion

... engineer Chang Lu has done just that with a new and cheaper method to electrically fuse cells - a vital technology for studying stem cells, creating clones and finding disease antibodies. "The only current method for electrofusion requires a very expensive and specialized electrical pulse generator," ...

PNAS study reveals why organs fail following massive trauma

... one of those immune cells, called lymphocytes, recognizes a bacterium or virus presented by the innate system, that lymphocyte expands into army of clones specifically designed to attack the invader at hand. Unfortunately, lymphocytes too are capable of mistakenly destroying human cells. Thus, they have ...

Scientists discover that ancient genes dictate flowering, fall bud set

... have been doing research to make genetically engineered trees sterile so that they cannot cross with wild trees -- used consecutive years of poplar clones to study the multi-year delay in flowering. The Science paper reports their discovery that the expression of the FT gene increases with age. "This ...

Cloned stem cells prove identical to fertilized stem cells

... source. As a result, the developing fetus inevitably has some degree of genetic abnormality. Most clones, in fact, die in utero or at birth. The few clones that make it into adulthood are often plagued by bizarre health complications. This is one reason why scientists generally believe that attempting to ...

Scientists observe how a close bond activates the immune system

... may last hours, and if the antigen is deemed a threat the T cell starts multiplying, eventually producing thousands of copies of itself. These T cell clones are capable of killing invaders outright and marshaling other cells to destroy them. In the new study, Gabriele Campi, a graduate student in Dr. ...

New study to explore cellular circuitry

... library of 6000 clones, or exact copies of the genes of the yeast cell, one clone for each known protein present in the cell. What makes the set of clones useful is that each one manufactures large amounts of a single protein with a "tag" attached. One common application of the library is to separate ...

Community MRSA is re-emergence of 1950s pandemic, study suggests

... waned throughout the 1960s as the antibiotic meticillin was used to treat these infections. Now researchers have shown that one of the key clones of community acquired MRSA (CA-MRSA) - infections picked up in public places which are resistant to treatment by powerful meticillin antibiotics - ...

Stem cell research - new cell lines

... In an Australian first, UNSW researchers have developed three clones of cells from existing human embryonic stem cells. The breakthrough could lead to new treatments for diabetes, Parkinson's disease and spinal cord ...

Building a human kinase gene repository

... of pathological conditions, which make kinases key targets in drug discovery efforts, primarily in oncology. This collection is unique because clones in the collection represent protein kinases as well as non-protein kinases, are fully sequenced verified, full-length, and can be sub-cloned by ...

New tumor-suppressor gene discovered

... ways. "A mutant gene is not going to make the protein product that the normal gene is able to make," Lai explains. Lai then generated mutant clones of this fly and found that they developed large tumors in many organs including the head, eye, wing, leg, and antenna. He also generated another ...

Cytoplasm affects the number of vertebrae in carp-goldfish clones

... to 28. Six of the seven cloned fish had between 26 and 28 vertebrae; one had 31. Although the initial rate of success in producing carp-goldfish clones is low--seven offspring in 501 attempts in this study--the authors believe that cross-species transplantation will lead to improved understanding of ...