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15-year hunt finds cause of pseudothalidomide syndrome

...drome, whose physical manifestations often include cleft lip and palate and shortened limbs that resemble those of babies whose mothers took thalidomide during pregnancy. The discovery, which is reported in the April 10 advance online section of Nature Genetics, proves that genes behind very rare inherite...

Determining The Fate Of Cells In The Human Body

... are many congenital defects - holes in the heart, cleft pallet, webbed hands -- which are outcomes of inappropriate molecular programs due to miscommunication at the cellular level. If we can understand what is going wrong, we may be able to correct these problems before birth," said Dr. Firulli. Co-auth...

One hit of crystal meth causes birth defects

...ing pregnancy is associated with low birth weight, cleft palates and other malformations but this is the first research demonstrating that even a single exposure can cause long-term damage," says Wells. "It's pretty remarkable that a single low dose can have such an effect. "It's an important finding, giv...

Defect in gene causes 'neuralgic amyotrophy'

...vers the inside corner of the eye, and sometimes a cleft palate. HNA is a relatively rare disorder: the disease appears in some 200 families worldwide. There is also a non-hereditary form of HNA, called the Parsonage-Turner Syndrome. The clinical picture of this more frequently occurring form - 2 to 4 ca...

UCSD study finds anthrax toxins also harmful to fruit flies

...f sutures in the epidermis, resulting in a hole or cleft in thoracic regions of embryos and adults. This developmental process disrupted by LF treatment is similar mechanistically to wound healing, which is mediated by the same signaling pathway in humans. The EF toxin is also lethal when applied to fly l...

Making a face: A new and earlier marker of neural crest development

...lls of the peripheral nervous system. In humans, cleft palate, heart valve malformations and various tumors are among the common malformations associated with disruption of neural crest development. Chick embryos have well-characterized stages and are a valuable model for examining vertebrate developm...