Chemotherapy in Biological News

Potential for non-invasive brain tumor treatment

... invasive treatment of brain tumors by combining chemotherapy with heat administered from the end of a ... the traditional approaches of surgery, systemic chemotherapy or radiation. The bioengineers designed and ... envision using this system in conjunction with chemotherapy drugs encased in heat-sensitive microbubbles ...

Common chemotherapy drug triggers fatal allergic reactions

... CHICAGO -- A chemotherapy drug that is supposed to help save cancer ... patients had received medications before the chemotherapy to reduce the risk of hypersensitivity reactions. ... of corticosteroids and other medications before chemotherapy administration to reduce the risk of ...

Tumor growth and chemo response may be predicted by mathematical model

... of tumors and their susceptibility to chemotherapy may become easier to predict based on a ... of tumor growth in brain cancer and chemotherapy response in breast cancer. Findings appear in two ... said Hermann Frieboes, Ph.D., lead author of the chemotherapy study and a post doctoral fellow at the UT School ...

New tool for next-generation cancer treatments using nanodiamonds

... ability to moderate the release of highly toxic chemotherapy drugs and other therapeutics. This provides a ... a polymer patch that could be used to deliver chemotherapy drugs locally to sites where cancerous tumors ... over a period of months, reducing the need for chemotherapy following the removal of a tumor. "An ...

Joining forces to improve lung cancer treatment

... with operable cancer, surgery followed by chemotherapy can result in good outcomes. Now, large clinical ... benefit in clinical trials. Combinations of chemotherapy and radiotherapy are also improving outcomes of ... study comparing radiotherapy alone to sequential chemotherapy and radiation in locally advanced non-small-cell ...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... predict how a given cancer will respond to chemotherapy would spare patients with non-responsive tumors ... treatment an initial phase of intense chemotherapy followed by additional chemotherapy cycles or bone marrow transplantation. Yet only ...

Taste, odor intervention improves cancer therapy, according to Virginia Tech, Wake Forest study

... 30, 2009 Cancer and its therapies, including chemotherapy and radiotherapy, may directly alter and damage ... two thirds of cancer patients who receive chemotherapy report altered sensory perception, such as ... as much as 55 percent of the patients receiving chemotherapy or radiotherapy. From their review of the ...

ChemoBrain: How cancer therapies can affect your mind

... who have undergone the standard or high-dose chemotherapy to defeat the disease unfortunately suffer from a ... but poorly understood side effect of chemotherapy treatment, while alsoin an objective journalistic ... jargon and explains in understandable terms how chemotherapy works at the most basic biological level. In ...

New test for breast cancer will help guide treatment choices

... high accuracy which women are going to respond to chemotherapy and which type of chemotherapy will work." Only recently have scientists ... beneficial. For some patients that could mean no chemotherapy at all. For others it will mean targeted ...

Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer

... gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer' i, published in Nature ... factors that influence response to cancer chemotherapy is crucial for improving its efficacy. The ... status), respond differently to the same kind of chemotherapy treatment. "Two breast cancer patients might ...

New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome

... chemotherapy is an integral part of modern cancer treatment, but it's not always effective. Successful chemotherapy depends on the ability of anticancer drugs to ... to the ability of a clinically approved chemotherapy agent to enter the tumor, allowing the ...

Weizmann Institute scientists discover how cancer cells survive a chemotherapy drug

... What separates the few cancer cells that survive chemotherapy leaving the door open to recurrence from those ... thousands of living cells to reveal exactly how a chemotherapy drug affects each one. For research student ... the cells, so the computer could identify them. A chemotherapy drug was introduced 24 hours into this period, ...

Hypertension and cholesterol medications present in water released into the St. Lawrence River

... treatment plant has revealed the presence of chemotherapy products and certain hypertension and cholesterol ... body in urine and end up in municipal wastewater. chemotherapy products, such as methotrexate, are excreted by ... (80 to 90 percent in their initial form). chemotherapy for fish? The pharmaceutical compounds studied ...

Research shows cell's inactive state is critical for effectiveness of cancer treatment

... of mature blood cells. They showed that when chemotherapy or radiation is delivered to a cell that lacks ... the sensitivity of normal bone marrow cells to chemotherapy and radiation. They have now identified p53 as ... cells, we may enhance the anticancer effects of chemotherapy and radiotherapy, thereby promoting their ...

MIT nanotubes sniff out cancer agents in living cells

... of carbon nanotubes wrapped in DNA, can detect chemotherapy drugs such as cisplatin as well as environmental ... . Such sensors could be used to monitor chemotherapy patients to ensure the drugs are effectively battling tumors. Many chemotherapy drugs are very powerful DNA disruptors and can ...

Repairing DNA damage: Researchers discover critical process in cancer treatment

... and promote cancer," adds Dr. Drobetsky. chemotherapy implications The goal of conventional chemotherapy is to kill tumour cells leaving normal cells ... may therefore be an important first step to chemotherapy prescribing practices," says Yannick Auclair, the ...

Nanodiamond drug device could transform cancer treatment

... biomedical device that could be used to deliver chemotherapy drugs locally to sites where cancerous tumors ... demonstrated that the device releases the chemotherapy agent Doxorubicin in a sustained and consistent ... side effects and complications from other chemotherapy treatments. "Several surgeons at ...

Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs

... to cancer patients. But some classes of chemotherapy drugs produce "oxygen free radicals," unpaired ... radicals, keeping the cancer cell alive despite chemotherapy treatment. Heaney and his colleagues tested a wide variety of chemotherapy drugs those that produce reactive oxygen and ...

Experimental chemotherapy regimen shows promise in treating advanced lung cancer

... PHILADELPHIA A combination of chemotherapy agents that have been tested in other tumor types ... from standard treatment with platinum-based chemotherapy regimens. Because the study had only a single ... experimental regimen and platinum-based "doublet" chemotherapy should be conducted to confirm what appears to be ...

Immunotherapy in high-risk pediatric sarcomas shows promising response

... the immune system of patients recovering from chemotherapy is malleable, so we just need to find the best ... the general idea of using immunotherapy following chemotherapy to prevent recurrence is not a flawed one. chemotherapy depleted the immune system, but we could restore ...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

... due to its high resistance against the current chemotherapy strategy. In order to improve the quality of ... regulation of cellular death and resistance to chemotherapy was not known. Cholesterol is an indispensable ... in the mitochondrial membrane was responsible for chemotherapy resistance. In collaboration with the University ...

CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients

... quality of life for cancer patients undergoing chemotherapy and radiation therapy. These data will be ... effect experienced by cancer patients receiving chemotherapy and radiation therapy, commented principal ... (COMFORT). Patients must have been undergoing chemotherapy and radiation and at high risk of developing OM. ...

Herceptin and chemo improves response rates without major adverse effects in HER2 breast cancer

... treated with a combined anthracycline and taxane chemotherapy regimen before surgery, together with trastuzumab ... no increase in toxicity for the combination chemotherapy plus trastuzumab compared with chemotherapy alone. There were no cases of congestive heart ...

New type of drug shrinks primary breast cancer tumors significantly in just 6 weeks

... residual cancers that were exposed to such chemotherapy showed an increase in tumour-causing cells and ... by regenerating the tumour after attack from chemotherapy drugs. This indicates that the stem cells themselves should be the specific target of chemotherapy drugs, said Dr: Rodriguez. Rather than the broad ...

New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients

... tumour had reacted to the administration of the chemotherapy drug. However, we found no difference in ... find was that the addition of capecitabine to the chemotherapy regime produced more non-haematological ... in early breast cancer. Prolongation of chemotherapy also has the effect of reducing patient ...

Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors

... The first study to investigate the effects of chemotherapy on metastatic breast cancer in women with the BRCA1 or BRCA2 gene mutation has shown that standard chemotherapy works better in these patients than in women ... methotrexate and fluorouracil 5FU) or other chemotherapy regimens. BRCA2 women had a higher response ...

Mounting evidence shows red wine antioxidant kills cancer

... Center. Although red wine consumption during chemotherapy or radiation treatment has not been well studied, ... cell membranes that are responsible for pumping chemotherapy out of the cell, making the cells ... process, however, ends up ridding the needed chemotherapy from cells in the pancreas. But just as ...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... single mass tumor, the combination of surgery and chemotherapy has led to cure rates of 90 to 95 percent. In ... cells are often able to survive ordinary doses of chemotherapy and radiation, leading to relapses that are ... has been a leader in developing high-dose chemotherapy used in combination with bone marrow transplants ...

A search for protection against chemotherapy cardiotoxicity

... pretreatment protects against acute chemotherapy toxicity in isolated rat hearts will be featured ... for oncology. Cardiomyopathy induced by chronic chemotherapy may result, at least in part, from acute ... administration could, therefore, be used during chemotherapy administration to reduce acute cardiotoxic ...

Ireland Cancer Center researchers advance stem cell gene therapy

... the ultimate goal of being able to use stronger chemotherapy treatment with less severe side effects. Under ... cells to protect these cells from the damage of chemotherapy regimens. In one of 24 presentations by ... and colleagues presented a novel way of treating chemotherapy -induced thrombocytopenia (decrease in number of ...

Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream

... them to test the effect of various experimental chemotherapy agents and therapeutic strategies in mice with multiple myeloma. Testing the effect of new chemotherapy agents in the bloodstream of a mouse has ... the team to observe what happens when different chemotherapy agents are given to rodentsa standard early ...

Nanoengineers mine tiny diamonds for drug delivery

... smaller scale -- are very effective at delivering chemotherapy drugs to cells without the negative effects ... were shown to be ideal for carrying a chemotherapy drug and shielding it from normal cells so as not ... and doxorubicin hydrochloride, a widely used chemotherapy drug. The drug was successfully loaded onto the ...

Trial seeks 'genetic fingerprint' for predicting drug effectiveness

... trial to test the effectiveness of combined chemotherapy and radiation therapy given to patients with ... Previous studies have established that either chemotherapy or radiation therapy after surgery can improve ... shown a benefit to follow-up therapy with either chemotherapy or radiation therapy, says Ahmad, assistant ...

Last chance for media to register for ECCO 14 -- the European Cancer Conference

... are likely to have a recurrence of cancer after chemotherapy treatment Figures on cancer control in Europe ... fingerprint for resistance to commonly used chemotherapy drug can predict response to treatment in breast ... or ultrasound in detecting a tumours response to chemotherapy and the patients likelihood of survival Can ...

UC health news: molecular pathway may predict chemotherapy effectiveness

... which lung cancer patients will benefit from chemotherapy drugs, according to new research from a ... cancer cells resulted in an altered response to chemotherapy agents and more cancer cell death. They report ... the RB pathway will help us better understand how chemotherapy works and predict which patients might benefit ...

American Chemical Society's Weekly PressPac -- Aug. 15, 2007

... women, study finds Cranberries may improve chemotherapy for ovarian cancer Source of coffees ... p.m., Eastern Time Cranberries may improve chemotherapy for ovarian cancer Compounds in cranberries ... effectiveness of platinum drugs that are used in chemotherapy to fight ovarian cancer, researchers have found ...

Advances in lung cancer research announced at conference

... tumors. In one, they are treated with TH-302 in combination with other chemotherapy agents. In the other, they are treated only with TH-302, which is produced ... In the study of those treated with TH-302 in combination with other chemotherapy agents, eight of 12, or 67 percent, of patients with NSCLC "achieved ...

Tips from the journals of the American Society for Microbiology

... findings in the June 2009 issue of the journal Antimicrobial Agents and chemotherapy . Innate immunity, the universal defense system shared by all ... L5, through activation of host immunity. Antimicrobial Agents and chemotherapy , 53. 6: 2510-2516.) New Vaccination Strategy May Protect Against ...

NC State researchers find soy may aid in treating canine cancers

... Research . "Humans have been using soy in conjunction with traditional chemotherapy for some time as a chemo potentiator," Suter says. "This means that the GCP makes the chemotherapy work more efficiently and faster, which translates to less stress on the ...

U-M researchers ID gene involved in pancreatic cancer

... is that it is biologically aggressive and it does not respond well to chemotherapy or radiation. We found that ATDC not only causes the cancer cells to grow ... aggressive, but it also makes the cancer cells particularly resistant to chemotherapy and radiation. By targeting this gene, we may be able to make cancer cells ...