A gene's first 'kiss' sets off that affair known as puberty
...tradiol, the culprits responsible for the physical changes and emotional baggage of male and female puberty, respectively. "We now have very good evidence that the GPR54 gene and its switch, the kisspeptin protein molecule produced by KiSS-1, are key to the initiation of puberty, when GnRH is released," Dr....Wisconsin scientists grow critical nerve cells
... believed. Rather, a series of complex overlapping changes may well be the developmental norm in higher vertebrates such as humans. "We cannot simply translate studies from animal to humans," says Zhang. The next step, Li says, will be to test if the newly generated neurons can communicate with other cells...Man and mouse share genome structures
... different genes are on." Many scientists believe changes in the regulatory scaffolding surrounding the genome may be as important as changes in the genome itself in causing diseases such as cancer. This regulatory structure, called chromati...A new mechanism of regulating RNA degradation
...cell signaling pathways, such as those mediated by changes in growth conditions." That would allow the cell to differentially control the level of SMD-target RNAs, while leaving the NMD-regulated RNAs untouched. This is likely to be the "tip of the iceberg" for Staufen1's function in mammalian cells, said M...FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
...cell signaling pathways, such as those mediated by changes in growth conditions." That would allow the cell to differentially control the level of SMD-target RNAs, while leaving the NMD-regulated RNAs untouched. This is likely to be the "tip of the iceberg" for Staufen1's function in mammalian cells, said M...Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
...mulation of DNA damage and accelerates the genetic changes involved in carcinogenesis. To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia Un...Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
...zed assunburn of the skin ?and may cause permanent changes in the DNA(mutations) that ultimately can result in the onset of skin cancer.Thus far it was not clear how the two major types of UV-induced DNAlesions ?cyclobutane pyrimidine dimers (CPDs) and (6-4)photoproducts(6-4PPs) ?contribute to the processes ...Elusive HIV shape change revealed; Key clue to how virus infects cells
...key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue ...Mouse brain cells rapidly recover after Alzheimer's plaques are cleared
...ages of nerve cellbranches.To correlate brain cell changes with plaque development, Brendzainjected another dye, developed by scientists at the University ofPittsburgh, that temporarily sticks to amyloid. He showed that as theplaques appeared, nearby branches of nerve cells developed bumps andswellings."If y...Key molecule in plant photo-protection identified
...ages of nerve cellbranches.To correlate brain cell changes with plaque development, Brendzainjected another dye, developed by scientists at the University ofPittsburgh, that temporarily sticks to amyloid. He showed that as theplaques appeared, nearby branches of nerve cells developed bumps andswellings."If y...Timing is everything: First step in protein building revealed
...r, thefluorescent chemicals subtly interact, which changes the color orwavelength of light that is given off. If the distance between thefluorescent molecules changes, the color of the emitted light changesas well.The researchers successfully used this phenomenon, known asfluorescence resonance energy transf...Plants respond similarly to signals from friends, enemies
...he plant. Signals from both outsiders induce rapid changes in distribution of the plant's cytoskeleton, which...part of a pathway that leads to a series of growth changes that include the formation of either nodules housing bacteria or giant cells from which the nematode...Whole genome fine map of rice completed
...ing distribution of the hybrid genes in F1 and the changes of physiological traits, thus revealing the source of the hybridization advantage in hybrid rice. ...Breakthrough Microarray-based Technology for the Study of Cancer
...comparative genomic studiesin cancer. Chromosomal changes incancer can be studied using Comparative genomic ...toanother, as cancer develops. Understanding these changes is key tounderstanding cancer progression as well as developing possibletherapies and prognostic and...New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
...ovement, of water through the brain and mapped the changes in diffusion from the start of therapy to three we...diffusion. "In the end, we found if the diffusion changes in any way, up or down, it correlates to a positive outcome. The magnitude or amount of change relat...Scientists collaborate to assess health of global environment
... will require significant policy and institutional changes not currently under way, the global assessment will conclude. ...Essential mangrove forest threatened by cryptic ecological degradation
... research team argues that early detection of such changes should be adopted and is essential for the prevention of further mangrove degradation. F. Dahdouh-Guebas, S. Hettiarachchi, D. Lo Seen, O. Batelaan, S. Sooriyarachchi, L.P. Jayatissa, and N. Koedam: "Transitions in Ancient Inland Freshwater Resource...Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine
...termine the shape of this protein, which undergoes changes as itinteracts with pIgR,?said Rensheng Luo, Ph.D., a post-doctoral fellowin St. Jude Structural Biology and Infectious Diseases and first authorof the paper....New comparative toxicogenomics database
...termine the shape of this protein, which undergoes changes as itinteracts with pIgR,?said Rensheng Luo, Ph.D., a post-doctoral fellowin St. Jude Structural Biology and Infectious Diseases and first authorof the paper....Scientists develop new color-coded test for protein folding
...ntists have developed a simple test that instantly changes color when a protein molecule attached to a gold n... inexpensive sensor for determining when a protein changes its conformation," said study co-author Richard N. Zare, the Marguerite Blake Wilbur Professor in Na...Highly adaptable genome in gut bacterium key to intestinal health
...r of its genes into high gear when its host's diet changes from sugar to complex carbohydrates. This adaptiv... and redistributes energy from the diet." Because changes in the composition of this "microbial organ" may be deleterious to human health, it is important to ...Researchers trace evolution to relatively simple genetic changes
... evolution at work, scientists have now found that changes in a single gene can produce major changes in the skeletal armor of fish living in the wild. The surprising results, announced in the March 25...Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
... evolution at work, scientists have now found that changes in a single gene can produce major changes in the skeletal armor of fish living in the wild. The surprising results, announced in the March 25...Studies reveal methods viruses use to sidestep immune system
...cally binds the virus genetic material. RIG-I then changes its shape, which sends a cascade of signals to other proteins to activate a transcription factor called interferon regulatory factor 3 (IRF-3). This protein turns on the genes responsible for producing interferon, which neutralizes viruses by suppres...Development of portable infectious disease detector
...iniaturized this sensor technology to record rapid changes in themetabolism and signaling of individual cells. To handle such smallnumbers of cells, they have adapted a method for molding micro-channelsand valves into a material similar to that used in soft contact lenses.This has given them the capability t...Alcohol's effects on gene expression in the central nervous system
...hange gene expression in the brain, and that these changes are likely responsible for many of the 'symptoms' ...ological processes," said McBride, "and that these changes are different in several brain regions which may be involved in alcohol addiction." # Researchers h...Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
..." The technique is effective because "it measures changes in the cell architecture, especially those arising...skeleton shape, and distribution of mitochondria - changes that occur when a cell becomes cancerous," says Gourley. "One would think that if a cell became non...Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease
...retracting the tip of their AFM, which can measure changes in force at the atomic scale. Pulling back the tip can induce a measurable tug on the chemical bonds that hold together the two elevated monomers. By pulling on such bonds, the Duke scientists can deduce how much energy was required to bring the mol...Tiny scaffolding allows stem cells to become working fat cells
... said. "And that biology is always translated into changes in gene expression and assemblies of proteins." That is why the three-dimensional scaffolding for cell growth in the laboratory is so important. The researchers' focus on fat cells as a test bed for this approach to cell growth offers important medi...Devising Nano Vision for an Optical Microscope
...attering patterns are extremely sensitive to small changes in the shape and size of the scattering feature,?explains Rick Silver, a physicist in NIST’s Precision Engineering Division. ...UCSD discovery may help extend life of natural pesticide
...ched to a tree-like arrangement of sugars. Because changes in the sugars impact Bt's ability to bind, the res...sect resistance in its early stages by looking for changes in glycolipids," said Aroian. "If changes are detected, switching to another pesticide, perhaps even...Study of genomic DNA leads to new advances in cancer diagnostics
...methods to treat cancer. Ultimately, the cellular changes that occur during cancer formation affect how the ...teracts with its microenvironment (ECM) and direct changes to the cytoskeleton and finally to the chromatin. Such changes can now be measured directly at the c...Bird Brains Show How Trial and Error May Contribute to Learning
...the brain is important for instructing or allowing changes in the song," said Mimi Kao, first author of a pap...ding females. Kao wondered whether she could cause changes in bird song by manipulating this region. Learning takes some time, so Kao expected to wait for her...The Bacteria's guide to survival
...lleagues present evidence that bacteria can induce changes in hosts' gene expression - and possibly keep the host cells alive longer - through tiny tugs on cell membranes. The study examined gene activity in human epithelial cells infected with Neisseria gonorrhoeae, the bacteria responsible for the sexually...South America's vast pantanal wetland may become next everglades, UNU experts warn
...ttle ranching, energy production, mining and other changes in land use in and around the Pantanal. "Without ...rough wetlands drainage and destruction. Already, changes in land use and land cover account for about 1.6 gigatonnes (17%) of annual human-caused carbon emis...X-Ray Beams And Fruit Fly 'Flight Simulator' Aid Scientists' View Of Muscle Power
...intense X-rays allowed the researchers to identify changes in the crystal-like arrangement of molecules respo...rchers could reconstruct a ‘movie?of the molecular changes in the powerful muscles as they lengthen and shorten to drive the wings back and forth 200 times eac...Implanted Devices Detect High-Risk Heart Failure Patients
...ices are giving cardiologists a new view of subtle changes in a key measurement of heart health -- heart rate...electrophsysiology at Duke. "This study shows that changes in heart rate variability just might be better in picking out those people at highest risk." In the...VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
...ersity researchers have identified several genetic changes in the brains of mice caused by ethanol, which may...l. Researchers also determined whether genes with changes in expression had a functional relationship with each other. For example, they determined that many ...Sequencing of marine bacterium will help study of cell communication
...processes that occur at the point that a bacterium changes its gene expression pattern in response to quorum sensing," she said. The genome sequence has allowed Stevens to begin exploring the connection between quorum sensing and other global regulatory networks through a combination of comparative genomics ...Opposing fat metabolism pathways triggered by a single gene
...nd fatty acid desaturation. Following up on these changes in gene expression, Yamamoto and colleagues show that in its normal actions, nhr-49 sets in motion two opposing pathways: it increases expression of a gene acs-2, which leads to reduction of fat content, and it increases expression of another gene fa...Vascular structure and function improve with diet and exercise
...ter the load on the heart. This often results from changes in blood pressure, blood glucose or cholesterol disorders such as dyslipidemia. Carotid artery distensibility was the only structural factor that significantly improved. It rose about 16 percent. Petrella said that the other factors may improve as p...Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
...ody can respond to future immune challenges. Those changes affect how well memories are stored. The early alterationS may be to the basic architecture of glial cells called astrocytes within the hippocampus, which in turn help the central nervous system respond to injury or infection. Because astrocytes also...Effective Cancer Treatments Follow The Clock
...that explains why sensitivity to anti-cancer drugs changes with the clock. They said their findings could lead to new drug treatments that may be more effective because they harness the power and precision of the body's internal clock. The research team, which included senior author Joseph S. Takahashi, a H...US life expectancy about to decline, researchers say
...are major contributors to obesity. "These adverse changes in diet have been driven by a multi-billion dollar marketing campaign by the food industry aimed at young children," said Ludwig. "Cutbacks in funding for regular, mandatory PE classes and limited insurance reimbursement for obesity prevention and tr...How the environment could be damaging men's reproductive health
... in order to investigate the implications of these changes on sex ratio of offspring as the number of childre...factors, the question arises as to whether adverse changes in the environmental factors affecting male reproductive health have taken place in Lithuania in the...Hirsute Or Hairless? Two Proteins May Spell The Difference
...etermine how targeted cells translate signals into changes in cell adhesion and remodeling, proliferation, and differentiation—the agents of most types of organogenesis. Since Snail, a protein that impedes the transcription of a subset of genes, functions in many developmental processes requiring epithelial...Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients
... that lead to disease. Interferon therapy produces changes in the gene expression profile of targeted cells—that is, it inhibits or activates certain genes—which in turn alters the cells' activity. Blood samples were taken from 52 patients with relapsing-remitting MS (marked by acute flare-ups followed by p...Wisconsin researchers identify sleep gene
...nd found evidence of the same electrophysiological changes occurring during sleep and wakefulness as in humans. "The electrical changes in humans look different that they do in flies because our brains are organized differently," Cirell...Live fast, die young true for forests too
...ferous forests growing at high latitudes, the same changes could take more than a century to occur. Another implication of the study is that environmental changes considered beneficial to forests may bring about unexpected forest changes. "Most attention so far h...BioMed Central welcomes the new National Institutes of Health public access policy
...n need to update their manuscript version with the changes introduced in the publication process, as many publishers specify that only the author's version of the manuscript can be submitted to archives. Those who choose to publish in any of BioMed Central's Open Access journals, which cover all areas of bi...New online portal merges vast data on Gulf of Maine ecosystem
... and currents. To illustrate, one can quickly see changes in the abundance and distribution of Atlantic Cod over the past 30 years without poring through pages of data. To see the type of visual analysis the website can offer at this time, follow this quick guide: 1- Go to: http://gmbis.iris.usm.main...Great White shark evolution debate involves WSU Lake Campus geology professor
...ysics and chemistry. "My work looks at large scale changes of life over time and how things like mass extinction affect the course of life," he said. Ciampaglio discussed his shark research findings at recent Geological Society of America meetings in Mississippi and Colorado. A scholarly journal article on ......ut. In this instance, leaving out part of the gene changes the protein. "The question is, 'How is this controlled?'" said O'Malley. He and his colleagues have shown in previous studies that hormones like estrogen and progesterone can change the amounts of proteins made by their target genes. When hormone b...Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
...erstanding the biological relevance of genome-wide changes in mRNA and protein expression, protein-protein and protein-DNA interactions. World Community Grid is enabling ISB researchers to predict three dimensional structures, which are more highly conserved than one dimensional structures. Understanding th...WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
...t of unknowns because of the violent environmental changes that have taken place here," explained Dr Jack Chow, Assistant Director-General responsible for malaria at WHO Headquarters during a visit to Banda Aceh today. "For example, we do not know whether mosquitoes - which generally mostly live and bite out...New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
...ug and medical product development process, urging changes to make the process “more predictable and less costly.?The latest estimates put the cost of bringing a new product to market at $1.6 billion to $1.8 billion. UF researchers are working on an approach known as PK/PD, which combines principles of phar...Researchers identify protein crucial for survival of Lyme-disease bacterium
...ers the tick gut, Dr. Norgard said it appears that changes in temperature and acidity signal the bacteria that the nutrient is present, triggering the bacteria to replicate in large numbers and migrate to the tick's salivary glands, where they are transmitted into animals or humans during the tick's feeding ...HIV-1 spread through six transmission lines in the UK
...cant impact on the growth of the epidemic and that changes in sexual behaviour have been more effective in sl...erally slowed in the early 1990s, more likely from changes in sexual behaviour than from reduced infectiousness resulting from antiretroviral therapy. The stu...Light therapy may combat fungal infections, new evidence suggests
...iversity Medical Center. The findings suggest that changes in light following fungal invasion of the human body may be an important and previously overlooked cue that sparks infection, the researchers said. The discovery in the human pathogen Cryptococcus neoformans further suggests that light therapy, in c...Computational Method Speeds Mapping of Cell Signaling Networks
...To function properly, cells must be able to detect changes in the environment and respond accordingly--usually by altering their behavior in some way. Cells are equipped with a sophisticated communications network that links surveillance with response, and allows the cells to perform a variety of tasks--such...