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Advances in lung cancer research announced at conference

... an Associate Investigator in TGen's Cancer and cell Biology Division and Director of Thoracic ... cancer from spreading to the brain. In non-small cell lung cancer (NSCLC), brain metastasis is a ... brain metastasis in patients with non-small cell lung cancer," Dr. Weiss said. "Identifying the ...

New cancer drug delivery system is effective and reversible

... a new cancer drug delivery system that, in cell culture, achieves all of the above. The findings ... Ideally the antibody will bind to a cancer cell receptor so that it can deliver the liposome and ... such folate, a vitamin, also work as cancer cell targeting agents, but those now in use are not as ...

Wastewater produces electricity and desalinates water

... Penn State The team modified a microbial fuel cell -- a device that uses naturally occurring ... is proof of concept." A typical microbial fuel cell consists of two chambers, one filled with ... University, Beijing, changed the microbial fuel cell by adding a third chamber between the two ...

'Green' energy from algae

... are developing closed photo-bioreactors and novel cell disruption methods. Microalgae are ... extraction methods to obtain a maximum amount of cell constituents from the algae that can be used for ... very short term. This causes a perforation of the cell membrane and the constituents are released." ...

New stem cell research could reduce number of animal experiments

... of Bath are embarking on a project to use stem cell technology that could reduce the number of animal ... She said: "These are exciting times for stem cell research and there is tremendous potential in the iPS cell technology both for medical applications and in ...

La Jolla Institute discovers novel tumor suppressor

... Center and a professor in Salk's Molecular and cell Biology Laboratory, called the finding an ... published online today in the journal Cancer cell in a paper entitled "Tumor Suppression by ... than can switch on many genes known to control cell proliferation, survival and, in the case of ...

Stem cell 'daughters' lead to breast cancer

... to normal luminal progenitor cells than any other cell type in the breast. This places the spotlight on ... faulty DNA repair and expanded luminal progenitor cell numbers ultimately resulting in breast cancer in ... c-KIT is a key marker of the luminal progenitor cell and I expect we will see an increase in ...

Got zinc? New zinc research suggests novel therapeutic targets

... volunteers to assess the effects of zinc on T cell activation. After isolating the T cells from the ... than those from the placebo group. Specifically, cell activation stimulated the zinc transporter in T ... "ZIP8," which transports stored zinc into the cell cytoplasm where it then alters the expression of ...

Study links virus to some cases of common skin cancer

... tissue samples from 58 people with squamous cell carcinoma (SCC), a highly curable form of skin ... play a role in causing some cases of squamous cell carcinoma," says principal investigator Amanda E. ... was first discovered in patients with Merkel cell carcinoma, a rare, aggressive skin cancer that ...

Little-known protein found to be key player

... McNew, associate professor of biochemistry and cell biology at Rice University. "In fact, that's ... that happens thousands of times a second in every cell of our bodies. "It is fitting that the ... tests on purified proteins, live fruit flies and cell cultures, the Italian and U.S. teams examined the ...

Reprogramming human cells without inserting genes

... LSBC, has discovered a novel way to turn on stem cell genes in human fibroblasts (skin cells) without ... its findings in the paper "Induction of Stem cell Gene Expression in Adult Human Fibroblasts ... be beneficial in development of patient-specific cell therapy approaches," the authors wrote in the ...

Stem cell research: From molecular physiology to therapeutic applications

... Stem cell research promises remedies to many devastating ... to summarize their pioneering works in the stem cell research field. Since 2001, Dr. Alex Yu Zhang ... Medical University in Beijing and is Director of cell Therapy Center at Xuanwu Hospital. His current ...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... the DLX5 gene gets flipped around during cell division cooperates with another known oncogene, ... performed in mouse cancer models and in human cell cultures. "While MYC has a definite role in ... in decreased expression of MYC and reduced cell proliferation. By adding an overabundance of MYC, ...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

... myeloid progenitors to convert them from a normal cell to AML," the authors noted, referring to several ... about what it takes to transform a normal cell into a cancer cell. "The complement of genetic ... from normal controls and allow the uncontrolled cell division that is a hallmark of cancer. Downing ...

Study reveals a reprogrammed role for the androgen receptor

... a protein ignition switch for prostate cancer cell growth and division is a master of adaptability. ... receptor of androgen hormones, thereby halting cell proliferation, the receptor manages to find an ... from androgen-dependent to androgen-independent cell growth occurs, in part, because the androgen ...

Placenta-derived stem cells may help sufferers of lung diseases

... team, publishing in the current issue of cell Transplantation (18:4), which is now available ... to evaluate the effects of fetal membrane-derived cell transplantation in chemically-treated (bleomycin) ... fetal membrane-derived cells may prove useful for cell therapy of fibrotic diseases in the future," ...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

... finding patterns of genes that regulate healthy cell differentiation are shut off in cancers. "These ... but once you have committed to become a certain cell type, like a skin cell, you need to turn the gene ... they also want to turn off, like ones that tell a cell to differenitate. For ...

Scientists track impact of DNA damage in the developing brain

... Ph.D., a member of St. Jude Genetics and Tumor cell Biology, said the work provides a new model for ... the damage triggered apoptosis, or programmed cell death. But the findings suggested the greatest ... pathway and blocked the cells from completing the cell cycle. "The cells appear to undergo permanent ...

Scientists closer to making implantable bone material, thanks to new research

... how to grow replacement bones with stem cell technology, thanks to research published today in ... types of bone cells and stem cells. All of these cell types are attracting considerable interest as ... three different commonly used clinically relevant cell types and have discovered significant differences ...

Protein that promotes cancer cell growth identified

... to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can ... from epidermal growth factor (EGF) that cause cell division and invasion. The researchers also ... through the protein kinase Src to the master cell proliferation regulator protein, MAPK. This same ...

Grant supports LSUHSC research on how like cell receptor systems determine very different functions

... on the mechanism by which seemingly similar cell receptor systems determine quite different ... such as proliferation, differentiation and cell migration," notes Dr. Catling. "We hypothesize ... that functions in the intracellular movement and cell division activity of growth factor receptors as a ...

Sticky protein helps reinforce fragile muscle membranes

... the sturdy basal lamina reinforces muscle cell membranes and keeps small tears from bursting ... basal lamina interaction, rendering the cell membrane susceptible to rupture. "Considering how essential cell membranes are for life, these barriers are ...

New windows opened on cell-to-cell interactions

... Applying biological molecules from cell membranes to the surfaces of artificial materials ... colleagues suggest that putting lipids and other cell membrane components on manufactured surfaces ... Controlling molecular orientation from cell membranes In a paper appearing online in the ...

A genetic basis for schizophrenia

... of cells and function properly. Disruption of cell migration can lead to inappropriate cell development and function, resulting in disease. ... are multi-potent cells that give rise to multiple cell types including craniofacial cartilage and the ...

International research team seeks to unravel flatworm regeneration

... which may play a role in regeneration and stem cell function, Nikolaus Rajewsky from the MDC points ... many genes specifically linked to planarian stem cell biology and regeneration are conserved in humans. ... insights into human regeneration and stem cell biology, the researchers are convinced. The ...

Skin-like tissue developed from human embryonic stem cells

... a single source of hESC can provide the multiple cell types needed to interact within a ... chemical nutrients and specialized surfaces for cell attachment, an hES cell line (H9) was directed to form two distinct ...

New research finds possible genetic link to cause of pregnancy loss and disorders

... the research team found that if a mother's egg cell has a mutation in just one copy of a gene, called ... are properly divided during meiosis, the cell division process that enables a stem cell to become an egg. This checkpoint hiccups when ...

Iowa State University researchers develop process for 'surgical' genetic changes

... a break is made in the DNA of that gene. When the cell begins to heal itself, existing DNA can be ... can be added near the break site. Afterward, the cell carries the genetic change and passes the change ... "It's just that you have three meters of DNA in a cell if you unwound it. Putting the break where you ...

UCLA researchers discover new molecular pathway for targeting cancer, disease

... in the maintenance of tissue integrity and stem cell generation. When stimulated in an unregulated ... researchers. How LXR was able to inhibit tumor cell growth by impeding the Hh pathway was previously ... Hh pathway activity and for targeting various cell types, including cancer cells, which may provide ...

Chasing tiny vehicles

... the activation of a transported gene inside a cell for example. Under the direction of LMU Munich ... separate phases: how the particles reached the cell membrane, came to rest there and then ultimately ... them and quickly transports them towards the cell nucleus the ultimate target for the gene. ...

LincRNAs serve as genetic air-traffic controllers

... in many biological processes, including stem cell pluripotency, cell cycle regulation, and the innate immune response. ... know to regulate one genomic location in a brain cell and regulate a different genomic region in a ...

Flexible neck in cell-receptor DC-SIGN targets more pathogens

... apart. In the current work, the surfaces were cell receptor DC-SIGN and a target membrane decorated ... protein binds to a pathogen, binding sites on the cell receptor rearrange slightly, to adapt to the ... the molecule's binding sites away from the cell surface," Leckband said. "A rigid presentation of ...

Study by NTU professors provides important insight into apoptosis or programmed cell death

... This process known as 'apoptosis' or programmed cell death, is a normal process in the human body ... (i.e. 'anti-factors' that are necessary to keep a cell alive) are no longer able to enter the cell's ... a role in a great many diseases. When programmed cell death does not work right, cells that should be ...

New technique can fast-track better ionic liquids for biomass pre-treatments

... Based on the natural auto-fluorescence of plant cell walls, this technique enables researchers for the ... observed a rapid swelling of the secondary plant cell walls within three hours of exposure at ... fiber that gives strength and structure to plant cell walls the subsequent addition of an ...

A matter of density, not quantity

... of quorum sensing, which cells use to "sense" cell density, is triggered when the concentration of ... that quorum sensing is also activated by a single cell if the cell finds itself in an extremely enclosed space, ...

Telomeres resemble DNA fragile sites

... led by Titia de Lange, head of the Laboratory of cell Biology and Genetics, and first author Agnel ... The work, published in the July 10 issue of cell , began when Sfeir deleted TRF1 and saw that the ... elongates telomeres, which shorten during every cell division. The second problem posed by telomeres, ...

Spontaneous assembly

... are able to assemble into clusters that direct cell movement to select chemicals in their ... single proteins. With PALM, we can examine a cell and see single proteins, protein dimers, and so ... display a nonrandom, periodic distribution in the cell membrane. "Chemotaxis proteins cluster into ...

Work in mice will contribute to the study of hereditary diseases that lead to blindness

... Santos Carro , researcher of the Department of cell Biology of the University of Granada , is based on the study of microglial cells, a type of cell of the Nervous System that develop a phagocytic ... meetings: VIII European Meeting on Glial cell Functions in Health and Disease (Londres), VII ...

Plant protein 'doorkeepers' block invading microbes, study finds

... one makes use of receptor proteins outside the cell to recognize specific molecular features of an ... the other branch uses similar proteins within the cell to recognize an invading microbe during the ... in the permeable plasma membrane that encases the cell on the inside of ...

Protein can help cells or cause cancer, Purdue researcher finds

... scientist has discovered a key process in cell growth that can lead to the formation of tumors. ... the polo-like kinase 1, or Plk1, molecule during cell growth, as well as a shortage of the p53 ... approach to treating that cancer." During cell growth, Plk1 uses its protein kinase activity ...
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