carrier

New protein discovered by Hebrew University researchers

...r tumors. The protein'stiny structure enables this carrier to penetrate specifically intotumors without harming healthy tissue and thus enhance theeffectiveness of chemotherapy. This selective penetration is based onthe fact that the blood vessels which feed tumors are considerably moreporous than those reac...

The death of a very special chimpanzee

...r tumors. The protein'stiny structure enables this carrier to penetrate specifically intotumors without harming healthy tissue and thus enhance theeffectiveness of chemotherapy. This selective penetration is based onthe fact that the blood vessels which feed tumors are considerably moreporous than those reac...

UCLA scientists transform HIV into cancer-seeking missile

...ne therapy has been hampered by the lack of a good carrier for therapeutic genes that can travel through the ...proves that it is possible to develop an effective carrier and reprogram it to target specific cells in the body." The UCLA team employed a two-step approach ...

A human parasite with a streamlined mitochondrion

...our complex mitochondria. The presence of a single carrier in the Entamoeba mitosome means that it must be ab...ts performed by the team reveal that the Entamoeba carrier can only transport ADP and ATP, suggesting that it could fuel energy-requiring reactions within the ...

Gene therapy promising for growing tooth-supporting bone

...MP-7 genes with an inactivated virus in a gel-like carrier and injected it into wounds. Giannobile said using a virus, with the harmful effects turned off, harnesses the virus' ability to enter into cells and use their genetic machinery. Once inside the cell, the viruses help BMP-7 genes get where they need...

Breakthrough: Scientists create world's tiniest organic particles

...ith tiny cavities in them. After that, we mold the carrier and fragile functional materials into whatever particles we want and gently wash them off the molds with buffer solutions into vials or other containers to concentrate them. Then they can be injected." DeSimone, his colleagues, UNC and others have f...

New insights into how Huntington's disease attacks the brain

...ce, leading to death within 10 to 25 years. Every carrier of the HD gene mutation will develop the disease. Each child of a parent with Huntington's disease possesses a 50 percent risk of inheriting the illness. In the United States, the disease strikes 30,000 people and places another 150,000 persons at ri...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...infect a human host, VA/U-M scientists use it as a carrier to deliver GAD to the nucleus of nerve cells in th... the nervous system. “When we inject our HSV gene carrier under the skin of a laboratory rat, the vector is taken up by sensory nerve terminals in the animal'...

Green diesel: New process makes liquid transportation fuel from plants

... of carbon. The carbon acts as an effective energy carrier for transportation vehicles. It's not unlike the way our own bodies use carbohydrates to store energy." About 75 percent of the dry weight of herbaceous and woody biomass is comprised of carbohydrates. Because the UW-Madison process works with a ran...

Scientists use gene transfer technology and common virus to block neuropathic pain

...infect a human host, VA/U-M scientists use it as a carrier to deliver GAD to the nucleus of nerve cells in th... the nervous system. "When we inject our HSV gene carrier under the skin of a laboratory rat, the vector is taken up by sensory nerve terminals in the animal'...

Novel protein complex enables survival in hostile environment

...lavin molecule called Factor 420 -- as an electron carrier for the reduction of sulfite. None of the previously described sulfite reductases use F420," Johnson said. By use of genome-sequence-driven proteomics techniques, they identified the gene for the enzyme. A search showed that this gene exists only in...

Driver of anthrax toxicity could lead to late-stage therapy

...s on separate complexes formed by interaction of a carrier protein, protective antigen, with lethal and edema factors responsible for the toxic effects and swelling that impairs the host's immune response. In the current study, the researchers inactivated genes randomly in human cells. They then examined t...

Virginia Tech scientists develop process for creating biocompatible fibers

...ial applications include drug delivery, that is, a carrier and matrix to control the release of drugs." Long's research group is working with Virginia-Maryland Regional College of Medicine researchers at Virginia Tech to develop a patch for drug delivery for horses. "We have not yet tested the specific bio...

U of S researchers develop new vaccine candidate against hepatitis C

...a vaccine candidate that decreased the amount of a carrier virus expressing hepatitis C virus (HCV) protein i... does not infect mice, mice were challenged with a carrier virus containing the hepatitis C protein. The levels of HCV protein in immunized mice using this mod...

Scientists force viruses to evolve as better delivery vehicles for gene therapy

...d a lot of attention in recent years as a possible carrier for genes in gene therapy. Because as many as 90 percent of people already have the virus, however, their immune systems are primed with antibodies to quickly tackle and neutralize it, thwarting any attempt at gene therapy. UC Berkeley's David Schaf...

Nano-particles effective in killing cancer with one-two punch of chemotherapeutics

... than either drug alone, but there hasn't been any carrier system that can carry both drugs as efficiently to a tumor," said Fariyal Ahmed, the lead author, former doctoral student in bioengineering,and now a fellow at Harvard Medical School. "Polymersomes get around those limitations". Discher developed...

Weighting cancer drugs to make them hit tumors harder

...s macromolecular weights in mouse tumors. The drug carrier they studied was dextran, essentially a chainlike string of sugar molecules. By measuring a range of dextran molecular weights in a three-dimensional model and over 30 minutes instead of a single time point, they determined the optimal weight for tu...

Ultrasound may help regrow teeth

...worked, we looked at creating a smaller ultrasound carrier where we can take the patient out as a variable," said El-Bialy. "Before this, a patient has to hold the ultrasound for 20 minutes a day for a year and that is a lot to ask." The researchers are currently working on turning their prototype into a m...

Rehydrate -- your RNA needs it

...se roles of RNA. Once thought to be only a passive carrier of encoded genetic information, RNA is now known to regulate gene expression and other important cellular processes and to act as a sort of sensor---detecting cellular signals and carrying out appropriate reactions in response. In fact, there are man...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

...ading of the correct amino acid, alanine, onto its carrier tRNA. This editing enables the enzyme to reject incorrect amino acids. The researchers found that the mutant enzyme would charge an incorrect amino acid, serine, which resembles alanine, to tRNAs meant to carry only alanine. That meant that these ...

Researchers find cause of frontotemporal dementia

...by a defect in chromosome 17. Chromosome 17 is the carrier of the tau protein's hereditary code, and defects in this protein cause tau-positive FTD. However, there is another form of FTD that occurs much more frequently than tau-positive FTD ?namely, ubiquitin-positive FTD (FTDU). Patients with FTDU do not h...

Eminent inventor of DNA fingerprinting gains new recognition

...mple the ability to determine whether someone is a carrier of certain pathogenic genes. Most recently, Jeffreys has concentrated on genetic mutations and environmental factors. He is, for example, studying how irradiation may have caused genetic mutations in families from Chernobyl."Luton-born Sir Alec has f...

Embryonic selection of sex avoids conceiving blind children

...out an embryonic sex selection in a woman who is a carrier of the disease Retinosis Pigmentaria, linked with the X chromosome ?in order to avoid giving birth to a male child. Retinosis Pigmentaria is a hereditary illness of the eyes of a degenerative nature. It causes a serious reduction in visual capacity ...

Pesticides need sunscreen to beat the heat

...er pesticides. We are considering it as a platform carrier material for pesticides and have looked at several pesticides, including this oil-soluble avermectin, and water-soluble validamycin, and a couple of others, all demonstrating the same behaviors," Wen said. ...

Walking molecule now carries packages

...25 Physics Stories for 2005." The new molecule carrier runs on a copper surface. It can pick up and relea...Bartels. "Attachment of one CO2 molecule makes the carrier need twice as much energy for a step, and a carrier with two CO2s requires roughly three times the e...

Researchers create artificial enzyme that mimics the body's internal engine

...eries of proteins known as electron carriers. Each carrier receives electrons from the preceding one, then tr... form of ATP and heat. CcO is the last electron carrier in the transport chain. It receives four electrons from the other carriers and transfers the electro...

Africa's first large-scale HIV vaccine study launches

...assed from person to person. The adenovirus is the carrier or vector which transports copies of three HIV genes called gag, pol and nef. The vaccine is made in the laboratory and does not contain live HIV. The test vaccine therefore cannot cause infection. The hope is that these HIV genes will produce a c...

Hybrid molecule causes cancer cells to self-destruct

...t the sugar partner to serve not just as a passive carrier but as additional ammunition in the fight against cancer." The researchers focused on a sugar called N-acetyl-D-mannosamine, or ManNAc, for short. The team created a hybrid molecule by linking ManNAc with butyrate. The hybrid easily penetrates a c...

Penn researchers show how nanocylinders deliver medicine better than nanospheres

...ver drugs to tumors. By using a cylindrical-shaped carrier they were able sustain delivery of the anticancer drug paclitaxel to an animal model of lung cancer ten times longer than that delivered on spherical-shaped carriers. These findings have implications for drug delivery as well as for better understand...

Cornell lab confirms deadly fish virus spreading to new species

...d Bowser. "The ability of the virus to go beyond a carrier state and cause disease in this important aquaculture species is a major research question we plan to investigate this year."...

Progress toward an antitumor vaccine

...to bind a molecule that is typical for tumors to a carrier protein without irritating the immune system. As t...essful if the vaccine is anchored to an immunizing carrier protein by means of a spacer,” explains Kunz. This would be very easy to accomplish with polysacchar...