carcinoma

U-M scientists find genes that control growth of common skin cancer

...f the Hedgehog (Hh) signalingpathway in basal cell carcinoma ?the most common form of cancer ?anduncovered a su...able now on the journal's Web site . Basal cell carcinoma (BCC) affects over 1,000,000 Americans each year and frequently develops onsun-exposed sites, such a...

Study of genomic DNA leads to new advances in cancer diagnostics

...elanoma cells, normal breast epithelium and breast carcinoma cells, and normal fibroblasts and fibrosarcoma cells) and diagnostic biopsy samples. Will these methods help clinicians in diagnosing cancer? Because the investigators utilized several practical methods in their study, potential exists for future di...

Biomarkers isolated from saliva successfully predict oral and breast cancer

...s" isolated in saliva predicted oral squamous cell carcinoma in about nine out of 10 cases. A recent study by ...d from 32 patients with primary oral squamous cell carcinoma and 40 breast cancer patients, and matched each with saliva and blood from otherwise normal subjects...

Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines

...ism (baker’s yeast) as well as in human small lung carcinoma cells. Their algorithm predicted, and subsequent experiments verified, that PTSB acted on thioredoxin and thioredoxin reductase, findings that not only validate the tool’s capability but could also pave the way to investigations of a potentially new...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

... possibility that adenocarcinoma and squamous cell carcinoma arise from an error in the same cell type and are driven to malignancy by similar genetic routes, the study authors say. Finally, the researchers compared their data for NSCLC with similar data for pancreatic cancer, and found that both diseases hav...

Compound from Chinese medicine shows promise in head and neck cancer

...eated cell cultures of head and neck squamous cell carcinoma with the (-)-gossypol compound and found it inhibited tumor cell growth. Additional testing in animals was also positive and showed (-)-gossypol did not harm surrounding healthy tissue. Researchers hope to begin a clinical trial in head and neck can...

Forsyth scientists find three bacteria associated with oral cancer

...saliva indicate the presence of oral squamous cell carcinoma (OSCC)--one of the deadliest of cancers because it often goes undetected in its early stages. "Finding bacteria associated with OSCC encourages us to hope that we have discovered an early diagnostic marker for the disease," said Donna Mager, DDS, Ph...

Study hints at role of stem cell genes in testicular, breast cancers

...ss detectable levels of the genes, both the breast carcinoma cell lines and stage 3 breast carcinoma expressed all four genes. The scientists suspect that expression of the genes may be elevated in ...

Minimally Invasive Cancer Treatments Highlighted

... surgery to treat single small cell hepatocellular carcinoma (liver cancer) in a study of 162 patients, in terms of overall survival and rate of tumor recurrences. (Author, Lencioni) ?A study assessing survival in patients with small solitary colorectal liver metastasis treated with RFA shows that their surviv...

Terahertz imaging may reduce breast cancer surgeries

...l and lobular carcinomas, two cases of pure ductal carcinoma in situ and one dense radial scar. In breast cancer excision surgery, the aim is to remove the entire tumor with an adequate margin of normal tissue, while minimizing the amount of healthy tissue being removed. If a histopathologist analyzes the tis...

Basic research leads to a novel cancer therapy

... all. Still other patients had advanced renal cell carcinoma with failed available treatment. In the case of th...e placebo group. Patients with advanced renal cell carcinoma saw a shrinking of the tumour; in 26 to 37 percent of them, the tumour shrunk to at least half its s...

HPV subtype associated with squamous cell skin cancers

...a major type of skin cancer known as squamous cell carcinoma (SCC), according to a new study in the March 15 issue of the Journal of the National Cancer Institute. In addition, the presence of antibodies to multiple types of HPV was associated with the highest risk of SCC, but the association had limited s...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...en in an early form of breast cancer called ductal carcinoma in situ, or DCIS. Hartmann said that COX-2 represents a potential target for chemoprevention. Her team plans to expand the test group and will continue to profile women with atypia who did and who did not develop breast cancer in an attempt to identi...

Speeding discovery of the 'human cancer genome'

...called hepatocellular carcinoma. Hepatocellular carcinoma is the fifth most frequent form of cancer worldwide but, owing to the lack of effective treatment options, represents the third leading cause of death, Lowe said. The only curative treatments involve surgery or transplantation as chemotherapies are i...

Cycles of cell death, proliferation key to liver cancer

...rs when compared to normal tissue. Hepatocellular carcinoma (HCC), the most common form of liver cancer, is the third leading cause of cancer deaths worldwide. Its major risk factors are persistent infection with hepatitis B and C viruses, and exposure to toxic chemicals, including alcohol ¡V all of which ca...

Scientists tie several cancers to common 'oncogene engine'

...a, alveolar soft part sarcoma, and pediatric renal carcinoma ?are often lethal if surgery cannot completely remove them. Dana-Farber researchers are already using these new insights in clinical trials of a cancer vaccine, GVAX, that previously has produced rare but dramatic responses in some patients with adv...

Long-term cancer risk follows stem cell transplant recipients

... was 3.1 percent. When nonmelanoma skin cancer and carcinoma in situ of the cervix were excluded, incidence was 2.3 percent. That risk was 1.85 times that of the general population. The median time to diagnosis was almost 7 years after transplant. The most commonly reported second cancers were cancers of the s...

Abnormal overexpression of p53 is a predictive molecular biomarker

...s, found that patients with advanced squamous cell carcinoma of the head and neck cancer (SCCHN) whose pre-treatment tumor samples over-expressed p53 protein were significantly more likely to respond to Advexin therapy than those whose tumor showed little p53 protein. Advexin is a gene based drug, injected dir...

Vaccine for brain tumors shows promising results

...h metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). The UCSF clinical trial is a phase1/2 study designed to establish the feasibility, safety and preliminary efficacy of vaccination in patients with recurrent, high-grade glioma. The trial involves two groups of six patients, both ...

Vaccination with embryonic stem cells prevents lung cancer in mice

...or ESCs + STO/GM-CSF. In mice that had Lewis lung carcinoma transplanted into them afterwards, ESCs were 80% effective in preventing tumour growth and ESCs + STO/GM-CSF were 100% effective. In mice subsequently exposed to a carcinogen that causes lung cancer (3-methylcholanthrene followed by repetitive dosin...

Molecular 'marker' on stem cells aids research, perhaps therapies

...e of embryonic stem cells, as well as on embryonic carcinoma cells, the malignant counterparts of embryonic stem cells. Dr. Perlingeiro’s ongoing studies also suggest that the SSEA-4 molecule might be present in other tissues, leading to the intriguing possibility that the SSEA-4 molecule could be a marker ...

Signal protein shows promise for blocking tumor promoters in skin cells

... to know whether Srcasm can decrease squamous cell carcinoma formation in skin, mentions Seykora. ...

Stress hormones may play new role in speeding up cancer growth

... had developed decades ago to study nasopharyngeal carcinoma (NPC), a serious, incurable head and neck cancer that occurs most frequently among people of Chinese descent. They treated Glaser's cell line with norepinephrine and, as predicted, the cells all produced MMP-2, MMP-9 and VEGF. This showed that the...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

...ence p53 as a vaccination target for squamous cell carcinoma of the head and neck: Abstract 5113 Researchers from the University of Pittsburgh and the Gunma University School of Medicine have developed a vaccine that enlists multiple parts of the immune system into targeting p53 in head and neck squamous c...

UCSF brain tumor vaccine trial shows promising results

...h metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). Reviewing the presentation at AANS, Henry Brem, MD, director of neurosurgery at the Johns Hopkins Medical Institutions, noted, “This is an encouraging study of a therapeutic cancer vaccine that targets multiple tumor antigens, su...

Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer

...rch. “Having the tools to identify hepatocellular carcinoma at earlier stages, is truly a breakthrough for addressing the challenges that result from this highly lethal form of cancer.? Dr. Santella and the team of researchers previously found that several environmental factors including aflatoxin B1, a die...

Targeting sugar on blood vessels may inhibit cancer growth

...tered the growth rate of tumors prepared from lung carcinoma cells in the mice. "We theorized that by targeting the sugar, heparan sulfate, we could affect angiogenesis, which is the formation of new blood vessels," said Fuster. "In cancer, angiogenesis sustains growth as well as metastasis of tumors. An ...

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

...skin cancers - basal cell carcinoma, squamous cell carcinoma and malignant melanoma - accounted for 27 per cent... were twice as likely to suffer from squamous cell carcinoma than women, accounting for 357 of the 640 cases reported each year. Women were, however, 30 per ...

Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes

...ast, the great majority of cases of hepatocellular carcinoma (HCC) occur in individuals with the virus. For most patients whose cancer is inoperable, chemotherapy is one of the main treatment options, and still the prognosis is dismal. Survival is often measured in months. Researchers, led by Winnie Yeo of ...