carcinogen

NYU and MSKCC research provides model for understanding chemically induced cancer initiation

...ite. Without this methyl group, the bulky chemical carcinogen resides at an external binding site in the minor groove of the DNA double helix. However, in the presence of this single methyl group, it assumes an intercalated structure in which the carcinogenic residue is sandwiched between adjacent base pairs in...

Red delicious, Northern Spy apples have most antioxidants, chemists find

...n Diego. * Breast cancer. Rats exposed to a known carcinogen and then fed the human equivalent of one, three or six apples a day respectively over 24 weeks were up to 44 percent less likely to develop breast tumors. That study was published in the April 6, 2005, issue of the Journal of Agricultural and Food Ch...

Change in gene may be underlying molecular defect in some colorectal cancers

... to a cancer or those who undergo an exposure to a carcinogen such as tobacco smoke. However, how the field defect may arise in most sporadic cancers in unclear. In colorectal cancer, the DNA repair gene O 6 -methylguanine-DNA methyltransferase (MGMT) is often methylated--that is, the gene's promoter region ha...

Zebrafish may hold key to improved cancer research

...ts which can be found in some foods are a powerful carcinogen ?and are still a major cause of liver cancer in some developing nations. Zebrafish, however, are a fascinating species because the fish embryos are literally transparent and can be directly observed at early developmental stages better than almost a...

Building a better mouse model of lung cancer: FHIT counts

...ene. They exposed all the mice to NNK, a powerful carcinogen commonly found in tobacco smoke that researchers believe plays a major role in human lung cancer. They discovered that while mice deficient in the FHIT gene's protein did not develop lung tumors any more frequently than did normal mice, the tumors t...

Cycles of cell death, proliferation key to liver cancer

...nase (JNK) activation after exposure to a chemical carcinogen used to elicit liver cancer in mice. Importantly, deletion of the gene that codes for the major isoform of JNK in liver cells, JNK1, prevented the development of liver cancer and reversed the tumor-enhancing effect caused by ablation of IKKƒÒ. "We ...

Vaccination with embryonic stem cells prevents lung cancer in mice

...100% effective. In mice subsequently exposed to a carcinogen that causes lung cancer (3-methylcholanthrene followed by repetitive dosing with butylated hydroxytoluene), ESCs resulted in 60% of mice remaining tumour free after 27 weeks and ESC + STO/GM-CSF resulted in 90% remaining tumour free. Importantly, tu...

New cigarette designs don't offer lower predicted cancer risks

...nown carcinogens, and you add up all the predicted carcinogen activity, you don't come close to what's observed ... of smoking," she said. Pankow's group examined carcinogen deliveries from 26 brands of conventional "regular," "light" and "ultralight" cigarettes. Using U.S....

Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer

...environmental contaminants; and 4-aminobiphenyl, a carcinogen found in cigarette smoke, are also associated with the development of HCC. While HCC incidence is highest in East Asia and Sub-Saharan Africa, it is also increasing in the U.S primarily as a result of HCV infection. “We are not only very excited...