Bowel in Biological News

NIH expands Human Microbiome Project; funds sequencing centers and disease projects

... The relationship between the inflammatory bowel disease, Crohn's disease, the intestinal ... with Crohn's disease, an inflammatory bowel disease. Huiying Li, Ph.D., University of ... Houston Digestive tract: Pediatric Irritable bowel Syndrome (IBS) $750,000 This project will ...

Stem cell focus for IBD wound healing

... healing in patients suffering from inflammatory bowel disease (IBD). The study could eventually lead ... of associated complications such as scarring, bowel obstructions and tumour growth. Funded with a ... more rapid healing. This may mean less scarring, bowel obstruction and fistulation and less chance of ...

Review of probiotic trial research finds only Bifantis able to claim efficacy for IBS symptoms

... of probiotics in the treatment of Irritable bowel Syndrome (IBS) found that Bifidobacterium ... of IBS, including abdominal pain, bloating and bowel movement difficulty. Bifidobacterium infantis ... publication's April 2009 issue 1 . Irritable bowel Syndrome affects one in five Americans and ...

Research uncovers promising target to treat chronic abdominal pain

... for chronic pain associated with a number of bowel disorders. The scientists at Ohio State ... The most common condition is irritable bowel syndrome, a disorder characterized by cramping, ... of the U.S. population. Visceral pain in bowel disorders is often difficult to treat because ...

Irritable bowel syndrome can have genetic causes

... Irritations of the bowel can have genetic causes. Researchers at the ... The causes of what is known as irritable bowel syndrome (IBS), one of the most common disorders ... Modified receptors lead to overstimulation of the bowel Serotonin plays an important role in the ...

Biodegradable polymers show promise for improving treatment of acute inflammatory diseases

... lung injury, acute liver failure and inflammatory bowel disease by delivering drugs, proteins and snips ... aimed at enhancing the treatment of inflammatory bowel disease an illness that causes the large and ... with therapeutics to treat inflammatory bowel disease. "We think these microparticles are ...

Weill Cornell science briefs June/July 2008

... malfunctions. News About Inflammatory bowel Disease, Crohn's Disease: Stem Cells Heal ... Drug for Treatment of Inflammatory bowel Disease New Formula Allows for Greater ... a new drug for those who suffer from inflammatory bowel disease (IBD), say it is the best option among ...

International team identifies 21 new genetic risk factors for Crohn's disease

... genetic variants associated with the inflammatory bowel disorder, bringing the total number of risk ... MD, of the Center for the Study of Inflammatory bowel Disease in the MGH Gastroenterology Unit and the ... targeted drugs for Crohn's and other inflammatory bowel diseases." Daly is an assistant professor of ...

'Addicted' cells provide early cancer diagnosis

... have detected subtle changes that may make the bowel more vulnerable to the development of tumours. ... from the cells lining the large intestine of bowel cancer patients. They found subtle changes that may make the whole surface of the bowel more vulnerable to the eventual development of ...

Getting better with a little help from our 'micro' friends

... offer a new type of treatment for inflammatory bowel disease, according to scientists at the ... offer protection from inflammatory bowel disease. "Thus, bacteria help reprogram our own ... as a natural therapeutic for inflammatory bowel disease," says Mazmanian. ...

Study suggests new way to screen infants for fetal alcohol syndrome

... the digestive system, were measured in the first bowel movement of the newborns. The babies were then ... Infants with higher levels of FAEE in their first bowel movement were found to be at risk for ... Measuring the levels of FAEE in an infants first bowel movement could be a useful method for identifying ...

Antibiotics take toll on beneficial microbes in gut

... patients. They could also aid in understanding and treating inflammatory bowel disease, which affects an estimated 500,000 to 1 million Americans, and ... how changes in the microbiota in the gut may influence how inflammatory bowel disease develops and progresses. The study will also inform ongoing ...

Immune genes adapt to parasites

... worms. SNPs in some of these genes are known risk alleles for inflammatory bowel diseases, such as Crohn's and celiac disease. These "risky" alleles were ... and bacteria. But this type of response also contributes to inflammatory bowel diseases. ...

Small molecules block cancer gene

... cancers, as well as chronic viral infections, asthma, and inflammatory bowel disease. He is also on the faculty of Dan L. Duncan Cancer Center. The ... a role in chronic virus infections, asthma, psoriasis and inflammatory bowel disease all areas that Tweardy and his colleagues hope to pursue in the ...

Form of Crohn's disease traced to disabled gut cells

... disease, an often debilitating and increasingly prevalent inflammatory bowel disorder. The link to immune cells intrigued researchers at Washington ... to the disorder." Crohn's disease is one of the most common inherited bowel disorders. In 2002, epidemiologists estimated that it affected 400,000 to ...

New genes found for inflammatory bowel disease in children

... discovered two new genes that increase the risk of developing inflammatory bowel disease (IBD) in childhood. While further study is needed to identify ... N. Baldassano, M.D., director of the Center for Pediatric Inflammatory bowel Disease at The Children's Hospital of Philadelphia. "We will resequence ...

Natural product discovery by Cleveland medical researchers blocks tissue destruction

... skin and gastrointestinal diseases, including osteoarthritis and irritable bowel syndrome. The publication revealed that Progrado, an extract from a ... therapeutic innovations for conditions ranging from arthritis, irritable bowel disease and wrinkles based on their involvement in tissue injury/repair ...

Major genetic breakthrough for ankylosing spondylitis brings treatment hope

... More rarely, it can affect other areas, such as the eyes, lungs, bowel and heart. High-profile sufferers of the condition include former England ... of autoimmune diseases, such as Crohn's disease (a type of inflammatory bowel disease) and psoriasis (a skin disease). Ankylosing spondylitis, Crohns ...

Colorectal cancer

... 106,100 cases of colon cancer will occur and 49,920 patients will die both from colon and rectal cancer in 2009. Beginning in glands in the bowel lining, colorectal cancer often remains undiscovered initially. "However, the main problem is not the primary tumor," explained the surgeon and ...

Powerful nutrient cocktail can put kids with Crohn's into remission

... Treating children with inflammatory bowel disease (IBD) usually involves the same steroids-based medication prescribed to adults. But such treatments can have negative side effects for kids ...

Chemical in blood may explain susceptibility to bladder pain

... symptoms because the underlying cause of the disease is unknown. Buffington plans to test human samples from patients diagnosed with irritable bowel syndrome and fibromyalgia to see if the same biomarker is associated with these chronic pain disorders as well. These disorders, like IC, are ...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

... and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). The team, co-led by Judith Bond, Ph.D., Distinguished Professor and Chair of Biochemistry and Molecular Biology at Penn State College ...

UAB professor receives HudsonAlpha Innovation Prize

... infections and cancer, but when T cells overreact and turn on the body, we see immune-mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, lupus and multiple sclerosis. "Our studies have contributed to the identification of a new class of T cells, called Th17 cells, which are ...

Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers

... that they absorbed less of the mineral. "We already know that fiber helps improve your cholesterol and glucose control and improves your bowel regularity. Our new findings suggest that dietary fiber reduces the body's capacity to absorb calcium," said Dr. Abhimanyu Garg, professor of ...

Monash scientists debug superbug

... therapy. The antibiotics destroy the 'good' bacteria in the gut, allowing a 'bad' bacterium to grow in the colon, where it causes a chronic bowel infection that is very difficult to treat," Dr Lyras said. "The disease produces two types of Toxins, known as A and B. Worldwide research has ...

La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery

... of the family to be discovered, with its receptors, is an approved treatment for several diseases, including rheumatoid arthritis and inflammatory bowel disease. It is therefore possible that blockade of other members of this family, such as OX40L, might benefit some patients with inflammatory ...

Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection

... Journal , may lead to entirely new therapies for a wide range of autoimmune disorders, such as colitis, lupus, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis, as well as new ways to prevent transplant rejection. "The possibility that these antibodies can be used to treat ...

Rethinking the genetic theory of inheritance

... of males (e.g. to autism) and females (e.g. to lupus), significant fluctuations in the course of a disease (e.g. bipolar disorder, inflammatory bowel disease, multiple sclerosis), among numerous others. "Traditionally, it has been assumed that only the DNA sequence can account for the ...

For fats, longer may not be better

... genes. Eckhardt and colleagues believe these findings may pave the way for future therapies for Crohn's disease and other inflammatory bowel disorders. In addition, they note that this study once again highlights the importance of the diverse bacteria that call our intestines home. ...

New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics

... pain. Ulcerative colitis and Crohn's disease, another chronic gastrointestinal inflammatory disorder, are the two major forms of inflammatory bowel disease (IBD). "Ulcerative colitis and Crohn's disease are chronic conditions that impact the day-to-day lives of patients," said senior author of ...

Collegiate Inventors Competition recognizes top student inventors

... Joshua Liu, Gayathree Murugappan, Kevin Yeh, & Vicki Zhou, Johns Hopkins University (Advisor: Robert Allen) SurgyPack A Novel Means for bowel Packing A device that can be inserted by a surgeon to keep the patient's intestines away from an abdominal surgery site. Greg Schroll, ...

Closing the gap: Journal launch brings together wound-healing knowledge

... disorders such as cardiovascular disease, pulmonary fibrosis, progressive kidney disease, systemic sclerosis, liver cirrhosis and inflammatory bowel disease. Fibrogenesis and Tissue Repair features high-quality studies providing novel insights into the mechanisms, diagnosis and treatment of these ...

The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia

... of the many different genetic variants associated with common complex genetic diseases, including autism, type 2 diabetes, and inflammatory bowel disease. Thursday, November 13, 2008: (WEBCAST SESSIONS) The recently-appointed ASHG Ancestry Testing Task Force Committee plans to unveil ...

The pepperoni pizza hypothesis

... heartburn, but when you give it to a person with an inflamed bladder, that will cause their symptoms to flare because the nerves from the bladder and bowel are converging on the same part of the spinal cord." MEASURING PELVIC PAIN IN A MOUSE When pain emanates ...

Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohn's disease study

... the study came from several organizations, including the National Institute of Diabetes and Digestive and Kidney Diseases, through the Inflammatory bowel Disease Genetic Consortium. ...

Complexity of Crohn's disease revealed as 'gene' count tops 30

... New research has trebled the number of genetic regions known to be implicated in Crohn's disease, a form of inflammatory bowel disease, to over thirty. The research, published today in the journal Nature Genetics , has identified a number of potential new targets for drug ...

NCI grant launches clinical trials for colon cancer screening

... to define the technology's prediction rules; the second will be a double-blind study of 3,000 patients. The screening test, which does not require bowel preparation, will be done in patients about a week before a colonoscopy. Each person will have a colonoscopy even if the results from the screening ...

New high fiber barley licensed to grow

... Human Nutrition has shown that products made with BARLEYmax such as breakfast cereals, muffins and breads have a low Glycaemic Index and strong bowel health attributes. "Further testing showed BARLEYmax has excellent processing properties and foods made with the new grain have a naturally sweet, ...

Early treatment of stomach infection may prevent cancer

... that have invaded the stomach. Gastric acid is a barrier to bacteria, and if there is no barrier, bacteria can move into the stomach from the lower bowel and colonize it, producing inflammation and progression to cancer, he said. . Findings in humans and mice now suggest that antibiotic treatment ...

Scientists successfully treat new mouse model of inflammatory bowel disease

... trying to improve cancer immune therapy have made an unexpected find: They've produced the most accurate mouse model to date of inflammatory bowel disease (IBD), a cluster of conditions that afflict approximately 1.4 million Americans with abdominal pain, constipation and diarrhea. The two ...