Bioartificial kidney under study at MCG
...ody of waste products and correct abnormalities in blood chemistry; they don't replace kidney function, " s... metabolizes calcium and phosphorus, stimulate red blood cell production, play a role in blood pressure regulation and clear and metabolize cytokines that he...Association of herpesvirus with lung disorder questioned
...on and a potentially life-threatening form of high blood pressure, as reported in the March 1 issue of The Journal of Infectious Diseases, now available online. The researchers reported that they were not able to detect human herpesvirus 8 (HHV-8), also known as the Kaposi's sarcoma virus, in the lungs of...Jump-starting T Cells In Skin Cancer
...es. Tumor-specific T cells can be detected in the blood and the tumors of many melanoma patients, and yet these cells are unable to kill the tumor. What causes the impotence of these T cells is a mystery. Equally mysterious is why vaccination against tumor-specific proteins sometimes causes tumor regressi...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...turated fats and trans-fatty acids causes elevated blood levels of cholesterol and triglycerides and increa...how saturated and trans fats caused an increase in blood cholesterol and triglycerides, while diets high in unsaturated and polyunsaturated fats did not. Evi...Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
... and colleagues analyzed cell lines generated from blood samples taken from pairs of sisters in which one sister had been diagnosed with breast cancer and the other had not. They found that DNA repair capacity was lower in breast cancer patients than in the control subjects. Deficient DNA repair capacity ...Spleen may be source of versatile stem cells
...to supplement the bone marrow in replenishing your blood supply. Wemay find that the spleen kicks in to help with many more biologicalemergencies. What has been considered a practically unnecessary organmay actually provide critical healing cells," says Faustman, anassociate professor of Medicine at Harvar...Source of molecular triggers in cutaneous T cell lymphoma identified
...ommon adult malignancy of T lymphocytes, the white blood cells of the immune system. Finding CTCL triggering factors has been a major goal of Richard L. Edelson, M.D., Director of the Yale Cancer Center, and professor and chair of dermatology at Yale, since he and his colleagues at the National Cancer Inst...Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
...ity to later secrete enough insulin in response to blood glucose. "The bottom line is that if you don't ha... with abnormal development of the placenta and its blood vessels, or high blood pressure, which damages vessels." In addition, many other factors can result ...Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
... cells generatedwithin the bone marrow to grow new blood vessels that could improvecirculation in patients ...disease (PVD). Individuals with PVD have decreased blood flow to the muscles ofthe legs, especially during exercise, which causes pain, aching,cramping or fa...Fox Chase Cancer Center scientists identify immune-system mutation
...on that keeps a mouse strain from developing white blood cells, or lymphocytes, called helper T cells. The ...ediated immunity) and also for helping other white blood cells (B cells, derived from bone marrow) generate antibodies against foreign agents that enter the ...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...y, a severe diarrhea that is often associated with blood in the feces. Unchecked, the diarrhea associated with the disease can be fatal, especially in children. One field study in Bangladesh found that E. histolytica infection occurred at least once in 80 percent of 300 children. Over a period of four year...Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
...was considered a uniform disease of immature white blood cells that didn't die, with the slow rise in leuke...cumulation of these immature and incompetent white blood cells. Scientists have since discovered that CLL cells do indeed turn over, with the accumulation ov...Another Look Finds Promising Proteomics Test is Not Biologically Plausible
...entify early ovarian cancer from a small sample of blood is unlikely to lead to a reliable clinical test right away. After conducting repeated checks of the data that supported the test’s effectiveness, the researchers say their findings indicate that claims about the experimental protein-based assay are ......entify early ovarian cancer from a small sample of blood is unlikely to lead to a reliable clinical test right away. After conducting repeated checks of the data that supported the test’s effectiveness, the researchers say their findings indicate that claims about the experimental protein-based assay are ...Cracking the olfactory code in bees
...entify early ovarian cancer from a small sample of blood is unlikely to lead to a reliable clinical test right away. After conducting repeated checks of the data that supported the test’s effectiveness, the researchers say their findings indicate that claims about the experimental protein-based assay are ...Signaling protein builds bigger, better bones in mice
...entify early ovarian cancer from a small sample of blood is unlikely to lead to a reliable clinical test right away. After conducting repeated checks of the data that supported the test’s effectiveness, the researchers say their findings indicate that claims about the experimental protein-based assay are ...New Technique for Tracking Gene Regulators
...y identityof cells ?be they brain cells, liver, or blood ?as well as what mightgo awry in certain conditions like cancer. TheBrookhaven scientists, together with collaborators from Oregon Health& Science University, Emory School of Medicine, and Stony BrookUniversity, have published the first results ...Iron Deficiency Sparks Dramatic Changes In Gene Expression
...recognized symptom is anemia, in which too few red blood cells areproduced, and the body is deprived of oxy...ncy also contributes to thepathology of hereditary blood disorders, Parkinson's disease andcertain cancers and develops during a number of chronic diseases, ...U of M researcher examines newly emerging deadly disease
...erized by the depletion of clotting factors in the blood and skin lesions. Purpura fulminans refers to wide...y centimeters in diameter caused by the leakage of blood into the skin. "It is important to alert medical professionals about the symptoms and treatments of...Leukemia Drug Breakthrough Study In New England Journal Of Medicine
..., Revlimid simultaneously blocks the growth of new blood vessels that nourish tumors (anti-angiogenesis) an...rvations that the agent improved the growth of red blood cell precursors from MDS bone marrow. Celgene will submit the seminal findings of List's phase I tri...Mitochondrial DNA mutations play significant role in prostate cancer
...e COI gene in 260 prostate cancer tissue samplesor blood cells from patients with confirmed cancer who had undergoneradical prostatectomies between 1995 and 2002, and 54 tissue samplesfrom patients who had prostate biopsies but were found to be cancerfree. Twelve percent of all the prostate cancer samples ...Gene therapy converts dead bone graft to new, living tissue
...paints it with the genetically modified virus. New blood vessels begin to grow around and into the bone splint, stripping it down in times when the body needs the calcium, and rebuilding it when calcium levels rise. The bone that is rebuilt is now fully the patient's own, as if the dead bone were a house b...Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey
...the environment near thebacterium, such as a human blood cell. They discovered how thesebacteria know when other cells are present, and respond accordingly.In the laboratory, the team found that Enterococcus releases twosubstances into the environment. One substance sticks to foreign cells.The second subst...Jefferson Virologists Coax HIV Out of Hiding
...an Virologyand Biodefense, and his co-workers took blood cells from HIV-infectedpatients who had been takin...been seen before. It’s probably asub-population of blood cells, lymphocytes not stimulated by IL-2 orOKT3. There could be other reservoirs as well.?Ultimatel...Novel Therapy Tested in Mice Could Chase Away Cat Allergies
... Dr. Saxon and his colleagues first tested GFD in blood donated by people allergic to cats. They cultured blood cells with either GFD or with a purified human antibody as a control. Then they added the cat protei...Sea skate experiment sheds light on human cell transport
...or, Goldstein conducted an experiment with the red blood cells of skates to understand how these skinny, gr...: Our cells would take in too much water, diluting blood and other body fluids and rapidly causing death. So how do skates do it? Goldstein and Musch learne...Mouse brain tumors mimic those in human genetic disorder
...model, the team made two importantdiscoveries: New blood vessels and immune system cells may be essentialto...rain. Butit was unclear whether the development of blood vessels and recruitmentof microglia helped trigger tumor formation or if they appeared onlyafter the......is without affecting primary tumor cells, or their blood supply," Dr. Huang said. "To our knowledge, that's a real first." Exact mechanisms remain unclear. "Obviously, these compounds are targeting some step in the cell-migration process," Dr. Huang said. The activity of a migration-linked protein called...Genetically modified natural killer immune cells attack, kill leukemia cells
...nt for acute lymphoblastic leukemia (ALL) or other blood cancers. Results of the St. Jude study are publis...ions of NK cells, the team started with samples of blood containing a variety of different immune system cells. They placed this sample into a dish containin...Scientists develop new color-coded test for protein folding
...ify antibodies and other signs of infection in the blood stream. Over the next few months, he and his colleagues plan to re-do the experiment using other protein molecules. ...Placenta Is A Rich Source Of Blood Stem Cells
...urprising finding about embryonic development: the blood system begins to form not only in the embryo itsel...ry early in development, are able to generate more blood stem cells and can give rise to a complete blood system when transplanted into an adult. Unlike othe...Open microfluidic and nanofluidic systems
..., they could provide fast and detailed analysis of blood samples in the physician's office without the need to wait several days before the sample has been returned from specialized laboratories. Other applications include customized chips for space travel in order to monitor microbes inside spacecraft or ...Researchers discover molecule that causes secondary stroke
...nown as cerebral vasospasm. A constriction of the blood vessels in the brain, cerebral vasospasm usually occurs three to 10 days following a massive brain bleed known as hemorrhagic stroke. Sixty percent of patients who survive the initial stroke develop vasospasm, and 40 percent of them die from it. Vas...Study shows nanoshells ideal as chemical nanosensors
...dly chemical agent."About 1/20th the size of a red blood cell, nanoshells are about thesize of a virus. They are ball-shaped and consist of a core ofnon-conducting glass that is covered by a metallic shell, typicallyeither gold or silver. The metal shell "captures" passing light andfocuses it, a property t...Studies reveal methods viruses use to sidestep immune system
...ransmitted primarily through intravenous drug use, blood transfusions or blood products, as well as through sexual contact and is the leading cause of cirrhosis and liver cancer. ...DNA Recombination and Repair—A New Twist to RecA Function
... work as a motor: for instance, the march of white blood cells toward pathogens is powered by the growth of actin filaments pushing against the cells?membranes. In all cases, coherent motion implies a coordinated and polarized use of energy. Now, Julia Cox, Oleg Tsodikov, and Michael Cox present evidence ...New protein discovered by Hebrew University researchers
...selective penetration is based onthe fact that the blood vessels which feed tumors are considerably morepor...rying the drug would invade only the tumor-feeding blood vessels andnot normal ones.More recently, the three-dimensional structure of the protein wasdecipher...NC State scientist finds soft tissue in T. rex bones
...le, and microscopic interior structures resembling blood vessels and even cells are still present. In a pa...hat, when examined microscopically, seemed to show blood vessels, osteocytes, or bone building cells, and other recognizable organic features. Since current...The death of a very special chimpanzee
...selective penetration is based onthe fact that the blood vessels which feed tumors are considerably morepor...rying the drug would invade only the tumor-feeding blood vessels andnot normal ones.More recently, the three-dimensional structure of the protein wasdecipher...Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation
...antity of a certain type of immune cell DNA in the blood could help physicians predict whether a bone marro...nts succeed, the donated stem cells repopulate the blood with healthy red and white cells. The St. Jude team showed that the more copies of tiny rings of DN...UCLA scientists transform HIV into cancer-seeking missile
... for therapeutic genes that can travel through the blood and aim itself at a precise location, thereby minimizing harmful side effects," explained Irvin S.Y. Chen, Ph.D., director of the UCLA AIDS Institute. "Our approach proves that it is possible to develop an effective carrier and reprogram it to target...New insight into people who 'see' colors in letters and numbers
... magnetic fields are used to map regions of higher blood flow in the brain, which reflects higher activity in those regions. Importantly, the researchers found evidence suggesting that synesthetes may be quite different from one another, which the researchers said "has profound implications for the studie...Discovery Could Lead To Novel Approaches In HIV Treatment
...entre as well as from Franceand Israel. Usingonly blood samples, these researchers first developed a metho...on. The researchers then used this method to study blood samplesfrom patients that had been recently infected with HIV and found that,already in the first mo...FDA Warns Consumers Not to Use Home-Use Diagnostic Kits Marketed by Globus Media
...tured by Home Access Health Corporation and allows blood samples to be taken at home which people then send to a laboratory for testing. No home-use test kits intended for diagnosing syphilis and dengue fever are approved for sale in the U.S. The FDA has issued an import alert which alerts FDA field perso...Scientists identify new model Of NK cell development
...rrow progenitor cells and 6 percent of circulating blood progenitor cells, they comprise virtually all of the progenitor cells found in lymph nodes. Interestingly, Gerard Nuovo, a pathologist and co-author of the study, discovered that these novel NK precursor cells are not randomly strewn throughout the ...White blood cell waste disposal system plays critical regulatory role
...ritical immune cells. Human neutrophils are white blood cells that are constantly being produced in the bone marrow and released into the blood stream where they migrate out of the blood and roam the body in search of potentially harmful foreig...TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas
...cytes) multiply uncontrollably and crowd out other blood cells. The St. Jude researchers report that TEL2 cooperates with MYC to increase the chance that a certain mutation will occur in precancerous B lymphocytes, permitting these cells to become cancerous. This mutation inactivates the function of p53, a...Falling ants glide back to trunk to avoid dangers of forest floor
...collects adult females who've had a recent meal of blood ?his own. He and Dudley are applying for grants to do a more systematic survey to see how common gliding is among the hundreds of species of canopy ants as well as other insects that live in the trees, and to explore the biomechanics of their glidin...UF Researchers Map Bacterial Proteins That Cause Tooth Loss
...ack, and the disease makes it difficult to control blood sugar levels in people with diabetes. If that’s not bad enough, pregnant women with periodontal disease are seven times more likely to deliver low-birth-weight, preterm babies. Proteins are important to study because they are the foundation of the ce...New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
...most common side effect is a temporary lowering of blood counts several weeks after the treatment. There is no hair loss and nausea is rare. Results from this study are even more promising than results using Bexxar after other therapies have failed. In those studies, 70 percent of patients responded to Be...Scientists discover how fish evolved to float at different sea depths
...s and veins, called the rete mirabile, and special blood proteins, which can release oxygen even at high ox...ncentrations. These systems drive oxygen from the blood into the swimbladder allowing the fish to float at different levels in the sea without coming to the...FDA Approves New Drug to Treat Type I and Type II Diabetes
...approved Symlin, an injectable medicine to control blood sugar for adults with type 1 and type 2 diabetes. ...ients who cannot achieve adequate control of their blood sugars on intensive insulin therapy alone. Symlin will be the only therapy for the treatment of typ...Implanted Devices Detect High-Risk Heart Failure Patients
...muscles to pump enough oxygen and nutrients in the blood to the body's tissues. Also known as congestive he...ctions of the heart, coronary artery disease, high blood pressure, previous heart attacks and valve problems. An estimated 4.7 million Americans suffer from ......ists at Rush University Medical Center to grow new blood vessels in the heart. The phase II clinical resea...art tissue that has been damaged from insufficient blood flow. Once the catheter reaches the targeted site inside of the heart, the VEGF-2 is injected into ...How an AIDS-Related Cancer Unleashes Inflammation
...e that they are visibly red because of all the new blood vessels that KS produces," he said. In cell culture studies, the researchers found evidence of an “activation loop,?by which kaposin B activation of MK2 promotes even further MK2 activity by other proteins. The over-production of cytokines resulting...Chemists identify key gene in development of type 1 diabetes
...d says. Prediabetic individuals are those who have blood markers ?either antibodies or genetic markers ?that are predictive of the disease but are still able to produce insulin. Al-Abed and his associates hope that the experimental compound can one day be developed into a long-acting oral drug that could ...International HapMap consortium expands mapping effort
...ciency." To create the HapMap, DNA was taken from blood samples from volunteer donors from the following populations: Han Chinese in Beijing, Japanese in Tokyo, Yoruba in Ibadan, Nigeria and Utah residents with ancestry from northern and western Europe. No medical or personal identifying information was o...Vascular structure and function improve with diet and exercise
...he vasculature, so it might lower the risk of high blood pressure, diabetes, heart attacks and stroke," sai...e counseling included 38 patients with high-normal blood pressure (systolic greater than 130 mmHg to 139 mmHg, diastolic greater than 85 mmHg to 89 mmHg) or ...Towards precise classification of cancers based on robust gene functional expression profiles
...d says. Prediabetic individuals are those who have blood markers ?either antibodies or genetic markers ?that are predictive of the disease but are still able to produce insulin. Al-Abed and his associates hope that the experimental compound can one day be developed into a long-acting oral drug that could ......ological "wall" that limits what can pass from the blood into the brain. Other researchers have reported that this antibiotic can protect brain cells in animal models of other diseases -- multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, stroke and more. The drug is being tested in ea...