New asthma research opposes current drug treatment, says UH prof
... improving their overall health.
currently are contraindicated for asthma because ... Bond has suggested, however, that although beta blockers
would not replace the need for emergency inhalers ... the negative effects associated with beta blockers
eventually taper off to provide long-term relief ...
2 beta blockers found to also protect heart tissue
... Duke University Medical Center tested 20 beta blockers
and found that two of them -- alprenolol and ...
"To our surprise, we found that these two beta blockers
can actually stimulate the beta receptor to ... blocker drug for heart failure patients. Beta blockers
now are part of a standard of care for heart ...
Many African-Americans have a gene that prolongs life after heart failure
... failure. The new study offers a reason why beta blockers
don't appear to benefit some African-Americans. ... because of conflicting reports about whether beta blockers
helped African-American patients," says senior ... the genetic variant makes it appear as if beta blockers
aren't effective in these patients," he explains. ...
Gene therapy reversed heart damage in heart failure
... not reversed, with the concomitant metoprolol.
"Our data show that beta blockers
and the ARKct peptide are compatible and can be given together," Dr. Koch said. "Although beta blockers
are effective at stopping the downward progression of the disease, they do ...
Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
... for AF. Recent experimental and clinical data showed that calcium channel blockers
have a specific efficacy to prevent AF in this specific situation. Thus, ... the potential pathophysiologic mechanism explaining why calcium channel blockers
are effective and useful to attenuate atrial cellular remodelling ...
UC Davis grant zeroes in on novel asthma diagnosis and treatment
... researchers have demonstrated that sEH inhibitors are
strongly synergistic with current asthma drugs: cycloxygenase
inhibitors and several of the blockers
of leukotriene biosynthesis.
"We hope to both evaluate sEH inhibitors alone in treating asthma but
also to combine them with other inflammatory ...
Limping rat provides sciatica insights
... or limping, which could prove important as we evaluate different treatments."
Further studies are planned to test the effects of different IL-17 blockers
on the mechanics of the animals' movement.
Targeted drug therapy prevents exercise-induced arrhythmias
... deaths in young athletes.
Current treatment has been limited to two medications beta blockers, often used at very high doses, and calcium channel blockers
to control the arrhythmias. Implantable cardioverter defibrillators (ICDs) are placed in patients at high risk for sudden death, but ongoing ...
Researchers may have found why women have an edge on salt-sensitive hypertension
... in the kidney's tubules and vasculature while colleagues at the University of Edinburgh in Scotland are beginning studies to look at how ETA receptor blockers
impact sodium excretion in humans.
Vitiligo skin disorder could yield clues in fight against melanoma
... Le Poole hopes to throw a wrench into this overactive immune response. In collaboration with Assay Designs, Inc. of Ann Arbor, Mi., she is developing blockers
that would stop immune cells from absorbing stress hormones and triggering the immune response.
"An active immune response can be bad for vitiligo ...
Duke Medicine physician-scientist receives National Medal of Science
... membranes surrounding cells, are the targets of almost half of the drugs on the market today, including antihistamines, ulcer medications and beta blockers
for heart disease. Lefkowitz and his group first identified, purified and cloned the genes for these receptors in the 1970s and 1980s, thus revealing ...
Blood pressure response to daily stress provides clues for better hypertension treatment
... an hour of stress, a few minutes of relief, then back to stress by getting the young people to play competitive video games, then measuring how gene blockers
affect sodium excretion. "Ultimately, you want to know how to treat people with this variation," Dr. Harshfield says. "There is still a need to ...
Hypertension treatment effective in reversing vascular damage
... Center at Wake Forest University Baptist Medical Center, said, "We believe the data add to the growing evidence for the role of angiotensin receptor blockers
in preventing or reversing vascular damage at many stages during this disease process."
The one-year study, titled Vascular Improvement with ...
Proteins that stop a major signaling pathway can also generate new proteins
... virtually all physiological processes, everything from heart rate to mood. Research on GPCRs has led to numerous successful drugs, including beta blockers
which help relieve hypertension, angina and coronary disease, as well as new antihistamines and ulcer drugs. They also formed the basis of Nobel ...
Genetic variant mimics effect of heart failure medications
... the Center for Pharmacogenomics at Washington University. By
mimicking the effect of beta-blockers, the genetic variant makes it appear as if beta blockers
arent effective in these patients.
According to Dr. Liggett, the discovery of this variant is another milestone on the road to ...
Insects evolved radically different strategy to smell
... insect repellent blocks insect olfactory receptors and unrelated ion channels makes sense," says Vosshall. "I am optimistic that we can come up with blockers
specific for this very strange family of insect olfactory ion channels."
Blood pressure drug telmisartan shows powerful activity against stroke
... Society of Hypertension.
Telmisartan (brand name Micardis) is one of a class of widely used antihypertensive drugs known as angiotensin receptor blockers
(ARBs). "These drugs primarily act on the vasculature to relax the small blood vessels," Dr. Catanzaro explains.
Telmisartan stands out from other ...
Scientists unveil structure of molecular target of many drugs
... More than 40 years after beta blockers
were first used clinically, scientists can finally get a detailed, three-dimensional look at the drugs molecular targetthe beta2-adrenergic receptor. ...
Gene may hold key to future cancer hope
... is the fact that drugs are already being developed that are able to block the actions of Bub 1-type enzymes, known as protein kinases; such kinase blockers
or inhibitors are already providing a whole new approach to tackling cancer and Bub1 inhibitors may be another weapon in the oncologist's arsenal.
Nicotine may accelerate atherosclerosis, may be as dangerous as tar
... are preliminary. Going forward we will want to look at whether doping cigarettes with extra nicotine increases their atherogenic potential; whether blockers
of nicotine reduce atherosclerosis; and if oral administration of nicotine has the same effects," says Dr. Catanzaro.
About 20 percent of ...
Inflammation and drugs to control this activity studied in a variety of tumors sites
... breast cancer, and animal studies have shown a profound effect by COX-2 blockers
against a variety of cancers," he said.
Harris said that these results ... such as Alzheimer's disease. He hopes to continue to look at COX-2 blockers
at sub-therapeutic doses in chemoprevention.
"We need to look at a ...
Nicotine triggers the same brain reward circuitry as opiates
... Pennsylvania, said their findings suggest more effective ways that opiate blockers
could be used to help smokers quit.
In their experiments reported in ...
The researchers noted that clinical studies of opioid receptor blockers
to relieve cigarette cravings "so far have produced mixed results, ranging ...
8 plants from South Africa may hold potential for treating high blood pressure
Hypertension is treated with medication, including drugs such as angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers
(ARB). These drugs not only lower blood pressure but offer additional protection to the brain and heart. ACEI, in particular, provide beneficial ...
Stress may help cancer cells resist treatment, research shows
... However, recent studies suggest that these laboratory findings may apply to cancer patients.
"A study from Canada showed that men who took beta blockers
for hypertension for at least four years had an 18 percent lower risk of prostate cancer," said Kulik. "These drugs block the effects of epinephrine, ...
Tarantula venom and chili peppers target same pain sensor
... toxins are incredibly useful for understanding how ion channels of the nervous system work. They give us clues as to how specific activators or blockers
on these channels can be designed to treat persistent pain ?from arthritis, bladder infections, or other diseases."
The researchers determined ...
Meth promotes spread of virus in HIV-infected users
... with dopamine receptors present on the cells, and meth increases DC-SIGN, which are the HIV attachment receptors, use of dopamine receptor blockers
during HIV infection in meth users could be beneficial therapeutically to reduce HIV infection in these high-risk populations," Nair said. ...
Researchers reverse juvenile diabetes in animal model
... by bringing these foreign substances to the attention of T cells.
Once harvested, researchers then combine the dendritic cells with specific blockers
of molecules, known as CD40, CD80 and CD86, all of which can be synthesized in a laboratory. This treatment strategy was found to inhibit the ...