bipolar

Beyond lithium for bipolar disorder

...godsend for many of the two million Americans with bipolar disorder, it is not without its downside. People o...n and gain weight. However, better treatments for bipolar disorder depend on a better understanding of the still-mysterious mechanism by which lithium damps t...

FDA Warns About Antipsychotic Drugs and Elderly

...r treatment of depressive episodes associated with bipolar disorder is also included in the agency's advisory. FDA is requesting that the manufacturers of all of these kinds of drugs add a boxed warning to their drug labeling describing this risk and noting that these drugs are not approved for the treatmen...

Structure-building cell signals also may influence learning and memory

...t there is a connection between synaptojanin-1 and bipolar disorders and schizophrenia. Until now, nobody had made the connection between EphB and the endocytosis involved in neurotransmitter regulation. "There's also an increased interest in endocytosis in cancer, in which the process may help diminish ant...

Scientists move forward understanding of schizophrenia

...se the chances of people developing schizophrenia, bipolar disorder (manic depression) and major clinical dep...nt role in the risk of developing schizophrenia or bipolar affective disorder. The new genetic link we have made to PDE4B and how that links back to DISC1 shed...

Key brain regulatory gene shows evolution in humans

...n are vulnerable to drug addiction, schizophrenia, bipolar disorders and a form of epilepsy. So, we reasoned that humans might uniquely need to make more of this substance, perhaps because our brains are bigger, or because they function differently. "Also importantly, the part of the gene that produces the ...

Clock molecule's sensitivity to lithium sheds light on bipolar disorder

...hed light on circadian rhythm disorders, including bipolar disorder. The findings, which also provide insight into clock-controlled aspects of metabolism, are reported in this week's issue of Science. "We're interested in the internal control of metabolism because feeding behavior is on a daily cycle, and h...

Hopkins scientists show hallucinogen in mushrooms creates universal 'mystical' experience

...middle-aged-with no family history of psychosis or bipolar disorder were selected. All had active spiritual practices. "We thought a familiarity with spiritual practice would give them a framework for interpreting their experiences and that they'd be less likely to be confused or troubled by them," Griffiths...

Speeding the search for elusive chromosomal errors

...grant to investigate chromosomal rearrangements in bipolar disease, a complex disorder thought to involve interactions among multiple genes. Dr. Shaikh is currently collaborating with other researchers at Children's Hospital to evaluate other, higher-density gene chips (holding more than 500,000 oligonucleo...

Brain's 'gambling circuitry' identified

...-taking in disorders including gambling addiction, bipolar disorders, and schizophrenia. In their experimen..., as well as a variety of mental illnesses such as bipolar disorder and schizophrenia, are partially characterized by risk taking. To date, it is unknown wheth...

Smoking changes brain chemistry

...d disorders, including schizophrenia, dementia and bipolar disorder, as well as in cases of substance abuse, particularly alcohol dependence. Choline concentrations in the ACC were slightly lower in the smokers compared with the nonsmokers, and lower still in the female smokers compared with the male smo...

Studies look at how genes affect antipsychotic drug response

...o treat mental illnesses such as schizophrenia and bipolar disorder. Jeffrey Bishop, assistant professor of...in in children ages 8-18 who suffer from pediatric bipolar disorder. An increase in prolactin (a pituitary hormone that may affect bone development) or weight ...

New gene linked to bipolar disorder

A new gene linked to both depression and bipolar disorder has been identified by UCL (University Co... Mors at the University of Aarhus, first looked at bipolar cases in families living in the UK and in Denmark, and then at large numbers of unrelated people wit...

Brain networks strengthened by closing ion channels

...aging, and for cognitive changes in schizophrenia, bipolar disorder, or attention deficit hyperactivity disor...y disrupted in disorders such as schizophrenia and bipolar disorder. The current study found that brain cells in PFC contain ion channels called hyperpolari...

Lithium builds gray matter in bipolar brains, UCLA study shows

...hown that lithium, long the standard treatment for bipolar disorder, increases the amount of gray matter in t...tire surface of the brain in people diagnosed with bipolar disorder. When the researchers compared the brains of bipolar patients on lithium with those of ...

Genetic roots of bipolar disorder revealed by first genome-wide study of illness

The likelihood of developing bipolar disorder depends in part on the combined, small e...tions in human genes to find those associated with bipolar disorder. Results were published online May 8 in Molecular Psychiatry by Amber E. Baum, PhD, lead r...

Gene malfunctions cause schizophrenia, depression symptoms in mice

...in one family to be associated with schizophrenia, bipolar disorder, and major depression. The researchers... to the growing recognition that schizophrenia and bipolar disorder share, at least in part, common genetic etiologies and thus underlying molecular mechanisms...

Brain holds clues to bipolar disorder

...al clues to understanding, diagnosing and treating bipolar disorder, according to findings being presented to...l Institute of Mental Health (NIMH), suggests that bipolar disorder arises from abnormalities in neuronal plasticity cascades – the complex machinery inside of...