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biosynthesis in Biological News

Experts from Stevens, Merck, publish joint paper, 'Biosynthetic Studies of Platensimycin'

... academia and industry). It reports biosynthesis of a novel antibiotic, said Attygalle. It is the ... biosynthetic pathways leading to the biosynthesis of both compounds is a prerequisite for combinatorial biosynthesis and is also helpful for improvement of the titer ...

U Alberta researcher in same group as Darwin and Hawking

... antibiotics. Currently, more than 50 per cent of hospital-acquired infections are resistant to common antibiotics. Veredas' work also centres around biosynthesis by fungi of important metabolites including cholesterol-lowering drugs such as statins. "The appointment is a great honour and I was very ...

Comprehensive genetic study paves way for new blood-pressure medicines

... several genes that probably play a role in regulating blood pressure. The CYP17A1 gene on chromosome 10q24, for instance, plays a key role in the biosynthesis of glucorticoid hormones, which influence the metabolism of salt. In another area on chromosome 1p36 there are genes for two peptides with ...

A new way to assemble cells into 3-D microtissues

... applications. Beyond that, Bertozzi hopes to refine the present method of modifying cell-surface DNA. "As it stands, the need for unnatural sugar biosynthesis limits the kinds of cells that we can use in microtissue construction," she says. "There are other ways in which DNA can be conjugated to cells, ...

A new gene silencing platform -- silence is golden

... RNAi." Gunderson went on to say that the range of possible targets is very broad due to the mechanism of action in which inhibition occurs during the biosynthesis of mRNA at the near universal 3' end processing step. Perhaps the most interesting aspect of this technology is that U1 Adaptors can possibly inhibit ...

American Chemical Society's Weekly PressPac -- Jan. 7, 2009

... perhaps in a class of its own." JS ARTICLE #4 FOR IMMEDIATE RELEASE "Salicylic Acid sans Aspirin in Animals and Man: Persistence in Fasting and biosynthesis from Benzoic Acid" DOWNLOAD FULL TEXT ARTICLE http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/jf800974z CONTACT: Gwen Baxter, ....

Modified plants may yield more biofuel

... genetic approach. Instead of decreasing the lignin content, they are trying to modify the connections in lignin, without compromising either the biosynthesis of lignin or the structural rigidity of the plant. The Penn State geneticists and biochemists took a gene from beans and engineered it into a ...

The Danisco Award 2008 goes to D.Sc. Barbara Ann Halkier from Faculty of Life Sciences, Copenhagen

... the pathways to organisms in which production of glucosinolates does not occur in the wild type. Although several genes are involved in the biosynthesis of glucosinolates, Barbara Ann Halkier and her research group have recently succeeded in producing glucosinolates in non-cruciferous plants. ...

NYU biologist Bonneau named among 20 "visionary" scientists under 40 by Discover magazine

... stresses. Bonneau notes that by understanding how biological systems function, researchers can then turn their attention to engineering the biosynthesis of biofuels and pharmaceuticals. "We are now gearing up to try this sort of analysis on several other organisms," he noted. "In addition, because ...

Clue to genetic cause of fatal birth defect

... that as the fetal mouse brain develops it forms a blood barrier, blocking maternal cholesterol from brain cells. The brain becomes dependent on the biosynthesis of its own cholesterol once this blood-brain barrier forms, at day 10 of gestation. The UIC researchers established that in the fetus, the brain ...

Researchers find an essential gene for forming ears of corn

... looked at the interaction between spi1 and genes of the plant that regulate auxin transport, we found, interestingly, that the transport of auxin and biosynthesis work together in a synergistic manner to regulate how the meristem and lateral organs of the maize plant develop." ...

Researchers create safer alternative to heparin

... a process called chemoenzymatic synthesis that used specialized synthetic chemicals and natural enzymes expressed in E. coli to replicate the normal biosynthesis of natural heparin within the cell. The dose that Linhardt and his team were able to produce with this method was a million times higher than any ...

Researchers analyze how new anti-MRSA abtibiotics function

... and integrity of the cell wall are critical to the survival of these organisms, it is not surprising that many antibiotics work by either impairing biosynthesis of the cell wall, or simply bind to it to inhibit full structural maturation. In 2006, Mobashery and his team of researchers provided the first clear ...

American Chemical Society's Weekly PressPac -- July 16, 2008

... with improved taste and smells, the researchers suggest. MTS ARTICLE #2 FOR IMMEDIATE RELEASE "Biochemistry and Molecular Genetics of the biosynthesis of the Earthy Odorant Methylisoborneol in Streptomyces coelicolor" DOWNLOAD FULL TEXT ARTICLE http://dx.doi.org/10.1021/ja803639g CONTACT: ...

Boost for 'green plastics' from plants

... is low greenhouse gas generating, sustainable and can reinvigorate agribusiness. We are confident we have the right genes, an understanding of the biosynthesis pathways and the right breeding skills to produce an oilseed plant with commercially viable UFA levels in the near future, Dr Green says. The team ...

American Chemical Society's Weekly PressPac -- March 26, 2008

... electricity. There were no adverse effects on the plants. MTS ARTICLE #2 FOR IMMEDIATE RELEASE "Sub-lethal Levels of Electric Current Elicit the biosynthesis of Plant Secondary Metabolites" DOWNLOAD FULL TEXT ARTICLE http://dx.doi.org/10.1021/bp0703329 CONTACT: Hans VanEtten, Ph.D. University of ...

New drug targets may fight tuberculosis and other bacterial infections in novel way

... believe their agent would inhibit production of PGLs there, as well. Work is already underway to come up with other, even more potent PGL biosynthesis inhibitors, Dr. Quadri says, with an eye to testing the best candidates in an animal model. "We are not saying that anti-infectives will ever ...

Molecular Biology of the Cell celebrates 25 years of publication

... this subject that is so central to all of biology. Contents in Brief I. Introduction to the Cell 1. Cells and Genomes 2. Cell Chemistry and biosynthesis 3. Proteins II. Basic Genetic Mechanisms 4. DNA, Chromosomes and Genomes 5. DNA Replication, Repair, and Recombination 6. How Cells Read the ...

Genetic technology reveals how poisonous mushrooms cook up toxins

... in fungi. Fungal natural products that benefit human health include penicillin and the immunosuppressant drug cyclosporin. Studying their biosynthesis could lead to the discovery and development of new medicines. To find the elusive gene for alpha-amanitin, they used what they term brute force a ...

Researchers discover natural herbicide released by grass

... works as a plant killer. Plants depend on the production of large amounts of another common amino acid, phenylalanine, which is essential for the biosynthesis of wood, cell walls and lignin. "Phenylalanine, m-tyrosine and p-tyrosine are structurally all very similar," said Schroeder. "Because of this ...

ASPB announces Summer Undergraduate Research Fellowship 2007 recipients

... Responses in Arabidopsis thaliana through int Mutants Mentor: Dr. Jian Hua Charles Mason, Pennsylvania State University Project: Heterologous biosynthesis of flavonoid metabolites and characterization of induction properties of a transcription factor in fungal challenged maize plants. Mentor: Dr. ...

MIT unraveling secrets of red tide

... coincidence that these cascades work best in water and that dinoflagellates are marine organisms, water may nevertheless be directly involved in the biosynthesis of the toxins or emulating an important part of it, said Jamison. Because of this result, the researchers now believe that organic chemists should ...

'Conversation stoppers' fight deadly bacterial infections

... than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines ... evidence of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are ... pursuit of additional enzymes involved in NAE biosynthesis should further enrich our understanding of the ...

Nanotechnology propels advances in regenerative medicine research

... than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines ... evidence of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are ... pursuit of additional enzymes involved in NAE biosynthesis should further enrich our understanding of the ...

Brown seaweed contains promising fat fighter, weight reducer

... than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines ... evidence of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are ... pursuit of additional enzymes involved in NAE biosynthesis should further enrich our understanding of the ...

Study shows enzyme builds neurotransmitters via newly discovered pathway

... than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines ... evidence of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are ... pursuit of additional enzymes involved in NAE biosynthesis should further enrich our understanding of the ...

CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts

... both the CO2 -dependent filamentation in C. albicans and the capsule biosynthesis in C. neoformans. The authors go on to show that CO2 sensing in C. ... accomplishes this by providing bicarbonate substrates for fatty-acid biosynthesis and other cellular processes. In contrast, the CA enzyme is dispensible ...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

... that Rv1347c was almost certainly a "missing enzyme" from the pathway for biosynthesis of the iron scavenging agent mycobactin," recalls Dr. Baker. ... that synthesize mycobactin are drug targets, because if mycobactin biosynthesis is stopped, the bacterium cannot acquire the iron that it needs for ...

To sleep, perchance to dream: New insight into melatonin production

... peaking in the middle of the night. Melatonin's expression pattern is mimicked by a protein called AANAT, which is a key enzyme in the melatonin biosynthesis pathway. Dr. Kim and colleagues uncovered the mechanism of rhythmic control of AANAT mRNA translation, and thereby melatonin synthesis. The ...

Researchers learn what sparks plant growth

... which include adjusting plant growth to reach light or strengthening stems to support leaves, are central to plant survival. Brassinosteroid biosynthesis has become a critically important area of plant biology research with significant implications for commercial agriculture. "It’s been a matter ...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

... This was a demonstration that stem cell efficacy could be enhanced even without the need for genetic engineering. (The drug, a glycosphingolipid biosynthesis inhibitor, is in a class of compounds called "substrate reduction therapy" drugs.) This part of the study not only represented the first ...

Lead with a poisonous electron shield

... becomes distorted and inefficient; the three remaining sites get a reduced efficiency. d-Aminolevulinic acid dehydratase is essential for the biosynthesis of hemoglobin. Inhibition of this enzyme disrupts the formation of blood to the point of anemia. At the active center, a zinc ion binds to four ...

Patients can report statins' adverse effects on new web site

... Statin Study. A statin is any of a class of lipid-lowering drugs that reduce serum cholesterol levels by inhibiting a key enzyme involved in the biosynthesis of cholesterol. Statin cholesterol-lowering drugs are among the most prescribed drugs in the United States. According to Consumer Reports, two such ...

Methane-belching bugs inspire a new theory of the origin of life on Earth

... insights into the evolution of the microbial production of methane, the primary component of natural gas. A detailed understanding of methane biosynthesis could lay the foundation for a new alternative energy source, by raising the possibility of cost-efficient conversion of renewable biomass into clean ...

The molecular post office inside the cell

... May 5, 2006). Sorting proteins is fundamental to the gene expression of every organism - from bacteria to humans. Particularly important during biosynthesis is sorting secretory and membrane proteins, which have to find the way to their final destination inside or outside the cell. Secretory proteins are ...

When the going gets tough, slime molds start synthesizing

... be restored. Noel and Michael Austin, Ph.D., a postdoctoral fellow in Noel's lab and co-lead author of the study, have an ongoing interest in the biosynthesis of diverse plant and microbial polyketides by enzymes known as type III PKSs. Plants make polyketide natural products such as flavonoids and ...

Novel protein complex enables survival in hostile environment

... Tech, who studies how metabolic systems evolved and collaborates with Mukhopadhyay. "It is possible that M. jannaschii had this enzyme for cofactor biosynthesis and having it in advance gave the organism a selective advantage when oxygen, and consequently sulfite, appeared," Mukhopadhyay said. "Since we now ...

Bacterial genome sheds light on synthesizing cancer-fighting compounds

... funded the study. "Furthermore, " he added, "by producing patellamides in the lab, the team demonstrated an important proof of principle for the biosynthesis of naturally occurring marine products." ...

Marine sponge yields nanoscale secrets

... Nature produces silica on a scale of gigatons –?thousands of millions of tons –?thousands-fold more than man can produce, said Morse. "This biosynthesis is remarkable because this nanoscale precision can't be duplicated by man." Besides this remarkable precision, nature manages to produce silica at ...
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