Bile in Biological News

Scientists link immune system's natural killer cells to infant liver disease

... atresia in infants, a disease where blocked bile ducts can cause severe liver damage and death. ... that blocking a gene that helps NK cells attack bile duct tissues lessens damage and may be a way to ... immune system's role in causing injury to bile ducts soon after birth, and they have ...

Toxic bile damages the liver

... damage. Because a protective component of the bile is missing, the liver cells are exposed to the ... Defective transporter protein makes the bile toxic The Heidelberg University Hospital ... the ABCB4 gene can cause inadequate secretion of bile in the liver, giving rise to cirrhosis. The ...

UT Southwestern's Mangelsdorf elected to National Academy of Sciences

... of the mechanisms that control cholesterol and bile acid metabolism. His work complements the Nobel ... and ligands play in the regulation of lipid and bile acid metabolism and the governance of ... said he had not expected to study cholesterol or bile acids when he first came to Dallas. As is ...

Story ideas from the Journal of Lipid Research

... of Atherosclerosis Breaking the Vicious Cycle of bile Acid Disorders Genetic Variants Affect ... Breaking the Vicious Cycle of bile Acid Disorders Researchers have found a ... new and improved avenue for treating defective bile acid absorption, a primary contributor to chronic ...

Olympus broadens portfolio with new biliary metallic stent

... to help relieve the symptoms associated with pancreatic, liver and bile duct cancers. The NIRflex advanced cell design biliary metallic ... rounded, helping to reduce stress to the tissue and prevent damage to the bile duct and duodenal walls. "Olympus provides the most extensive line of ...

American Chemical Society's Weekly PressPac -- May 20, 2009

... help digest fats. The researchers showed in laboratory studies that the bile acid-derived resins form a hard, durable plastic that resists cracking ... "New Dental Composites Containing Multimethacrylate Derivatives of bile Acids: A Comparative Study with Commercial Monomers" DOWNLOAD FULL TEXT ...

Burnham researchers present at 100th AACR Meeting

... Inhibitor of NFκB Activation Induced by Protein Kinase C and Antigen Receptors. Changming Fang, Ph.D., who will also present two papers: Ileal bile Acid Binding Protein Mediates the Chemopreventative Effect of Ursodeoxycholic Acid by Activating Nuclear Receptor FXRα in Colorectal Cancer and ...

Mapping the genetic locus for triglycerides

... enzymes that break down fats; the receptor for the appetite hormone leptin; and sterol carrier protein 2, which helps convert cholesterol into bile acids. The researchers also note that another recent study identified a single nucleotide polymorphism associated with elevated TG levels in the ...

Gut protein found to protect against infection and intestinal breakdown

... A protein that binds to bile in the small intestine may hold the key to ... be the size of a tennis court. When there's no bile in the intestine, as happens in people with ... blood infection known as sepsis. Simply giving bile acids orally as a substitute isn't a good ...

U-M researchers take new approach to defeating Gram-negative bugs

... modification, Woodard said. Also, E. coli can typically withstand the bile salts found in the human digestive tract, but by weakening it, Woodard's team found E. coli would die in the presence of normal levels of bile salts to which the bacteria would be exposed in the human gut. Besides ...

Fat overrides effects of vitamin C

... acidic environment of the stomach, nitrite spontaneously forms nitrosating species able to convert a range of targets, such as secondary amines and bile acids, into carcinogenic N-nitrosocompounds. Antioxidants such as ascorbic acid protect against the formation of these nitrosocompounds by converting ...

Primitive yeast yields secrets of human cholesterol and drug metabolism

... be. Dap1 locked on to all four P450s, including one required for clearing half of all known drugs from the body, another involved in making bile and one required for making natural steroid hormones in the adrenal glands. “Collectively, our experiments suggest that Dap1 acts as a common ...

Liquorice cancer care

... and liver tumours are very resistant to chemotherapy. The American Cancer Society estimates that 18,510 new cases of primary livercancer and bile duct cancer will be diagnosed in the United States during2006, and around 16,200 people will die of liver cancer. Studies in mice by Zhi Yuan and ...

Gene discovery may shed light on kidney disease

... cells to develop into specialized organs. Mutations in those genes are thought to disrupt normal development, by, for instance, causing the defective bile ducts found in the livers of many patients with Alagille syndrome. "Ligands and receptors are like keys and locks," said Dr. Spinner. "If either ...

Jefferson scientists identify gene defect leading to abnormal skin development and cancer

... that feed tumors but not other blood vessels. The other two components of the pheromone are a second steroid and an already known, lamprey-specific bile acid derivative. Until the pheromone can be synthesized in bulk, extracts of water from larval lamprey nurseries are being used to trap adults ...

Leading lampreys to slaughter: Pheromone for scourge of Great Lakes identified

... that feed tumors but not other blood vessels. The other two components of the pheromone are a second steroid and an already known, lamprey-specific bile acid derivative. Until the pheromone can be synthesized in bulk, extracts of water from larval lamprey nurseries are being used to trap adults ...

Plant wounds trigger bacteria

... these host organisms," Winans said. "For example, others have shown that the bacteria that cause cholera express protein toxins only when they detect bile salts in the host's intestine. It will be interesting to see whether those bacteria also increase the replication of the genes necessary for ...