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Protein discovery could unlock the secret to better TB treatment

...icker, more effective treatment of TB by waking TB bacteria in the body. Once the TB bacteria are active again, the disease becomes treatable using common drugs like antibiotics. Scientists beli...

W.M. Keck Foundation funds study of friendly microbes

...equence genes belonging to the vast communities of bacteria that normally live on and in us. Now a $1.45 mill...sequencing and analyzing the genomes of "friendly" bacteria that inhabit the intestine and identifying the natural metabolic products that they synthesize in th...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

... on other planets and couldadd to understanding of bacteria inside the human body.A team of CU-Boulder biologi...be using that," he said.There are many examples of bacteria living in extreme environments --including the human body -- using hydrogen as fuel, according to Sp...

Dysentery uses 'sword and shield' to cause infection

... Institut Pasteur, Paris, found that shigella, the bacteria which causes dysentery, is able to invade cells, w...ile lipopolysaccharide (LPS) on the surface of the bacteria acts as a shield to protect the dysentery bacterium from being destroyed by the body's immune system...

Growth in the sea comes down to a struggle for iron

...ys Wells. "It's basically chemical warfare by the bacteria in soils, trying to get the iron. They specificall... "Now in reality it's warfare. In some cases other bacteria have figured out ways to get the iron from molecules that they didn't produce. So, they can pirate t...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...roject. E. histolytica is a voracious predator of bacteria and shares a close relationship in the human gut w...Because the parasite uses the same methods to kill bacteria as it uses to damage human cells and cause disease, the level of certain bacteria in the colon can b...

Plants respond similarly to signals from friends, enemies

...at include the formation of either nodules housing bacteria or giant cells from which the nematodes feed. The scientists also discovered that, like rhizobia and contrary to popular belief, the root-knot nematode signals plants from a distance and therefore does not need to attach itself to the plant to elici...

The secret to longevity in tubeworms

...fide this worm needs is created by a consortium of bacteria and archaea that live in the deep sea cold sediments surrounding the seep where the worm lives. These chemoautotrophs use energy from hydrocarbons to reduce sulfate to sulfide, which L. luymesi absorbs through its unique "roots," extensions of its bo...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

... that previous attempts to linkKawasaki disease to bacteria or other viruses had failed and thusjustified healthy skepticism about the present findings, Dr. McIntoshpointed out some "tantalizing facts": onset of Kawasaki disease isoften preceded by a respiratory syndrome; both the disease andrespiratory coron...

Bacteria collection sheds light on urinary tract infections

... to get UTIs than men because it is easier for the bacteria to reach their bladder. Fifty percent of all women...cted over 40 years from the center to match up the bacteria causing UTIs with bacteria found in animals. They tested E.coli samples from dogs, cows, sheep, wate...

Research on Worms Yields Clues on Aging

...extend life by protecting theworms from pathogenic bacteria in their environment.Ethosuximide and trimethadione did, however, significantly delayage-related declines in neuro-muscular activity. Treated wormscontinued to display the youthful traits of fast body movement and fastpumping of mouthparts during the...

U-M scientist to talk about tissue engineering at AAAS

...ion therapy for cancer means managing the constant bacteria bath of a human mouth as well as compensating for the damage of radiation. "It's not just a question of whether we can make new tissue in a perfect condition. Now we're mimicking what can really happen in a person, and we don't know if the rules of ...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

... the biosynthetic pathway for an agent used by the bacteria to scavenge iron. The research appears as the "Pa...er. "Importantly this seems to be true even of the bacteria that are taken up by macrophages in the lung and enter a dormant state ?these are the hardest to att...

Scientists seek answers on what activates deadly anthrax spores

...earch stems from lessons learned from studying the bacteria that cause Staphylococcus infections and two other bacteria in the same group as anthrax. Claiborne said the group proposes that a vitamin B5 derivative known ...

Dinosaur DNA? New Patent Covers Degraded DNA recovery

...rgene Corporation for the recovery of live ancient bacteria and fungi fossilized in amber. By reconstituting nucleic acid molecules that have been degraded but still contain useful information scientists at MatrixDesign are able to create a template from which to multiply the genetic material. That process i...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

For the first time, scientists have foundthat bacteria can use a Sonar-like system to spot other cells (e...24 issue of Science, this finding explains howsome bacteria know when to produce a toxin that makes infection moresevere. It may lead to the design of new toxin...

A bacterial genome reveals new targets to combat infectious disease

...e worldwide. The nematodes themselves play host to bacteria that live within their cells, but in this case, the relationship is classic mutualism, with each benefiting from the other. Indeed, the Wolbachia bacterium is so crucial to its host nematode that apparently eradicating it with antibiotics severely co...

Solution to Pollution: New Bacteria Eats Toxic Waste

...e University researchers recently discovered a new bacteria that is a natural cleanser for contaminated soil. ... understand the genetic material that allows these bacteria to degrade the PAHs and survive in the soil. Such knowledge may help researchers better understand a...

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

... the shape of a protein on the surface ofpneumonia bacteria helps these germs invade the human bloodstream. Th... paddle-like molecule thatStreptococcus pneumoniae bacteria use to latch onto cells lining thethroat and lungs. The protein, called CbpA, binds to a molecule on...

Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses

...rless handwipes only removed roughly 50 percent of bacteria from volunteer subjects?hands. "We studied the ef...cy of 14 different hand hygiene agents in reducing bacteria and viruses from the hands," said Emily E. Sickbert-Bennett, a public health epidemiologist with the...

New comparative toxicogenomics database

... the shape of a protein on the surface ofpneumonia bacteria helps these germs invade the human bloodstream. Th... paddle-like molecule thatStreptococcus pneumoniae bacteria use to latch onto cells lining thethroat and lungs. The protein, called CbpA, binds to a molecule on...

Scientists identify genetic pathways essential to RNA interference

...ne of the worms' 19,000 genes by feeding the worms bacteria that produce double-stranded RNA for each gene. Inactivation of about 90 genes caused the worms to glow, indicating that those genes were essential to the RNAi process that had been suppressing expression of the fluorescence gene. Some of the identi...

Scientists discover unique microbe in California's largest lake

...duceoxygen by photosynthesis."While there are some bacteria that can use infrared light forphotosynthesis, the...e more primitive non-oxygen evolvingphotosynthetic bacteria and the chlorophylls found in oxygen evolvingphotosynthetic organisms. It may have an important plac...

New SARS Protein Linked To Important Cell Doorway

...ratory, transplanted orf7a into bacteria. When the bacteria made the protein, researchers purified it and used it to determine the three-dimensional structure of orf7a. This purified protein also allowed colleague Michael Diamond, M.D., Ph.D., assistant professor of molecular microbiology, to generate orf7a-s...

Jumping gene helps explain immune system's abilities

...s, Craig notes. Bacterial jumping genes canprotect bacteria from certain antibiotics. Scientists also are studyingjumping genes as vectors to carry gene therapies and as potentialmodifiers to disrupt the growth-controlling genes of organisms such asmosquitoes and medflies....

UCSD Discovery Shows How Embryonic Stem Cells Perform 'Quality Control' Inspections

...s, Craig notes. Bacterial jumping genes canprotect bacteria from certain antibiotics. Scientists also are studyingjumping genes as vectors to carry gene therapies and as potentialmodifiers to disrupt the growth-controlling genes of organisms such asmosquitoes and medflies....

New therapy for HIV/AIDS eliminates needles and excessive toxicity

...s, Craig notes. Bacterial jumping genes canprotect bacteria from certain antibiotics. Scientists also are studyingjumping genes as vectors to carry gene therapies and as potentialmodifiers to disrupt the growth-controlling genes of organisms such asmosquitoes and medflies....

Gene sequencing explains bioremediation 'bug'

...s, Craig notes. Bacterial jumping genes canprotect bacteria from certain antibiotics. Scientists also are studyingjumping genes as vectors to carry gene therapies and as potentialmodifiers to disrupt the growth-controlling genes of organisms such asmosquitoes and medflies....

The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures

...resent the variety found in organisms ranging from bacteria to humans. Researchers can use these structures, which are determined experimentally, to build computer models of the structures of other proteins with related amino acid sequences. Although the main focus of the second phase of the PSI will be on s...

UCSD discovery may help extend life of natural pesticide

...iensis toxin, or Bt toxin--a pesticide produced by bacteria and widely used by organic farmers and in genetically engineered crops to ward off insect pests. Their findings should facilitate the design and use of Bt toxins to prevent insects, which the researchers believe also possess the molecule, from devel...

The Bacteria's guide to survival

If there was a market for it, a survival guide for bacteria might include topics like "How to use your pili to...tion with apoptosis, or programmed cell death. For bacteria that pass directly from host to host, this can pose a problem. If the bacteria are highly virulent a...

Scientists discover that host cell lipids facilitate bacterial movement

... into adjacent cells and are ingested by them. The bacteria then enter the new cell and begin the cycle anew. ...oticed that Listeria movement slowed down when the bacteria were treated with molecules that inhibited PI3-kinase, proving that Listeria depend on PI3-kinase to...

UF Researchers Map Bacterial Proteins That Cause Tooth Loss

...um cell proteins with the proteins produced by the bacteria when grown in a neutral medium. Bacterial proteins from the two conditions were separated using a new technique called Multidimensional Protein Identification Technology, or MudPIT. Once separated, mass spectrometry was used to measure each protein’...

Scientists solve structure of key protein in innate immune response

When bacteria invade the body, a molecule called CD14 binds to substances liberated from the bacteria and initiates the cellular defense mechanisms. In a report published in the Journal of Biological Ch...

Family trees of ancient bacteria reveal evolutionary moves

...y movements in Cyanobacteria at this time, and the bacteria were making an impact on the Earth's development. Geologists in the past have been relying on geological events for transitions that triggered change, but I'm arguing that a lot of these things could be evolutionary." Blank presented her research at...

Sequencing of marine bacterium will help study of cell communication

...s been studying for several years. Many different bacteria use quorum sensing. Stevens explains that cells re...ogen, the release of toxin once a certain level of bacteria build up. Stevens studies the regulation system of the cell-to-cell communication. "Our quorum sens...

Researchers develop rapid diagnostic tool for pathogen identification

...d discriminates 22 pathogens including viruses and bacteria that can present as clinically similar pulmonary disease. This new technology platform addresses important challenges for infectious disease identification—sensitivity and breadth. Mass Tag PCR provides the ability to be precise in identification, ...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

... postnatal Day 4 either with the common intestinal bacteria E. coli, with salt water, or with nothing. In rats, Day 4 is like the third trimester in human pregnancies, a time when the brain grows significantly. Once the pups grew up, Bilbo and her colleagues tested the adults' memory about 60 days after birt...

LUCA technologies confirms real-time methane generation

... this consortium. Clostridia form a broad genus of bacteria known for their diverse metabolic pathways. Clostridia frequently thrive in anaerobic environments and many species are known for their heat tolerance. Thermatoga microorganisms are known to play a role in the anaerobic oxidation of hydrocarbons to a...

Multiple Campylobacter Genomes Sequenced

... sequences may provide useful clues about why some bacteria cause human disease, how to control their spread, ... scientists can learn much more about what makes a bacteria tick than they can learn from a single sequence. Derrick Fouts and his colleagues have taken this c...

Drug-resistant bacteria on poultry products differ by brand

The presence of drug-resistant, pathogenic bacteria on uncooked poultry products varies by commercial ...tibiotics foster the development of drug-resistant bacteria which can spread to the human population. Claims have been made that using antibiotics increases foo...

Programmable cells: Engineer turns bacteria into living computers

... computers, engineers at Princeton have programmed bacteria to communicate with each other and produce color-c...d graduate student Subhayu Basu programmed E. coli bacteria to emit red or green fluorescent light in response to a signal emitted from another set of E. coli. ...

Substance protects resilient staph bacteria

...e during Dr. Otto's research of how Staphylococcal bacteria biofilms contribute to evading human immune defenses. Biofilms are protective cell-surface structures. Biofilm formation does not depend on PGA, but other research in Dr. Otto's laboratory has indicated that PGA production is greater when a biofilm i...

PGA on a tour under the skin

...A) to facilitate growth and ensure survival of the bacteria inside the human host. PGA protects the pathogen from innate host defenses during infection. S. epidermidis is the only human pathogen known to produce PGA other than Bacillus anthracis, but several differences exist in how the two pathogens use PGA ...

Robot-based system developed at Carnegie Mellon detects life in Chile's Atacama desert

...ts found that they contained life. The lichens and bacteria in the samples are growing and awaiting analysis."...f Biological Sciences. "Every sample we tested had bacteria in it." Minkley is conducting analyses to determine the genetic characteristics of the recovered ba...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

... a new drug to market.?/p> About 70 percent of bacteria found in hospitals resist at least one of the drug...in the body, and pharmacodynamics, their effect on bacteria or how a drug kills bacteria. “In the past, blood samples were taken and the serum concentration of...

Researchers identify protein crucial for survival of Lyme-disease bacterium

...n an infected tick bites an animal or a human, the bacteria are transmitted to the new host. Infection causes ...t codes for the protein BptA. Without the protein, bacteria were unable to utilize the blood on which the tick feeds when it bites a victim. "As far as we can ...

New lab technique identifies high levels of pathogens in therapy pool

...rms, eventually matching some cloned and sequenced bacteria to the "Mycobacterium avium" bacterium present in ...gen species, an approach that misses many airborne bacteria that are difficult to grow in a lab environment. The new approach allowed researchers to survey more...

Microbial fuel cell: High yield hydrogen source and wastewater cleaner

...Inc. have developed the first process that enables bacteria to coax four times as much hydrogen directly out o... as acetic and butyric acids. However, giving the bacteria a small assist with a tiny amount of electricity -- about 0.25 volts or a small fraction of the volt...

To control germs, scientists deploy tiny agents provocateurs

...e formation of biofilms, goo-like amalgamations of bacteria that are widespread in nature and have serious imp... Biofilms can often constitute several species of bacteria and can be both harmful and beneficial. In one role, biofilms can coat plant roots and symbiotically...

Researchers make gains in understanding antibiotic resistance

...lanation of how the drugs' main cellular target in bacteria evolves to become resistant to some of these medic... jam the activity of the protein-making factory in bacteria in much the same way. They studied the MLSBK antibiotics, an acronym for a group of antibiotics whic...

Scientists identify genetic pathways essential to RNA interference

...ne of the worms' 19,000 genes by feeding the worms bacteria that produce double-stranded RNA for each gene. Inactivation of about 90 genes caused the worms to glow, indicating that those genes were essential to the RNAi process that had been suppressing expression of the fluorescence gene. Some of the identi...

NASA study finds snow melt causes large ocean plant blooms

...vironment for the growth of a specialized group of bacteria called denitrifying bacteria. These bacteria convert a nitrogen-based nutrient readily consumable by plants in seawater, called nitrate, into for...

Genetic defects give the immune system the green light to attack the pancreas

...t normally work together to fight invaders such as bacteria or viruses, adapting specifically to each new invader. Formed in the thymus gland, T-cells begin as “precursor?cells and mature ?during this time, receptor sites on their outer membrane are shaped to dock with each invader and destroy it. “As T-cell...

Leprosy microbes lead scientists to immune discovery

...n patients with lepromatous leprosy, or L-lep, the bacteria have overwhelmed the immune defenses and can spread along nerves throughout the body and may cause blindness. The scientists found DC-SIGN+ macrophages in both types of leprosy infections. The CD1b+ cells were present only in the milder form, indica...

Physiological effects of reduced gravity on bacteria

...n Journal of Applied Microbiology investigates how bacteria respond when they are subjected to environmental a...onses to reduced gravity and how for some species, bacteria from the International Space Station (ISS), potentially are adapted to the unique environmental cond...

Anammox bacteria produce nitrogen gas in oceans' snackbar

...wth rate. The researchers discovered this type of bacteria for the first time a few years ago in the oxygen p...cluding giant whales. The newly discovered anammox bacteria remove ammonium from the ocean, which as a result can not be taken up anymore by other organisms. Al...

Roots Engage in Underground Chemical Warfare

...al chemicals offers one explanation for why so few bacteria types actually cause disease in plants. Of the more than 50,000 plant diseases occurring in the United States, fungal pathogens are the leading cause. "Current understanding of plant defenses does not readily explain why a pathogen can cause disease...

Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.

...alve immune system in the light of the capacity of bacteria to evade the hemolymph bactericidal activity and t...s, soluble hemolymph components and the ability of bacteria to affect distinct signaling pathways responsible for the hemocyte immune response. Laura Canesi, f...

Friendly bacteria in humans may protect against HIV

Scientists have identified good bacteria already living in some humans that target and trap...tively, just as we use cats to control mice." The bacteria are strains of lactobacillus, commonly found colonizing the oral and vaginal cavities of humans. The...
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(Date:10/9/2008)... , , It,s hard being a mussel: you have to worr...not to mention an environment that can change your...few hours. , "It,s one of the most variable habi..."Mussels can spend part of the day bathed in cool ...e California sun." , Gracey led the first real-t...
(Date:10/9/2008)... ,, RIVERSIDE, Calif. Essential for life in...ne diseases such as rickets and osteoporosis, is n... overall human health, emphasizes UC Riverside,s ...n D. , In a paper published in the August issue ... Norman identifies vitamin D,s potential for contr...
(Date:10/9/2008)... , Work by researchers at North Carolina State Un... blue crabs grown and harvested from freshwater po...ldn,t worry, researchers say, because the pond-rai...sed brethren. , North Carolina,s native blue cra... Dr. Dave Eggleston, director of NC State,s Center...
(Date:10/9/2008)... , Nanotechnologies can be used to develop sustai...fects of fossil fuels as they are gradually phased...io is coming closer to reality as new technologies...s (DSCs) emerge with great promise for capturing o... efficient catalysts for energy-saving industrial ...
Breaking Biology News(10 mins):Brainy genes, not brawn, key to success on mussel beach 2Brainy genes, not brawn, key to success on mussel beach 3Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist 2Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist 3Turning freshwater farm ponds into crab farms 2Europe rallies behind nanotechnology to wean world from fossil fuels 2Europe rallies behind nanotechnology to wean world from fossil fuels 3Europe rallies behind nanotechnology to wean world from fossil fuels 4New study likely to fuel debate over annual physical exams 1928 1New study likely to fuel debate over annual physical exams 1928 2New study likely to fuel debate over annual physical exams 1928 3Scientists discover how cancer may take hold 799 1Scientists discover how cancer may take hold 799 2Lymph nodes can be key in spreading prion infectivity 541 1Lymph nodes can be key in spreading prion infectivity 541 2Rare albino ratfish has eerie silvery sheen 539 1Rare albino ratfish has eerie silvery sheen 539 2Rare albino ratfish has eerie silvery sheen 539 3
(Date:10/10/2008)...Michigan received $5 million from the National Ins...esource of high-quality experimental data sets of ...mputer-aided drug design to a new level. , The ...puter programs that can predict the effectiveness ...ciate professor in the U-M College of Pharmacy and...
(Date:10/10/2008)... Johns Hopkins University School,of Medicine is la...ptimizing Adjuvant Breast Cancer Strategies: From ...ent key research data on the latest advances in,br...ents in the treatment of breast cancer have,led to...ons that are,increasingly tailored to the specific...
(Date:10/10/2008)... The Mobile Massage Team, (http://www.mobilemassag...massage,services for corporate wellness programs, ... today that it is expanding its service area throu...lphia metropolitan region., "We are quite excited...ed, massage programs and services throughout both...
(Date:10/10/2008)...nationally recognized faculty will,present the ver...east,cancer in the multimedia course "Optimizing A...to Treatment Selection" during National Breast,Can...icing oncologists and other interested,health care...t care,advances. This accredited course offers con...
Breaking Medicine News(10 mins):Health News:U-M to house leading drug database 2Health News:Latest Research on Breast Cancer Presented in a Virtual E-Conference CME Course 2Health News:Mobile Massage Team Announces Expansion of On-Site Seated Massage Services Throughout Eastern Pennsylvania and the Greater Philadelphia Region 2Health News:Nationally Recognized Faculty Presents Latest Advances in Care of Patients with Breast Cancer 2
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