atherosclerosis

Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

...ic application of AIM regulation for prevention of atherosclerosis in the future. Most importantly and attractively for patients, this approach may not need dietary restriction." Dr. Miyazaki, associate professor in the Center for Immunology and of pathology, and his colleagues first discovered the protective role ...

Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes

...ypically, it has been considered a complication of atherosclerosis ("hardening of the arteries"), and not directly life-threatening. However, there is recent evidence that people with dolichoectasia are more likely to have aortic aneurysms, a potentially fatal weakening of the main artery that carries blood out from...

Mouse gene shows new mechanism behind cardiac infarction in man

...rent variants, increases or decreases the level of atherosclerosis has been identified in mice. The corresponding hum...urn, play an important role in the pathogenesis of atherosclerosis and of a number of chronic inflammatory diseases. The new finding will spur further research into th...

Excess liver gene protects against high-fat diet

...s." The researchers examined lipid metabolism and atherosclerosis in mice with an approximately 3-fold increase in the concentration of LXRa receptors in their livers. The mice also lacked a second gene that made them particularly prone to cardiovascular disease. When fed normal mouse chow, mice with a greater tha...

Promising therapies for haemophilia & heart disease

...s have shown that inhibition of P-selectin reduces atherosclerosis (hardening of the arteries) and the work of our collaborators shows that the events leading to deep vein thrombosis are reduced. P-selectin inhibitors have also been shown to be anti-thrombotic in early human trials" Measurement of P-selectin levels...

Researchers show how air pollution can cause heart disease

...res of vascular inflammation, which is involved in atherosclerosis on a number of levels. In the aortas of PM2.5–exposed mice, for example, they found increased levels of macrophages, immune cells that are an important ingredient in plaque deposits and also active participants in a biochemical pathway related to inf...

Intensive statin therapy may partially reverse plaque build-up in arteries

...n this study resulted in significant regression of atherosclerosis as measured by intravascular ultrasound (IVUS), a technique in which a tiny ultrasound probe is inserted into the coronary arteries to measure plaque. The study showed that regression occurred for all three pre-specified IVUS measures of disease burd...

Measuring artery repair cells could become new heart disease test

...ked the progression of the artery-clogging disease atherosclerosis to the inability of EPCs to continuously repair da...and inactivity are important in the development of atherosclerosis --the disease progresses as the body's loses its intrinsic ability to repair and rejuvenate itself. ...

Free-radical busting antioxidants might not promote healthy hearts

...ygenase-1 (HO-1). HO-1 is known to protect against atherosclerosis in animal models, although the mechanism is not completely clear. Not surprisingly, HO-1 was not induced by Vitamin E. Drugs closely related to probucol that contain the protective part of the drug were just as protective as the original drug. If th...

Use of amino acid supplement following a heart attack provides no benefit, may be harmful

... L-arginine therapy in older patients with diffuse atherosclerosis may worsen clinical outcomes," the authors write. ...

Little known DNA repair enzyme may be a tumor suppressor gene

... L-arginine therapy in older patients with diffuse atherosclerosis may worsen clinical outcomes," the authors write. ...

An elephant tail

... L-arginine therapy in older patients with diffuse atherosclerosis may worsen clinical outcomes," the authors write. ...

Thinner and younger

...ats by about 30 percent and protected them against atherosclerosis and cancer. Human study has been difficult because calorie restriction requires a very strict diet regimen, both to keep the total number of calories low and to insure that people consume the proper balance of nutrients. Some people from a group ca...

Pigeons provide clue to solving common problem in heart patients

...ys involving STAT4 may be potentially important in atherosclerosis therapy," he said. "We may identify ways to reduce or block its effect and slow or stop the unwanted growth of cells." He said that by finding the transcription factor, researchers can concentrate on modifying its pathway, and won't need to know wh...

Gene transfer using mutant form of good cholesterol cuts vascular plaque and inflammation

...lar) apo A-I in terms of protective effect against atherosclerosis and vascular inflammation, which are tied together," said Prediman K. Shah, M.D., director of the Division of Cardiology and the Atherosclerosis Research Center at Cedars-Sinai. "We used a unique approach to do a head-to-head comparison, which all...

Scientists work to identify genes that contribute to early heart attack risk

... that genetic factors contribute to risk for early atherosclerosis but the exact genes involved are not yet known. ...udy, the scientists will work to pinpoint specific atherosclerosis genes. This autopsy study included about 3,000 young people, ages 15 to 34, who died from accidental...

How blood flow dictates gene expression

...hrough the main vessels. This relationship between atherosclerosis and flow has been known for decades. More recently, tissue- culture studies have shown that Klf2 is activated by increased blood flow, or "fluid sheer stress." Indeed, in this study Kahn; first author John S. Lee, MD, PhD, Instructor in the D...

Tiny clue reveals new path toward heart disease

...SNP is significantly correlated with the degree of atherosclerosis in human aortas, the large blood vessel that brings blood from the heart to all parts of the body. Kalirin contains the hereditary information for the production of a protein that is involved in the migration of cells from one spot to another with...

New research shows that flu is a trigger of heart attacks

...in Western countries live with different stages of atherosclerosis and many will never show any clinical manifestations of the atherosclerosis. However, in some patients the quiescent, stable atherosclerotic plaques undergo sudden changes, mainly due to exaggerated inflammation, leading to rupture of these vulnerabl...

In mice, drug protects against diabetes and atherosclerosis

...rug prevented and treated both type 2 diabetes and atherosclerosis in laboratory mice that had been fed unhealthy die...genetically engineered to be highly susceptible to atherosclerosis were fed high-fat diets and assigned to receive the drug or an inert substance. One set of mice was ...