association

Association of herpesvirus with lung disorder questioned

...recent U.S. study, investigators in Japan found no association between a herpesvirus infection and a potentially ...rther studies are required to clarify the possible association of human herpesvirus 8 with this disease." ...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...Although Feinberg and others have already noted an association between loss of imprinting of IGF2 and colon cancer in people, the current experiments were designed to find out whether the loss of imprinting is involved in cancer's development or just in its progression. "Most researchers, including me, expect e...

Research advances quest for HIV-1 vaccine

...o determine the structure of the complex formed by association of 4E10 with a peptide fragment that is identical to the section of gp41 that the antibody recognizes. The researchers identified the specific amino acids on gp41 that 4E10 interacts with and the 3D structure adopted by these amino acids. These study...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...e unavailable at thetime. The statistically strong association with Kawasaki disease,however, was "quite surprisi...eliminary observations, Dr.McIntosh noted that the association between this novel coronavirus andKawasaki disease will require confirmation by others in larger fut...

Gene variations explain drug dose required to control seizures

...ng phenytoin, the researchers then searched for an association between clinical use of the drugs and variation in... involved in drug metabolism, showed a significant association with the maximum dose of phenytoin taken by patients with epilepsy. Moreover, a variant of a second...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

... perform high-density genome scans and genome-wide association studies on the genetics of complex diseases. About Affymetrix: Affymetrix scientists invented the world's first high-density microarray in 1989 and began selling the first commercial microarray in 1994. Since then, Affymetrix GeneChip(R) technology ...

Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth

... birth was associated with increased risk. Neither association was found in women with a history of smoking. Res...tively, who were lifetime nonsmokers, there was no association of traffic emissions with breast cancer for the other time periods. Nie said these findings related...

Use of Insecticides Linked to Lasting Neurological Problems for Farmers

...than 50 days. The researchers found no significant association between neurological symptoms and other chemicals,...ncluding herbicides or fungicides, and only a weak association between fumigant exposure and neurological symptoms. Some of the insecticides used by the licensed ...

How the environment could be damaging men's reproductive health

...ies will be able to show whether this is a genuine association or not." The study did not find a statistically significant difference between boys born to mothers who smoked or who worked in a potentially harmful environment where they might be exposed to heat, vibration or chemical, but the prevalence of crypt...

Computational Method Speeds Mapping of Cell Signaling Networks

...Bayesian network analysis can not only identify an association between signal molecules A and B, it can detect whether B depends on A for transfer of the signal. The team's analysis predicted all but three of 18 well-studied T-cell network relationships. Although the work was largely a "proof of principle" repo...

Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes

...ssel disease. "This study is the first to show an association between intracranial arterial dolichoectasia and the whole spectrum of small vessel disease abnormalities, thus defining a new cerebrovascular syndrome," said Amarenco. The researchers will continue to follow the patients in this study (the GENIC st...

Researchers make surprise discovery that some neurons can transmit three signals at once

...se glutamate to still be released. Finding such an association would be intriguing, but for now this remains just an hypothesis that will require much study, Dr. Gillespie said. The third author of the study is Gunsoo Kim, Ph.D., who is now pursuing post-doctoral studies at the University of California, San Fra...

Radio-tracking associated with 'dramatic shift' in water vole sex ratio

...llars. However, this is the first study to show an association between radio-collars and sex ratio, although further work is needed to establish a causal link. According to Moorhouse and Macdonald: "We would expect any such effect to be species-specific, but our results will alert those studying other small mamm...

Major new UNC-based drinking water study suggests pregnancy fears may be overstated

... and published in 1998. That research suggested an association between byproducts known as trihalomethanes and loss of pregnancy. "We think our new work should be an important contribution to policy studies," said principal investigator Dr. David A. Savitz of the UNC School of Public Health. "While it is not th...

Survey reveals women and doctors aren't talking about HPV

...essionals (ARHP) is a multidisciplinary non-profit association composed of professionals who provide reproductive health services or education, conduct reproductive health research, or influence reproductive health policy. Founded in 1963, ARHP's mission is to educate health care professionals, public policy mak...

Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants

...mission. One possible explanation for this lack of association between antiretroviral therapy and HIV DNA levels, the investigators hypothesized, may be the short duration of treatment in the study (a median of 98 days). Combination antiretroviral therapy may reduce HIV DNA in breast milk more slowly than HIV RN...

Circulating stem cells play small role in lung repair

...tus cannot be ruled out, Zander said. However, the association between the number of those cells found in the lung tissue with damage from rejection makes that unlikely. There was no sign of fusion between the bone marrow-derived cells and the donor pneumocytes, said Zander, who holds the Harvey S. Rosenberg, M...

Candida albicans Genome Fully Annotated

...tus cannot be ruled out, Zander said. However, the association between the number of those cells found in the lung tissue with damage from rejection makes that unlikely. There was no sign of fusion between the bone marrow-derived cells and the donor pneumocytes, said Zander, who holds the Harvey S. Rosenberg, M...

Revueltosaurus skeleton unearthed at Petrified Forest upsets dinosaur tale

...e these remains were not found with the teeth, the association could not be made. The newly discovered full skeleton of a Revueltosaurus makes it clear that the teeth are not of a plant-eating dinosaur, but of a herbivorous or perhaps omnivorous crocodilian ancestor living a mostly terrestrial life in the uplan...

Agilent Technologies introduces high-capacity human protein removal system for proteomics research

...e these remains were not found with the teeth, the association could not be made. The newly discovered full skeleton of a Revueltosaurus makes it clear that the teeth are not of a plant-eating dinosaur, but of a herbivorous or perhaps omnivorous crocodilian ancestor living a mostly terrestrial life in the uplan...

Virginia Tech group adds tools to DNA-targeted anti-cancer drugs

...target," Brewer said. "The previous systems had an association with DNA but could release, which might result in an impact on other parts of the cell." Because the therapeutic complexes only activate with visible light, the researchers are now able to add a luminescent tag that glows in the presence of ultra vi...

Bad aftertaste? New sensory on/off switch may 'cure' bane of artificial sweetener search

...target," Brewer said. "The previous systems had an association with DNA but could release, which might result in an impact on other parts of the cell." Because the therapeutic complexes only activate with visible light, the researchers are now able to add a luminescent tag that glows in the presence of ultra vi...

Male Combat Veterans Rank High In Heart Disease Risk

...Economic Status (LCSES) study is investigating the association between exposure to combat stress and behavioral a...tween wars. The LCSES study also is examining the association between socio-economic status and cardiovascular disease. More non-veterans tended to have higher in...

Study: Harmless virus kills some cancers

...ociated cervical cancer. In general, AAV2 requires association with a helper virus in order to replicate. When it finds a helper virus, such as HPV, AAV2 disrupts the life cycle of the host and induces apoptosis, a type of cell death. "Even without co-mingling with another virus, AAV2 seems to be able to infect...

A novel virus for croup

...access journal PLoS Medicine makes the strongest association yet between a newly identified virus and the pedia...atterns of HCoV-NL63 occurrence. This systematic association of croup with HCoV-NL63 is particularly timely as the newly identified virus has spread worldwide, r...

Biased reporting found in cancer prognostic studies

...zed information from studies that investigated the association between TP53 and mortality or survival rates. They...eved from researchers. The authors found that the association between TP53 status and head and neck cancer mortality weakened as they expanded their analyses from...

Naturally occurring asbestos linked to lung cancer

... researchers found a consistent and dose-dependent association between mesothelioma and residential proximity to ...was selected (since pancreatic cancer has no known association to asbestos exposure). For both the mesothelioma and pancreatic cancer cases, the researchers employ...

Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure

...fected individuals, the researchers noted a direct association between the severity of the infection and greater loss of brain matter. In methamphetamine abusers who are also HIV-positive, decreased volumes are correlated with increased cognitive impairment in one brain region, the hippocampus. Dr. Jernigan ex...

Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

... aggressive types of cancers," says Ippolito. The association of GABA with aggressive tumors was uncovered by a novel combination of techniques that can now be employed for further identification of substances linked to tumors and other diseases. The resulting information will significantly advance diagnosis an...

Hepatitis C complicated by morphine withdrawal

... abusers infected in the United States. This high association has peaked interest in determining the effects of ...gression of the disease. The discovery of such an association would impact treatment of both HCV infection and drug abuse. Dr. Wen-Zhe Ho has been interested i...

California computer scientists double volume of data in NIH biotech repository

...tic data and the incidence of disease." Disease association research is the main reason why the group from Cal...d Halperin: "If you are going to perform a disease association study, it's more economical to use these tag SNPs than the entire data." ...

U-M scientists say fused genes trigger the development of prostate cancer

...tic data and the incidence of disease." Disease association research is the main reason why the group from Cal...d Halperin: "If you are going to perform a disease association study, it's more economical to use these tag SNPs than the entire data." ...

Bacteria in Household Dust May Trigger Asthma Symptoms

...at NIEHS and the University of Iowa found a strong association between endotoxin levels and the prevalence of dia...red furniture and assayed for endotoxin. A disease association analysis was performed to correlate endotoxin concentrations to specific health outcomes. “When we ...

Studies on human genome variation provide insight into disease

...ssigned to specific genomic regions based on their association with DNA markers. The success of disease-association studies is dependent upon several characteristics of the DNA markers, including allelic frequency and genomic coverage. In some cases, a particular variant at one locus is perfectly associated wi...

Housecat-sized Siberian tiger cubs get collared

...ssigned to specific genomic regions based on their association with DNA markers. The success of disease-association studies is dependent upon several characteristics of the DNA markers, including allelic frequency and genomic coverage. In some cases, a particular variant at one locus is perfectly associated wi...

Oldest dated evidence of cattle in southern Africa found

...ew dates support this view and confirm a long-term association between people and livestock in this part of the Kalahari. The discovery of the 2000 year old cow and sheep bones are important because of the long held view that the Kalahari was a comparatively isolated area that was primarily occupied by foraging ...

Researcher uncovers details of how cancer spreads

...alled focal adhesion kinase, inside the cell. This association jump-starts a series of cascading interactions bet...ked to viruses, including the herpes virus and its association with cervical cancer. "Critics of this work will ask why v-Src has not been found in human cancer,"...

A bug's life: Exceptional genomic stability yet rapid protein evolution in a carpenter ant mutualist

...tionally unbalanced food sources. This mutualistic association is thought to contribute to the astounding ecological success of Camponotus, which, with approximately 1,000 species, represents the second largest ant genus. By sequencing the genomes of symbiotic microbes, scientists are currently uncovering the b...

Protein behind autumn color splendor identified

...earch team at Umea Plant Science Center (UPSC), in association with a Polish scientist, has identified a protease that degrades LHCII. The researchers assumed that the protease belonged to a certain family of proteases, the so-called FtsH proteases, and they used genetically modified mouse-ear cress plants in w...

Cornell finds natural selection in humans

... amino acid variants that could then be tested for association with human disease in subsequent studies. The Cornell researchers became involved at the analysis stage in order to make predictions about what types of changes are most likely to be functionally important. ...

Researchers identify molecular anchor that allows bacterial invasion of central nervous system

... found that a gene called iagA (short for invasion association gene-A) played a central role. By producing a fat-sugar complex that anchors LTA, iagA establishes a link that allows bacteria to begin making its way into the nervous system. The researchers found that removing the iagA gene from the Streptococcus ...

Gene controls whether fear is a factor

...ctric shock, he explained. That process of learned association occurs in a portion of the amygdala called the lateral nucleus. As a first step to unravel the molecular events underlying fear learning, Shumyatsky's group recently identified several genes present at particularly high levels in the lateral nucleus...

Rutgers researchers scientifically link dancing ability to mate quality

...ems it encounters as it matures. Symmetry, and its association with attractiveness, therefore indicates an organism's underlying quality as a potential mate. The study showed that higher-rated dancers were typically people with greater body symmetry. "At least since Darwin, scientists have suspected that dance ...

Brain activity related to processing faces is similar in people with, without autism

...ons of the brain increase their neural activity in association with various actions or thought processes, they emit enhanced blood oxygen level dependent signals. The signals can be localized in the brain and translated into digital images that portray neural activity level as a ratio of oxygenated to de-oxygena...

Same-sex mating by fungi spawned infection outbreak, evidence suggests

... death. While C. neoformans is found worldwide in association with pigeon droppings, the rarer C. gattii is norm...ricted to tropical and subtropical areas, often in association with Eucalyptus trees. "It is suspected that the infectious propagules of Cryptococcus are airborne...

New methods offer insight into regulatory DNA

...carried out to provide increased confidence in the association between gene activity and sequence variation. "Ou...etation of variation and disease. Such genome-wide association studies will be able to identify some regions of the genome with strong disease effects. "The HapMa...

No link found between caffeine intake and development of hypertension in women

...creased risk of hypertension in women, although an association was found with the consumption of sugared or diet ...Several previous studies have indicated a possible association between caffeine intake and the risk of hypertension. Short-term studies have demonstrated that caff...

New technique helps researchers determine amino-acid charge

...esolution to let researchers accurately detect the association and dissociation of protons to and from individual amino-acid residues in real time. Using the patch-clamp technique, the researchers were able to probe the electrostatic properties of the inner lining of the ion-channel's pore, and, from there, the...

Chlamydia parasite lives off our fat

...ption also suggests a possible explanation for the association between chlamydial infections and heart disease. ...

Bioengineers create stable networks of blood vessels

...or cells from the brain. Because there is often an association of nerve connections with vascular networks, they tested to see if a combination of the blood vessel-forming and nerve-forming cells would enhance development of the vascular networks. "By their nature, hydrogels are well suited for the transport of...

Mouse study reveals human X-SCID gene therapy poses substantial cancer risk

...ndings. "We were surprised by the strength of the association between IL2RG gene therapy and development of lymphoma," says Woods. "These results suggest that curing X-SCID by replacing IL2RG in the manner it is currently being done puts patients at an increased risk of developing cancer." Woods adds that the...

Ocean virus identified in human blood samples

...n Virginia Medical School, and AVI BioPharma. The association between viral infection and the presence of a disease of unknown cause does not prove cause and effect, the researchers say, but the data are intriguing and raise important new questions. Further research is needed to establish proof that infection w...

Antioxidant selenium offers no heart-disease protection

...rial covering 13 years has shown. The selenium-CVD association was a secondary endpoint in the Nutritional Preven...d for an average of 7.6 years. Results showed no association between selenium supplementation on any of the endpoints studied: coronary heart disease, stroke or ...

Relic of life in that Martian meteorite? A fresh look

...always associated with the mineral magnetite. This association is important because magnetite is known to act as a catalyst in the formation of MMC. Macromolecular carbon present within the carbonate globules in ALH84001 may represent the first evidence of non-biological synthesis of organic molecules on Mars. ...

Virginia Tech scientists develop process for creating biocompatible fibers

...ogical experiments to fundamentally understand the association of small molecules, then he determined that once phospholipids form an entangled network they can be treated similarly to higher weight molecules and electrospun. The size of the mats is limited only by the amount of material, such as lecithin. "Th...

Engineered mouse mimics cognitive aspects of schizophrenia

...y were less able than normal mice to reverse their association of a particular odor with a reward. Biochemical analyses of the animals' brains revealed that the excess dopamine receptor activity in the striatum contributed to abnormal prefrontal cortical function. Importantly, found the researchers, they could...

Protein 'nanosprings' most resilient found in nature

...tt said. For example, ankyrin repeats are found in association with specialized hair cells of the inner ear, where they play a critical role in converting sound (a mechanical stimulus) into an electrical signal that can be transmitted to the brain ?a process known as mechanotransduction. Ankyrin proteins also c...

Breast implants not associated with cancer risk, study reports

... authors conclude. Past reports have examined the association between cosmetic breast implants and cancer risk, ...een found. However, few studies have examined this association after more than 15 years. Joseph K. McLaughlin, Ph.D., of the International Epidemiology Institute ...

U-M scientists identify major psoriasis susceptibility gene

...asis," Nair says. "Many studies confirmed a strong association with the MHC, but no one could determine which gene in the MHC was involved in psoriasis." In a previous study, Nair and his U-M colleagues narrowed the search for the PSORS1 gene down to a 300,000-base-pair segment of chromosome 6 that included HLA...

Exposure to volcanic mineral associated with increased mesothelioma incidence in Turkey

...nvironmental exposures and additional study of the association between environmental exposure to nonasbestos fibers and the risk of cancer." ...