Arthritis in Biological News

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... predict outcome, and treat juvenile idiopathic arthritis (JIA). Eventually such findings could enable ... were supported by the National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS), a ... studies to be published in the July issue of arthritis & Rheumatism , scientists led by Michael Barnes, ...

New trigger for chronic inflammation in rheumatoid arthritis discovered

... it may be possible to develop more effective arthritis treatments. Rheumatoid arthritis is the most common autoimmune disease, affecting ... at Imperial College London, said: "Rheumatoid arthritis is a debilitating and painful disease and, ...

Researchers identify new risk factor gene for rheumatoid arthritis

... seeking to identify risk genes for rheumatoid arthritis (RA). The hope is to figure out the genetic ... scientists through the North American Rheumatoid arthritis Consortium," said Daniel Kastner, MD, PhD, clinical director of the National Institute of arthritis and Musculoskeletal and Skin Diseases. "In ...

Bad mix of bacterial remnants and genetics leads to arthritis

... show that a specific gene called NOD2 triggers arthritis or makes it worse when leftover remnants of ... is a step toward understanding the root cause of arthritis which one day may allow certain forms of arthritis to be prevented altogether." Davey and ...

Inhibiting proteins may prevent cartilage breakdown in arthritis patients

... COLUMBIA, Mo. Current arthritis medications can ease the pain, but stopping the ... hope to find new therapeutic targets for arthritis by studying the interaction between two proteins that, if interrupted, may prevent arthritis pain caused by joint damage. In a new study, ...

Gene therapy demonstrates benefit in patients with rheumatoid arthritis

... a study of two patients with severe rheumatoid arthritis conducted in Germany and led by an investigator ... Orthopaedic Studies at BIDMC. "Rheumatoid arthritis [RA] is an extremely painful condition affecting multiple joints throughout the body. arthritis is a good target for this treatment because the ...

Anakinra for rheumatoid arthritis: A modest benefit with some risk

... beneficial effect of anakinra for rheumatoid arthritis patients, but warns against potential risks for ... with other biologic medications. Rheumatoid arthritis is a chronic inflammatory disease affecting as ... and painful. Anakinra is one of a new breed of arthritis drugs licensed in the past decade called ...

Geisinger research: Antimalarial drug prevents diabetes in arthritis patients

... patients who received treatment for rheumatoid arthritis from 2000 to 2008. The study looked at, among ... but it has also been used to treat rheumatoid arthritis and other autoimmune diseases. In patients ... rheumatoid arthritis. People with rheumatoid arthritis are at increased risk for diabetes due to more ...

Small protein may have big role in making more bone and less fat

... such as TNF- and IL-1, involved in rheumatoid arthritis and other inflammatory diseases, Dr. Shi showed ... be needed to produce, for example, a powerful new arthritis treatment minus the undesirable effects. About 50 percent of arthritis patients who take glucocorticoids develop ...

Blood clotting protein linked to rheumatoid arthritis

... of inflammatory cells and fibrin may help arthritis patients. Our study establishes that fibrin is ... million people in the United States, rheumatoid arthritis is a painful and debilitating disease involving ... function, according to the National Institute of arthritis and Musculoskeletal and Skin Diseases. Although ...

New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis

... The innovative new rheumatoid arthritis drug Actemra (tocilizumab) has been shown to ... improve the signs and symptoms of rheumatoid arthritis (RA) in patients who failed to achieve an ... generally well tolerated. About rheumatoid arthritis ...

First-ever study: lack of critical lubricant causes wear in joints

... association before. The finding, published in arthritis & Rheumatism, sheds important light on how joints ... into hips, knees or other joints inflamed from arthritis or injury a preventive treatment that could ... Whats exciting are the clinical implications. arthritis and sports injuries damage the joints of ...

Rheumatologists win $1.2M for arthritis research

... to study the underlying causes of rheumatoid arthritis and to help find a cure for the disease. The ... deeply the molecular development of rheumatoid arthritis with the hope of finding new medicines and drug ... and biological differences between some arthritis patients, and whether genetic markers could ...

Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients

... utility in Crohn's disease (CD), rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), ulcerative colitis (UC), pediatric Crohns ... for reducing signs and symptoms of active arthritis in patients with PsA. Additionally, in September ...

Study identifies genetic risk factor for rheumatoid arthritis, lupus

... autoimmune inflammatory diseases: rheumatoid arthritis (RA) and systemic lupus erythematosus (lupus). ... Program (IRP) of the National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS) and ... Research Program at the National Institute of arthritis and Musculoskeletal and Skin Diseases. Dr. ...

Scientists discover new genetic immune disorder in children

... dangerous inflammation. Now, researchers from the National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National ... allwere treated with anakinra, a drug that is normally used for rheumatoid arthritis and is a synthetic form of human IL-1Ra. Although the patients were ...

Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research

... factor-alpha (TNF-alpha) as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions. "Thanks to their pioneering ... that our research defining TNF as a good therapeutic target for rheumatoid arthritis has subsequently led to TNF blockade in Crohn's disease, psoriasis, ...

Stem cells offer cartilage repair hope for arthritis sufferers

... number of cells can be generated. The research team, funded by the arthritis Research Campaign and the Swiss AO Foundation, have identified a ... overcome this limitation. This research could have real benefits for arthritis sufferers and especially younger active patients with cartilage lesions ...

Study helps explain how allergic reactions are triggered

... are involved in diseases ranging from multiple sclerosis and rheumatoid arthritis to cancer and atherosclerosis. In order for mast cells to function, ... other debilitating diseases, including multiple sclerosis, rheumatoid arthritis and cancer, an inhibitor of the CRAC channel could, in the future, help in ...

Osteoarthritis risk linked to finger length ratio

... has found. A study of more than 2,000 people, published in the journal arthritis and Rheumatism, suggests that people whose index finger is shorter than ... trait affects the risk of osteoarthritis (OA), the most common form of arthritis that may associate with both physical activity and oestrogen deficiency, ...

Study reveals 2 genes linked to disabling arthritis

... Center geneticist has discovered two genes linked to a disabling form of arthritis called ankylosing spondylitis, a painful and progressive disease in which ... significant findings, however, were in ankylosing spondylitis, a type of arthritis that not only affects the spine but also can attack other joints and ...

Major genetic breakthrough for ankylosing spondylitis brings treatment hope

... Research funded by the Wellcome Trust and the arthritis Research Campaign has identified two genes implicated in the disease ... Spondylitis Consortium funded by the National Institute of arthritis and Musculoskeletal and Skin Diseases. These genetic studies involve ...

All-in-1 nanoparticle: A Swiss Army knife for nanomedicine

... gold nanoparticles have been used since ancient times in stained glass; more recently they are being developed for delivering drugs, for treating arthritis and for a type of medical imaging that uses infrared light. Gold also reradiates infrared heat and so could be used in medical therapies to cook ...

They are young and need the job: A second chance for dangerous T-cells

... interest. Deciphering these processes could lead to new therapeutic approaches for autoimmune diseases such as multiple sclerosis, rheumatic arthritis and type-1 diabetes, which are triggered by autoreactive T-cells." Klein and his colleagues are working on a study into unexplained aspects of ...

Aussie and Kiwi researchers make double MS genetic discovery

... Kilpatrick. "They also reveal a link between genetic susceptibility to MS and other autoimmune diseases including Type 1 diabetes, Rheumatoid arthritis and Graves' Disease and the also the potential involvement of Vitamin D metabolism in the risk of developing these diseases." "These results are ...

Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine

... at Jefferson Medical College have received a five-year, $1.7 million National Institutes of Health grant funded by the National Institute of arthritis and Musculoskeletal and Skin Diseases to study mechanisms regulating stem cell self-renewal and differentiation with the aim of regenerating diseased ...

American Chemical Society's weekly PressPac -- May 27, 2009

... Although acting like conventional detergents, they seem unlikely to irritate the stomach. In test tube experiments, microcapsule versions of the arthritis drug, indomethacin, dissolved up to five times faster than a regular version of the drug. Lab rats given the new microcapsule version absorbed almost ...

Is cherry juice a new 'sports drink?'

... pain medications to reduce muscle pain and beyond. A growing body of research suggests cherries could affect inflammation related to heart disease, arthritis and may even help maintain muscle strength for those suffering from fibromyalgia (a common, chronic widespread pain disorder), according to a second ...

Limping rat provides sciatica insights

... involved in regulating the inflammatory response. Elevated levels of IL-17 have already been implicated in such autoimmune diseases as rheumatoid arthritis and asthma. "This finding suggests a possible role for immune system activation in contributing to symptoms of sciatica," said Shamji, now ...

KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex

... (Celebrex®, Pfizer). Celecoxib is a non-steroidal, anti-inflammatory Cox-2 inhibitor approved for the treatment of osteoarthritis, rheumatoid arthritis and acute pain. In addition, celecoxib’s anti-proliferative effect has earned it a place in numerous clinical trials against several ...

Biomedical researchers invited to design experiments for the International Space Station

... access to our nation's life sciences laboratory in space," said Stephen I. Katz, M.D., Ph.D., director of the NIH's National Institute of arthritis and Musculoskeletal and Skin Diseases, and NIH liaison to NASA. Already, biomedical experiments conducted on the International Space Station ...

Fireflies and jellyfish help illuminate quest for cause of infertility

... Scientists are using the luminescent and florescent genes to illuminate cells that produce a hormone linked to conditions, which include rheumatoid arthritis and lupus. The technique will help scientists track the production of the hormone prolactin, which is crucial in ensuring supplies of breast milk ...

Stopping autoimmunity before it strikes

... appears in the April 2009 issue of The American Journal of Pathology . Autoimmune diseases such as lupus, multiple sclerosis, rheumatoid arthritis and diabetes are caused when the immune system attacks the body's own cells. Normally, immune cells are prevented from attacking normal cells; ...

La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery

... of TNF, the first member of the family to be discovered, with its receptors, is an approved treatment for several diseases, including rheumatoid arthritis and inflammatory bowel disease. It is therefore possible that blockade of other members of this family, such as OX40L, might benefit some patients ...

Molecule that suppresses immune response under study in type 1 diabetes

... to get rid of IDO and observe what happens. He'll also enhance IDO expression in the females by giving a drug commonly used to treat rheumatoid arthritis that the MCG team has learned can boost IDO expression. "The mouse has an endogenous mechanism; it's just defective," said Dr. Mellor. "If you have ...

Compounds could be new class of cancer drugs

... in addition to studying the inhibitors in breast cancer models, they will explore how they work in cell systems that model brain tumors, rheumatoid arthritis and viral infections. ...

Exercise after knee replacement critical

... your new knee to nearly that of a healthy adult your age. That's the finding of a University of Delaware study published in the February issue of arthritis Care & Research . The authors include Lynn Snyder-Mackler, Alumni Distinguished Professor of Physical Therapy at the University of Delaware, ...

Scientists uncover new genetic variations linked to psoriasis

... the newly discovered variants have been associated with other inflammatory diseases such as Crohn's disease and autoimmune diseases like rheumatoid arthritis and lupus. Additional studies will help to tease apart the ways in which these diseases are connected at the level of DNA. This information will also ...

Jefferson scientists discover a key protein regulator of inflammation and cell death

... activity," Dr. Alnemri said. "Such therapeutics may be useful for the treatment of nucleic aciddependent pathogenic and autoimmune diseases, such as arthritis and systemic lupus erythematosus," Dr. Alnemri said. ...

Superglue from the sea

... "When you break the top of a bone in a joint, those fractures are difficult to repair because if they are not aligned precisely, you end up with arthritis and the joint won't work anyway. So it's very important to get those pieces aligned as well as possible." In lab tests using cow bone pieces from ...