arterial

Vascular structure and function improve with diet and exercise

...rteries were tested for intima-media thickness and arterial distensibility. Both reflect the health of the blood vessels. The thicker and less distensible (elastic) the arteries are, the greater the load on the heart. This often results from changes in blood pressure, blood glucose or cholesterol disorders su...

Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes

...ng been puzzled by a condition called intracranial arterial dolichoectasia, in which the larger arteries of th... first to show an association between intracranial arterial dolichoectasia and the whole spectrum of small vessel disease abnormalities, thus defining a new cer...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

...ll lead to more effective treatments for pulmonary arterial hypertension (PAH)--a deadly form of high blood pr...ulmonary vascular apoptosis and reverses pulmonary arterial hypertension. It's published in the June issue of The Journal of Clinical Investigation. In an accom...

Smoking damages key regulatory enzyme in the lung

...an nonsmokers, and the delivery of tracer into the arterial blood supply was much lower for smokers, particularly for the first few minutes after being injected, Fowler added. This finding could imply that smokers and nonsmokers respond differently to other substances that enter the body via the bloodstream, ...

Researchers learn how blood vessel cells cope with their pressure-packed job

...gs of the National Academy of Sciences (PNAS) that arterial endothelial cells subjected to repeated stretching (10 percent of their length, 60 times per minute) produced intracellular arrays of parallel "stress fibers" in a few hours. The tests were performed on endothelial cells lining the aorta of a cow, b...

Scientists pinpoint inflammation gene

...mmation, which is known to initiate the process of arterial wall hardening and the onset of Type 2 diabetes, we are developing an understanding of why obese persons with a faulty SEPS1 gene may be at higher risk of developing heart disease and diabetes," he said. The path to discovery: finding SEPS1 and its...

Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

...fully delivered genes from alloy samples to animal arterial smooth muscle cells. In a second experiment using rodents, the researchers detected gene expression with significantly lower restenosis in the carotid arteries of animals with the experimental stents, compared to control animals with conventional, po...

Feds give researchers ok for safety test of adult stem cells in patients with heart disease

... therapy, and vascular interventions for relief of arterial obstructions. In 2003, approximately 750,000 coronary artery bypass graft (CABG) surgeries were performed worldwide and approximately 1.8 million balloon angioplasty procedures were performed. While these interventional therapies are now the standar...

Genetic key to growth of new arteries is identified

... some patients grow new arteries in response to an arterial blockage and others do not," observes Sarkar, who ...lood flow is decreased. The researchers mimicked arterial blockage in transgenic mice created by David Lovett, MD, chief of nephrology at SFVAMC, professor in...

Intensive statin therapy may partially reverse plaque build-up in arteries

...nt the progression of coronary atherosclerosis, or arterial plaque build-up, but not actually reduce disease b...rcent increase, which was also unprecedented. The arterial plaque overall was reduced by 6.8 to 9.1% for the various measures of disease burden. This study wa...

Measuring artery repair cells could become new heart disease test

...culate in the bloodstream and repair damage to the arterial lining has been discovered by Duke University Medi...duced in the bone marrow and travel to the site of arterial damage. The researchers said that tests for EPCs could be used to assess a patient's degree of coro...

Epidemic of unneeded amputations

Non-traumatic amputations ?those caused by arterial blockages related to diabetes, smoking, obesity an...d by Spectranetics Corp. (NASDAQ: SPNC), vaporizes arterial blockages, restores blood flow, and this surgery promotes wound healing, often enabling patients to ...

Genes discovered that allow gum disease bacterium to invade arteries

...acteria that allow them to invade and infect human arterial cells, offering one possible explanation for a perceived connection between gum disease and heart disease. Scientists from the University of Florida, Gainesville, present their findings today at the 106th General Meeting of the American Society for ...

Viagra improves high altitude exercise performance up to 45% for some

...bo trial. Sildenafil also minimized the decline of arterial oxygen saturation of the arteries when the cyclists were at simulated altitude of 12,700 feet. But the researchers discovered that these improvements occurred largely because some people achieve major gains with sildenafil at altitude while others ...

Stanford doctors advance in bid to turn mice stem cells into blood vessels

...iagnosed with cardiovascular disease, the need for arterial vascular grafts continues to grow. In 2002, there were 1.5 million medical procedures done that required replacement blood vessels. "This is an exciting, emerging research front," said John Cook, MD, PhD, professor of medicine (cardiovascular medici...

Gene transfer using mutant form of good cholesterol cuts vascular plaque and inflammation

...nes, they develop very high cholesterol levels and arterial plaque and are incapable of producing their own ap...he donor bone marrow. To deliver the gene to the arterial wall, the researchers used a "signal molecule" when they put the genes into the bone marrow. The sig...

76 percent of workers older than 60 years of age are overweight or obese

...ty. On the other hand, it was demonstrated that arterial hypertension, the alterations of the glucose metab...ith the development of diabetes, closely linked to arterial thrombosis; and in the second place, it is a self-generating spur for acute myocardial infarction, c...

Therapeutic role found for carbon monoxide

...en effective in treating the symptoms of pulmonary arterial hypertension (PAH), an extremely debilitating cond...e gas might prove beneficial in treating pulmonary arterial hypertension. To test this hypothesis, the scientists first exposed a PAH mouse model to a short, d...

Fast test for low blood flow in dogs detects early heart trouble

...ck up the subtle clues that signal the presence of arterial disease. He notes that blood vessels begin to nar...ngiograms or cardiac catheterization, to check for arterial blocks. More than 1 million Americans undergo cardiac catheterization each year, and the procedu...

Heart smart: new drug improves blood flow

...e. "Free radicals contribute to the formation of arterial blockages. What's more, as the number of free radi...the arteries produce nitric oxide to signal to the arterial muscles that they need to dilate the artery and allow more blood through. But free radicals destroy ...

Researchers show that veins stiffen as we age

...Care's cardiovascular research office. While the arterial side of the human circulatory system has been stud... computers, were placed on their arms and legs. An arterial cuff was attached to an upper arm to monitor blood pressure, and venous cuffs were placed around the...

Active ingredient in common Chinese herb shown to reduce hypertension

...o weeks. After the two-week treatment period, mean arterial blood pressure was measured in the right carotid a...al constriction of the renal artery increased mean arterial pressure to 161.2¡À6.9 mmHg relative to 114.3¡À9.2 mmHg in age-matched hamsters. Treatment with 50 ¦...

Nanotextured implant materials: blending in, not fighting back

...cker layer of smooth muscle cells that make up the arterial wall. The proteins collagen and elastin make up much of this lining and create a texture of fine nanoscale bumps on the inside of the blood vessel. This contrasts strongly with most of the materials used in implants, which have microscale texture, bu...

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

...xpressed on the surface of the cells that line the arterial walls (endothelial cells) and to cause their death (apoptosis) through a mechanism called "molecular mimicry." Using a biocomputational technique, the new study shows that the same anti-Cytomegalovirus antibodies, isolated from patients with coron...

University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts

...e is an ongoing search for the ideal small-caliber arterial substitute for revascularization procedures. The University of Pittsburgh team, led by David A. Vorp, Ph.D., associate professor of surgery and bioengineering and a faculty member of the McGowan Institute for Regenerative Medicine, University of P...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...very of intracavernous pressure (ICP) and systemic arterial pressure (AP) compared with rats treated with the control virus or untreated mice with ED. Rats treated with HSV-neurturin also exhibited significant recovery of ICP and AP compared with the control or untreated mice at four weeks after treatment. Fl...