Antisense in Biological News

Newly discovered gene plays vital role in cancer

... that Wrap53 gives rise to a molecule, called antisense RNA, the presence of which is necessary for the ... The study is also one of the first to show how antisense RNA regulates genes in the human body. It is ... usually proteins on gene expression. With antisense regulation, control is effected instead through ...

UD researchers discover novel 'gene toggles' in world's top food crop

... long, these novel molecules, called natural antisense microRNAs (nat-miRNAs), target the genes sitting ... are a special type of microRNA that have an antisense configuration relative to their targets. It's an ... the unique new group of molecules called natural antisense microRNAs. When a gene is ready to produce a ...

Making sense of antisense microRNAs

... Eric Lai (MSKCC) and colleagues, both reveal that antisense transcription of the Hox miRNA locus, miR-iab-4, ... the opposite strand. Furthermore, the loss of the antisense miRNA causes subtle derepression of a hox gene ... mutant flies. The identification of additional antisense miRNAs in Drosophila and mammals suggests this as ...

ISU researchers find possible treatment for spinal muscular atrophy

... protein because of the presence of a specific intronic sequence in the gene or DNA. To make SMN2 behave as SMN1, Singh has introduced a small antisense oligonucleotide that blocks this specific intronic sequence. When the intronic sequence is blocked, SMN2 produces normal proteins and acts, in ...

A new gene silencing platform -- silence is golden

... Gene silencing molecules also have potential prophylactic and therapeutic applications based upon ongoing clinical trials using RNAi and traditional antisense approaches. For some genes that cause disease, these other approaches may not be effective enough and U1 Adaptors may provide a novel solution.' ...

Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy

... copy of the gene to include the missing piece. Dr. Krainer and his team sought to change the splicing by introducing synthetic molecules, called antisense oligonucleotides or ASOs, that precisely match various sections of the RNA. They reasoned that if these molecules stuck to the right part of the RNA, ...

Scientists discover role for dueling RNAs

... to that of the messenger, or sense, RNA. antisense RNA has been detected for a number of genes, but ... that in the case of a gene called IME4, the antisense RNA blocks the sense RNA. In other words, the ... where a specific function in a higher cell for antisense RNA has been found," says Fink, senior author on ...

Gold nanoparticles could improve antisense cancer drugs

... In the fight against cancer, antisense drugs, which prevent genes from producing harmful ... now have demonstrated a new method for developing antisense drugs that outperform conventional antisense agents. The findings will be published May 19 in ...

Mammalian Transcriptome Mapped

... his colleagues in the same issue of Science. antisense transcription (see section below) was once ... research, medicine, and biotechnology because antisense genes are likely to participate in the control of ... http://www.scripps.edu/news/press/090105a.html antisense Transcription--What Is It? Another major ...

MUHC researchers make cancer target breakthrough

... growth of tumors." Researchers found that the antisense reduced lung and colon cancer tumors in both ... cultures and in mice. "Discovering that the antisense works in animal models is a major step forward, ... spin-off company--also indicated that the antisense was particularly effective in reducing cancer ...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

... regions, genes have more stable sense RNA/DNA duplexes than potential antisense RNA/DNA duplexes. "The difference between stability of sense and antisense mRNA/DNA is a property that can aid gene discovery," explains Stoynov. ...

Gene-specific Ebola therapies protect non-human primates from lethal disease

... BioPharma, a U.S. biotechnology firm. According to the study's authors, antisense drugs are useful against viral diseases because they are designed to enter ... and clear the virus." Working with a class of compounds known as antisense phosphorodiamidate morpholino oligomers, or PMOs, the team first performed ...

Researchers rein in regulatory RNAs

... level, such as that which has been documented for several imprinted loci. antisense transcripts have been shown to alter the methylation status of the ... form double-stranded RNA (dsRNA) molecules. A large proportion of these antisense RNAs represent non-coding RNAs. Thus, the researchers expect that these ...

Researchers discover that sheep need retroviruses for reproduction

... retrovirus might have a role in development of the human placenta. The team blocked expression of the envelope of the enJSRVs using morpholino antisense oligonucleotides, which inhibit translation of specific messenger RNA. When production of the envelope protein was blocked in the early placenta, ...

Ocean virus identified in human blood samples

... researchers say, that have been developed at OSU and licensed to private industry. "AVI BioPharma has investigated their proprietary NeuGene antisense as an anti-Vesiviral treatment, and is currently conducting further research and development," said Patrick Iversen, a co-author on the study and ...

Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis

... oligonucleotide industry. Solid support is the base structure used in the synthesis of oligonucleotides, including diagnostic probes and primers, antisense including RNAi, microRNA, DNA-based and aptamer drugs and represents a substantial portion of the cost to manufacture these oligonucleotides. ...