androgens

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

... this year.Many cases of prostate cancer depend on androgens like testosterone fortumor growth and cancer cell proliferation, said Dr. Knudsen, thestudy’s senior author. A common treatment for prostate cancer includeslimiting testosterone synthesis. Patients with mutated androgenreceptors may not respond to th...

Tendency to hair loss inherited from the mother

...kly. Both mechanisms can lead to the effect of the androgens becoming greater, which in turn brings about hair loss." The findings are also interesting for the aspect of how hair loss is inherited. The gene for the androgen receptor lies on the x chromosome. Men always inherit the x chromosome from their moth...

Tamoxifen-like drug suggests new ways to selectively block estrogen

... hormones," Greene said. "We could create designer androgens for prostate cancer, or designer glucocorticoids to treat inflammation." Since "the primary regulator of cofactor recruitment is receptor conformation," added study co-author Donald McDonnell of Duke, findings such as this should lead to the emergen...

Pain killer fights breast cancer by targeting key enzyme

...opausal women. Aromatase converts hormones called androgens into estrogens, such as the hormone estradiol. Estrogen is a powerful mitogen ?an agent that causes cells to divide, and too much estrogen can cause cells to divide too quickly. While many women with estrogen-dependent breast cancer take aromatase i...

Macrophage signaling may affect hormone resistance in prostate tumors

...(UCSD) School of Medicine. Male hormones called androgens are essential for the physiological function and growth of the prostate gland, and anti-androgen treatment, which blocks the expression of androgen target genes, is widely used for the treatment of prostate cancer. Unfortunately, most patients eventu...

Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers

...o the development of the testes and high levels of androgens in males, which is partly responsible for aggression. Sry was deleted from the Y chromosome and replaced by a transgenic copy. In their experiments, the researchers compared mice with or without the Sry gene (either males with testes or ovary-bearin...

Spike in testicular cancer is focus

...hernia, venereal diseases, and any medication with androgens and other hormones. They will also examine lifetime occupational history, tobacco smoking, alcohol consumption and dietary information. “Recent studies show that environmental exposures may affect development of testicular cancer,?said Zheng. “Dete...

Monitoring poisons in the environment -- a woolly matter

...male sheep, which has been linked to the effect of androgens on metabolism. Dr Sneddon comments, "Sheep wool evidently has potential as a bio-indicator of naturally occurring heavy metal concentrations in upland areas, which have previously not been assessed in this way". Future studies are planned to asses...