Androgen in Biological News

Study reveals a reprogrammed role for the androgen receptor

... BOSTONThe androgen receptor a protein ignition switch for prostate ... When drug therapy deprives the receptor of androgen hormones, thereby halting cell proliferation, the ... cell growth occurs, in part, because the androgen receptor switches on an entirely different set of ...

3-D research model tackles prostate cancer spread

... removal surgery should have low levels of androgen and the cancer cells should be suppressed. ... fact that the cancer cells are very sensitive to androgen and even low levels of androgen in the body could promote the growth of these ...

New drug shows promise in treating drug-resistant prostate cancer

... compounds, MDV3100 and RD162, which block the androgen receptor (AR) in CRPC cells, and report results ... was "designed as a very strong antagonist of the androgen receptor to stop the growth of any prostate ... cancer cells begin to increase production of the androgen receptor, Sawyers said. When the level ...

New medications show promise in treating drug-resistant prostate cancer

... cancer cells begin to increase production of the androgen receptor, said Sawyers. When the level of androgen receptors on the cells' surface reaches a certain ... scientists have questioned whether blocking the androgen receptor is a wise course of action. But Sawyers ...

Why a common treatment for prostate cancer ultimately fails

... help explain the process by showing that the androgen receptor, through which male hormones like ... in men. Understanding the effects of the androgen receptor gives physicians a toehold in efforts to ... One form of hormone therapy works by blocking the androgen ....

Important new hair-loss gene discovered

... in hair-loss. "In one of these conspicuous regions lies the gene for the androgen receptor", Dr. Axel Hillmer of the Life&Brain Forschungszentrum (research ... inheritance of baldness in that hitherto the only known risk gene for the androgen receptor lay on the X-chromosome, and was thus inherited from the mother ...

July 2008 highlights

... release both prenatally and postnatally, as well as leading to increased androgen levels in female infants. While these changes occurred in the absence of ... the constellation of symptoms that define PCOSlocal tissue conversion of androgen to estrogen may provide additional programming. David H. Abbott, ...

Estrogen helps drive distinct, aggressive form of prostate cancer

... in 2005. "The discovery showed that these malignancies occur after an androgen (male hormone)-dependent gene fuses with an oncogene -- a type of gene ... treatment against the disease. And yet the disease can progress despite androgen reduction, suggesting that other pathways might be at work. "So, we ...

Contraception: progress brings hope for new methods for men

... studies will be the next step. A testosterone-like pill ("selective androgen receptor modulator") already in human testing as an osteoporosis and ... (by GTx, Inc.) gives it a good chance at commercialization. Another androgen that can be taken orally, Dimethandrolone Undecanoate (DMAU), was ...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

... only been on the market a few years and are targeted to inhibit aromatase specifically. But because the structure was not known, nor the mechanism of androgen to estrogen conversion, the AIs currently in use have been developed using trial and error methods resulting in greater vulnerability to ...

Why the 'perfect' body isn't always perfect

... testosterone, increase waist-to-hip ratios in women by increasing visceral fat, which is carried around the waist. But on the upside, increased androgen levels are also associated with increased strength, stamina, and competitiveness. Cortisol, a hormone that helps the body deal with stressful ...

Anabolic steroids provide a competitive edge in power lifting years after doping has ended

... (PAS). The researchers examined muscle fiber distribution, fiber area, subsarcolemmal and internal myonuclei number per fiber, myonuclei expressing androgen receptors, satellite cell numbers per fiber, and proportion of split fibers in each muscle for each individual. Findings The researchers found ...

News tips from the Journal of Neuroscience

... Cell Death In Vivo Christopher K. Thompson and Eliot A. Brenowitz The size of song nuclei in some songbirds varies with seasonal changes in androgen levels, growing during the reproductive season and then shrinking via neurodegeneration. These changes can be induced experimentally in white-crowned ...

MIT: Why men are more prone to liver cancer

... male mice at one year of age when they had chronic hepatitis, but not cancer, would have a protective effect. They also gave some mice a powerful androgen to see if that would promote tumors. Neither treatment had any effect, demonstrating that male sex hormones such as testosterone do not directly ...

Vaginal reconstruction not needed for most inter-sex females, Hopkins study shows

... of the research are being presented at the American Academy of Pediatrics Conference Oct. 26 through Oct. 30 in San Francisco. Women with complete androgen insensitivity are born with relatively shallow vaginas that may or may not require surgical repair and with undescended testes that do require ...

American Chemical Society's Weekly PressPac - Oct. 10, 2007

... bone density and strength in the lab rats. ARTICLE #2 FOR IMMEDIATE RELEASE Substituted 6-(1-Pyrrolidine) quinolin-2(1H)-ones as Novel Selective androgen Receptor Modulators DOWNLOAD PDF http://pubs.acs.org/cgi-bin/sample.cgi/jmcmar/asap/pdf/jm070231h.pdf DOWNLOAD HTML ...

Cancer researchers add spice to research against rare neuromuscular disease

... is caused largely by the activity of the androgen receptor, the protein that is central to the ... of compounds for their activity involving the androgen receptor, which is also involved in prostate ... In 1988 Chang was the first to clone the androgen receptor, and he was the first to discover that ...

Jefferson scientists find aging gene also protects against prostate cancer development

... with cells overexpressing a mutation for the androgen receptor, which is resistant to current forms of ... therapy. Such therapy focuses on inactivating the androgen receptor by giving agents that shut off ... the scientists took a series of mutations in androgen receptors from prostate cancer patients who are ...

Macrophage signaling may affect hormone resistance in prostate tumors

... signals capable of impacting the effectiveness of androgen antagonists, the most common and effective ... treatment, which blocks the expression of androgen target genes, is widely used for the treatment of ... for at least one form of resistance to androgen antagonists. "It was of particular interest ...

Tendency to hair loss inherited from the mother

... contribution was suspected lay the gene for the androgen receptor. "One variant of this gene was found ... when over 60," Professor Nöthen says. More androgen receptors in the scalp Probably the genetic variant results in more androgen receptors in the scalp. "Our findings permit two ...

Scientists discover way to block growth of prostate cancer cells

... Prague today (Wednesday 8 November): "Previous work has demonstrated that androgen treatment increased reactive oxygen species levels in androgen-dependent ... of this pathway is a major step forward in understanding the role of androgen in prostate cancer development. "Many scientists in the polyamine ...

Hyena mothers give their cubs a helpful dose of hormones

... Kay Holekamp, together with her colleagues, spent almost 10 years sampling androgen levels from free-ranging hyenas in Kenya. Androgens are hormones, such as ... and sexual behavior. The team found that alpha females had higher androgen levels late in pregnancy when compared to the subordinate, pregnant ...

Hormonal male contraception reversible after few months for all men

... by hormone treatment in women, sperm production can be fully inhibited by androgen or androgen-progestagen treatment combinations in men. With such hormone ... purposes, can be achieved. Currently, a large phase III study with an androgen treatment and a large, multicentre phase II study of androgen-progestagen ...

Scientists use gene signatures to match cancer and other diseases with potentially effective drugs

... of other drugs. It turned out that celastrol and gedunin inhibit a molecule called HSPH90, which in turn blocks the overactive cell signaling of the androgen receptor in prostate cancer cells that drives their aggressive growth. Dana-Farber researcher Haley Hieronymus, PhD, who used the Connectivity Map to ...

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

... the male hormone, can proliferate in response to BPA. “The results may have implications for men who develop BPA-susceptible mutations in their androgen receptor genes during the course of prostate cancer treatment, although these concepts will need to be verified in animal systems,?according to Karen ...