adrenal

Disease progression model of pancreatic cancer developed by Penn researchers

...r metastasizes to the liver, lungs, diaphragm, and adrenal glands, all the same places that human pancreatic cancer metastasizes," says Tuveson. The frequency of metastases to these various organ sites was also highly similar to that seen in humans. In human patients, 60 to 80 percent develop metastases to ...

Building a better mouse model of lung cancer: FHIT counts

...ood vessel growth in the eyes, brain, spinal cord, adrenal gland and other parts of the body. The scientists exposed mice deficient in both genes to a second carcinogen, DMN, which is also found in smoke but also in beer, fish meal and some preserved meats. They discovered that when the VHL gene was missing...

Worm hormone discovery may aid fight against parasitic disease

...r example, in patients with Addison's disease, the adrenal glands do not produce enough of the steroids cortisol and aldosterone; in some cases, these glands produce none at all. Replacing the missing hormones through replacement therapy can relieve the symptoms of the disease, much as providing the missing ...

New pathways for autoimmune treatment identified

...t infection of the skin and/or mucous membrane and adrenal gland insufficiency ?by age 5 and up to 16 autoimmune diseases over a lifetime. The same mutation causes a defect in i NKT cells, a type of regulatory cell that helps the immune system fight infections while suppressing errant T cells bent on atta...

Combined treatment extends life expectancy for lung cancer patients

...o has pioneered the use of RFA in thyroid, kidney, adrenal and bone cancer. The combined treatment may have far-reaching effects, Dupuy says. "You might be able to treat tumors elsewhere in the body with similar results," Dupuy says. "There are a lot of opportunities for exploring the synergy of thermal ab...

Lack of key enzyme associated with development of rare tumor

...of Health have discovered that a rare tumor of the adrenal glands appears to result from a genetic deficiency...and, in collecting samples from patients with rare adrenal disorders. Scientists from Sapio Sciences in York, Pennsylvania, assisted in the analysis of the da...

Researchers find docking sites for glucocorticoid receptor and Hsp90

.... Glucocorticoids are naturally produced by the adrenal glands and are important for a variety of tissue-r...mmatory, and are prescribed for such conditions as adrenal insufficiency as in Addison's disease, arthritis, asthma, inflammatory bowel disease and childhood a...

Scientists unravel clue in cortisol production

When a person's under stress or injured, the adrenal gland releases cortisol to help restore the body's...begins when the hypothalamus sends a signal to the adrenal glands. Proteins then flood into the nucleus to bind to the DNA, creating the gene CYP 17. What happ...

Primitive yeast yields secrets of human cholesterol and drug metabolism

...equired for making natural steroid hormones in the adrenal glands. “Collectively, our experiments suggest that Dap1 acts as a common regulator of cytochrome P450s in mammals,?says Espenshade. Because Dap1 affects one particular P450 responsible for drug metabolism, Espenshade suspects that genetic var...

Twin studies reveal genetic components leading to cardiac and kidney disease

...catecholamines, chemical compounds produced in the adrenal gland that are released in reaction to stress. The study measured the plasma concentration of ET-1 in about 300 twins. The results establish and verify a previously unsuspected link between catecholamines and the endothelial system, showing that this...

3-D ultrasound identifies women at risk for impending preterm birth

...D ultrasound was used to measure the size of fetal adrenal glands, according to an abstract presented by Yale.... "Our results suggest that examining the fetal adrenal gland at the time a woman is evaluated for symptoms of preterm labor, may have major beneficial clin...

Stress may help cancer cells resist treatment, research shows

... Levels of epinephrine, which is produced by the adrenal glands, are sharply increased in response to stressful situations and can remain continuously elevated during persistent stress and depression, according to previous research. The goal of the current study was to determine whether there is a direct l...