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Weakness in Biological News

August 2009 Geology and GSA Today media highlights

... alteration halos. Elevated fluid pressure and extreme mechanical weakness of a plate boundary thrust, Nankai Trough subduction zone Harold J. ... based on measurements of rock strength. The cause of this mechanical weakness may be a key to understanding earthquake rupture processes and tsunami ...

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

... is an X-linked genetic cardioskeletal muscle disease resulting in muscle weakness and fatigue in patients. The debilitating disorder is caused by a mutation ... neutrophils or white blood cells that fight bacterial infections), muscle weakness & fatigue (caused by cellular deficiency), growth delay, and increase of ...

Motor neuron disease and toxic substances: Possible link?

... nerves. Fink examined members of two families who had progressive weakness and spasticity (tightness) in their legs, as well as muscle atrophy in ... disease. It begins in childhood and progresses slowly, with symptoms of weakness and spasticity in the legs and muscle atrophy in the hands and lower legs. ...

Stress signals link pre-existing sickness with susceptibility to bacterial infection

... with mitochondrial disease exhibit a wide range of symptoms including diabetes, blindness, deafness, stroke-like episodes, epilepsy, ataxia, muscle weakness and kidney disease. The metabolic abnormalities that cause these effects also induce a stress signal intended to help the body overcome its energy ...

'Show me the money!' MDA greenlights grants

... into diseases of the mitochondria caused by genetic mutations. Mitochondria are the powerhouse of the cell and, when they fail, can cause muscle weakness and pain, diabetes, blindness and heart disease, along with other debilitating and/or fatal conditions. Schon's research may provide the key for ...

Our 'caveman logic' embraces ESP over evolution

... Maggie Jackson, author of Distracted: The Erosion of Attention and the Coming Dark Age adds, "Hank Davis reveals the deep roots of humanity's weakness for superstitions, blind assumptions and primitive thinking, and shows how we can start to overcome 'caveman logic.'" Davis advocates a world in ...

Aussie meat ants may be invasive cane toad's Achilles' heel

... for meat ants than cane toads, they discovered. The results are interesting not only because they reveal the cane toad's Achilles' heel a weakness that could be exploited to help control the spread of the toxic toad but because the same "evolutionary trap" could be used to snare invasive ...

Information warfare in the 21st century: Ideas are sometimes stronger than bombs

... be shown that the terrorists are those who are injuring the population that they claim to be defending. Another technique is to identify the point of weakness between the population and the organization, and use that to our advantage. For example, if basic needs are lacking, the army provides assistance for ...

Why 'lazy Susan' has a weak heart

... due to hereditary cardiac disease. Researchers at the Heidelberg University Hospital have now discovered a genetic modification that leads to cardiac weakness in an animal model. Just one "false" amino acid can give zebrafish a heart condition. Since the fish have a genetic makeup similar to that of humans, ...

Researchers genetically link Lou Gehrig's disease in humans to dog disease

... in humans." ALS causes progressive neurodegeneration, affecting both the central and peripheral nervous systems. The disease leads to advancing weakness and muscle atrophy, and culminates in paralysis and death. DM has been recognized for more than 35 years as a spontaneously occurring, spinal cord ...

Human genomics in China

... for our new journey, while the lessons of the past may teach us to be smarter. China, a developing socialist country rising from a hundred years of weakness and poverty, needs genomics to make historic contributions to the rejuvenation of the nation. ...

Researchers find chink in the armor of viral 'tummy bug'

... is a common chink in the armour of these rotaviruses. "This discovery is the first step in designing a broad-spectrum drug able to exploit this weakness to combat many types of human and animal rotaviruses." ...

UC Davis team refines cancer treatments to reduce potential nerve damage

... noticed a trend following treatment for cancers of the tonsil, tongue, throat, and other head and neck organs: A number of patients reported ongoing weakness and sensation problems in their necks, shoulders and upper arms. Chen recognized that these symptoms could be attributed to injury of the brachial ...

Study may explain exercise-induced fatigue in muscular dystrophies

... that the prolonged fatigue after mild exercise that occurs in people with many forms of muscular dystrophy is distinct from the inherent muscle weakness caused by the disease. The research, which is published in Nature Advance Online Publication Oct. 26, identifies a faulty signaling pathway ...

Running on rocket fuel

... effective hunters, and thus have to undertake energetically expensive extra hunts to secure their prey. The results from this study highlighted a weakness in the business plan, for when the financial energetic annual accounts were done, the benefits of having fewer individuals to feed in a smaller packs ...

Swamping bad cells with good in ALS animal models helps sustain breathing

... - reap the most benefit. Forty-seven percent more motor neurons survived there than in untreated model animals. Respiratory failure from diaphragm weakness is the usual cause of death in ALS, also called Lou Gehrig's disease. "While the added cells, in the long run, didn't save all of the nerves to ...

CU-Boulder, biotech firm team up on python project in search for human cardiac therapeutics

... for humans." Leinwand has studied hypertrophic cardiomyopathy, or HCM, a genetic disease marked by a thickening of heart muscle related to a weakness in individual muscle fibers that causes them to work harder to pump blood and consequently enlarge. HCM occurs in one in 500 people in the United ...

Potential new drug target to fight tuberculosis identified

... ever before. But now, innovative research at Weill Cornell Medical College suggests that Mycobacterium tuberculosis has an as yet unsuspected weakness -- one that could be a prime target for drug development. "Using novel techniques, we have identified a key membrane protein that's essential to ...

Vitamin D: New way to treat heart failure?

... go on to experience a form of heart failure called congestive heart failure, in which the heart's inability to pump blood around the body causes weakness and fluid build-up in lungs and limbs. Many people with heart failure, who tend to be older, have been found to be deficient in vitamin D. "Heart ...

Scientists debate the accuracy of Al Gore's documentary 'An Inconvenient Truth'

... of man-made global warming and explains why increased atmospheric concentrations of greenhouse gases lead to warming. They also agree that its main weakness is that it tries to use individual extreme events, such as Hurricane Katrina, to prove the existence of global warming. In the first opinion piece ...

Kids with autism may have gene that causes muscle weakness

... April 1219, 2008. The study looked at 37 children with autism spectrum disorders who were evaluated for mitochondrial disease, which causes muscle weakness and prevents a child from being able to participate in physical activities and sports. Mitochondrial disease occurs when genetic mutations affect the ...

Pitt and University of Chicago researchers uncover process behind heart muscle contraction

... for such conditions as congestive heart failure, this technique could present an alternative to current therapies that counteract heart muscle weakness by boosting cellular calcium content, Shroff said. The heightened calcium improves muscle contraction but also results in more energy consumption in ...

Veterinary college researcher studying brain tumors in people and animals

... animals, according to Rossmeisl. Clinical signs associated with brain tumors in both people and animals can include seizures, abnormal behaviors, weakness of the limbs, loss of balance, blindness and other problems. Gliomas arise from glial cells, according to Rossmeisl, which play numerous ...

Subterfuge, counter-surveillance and assassination: The body's fight with cervical cancer

... The virus responsible for most cases of cervical cancer has a serious weakness which may provide hope for new treatments for the disease. Human Papillomavirus (HPV), a virus which causes several types of cancer but is ...

Team IDs weakness in anthrax bacteria

... CAMBRIDGE, Mass.--MIT and New York University researchers have identified a weakness in the defenses of the anthrax bacterium that could be exploited to produce new antibiotics. The researchers found that nitric oxide (NO) is a ...

Listen-up ladies: Don't postpone knee-replacement surgery

... and benefits of knee-replacement surgery, Snyder-Mackler said, and heed the warning signs of serious problems. When you feel profound buckling and weakness in your knee when climbing stairs, that is a major problem. You compensate--eventually, you may come downstairs only once a day, Snyder-Mackler said. ...

Mutation may cause inherited neuropathy

... spinal cord. Symptoms include pain in the hands and arms, legs and feet--sometimes constant and quite severe--as well as progressive numbness and weakness in the arms and legs. Despite its prevalence, little is known about the precise causes of the disease or how to prevent or treat it. In the ...

Further development of Water Framework Directive necessary

... Water Framework Directive encourages a holistic view of these ecosystems with their multiple stresses. However, this strength can also prove to be a weakness if the concepts needed to assess and predict the importance and combined effect of the various stress factors are not available. The scientists see a ...

West Nile virus' spread through nerve cells linked to serious complication

... infection affects the central nervous system. One form of infection, encephalitis, causes inflammation of the brain and leads to fever, headaches, weakness and seizures. It is much more likely to occur in patients who are elderly or have weakened or suppressed immune systems. The other form of infection, ...

Massive microRNA scan uncovers leads to treating muscle degeneration

... body myositis). While past studies have linked them with an increasing number of genes, it's still largely unknown how these genes cause muscle weakness and wasting, and, more importantly, how to translate the discoveries into treatments. For instance, most muscular dystrophies begin with a known ...

Survivors of childhood polio do well decades later as they age

... but rather experience only modest increased weakness which may be commensurate with normal aging. ... questionnaires about symptoms of progressive weakness at the beginning and end of the study period. Though the majority complained of progressive weakness during the time they were studied, these symptoms ...

Cancer researchers add spice to research against rare neuromuscular disease

... motor neurons that go from the spine to certain muscles, causing muscle weakness and wasting throughout body. Symptoms typically include difficulty speaking and swallowing, and weakness in the arms and legs. Patients are often diagnosed in their 30s and 40s, ...

Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy

... Muscle weakness and fiber deterioration seen in muscular dystrophy can be countered by a ... is a group of more than 30 genetic diseases, characterized by progressive weakness and deterioration of skeletal muscles. All are inherited, caused by a ...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

... cell membrane protein known as delta-sarcoglycan lead to severe damage and weakness to muscles, particularly around the hips and shoulders--hence the name ... particular delta-sarcoglycan gene defect have severe muscle wasting and weakness and significantly shortened lifespans due to cardiac and respiratory ...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

... levels or inhibited HDAC activity with a drug, muscle cell health was restored in mice genetically engineered to lack CREB and suffering from muscle weakness as a result. "We’ve discovered that SIK1 provides a completely unexpected link between two important mechanisms of gene regulation, CREB ...

Robotic therapy helps restore hand use after stroke

... grasp and release objects after therapy sessions using the Hand-Wrist Assisting Robotic Device (HOWARD). Each patient had at least moderate residual weakness and reduced function of the right hand, although the affected hands were neither totally paralyzed nor unable to feel. Seven women and six men who ...

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

... gp120 to create a stable bond between the two molecules. Essentially, the scientists found that the initial point of CD4 contact is a site of gp120 weakness because it is the site of recognition—called an epitope—for b12. "One of our primary goals is to develop HIV vaccines that can stimulate broadly ...

Key found to kill cystic fibrosis superbug

... where the lungs become clogged with thick mucus, often leading to chronic respiratory infections. The team of researchers has identified a weakness in the armour that protects the B. cenocepacia bacterium from the effects of antibiotics. They hypothesize that preventing the synthesis of a key ...

Moonlighting enzyme linked to neurodegenerative disease

... you know someone with the condition. For that individual -- usually a child or teenager -- it is devastating. Symptoms are mild at first: muscle weakness in the arms and legs, vision impairment and slurred speech, but eventually the symptoms progress and most patients become wheelchair-bound and ...
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