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Viral in Biological News

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

... hematopoietic stem cells using engineered viral vectors. The article, "Hematopoietic Stem Cell ... ). Though viral vectors are highly efficient, their use can raise ... that avoids the safety concerns associated with viral vectors. Use of the "Sleeping Beauty Transposon ...

Study links virus to some cases of common skin cancer

... tumor cells had a mutation that could enable the viral DNA to integrate into the DNA of the host cell. ... and one sample from a mouthwash. They found no viral DNA in any of the blood samples from 57 patients. ... positive for the virus. By sequencing the viral DNA from 31 normal and tumor samples, the ...

UCSF researchers identify new drug target for Kaposi's sarcoma

... antiviral drugs target the active sites of viral proteins, where enzymes and receptors work in a ... enzyme, or receptor from being effective. Some viral enzymes known as proteases, however, including ... treat Kaposi's, as well as other members of this viral family. "All known herpes virus proteases are ...

Reviews of microbial gene language published in special issue of Trends in Microbiology

... far is the use of Gene Ontology terms to address viral infection, in part due to fundamental differences ... hosts. One article in the series outlines how viral pathogens can also be attributed Gene Ontology ... to apply Gene Ontology to the modeling of viral infections. Brett Tyler, also the PAMGO ...

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

... to the phenomenon of "viral mimicry," in which viral proteins can resemble host proteins to hijack ... showed that host proteins can evolve to defeat viral mimicry, providing yet another nuance to a ... "reverse mimicry," in which host genomes hijack viral proteins to protect themselves ...

MicroRNAs help control HIV life cycle

... or destroyed. This results in a reduction of viral replication and infectivity. The study also showed that inhibition of miR29 enhances viral replication and infectivity. The scientists ... Dr. Rana. "Retroviral therapies greatly reduce viral load but cannot entirely eliminate it. This ...

Study characterizes eczema patients most at risk for dangerous viral infections

... Eczema patients at risk for serious viral infections have more severe disease, are more ... have increased susceptibility to disseminated viral infections," said senior author Donald Leung, MD, ... who have suffered widespread herpes simplex viral infections of their skin. It is also the first to ...

Research uncovers clues to virus-cancer link

... can cause cancer through a mechanism where the viral genes take over the cell and induce cancerous ... since it is much more feasible to block viral infection or develop specific inhibitors of the viral genes than try to inhibit all of the genetic ...

Amarna Therapeutics B.V. and TNO announce SVac research and development partnership

... agreement to further develop Amarna’s viral gene delivery platform SVac . Under this ... for the manufacture, formulation and testing of viral gene delivery systems such as the SVac platform ... “We have developed a revolutionary novel viral gene delivery vector platform technology SVac for ...

Princeton team's analysis of flu virus could lead to better vaccines

... the effectiveness of the antibody response to a viral infection," said Ned Wingreen, a professor of ... effects on the body. Analyzing data about viral structure, antibody types and the reactions ... of multiple types of antibodies. During a viral attack, what then transpires is that antibodies ...

HudsonAlpha investigator develops rapid response swine flu test

... less than six hours, will be incorporated into a viral respiratory panel made available by Diatherix ... capability to identify multiple pathogens, both viral and bacterial. This technology can test for ... rapid molecular test that can subtype multiple viral and bacterial strains in a single test. ...

Moving gene therapy forward with mobile DNA

... into the patients' cells. However, some of these viral vectors can induce side-effects, including cancer ... overcomes some of the limitations associated with viral vectors. Lessons from evolution Using the ... DNA. Doing so, they obviate the need to rely on viral vectors. 'We show for the first time that it ...

Potential new HIV drug may help patients not responding to treatment

... or 'viral load', is important because when the viral load is high, the disease progresses and it ... (HAART), a cocktail of drugs that reduces the viral load by stopping the virus from replicating. ... four months. Eight of the macaques had higher viral loads (reaching up to 100,000 copies of the virus ...

West Nile virus studies show how star-shaped brain cells cope with infection

... physicians new ways to reduce deadly responses to viral infections of the brain and spinal cord. In the ... called MDA-5) that astrocytes use to "see" viral invaders. They also identified recognition ... of astrocytes not only to devise treatments for viral invaders from abroad, but also from deadly ...

Scripps research team identifies key molecules that inhibit viral production

... deactivate the virus, in contrast to mutations in viral enzymes which often lead to increased resistance ... genotypes, plays several essential roles in the viral cycle in the host cell; studies have suggested ... an essential step in the formation of infectious viral particles; the nucleocapsid is ...

Using hair to manage HIV/AIDS and predict treatment success

... in hair correlated with success in HIV viral suppression in treatment and did so better than ... this method has also not been a good predictor of viral suppression, according to Gandhi. Single drug ... settings where blood collection and viral load monitoring may be expensive and difficult. ...

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

... HIV. The new Fellowship recipients will examine viral latency and new targets for microbicide and ... that faithfully replicate the conditions of this viral latency and persistence. Dr. Bosque and ... inside infected cells that help to establish this viral latency, the signals that reactivate the virus, ...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... change in the protein that is necessary for viral entry into the host cell, thereby preventing ... dramatic conformational change to allow entry of viral RNA into the host cell. It's very difficult to ... H5 type HA, the influenza protein responsible for viral entry into the host cell. The scientists ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... change in the protein that is necessary for viral entry into the host cell, thereby preventing ... dramatic conformational change to allow entry of viral RNA into the host cell. It's very difficult to ... H5 type HA, the influenza protein responsible for viral entry into the host cell. The scientists ...

Shades of 1918? New study compares avian flu with a notorious killer from the past

... occur under these conditions, giving rise to new viral forms which share genetic characteristics with ... from nature in order to create deactivated viral strains for use in yearly influenza vaccines.) ... the body's first line of defense for combating viral challenges. The group sought to compare the ...

Scripps scientists create first crystal structure of an intermediate particle in virus assembly

... fresh insights into the elegant dance that viral proteins perform to create the infectious ... viruses build these vessels to protect the naked viral DNA inside is also useful in the field of medical ... of times narrower than a human hair. The thin viral armor offers protection and stability as well as ...

Potential new herpes therapy studied

... protein involved in the maturation and release of viral particles in an infected cell. The technique ... work because the active ingredients target viral building blocks, and become incorporated into the ... who has studied the use of ribozymes for treating viral infections. Burke, who is not affiliated with ...

Peering inside the skull of a mouse to solve meningitis mystery

... cause for the fatal seizures seen in mice with viral meningitis, an infection of the central nervous ... about how the human immune system responds to viral diseases. The NYU researchers, Michael L. ... allergies and autoimmune diseases to stroke and viral infections. High-Tech Imaging Shows Cells in ...

Just a little squeeze lets proteins assess DNA

... that bacteria use to protect themselves from viral infections. The finding has implications for ... invading viruses. Without the protective protein, viral DNA would commandeer the bacterium's cellular ... protein distinguishes between bacterial DNA and viral DNA by recognizing certain sequences on DNA. Such ...

Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer

... such as division or expansion, controlling viral replication, and local killing of infected cells ... a lot of weapons at their disposal to control viral infection and most of them are disarmed when ... they had not been known to play a role in chronic viral infection. LAG-3, for example, is associated with ...

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

... in preclinical development for the treatment of viral hemorrhagic fevers under a contract worth up to ... in HIV, cytomegalovirus (CMV) and other serious viral infections. "Based on these findings, ... of drugs for the treatment of life-threatening viral infections," said study co-author Dr. Philip ...

Extreme nature helps scientists design nano materials

... that could be used as a nanobuilding block. viral nanoparticles (VNPs) are ideally sized, can be ... was assessed for its suitability for use as a viral nanobuilding block. SIRV2 is a virus that ... block. To be potentially useful as a VNP, the viral capsule also needs to be open to modification or ...

Body's anti-HIV drug explained

... when the retrovirus transcribes its RNA into viral DNA. The study's authors, led by Xiaojiang ... suggests how and where the enzyme binds to the viral DNA, mutating and destroying it. "We ... the HIV virus can be successfully transcribed to viral DNA, an essential step for infection and for ...

Scripps research team solves structure of 'beneficial' virus

... any other known member of the Picornaviridae viral family, and confirms its recent designation as a ... resource for information on the structure of viral particles; it contains details of 253 viruses to ... went on to identify several areas on the viral protein coat that they think might hook onto ...

Research about plant viruses could lead to new ways to improve crop yields

... similar even though they come from two different viral families, Potyviridae and Flexiviridae. ... it could not determine the structure of the viral protein coat directly, STEM was able to put ... include engineering molecules based on the viral structure that interfere with the viruses' ...

Structures of important plant viruses determined

... and are responsible for more than half the viral damage to crop plants throughout the world. New ... STEM cannot determine the structure of the viral protein coat, it is able to put boundaries on the ... include engineering molecules, based on the viral structure, that interfere with the viruses' ...

Study reveals how viruses collectively decide the fate of a bacterial cell

... infect a cell, this increases the number of viral genomes and therefore the overall level of viral gene expression. Changes in viral gene expression can have a dramatic nonlinear ...

Simian foamy virus found in several people living and working with monkeys in Asia

... an important setting for future primate-to-human viral transmission. The study appears in the August ... of primates. Though much of the research on viral transmission between humans and other primates ... in Asia. Some Asian countries are prime areas for viral transmission between monkeys and humans, she ...

UCSF researchers identify virus behind mysterious parrot disease

... technology that uses a DNA microarray to test viral samples. The team was able to recover virus ... Scientists have theorized for decades that a viral pathogen was the source of the disease, but until ... compelling lead in the long-standing search for a viral cause of PDD," Ganem said. "With the development ...

Viral recombination another way HIV fools the immune system

... with a second strain of the virus, the two viral strains can exchange genetic information, ... virus. It is known that the presence of multiple viral strains, called superinfection, frequently leads to a loss of immune control of viral levels. Now a study from the Partners AIDS ...

A viral cloaking device

... Sciences . They describe the underpinnings of a viral cloaking device, partly made of stolen goods from ... If a cell has been infected, MHC presents viral peptides to signal T cells to kill it. So some ... virtually undetectable. "It's a good example of a viral protein that evolved from its host ancestor to ...

Scripps research scientists reveal key structure from ebola virus

... Ebola virus spike protein, which is necessary for viral entry into human cells, bound to an immune system ... The structure of the antibody together with the viral glycoprotein helps reveal the mechanisms by which the molecules assemble on the viral surface and helps explain how the pathogen evades ...

Hebrew University study opening new route for combating viruses

... raised the intriguing possibility that upon viral infection of a host cell, the virus may use ... response against viruses, is inhibited by a viral microRNA. This prediction was confirmed in ... This study showed for the first time that a viral microRNA inhibits the activity of a gene of the ...

Scientists discover DNA knot keeps viral genes tightly corked inside shell

... A novel twist of DNA may keep viral genes tightly wound within a capsule, waiting for ... protein envelope of an asymmetrical virus and the viral DNA packed within, they report this week in the ... more than 12,000 microscopic views of frozen viral particles from different angles, UCSD chemists ...

LIAI researchers discover new cellular mechanism that will significantly advance vaccine development

... CD4 T cell help for antibody responses to a large viral pathogen: deterministic linkage of ... built up that can fight off this stronger viral attack before it can overtake the body and cause ... able to more easily figure out the most important viral pieces to focus on in developing a vaccine. "The ...
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