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Vesicle in Biological News

Caltech biologists spy on the secret inner life of a cell

... vesicle, which pinches off from the membrane. The vesicle is then transported to the other side of the ... clathrin cage was completely shed before the vesicle fused with the cell membrane. The new results ... that coating is sloughed off, which may allow the vesicle to more quickly drop its load and move on for ...

Tips from the Journals of the American Society for Microbiology

... their ability to sequester the bacteria and for vesicle production (food vacuoles released by protozoa ... bacterial strains and Tetrahymena also displayed vesicle production, but only of E. coli O157:H7 and S. ... Further studies of E. coli O157:H7 following vesicle production revealed that 4 hours after the ...

Media highlights in the January issues of Biophysical Journal

... a biomechanical perspective to the knowledge of vesicle transport regulation. Shuttling vesicle-embedded ... on rat kidney cells favor this view. The vesicle transport is accelerated when the network fibers ... a physically relaxed cell is doing much better in vesicle transport compared to a cell under tension. This ...

A key enzyme helps keep the synapse on track

... was key to certain late steps in the synaptic vesicle cycle, a critical aspect of synaptic function. ... slows one of the very first steps in the vesicle cycle in a process known as endocytosis. "By ... to the cell interior," Dr. Ryan says. When a vesicle empties, it isn't discarded, however. Instead, it ...

Breakthrough technology observes synapse in real time, supporting theory of vesicular recycling

... about how that recycling occurs -- either the vesicle fragments upon delivering its cargo and must be ... -- accurately and in real time -- synaptic vesicle recycling as it occurs. That has changed with ... tag move outside of the vesicle, then the vesicle itself must have ruptured in some way. This gives ...

Cells use import machinery to export their goods as well

... microscopy) capable of focusing solely on the narrow plane in which the vesicle and membrane merge. "It's a little like the guy looking under the ... of post-Golgi cargo is a so-called kiss-and-run exchange in which the vesicle partially merges with the membrane and delivers some, but not all, of its ...

Yale researchers uncover secrets of salmonella's stealth attack

... compartment called a vesicle. SopB's second trick helps prevent the vesicle from being sucked into the lyosome, the organelle within the cell that ... move from the plasma membrane of the cell to the membrane of the internal vesicle containing the pathogen. The Yale group found that Salmonella coaxes the ...

How Toxoplasma gondii gets noticed

... in mice to study how portions of the parasitic proteins escape the vesicle in a process known as cross-presentation. They find that the parasite gets noticed by the immune system when the membrane of the bug-containing vesicle fuses to the endoplasmic reticuluman organelle normally involved in ...

Very cold ice films in laboratory reveal mysteries of universe

... much simpler than today's cell membrane, probably some sort of simple vesicle of the sort found in soap bubbles. This sort of vesicle can be found in abiotic systems today, both in hot conditions, in the ...

Leading scientist named new chair of Cell Biology at Yale

... processes in cell-free systems, but no one imagined that you could study vesicle trafficking in a cell-free system. Jim had the courage to try and the ... the Sloan-Kettering Institute. In 1993, Rothman discovered a complex of vesicle membrane proteins which he implicated in membrane fusion and formulated ...

Talking to cells

... that this first communication occurred by way of sugar groups on the vesicle surface. The vesicles subsequently transfer information to the cellsin the ... with side chains bearing glucose units that wind up being exposed on the vesicle surface. The researchers brought the vesicles together with bacteria ...

Nixing immaturity in red blood cells

... author of the report. During autophagy, the cell forms an envelope or vesicle around components of the cell that need to be degraded and removed. The vesicle then fuses with a cellular component called a lysosome that degrades its ...

Scientists determine drug target for the most potent botulinum neurotoxin

... a nerve cell membrane, which curves inward, incorporating the toxin into a vesicle that drifts inside the cell. The toxin eventually travels from the vesicle to the cytosol, the internal fluid of the cell. The toxin then cleaves ...

New study finds uncontrollable stress worsens symptoms of endometriosis

... animals developed vesicles. the endo-control group developed a total vesicle length that averaged 6.570.96mm per animal. the endo-stress group developed a total vesicle length that averaged 11.265.27mm per animal. the endo-control rats had ...

Where college students live can impact their weight, eating and exercise habits

... animals developed vesicles. the endo-control group developed a total vesicle length that averaged 6.570.96mm per animal. the endo-stress group developed a total vesicle length that averaged 11.265.27mm per animal. the endo-control rats had ...

Chasing tiny vehicles

... team could even define separate phases: how the particles reached the cell membrane, came to rest there and then ultimately enclosed in a membrane vesicle invaded the cells. The vesicles move randomly, often downright erratically inside the cell, until a so-called motor protein binds them and quickly ...

ChloroFilms announces video contest winners

... at http://www.lelavision.com/ . First prizes ($500 cash awards) go to Daniel von Wangenheim of Cologne, Germany for his entry "fantastic vesicle traffic" http://www.youtube.com/watch?v=7sRZy9PgPvg ; Kris Holmes of Rochester, NY for his entry "La Bloomba" ...

A budding role for a cellular dynamo

... into networks of filaments that give the cell structural plasticity while driving many essential functions, from cell motility and division, to vesicle and organelle transport within the cell. In a groundbreaking new study in the current issue of Developmental Cell , Brandeis researchers raise the ...

Protein that regulates hormones critical to women's health found in pituitary

... are triggering molecules that drive a vesicle's membrane into the membrane that surrounds a neighboring cell so that chemicals inside the vesicle can come out," says Jackson. But Syt IV is an odd member of the family because it doesn't bind to calcium, said Jackson. In addition, Syt IV is ...

New cell division mechanism discovered

... Rolf Bernander says. Two of the three proteins are instead related to eukaryotic so-called ESCRT- proteins, which play important roles in vesicle formation during intracellular transport processes, and which also have been implicated in virus budding, including HIV, from the cell surface. The ...

How neuronal activity leads to Alzheimer's protein cleavage

... associates with microdomains that contain BACE. It's unclear why APP should be associated with syntaxin, though it might suggest a role for APP in vesicle trafficking and exocytosis. Also unclear is why neuronal activity should cause APP to jump from syntaxin domains to BACE domains. What is clear, ...

Tracking down the cause of mad cow disease

... by means of a native chemical ligation, in which the cysteine group reacts with the thioester. This allowed the prion protein to firmly attach to the vesicle membranes by way of the artificial anchor. This new concept will allow production of sufficient quantities of proteins modified with GPI anchors ...

Researchers reveal types of genes necessary for brain development

... signaling molecules, enzymes, channels, receptors, and cytoskeletal proteins. Results also determined that genes known to be involved in protein and vesicle trafficking show similar RNAi phenotypes. The researchers believe that this study provides an effective method for future studies of a large ...

Cellular self-eating promotes pancreatitis

... as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by prematurely activating a digestive enzyme. In autophagy, a vesicle swallows a portion of cytoplasm and ferries it to the lysosome for digestion. The process is often beneficial, allowing hungry cells to recycle ...

BWF awards $7 million to infectious disease investigators

... and Mycobacterium tuberculosis persistence Timothy L. Tellinghuisen, Ph.D. The Scripps Research Institute Subversion of a host kinase and vesicle trafficking components for the production of infectious hepatitis C virus David Wang, Ph.D. Washington University School of Medicine A ...

Carnegie Mellon develops computer model to study cell membrane dynamics

... that many critical membrane-mediated processes take place. Deserno will describe the application of this model to the biophysical problem of vesicle creation on Tuesday, April 8 at the 235th national meeting of the American Chemical Society in New Orleans. Our model is coarse-grained, ...

Biophysical Society announces winners of 2008 Student Travel Awards

... of Essential Degrees of Freedom in Proteins. Thomas E. Frederick, University of Florida, Characterization of Acyl Chain Dynamics, Packing, and vesicle Morphology of 18:1 BMP: An NMR and EPR Investigation. Aurelia R. Honerkamp-Smith, University of Washington, Line Tensions, Correlation Lengths, ...

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

... Once inside the cell, the bacteria dissolve the vesicle membrane and release the cargo. The method ... bacteria are naturally programmed to dissolve vesicle membranes, a critical step to delivering the ... same time that the bacteria are breaking up this vesicle membrane, the cargo dislodges from the bacteria, ...

High-resolution light microscope reveals the fundamental mechanisms of nerve communication

... contents are released at the synapse when the vesicle membranes fuse with the membrane of the nerve ... was unclear whether the proteins sticking in the vesicle membrane (e.g. synaptotagmin) spread out over the ... show that the synaptotagmin molecules of a single vesicle remain together after fusion. The membrane ofthe ...

Common bacteria pirate natural mechanism to get inside cells

... can either stay inside the newly created vesicle and be degraded or resurface to be activated once ... active protein that mediates the fission of the vesicle inside the cell." Apparently, bacteria and ... inside the vesicles because fusion with a second vesicle that enables the degredation doesn't happen, says ...

Biologists prove critical step in membrane fusion

... of proteins and other chemicals. Before the swap can take place, the vesicle membrane must fuse with another membrane, creating channels packages can ... egg’s membrane. What about the membranes? What do they look like before vesicle cargo is released? Wessel and his collaborators discovered that the ...

American scientist's research of life's first cells

... a self-replicating genome (in this case made of RNA) contained in a vesicle that separates the genome from the external environment. Chen describes ... when the genome replicates inside a vesicle, osmotic pressure leads the vesicle to "steal" membrane from other, empty vesicles. This could be an example ...

New research questions basic tenet of neuron function

... for the two different modes of neurotransmitter release ?one type of vesicle for spontaneous release, another vesicle associated with activity-dependent release. "These findings question ...

Fast-freeze snapshot yields new picture of nerve-muscle junction

... but hasn't before been demonstrated." Richmond said the conventional gluteraldhyde fixation technique was the problem with the earlier view of vesicle positioning in nerve synapses, and she predicted that future use of the new technique will open up new discoveries of the roles various proteins play ...

With record resolution and sensitivity, tool images how life organizes in a cell membrane

... combination of sensitivity, analytical information and spatial resolution.'' For the Science study, Boxer and colleagues made a spherical lipid vesicle to model a cell membrane, placed it on a small silicon wafer to make the lipid bilayer flatten into two dimensions and organized the flat membrane ...

Nanosecond-scale release of stinging jellyfish nematocysts

... stored in the stretched configuration of the collagen-polymer of the nematocyst capsule wall. This ingenious solution allows the cellular process of vesicle exocytosis to release kinetic energy in the nanosecond range by a powerful molecular spring mechanism. ...

Think fast! Rice undergrad unlocks nerve speed secret

... called synaptotagmin is the actuator," McNew said. "We also knew there was a chemical brake in the system, something that held the pre-positioned vesicle in check, but poised for release. These new studies clearly show that the brake is a protein called complexin." Rice's study, which was conducted ...

Newly identified protein complex sheds light on axon growth mechanism

... called kinesins that transport vesicles along growing axons. Hengartner and colleagues propose that the UNC-69/UNC-76 complex may be implicated in vesicle trafficking, a process that is necessary for axon growth and new synapse formation. The short coiled-coil domain-containing protein UNC-69 ...

Protein receptor cools passion of 'kiss and run' nerve cells

... a specific molecular mechanism that targets the machinery that causes the fusion process and found that instead of an all-or-none release, the vesicle just kisses the cell's presynaptic membrane. Neuroscientists call it 'kiss and run.' When it does it, our lab has now shown that only a little bit of ...
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