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Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA

... of the stronger splice site and in 12 just upstream of it, their exact positions chosen so that they ... In control synthetic pre-mRNA's where the weak upstream splice site was left out, splicing always took ... common splice ending point. But when the weak upstream site was present, changes in nucleotide type and ...

New study ranks 'hotspots' of human impact on coastal areas

... fail if they don't directly address what people are doing on land upstream from these locations." Nutrient runoff from upstream farms has caused a persistent "dead zone" in the Gulf of Mexico, where the ...

EPA and USDA should create new initiative to better monitor nutrients

... for the northern Gulf of Mexico in order to complement data gathered upstream and document the effectiveness of upstream nutrient-control actions. ...

Alpine rivers hold important clues for preserving biodiversity and coping with climate change

... systems, not only because water, sediment and organisms move between upstream and downstream reaches, but also because the faster flowing and deeper ... that this process is applied at different sites along rivers to maintain upstream to downstream connections between affected sites if sustainable benefits ...

Where optics meets medicine

... vessels of the venule system and then monitor the effect on blood flow in upstream capillaries in the brain. They find that blockages in venules can cause a significant decrease in blood flow in upstream capillaries, which in turn could cause the death of neurons. These ...

Project succeeding to relocate Caspian terns

... terns to East Sand Island from another Columbia River location 16 miles upstream Rice Island after an OSU-led research team discovered the colony there ... of fish, including herring and anchovies, than do the fresher waters upstream near Rice Island. "Terns are fish-eating birds that eat large ...

Present-day species of piranha result from a marine incursion into the Amazon Basin

... piranhas would subsequently have dispersed to colonize the more upstream reaches of the river system. However, the results of the study give ... marine incursion phase some piranha populations would have survived in the upstream parts of the network. Such populations would have differentiated into ...

Ecologist finds dire devastation of snake species following floods of '93, '95

... hunting, fishing, hiking and bird watching. The preserve lies slightly upstream of the convergence of the Missouri and Mississippi rivers. It is managed ... few months after the 1993 flood waters receded. Sexton heard of a farmer upstream of Marais Temps Clair whose house and farmyard did not suffer flooding but ...

University of Houston diesel testing center teams with state transportation agency to cut emissions

... emissions from medium- and heavy-duty diesel engines, using a control strategy that relies on a NOx concentration measurement by a sensor positioned upstream of the SCR catalyst. "The NOx sensor-based control strategy makes the system very suitable for retrofit applications," said M.A. Mannan, business ...

Muscle atrophy through thick but not thin

... is responsible for degrading only some muscle components, whereas others fall victim to other ubiquitin ligases and autophagy. Inhibitors that work upstream to block signals that activate ubiquitin ligases and initiate autophagy are a better bet. ...

ExcellGene SA first company to offer contract manufacturing in 250 Liter OrbShake bioreactor

... technologies for the production of recombinant proteins from mammalian cells in bioreactors. As a service company, ExcellGene generates entire upstream cell culture processes for its customers, from DNA to scalable manufacturing under cGMP. Additionally, the company provides protein production ...

Double trouble for water life

... to many freshwater and marine ecosystems. He adds that focusing on phosphorus alone ignores the fact that natural and human influences that affect upstream waters have significant adverse consequences on downstream waters. Therefore, it is essential to look at nutrient control measures and their effects ...

Supply-Chain Council Announces Winners of 2009 Supply Chain Excellence Awards

... shop floor execution between subcontractor and manufacturer with clear mapping to SCOR mega processes in order to gain process and data visibility of upstream and downstream supply chain," said Dr. Tom Janoshalmi, Chair of the SCC Technical Development Steering Committee and Manager, Corporate Strategy, SAP ...

ExcellGene and Khner achieved milestone in development of novel 250 Liter mammalian cell culture bioreactors

... technologies for the production of recombinant proteins from mammalian cells in bioreactors. As a service company, ExcellGene generates entire upstream cell culture processes for its customers, from DNA to scalable manufacturing under cGMP. Additionally, the company provides protein production ...

Building the lymphatic drainage system

... long list of target genes that might be controlled by the two factors. The team now plans to investigate these targets as well as to work out the upstream molecular pathways controlling Foxc2 and NFATc1. Whatever the mechanisms, if the team can show that Foxc2 and NFATc1 also prompt lymph vessel ...

New drug agent knocks out multiple enzymes in cancer pathway

... cell signaling to go awry. These efforts have met with limited success. Bisphosphonates act on other enzymes, called FPPS and GGPPS, which are upstream of Ras in the cell survival pathway. Inhibiting these enzymes appears to be a more effective strategy for killing cancer cells. When used in ...

GEN reports biomanufacturers target a fully disposable process stream

... 4, 2009--The disposable bioprocessing market has moved far beyond plastic bags for buffer preparation toward a range of products for cell culture and upstream and downstream operations, reports Genetic Engineering & Biotechnology News (GEN). Increasing numbers of biomanufacturing experts now believe that ...

Hypertension and cholesterol medications present in water released into the St. Lawrence River

... This press release is available in French . Montreal, January 26, 2009 A study conducted by Universit de Montral researchers on downstream and upstream water from the Montreal wastewater treatment plant has revealed the presence of chemotherapy products and certain hypertension and cholesterol ...

Chemist receives NIH funding to unravel tricks of neuronal wiring

... because these proteins can have multiple functions. "If you knock out a developmental protein, there is a potential that you affect some upstream event so you never do the event you are interested in," Maurer said. Maurer's neuronal "road map" overcomes this problem by isolating the ...

Transporting juvenile salmon hinders adult migration

... naturally, transported juveniles had lower survivorship as adults and were less likely to find their way home. "Adult fish usually move steadily upstream toward their spawning grounds, but some will instead move back downstream over dams," says Keefer. This phenomenon, called fallback by fisheries ...

Using the other guy's toolkit: Similarities of pumping blood, oil examined

... rely on constant innovation, which requires diversity of thought," said William E. Kline, manager of the Wells and Materials Division at ExxonMobil upstream Research Co. "That's why the opportunity to rummage around in 'the other guy's toolkit' is so exciting." Program directors from the co-hosting ...

It takes 2 to tango

... to thousands of neighbouring cells. At these points of contact, known as synapses, the neuronal information flows along a one-way channel; from the upstream cell to the downstream cell. The brain can deal with its complicated tasks only when the nerve cells manage to exchange information at the right time ...

Wetlands expert: China should think outside the flooding box with Three Gorges Dam

... factory toxins and raw sewage and that sediment might cause the reservoir level to rise higher than planned, threatening to flood a large city upstream and possibly even send water spilling over the top of the dam. The flooding is expected to extend as much as 185 miles upstream. Almost 14,000 ...

AGU journal highlights -- Oct. 16, 2008

... by topography such that flow of intermediate waters within and the exchange between the basins took place along depth contours. By contrast, just upstream of the outflow of intermediate water from the Nordic seas to the North Atlantic, the flow is forced to cross depth contours. As a result, the flow ...

Bays on US Gulf Coast vulnerable to flooding

... the Gulf Coast has doubled in the past century to a current rate of about three millimeters per year. At the same time, the installation of dams upstream has slashed the amount of sediment flowing into every southern U.S. bay. "Our research paints a pretty clear picture of what happened in these ...

Researchers develop new self-training gene prediction program for fungi

... is not deterministic. Locating the branch site which is nine nucleotides in length, almost always contains an adenine and is located 20-50 bases upstream of the acceptor site helps to accurately identify an intron. An initial run of the program with a reduced model containing heuristically defined ...

Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue

... focused on the nicotinic acetylcholine receptor, an ion channel found in both brain and muscle cells. The neurotransmitter acetylcholine, released by upstream nerve cells, binds to portions of the protein on the outside of brain and muscle cells causing the channel to open and allow ions to cross the ...

August 2008 Geology and GSA Today media highlights

... to the riparian ecosystem, be rebuilt and maintained over extended periods with the existing sediment supply (i.e., without augmentation from the upstream reservoir). By adopting a best-case scenario, they demonstrate that the sandbars could be rebuilt, albeit slowly. The viability of operating the dam ...

Genome communication

... be involved in paramutation, although they may differ among species. One important player is an array of repeated non-coding DNA sequences that lies upstream of the gene sequence of the paramutagenic allele. Seven of these tandem repeats are required for b1 paramutation. If only three tandem repeats are ...

Montana State University research reaches Supreme Court of India

... Court. In doing so, it referenced MSU's findings and echoed MSU's concerns. The Lucknow Institute tested a portion of the Ganges about 200 miles upstream from Hamner's sampling. He doesn't expect to see a pure Ganges in his lifetime, but the Supreme Court involvement is encouraging, Hamner said, ...

Montana State researchers study spread of lake trout in Glacier National Park

... bull trout, but both are top-level predators and grow to similar sizes. Bull trout are getting "pinched" by downstream threats like lake trout and upstream threats such as reduced runoff from glaciers. To study Glacier's fish, Meeuwig spent the summers of 2004 through 2006 in the park. He camped in ...

Bikini corals recover from atomic blast

... seeding Bikinis recovery, because it is the second largest atoll in the world with a huge amount of coral reef diversity and biomass and lies upstream from Bikini. Zoe says that ironically, thanks to the bombs, Bikini Atoll represents a priceless laboratory showing how in the absence of ongoing ...

Genetic variants of USF1 are associated with the increased risk for cardiovascular disease

... of Professor Leena Peltonen at the National Public Health Institute and the University of Helsinki, Finland, has investigated variation within the upstream transcription factor 1 (USF1) gene locus in relation to CVD risk factors, atherosclerosis, and incidence and prevalence of CVD. USF1 gene was ...

Changes in ocean conditions in Sargasso Sea potential cause for decline in eel fishery

... eel-shaped transparent juveniles, or glass eels, named for their appearance. They gather in estuaries and wait for the river to warm before swimming upstream into freshwater, where they change color and acquire green and brown pigments to become known as yellow eels. They can spend up to 20 years living in ...

Studying rivers for clues to global carbon cycle

... on a project funded by the National Science Foundation on the dynamics of organic carbon in rivers and trying to understand how carbon delivered from upstream areas influence the ecology of downstream locations. The broadest idea is really part of global change efforts to understand carbon cycling over ...

LSU and Ohio State battle on football field, collaborate in research field

... focus on Louisiana, addressing the issues of dramatic wetland loss and the continuously growing dead zone, OSU researchers are developing wetlands upstream so that nutrient loads in the Mississippi that would increase the size of the dead zone will be dramatically reduced by the time they reach the delta ...

New map outlines risk of zebra mussel invasion

... These mussels also need colonies in still water to maintain populations over the long term. In rivers, this means there needs to be an invaded upstream lake, canal or reservoir to supply new larvae. Zebra mussels were first found in the lower Great Lakes in the late 1980s, likely introduced to the ...

New national map shows relative risk for zebra and quagga mussel invasion

... reflects the water source rather than the local conditions. The other key requirement for Dreissena in river systems is the presence of an invaded upstream lake or reservoir to maintain a supply of larvae," said Whittier. According to the authors there is conflicting evidence of the quagga mussels ...

Everglades phosphorus limits on the right track, but more is needed

... have begun massive efforts to reduce phosphorus levels by impounding and treating flood waters and encouraging best management practices on upstream farmlands. Florida and U.S. Environmental Protection Agency guidelines limit phosphorus levels to 10 micrograms (millionths of a gram) per liter ...

JCI table of contents: Aug. 9, 2007

... development of cancer. Studies in mice indicate that the protein PU.1 is a tumor suppressor. Mice lacking a specific portion of the DNA (known as the upstream regulatory element; URE) that controls the level of expression of the PU.1 gene develop acute myeloid leukemia (AML). When researchers from Harvard ...
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