Saved by junk DNA
... in the evolution of our genome. They found that unstable
pieces of junk DNA help tuning gene activity and ... nature would foster such a wasteful system'.
The international team of scientists ... Interestingly, tandem repeats are very unstable
- the number of repeats changes frequently when ...
NSF provides $3.4 million to study climatically important Agulhas Current
... around to eventually flow eastward toward Australia. This retroflection is unstable
and regularly sheds large Agulhas Rings, which carry Indian Ocean waters ... climatic impacts such as heat transport into the Southern Ocean via the unstable
The Agulhas Current Time-series (ACT) project will be ...
Singapore researchers first to transform carbon dioxide into methanol
... In contrast to heavy metal catalysts that contain toxic and unstable
components, NHCs are stable, even in the presence of oxygen. Hence, the ... time. They also require transition metal catalysts, which are both unstable
in oxygen and expensive. Ongoing research at IBN aims to find cheap ...
Fungi have a hand in depleted uranium's environmental fate
... Iraq and the Balkans has led to contamination of the environment with the unstable
metal, Gadd explained. Depleted uranium differs from natural uranium in ... and biological factors is involved in the process. First, the unstable
uranium metal gets coated with a layer of oxides. Moisture in the ...
Parasites ready to jump
... play the central role. "Transposons are genomic parasites, so to speak", says Frstemann. "If they are allowed to proliferate, the genome can become unstable
or cancers can develop. We now want to find out whether mammalian cells possess this newly discovered defence mechanism and to elucidate precisely ...
Common allergy drug reduces obesity and diabetes in mice
... blood flow to the site. However, in certain conditions mast cells build up to levels far beyond what the body needs. As a result these cells become unstable
and eventually, like punctured trash bags, leak molecular "garbage" into the tissue. This can result in chronic inflammation that causes asthma and ...
Telomeres resemble DNA fragile sites
... chromosome ends from molecular attack. Researchers at Rockefeller University now show that telomeres have their own weakness. They resemble unstable
parts of the genome called fragile sites where DNA replication can stall and go awry. But what keeps our fragile telomeres from falling apart is a ...
New nanoparticles could revolutionize therapeutic drug discovery
... just been published online in the Journal of the American Chemical Society , will give scientists access to previously ignored proteins deemed too unstable
to work with.
Professor Michael Overduin, from the University of Birmingham, who led the study, explained: "We have shown how a polymer can wrap ...
Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
... directly or its helpers, is a good thing."
While every cell needs heat shock proteins, cancer cells need them even more to maintain their mutated, unstable
and extremely busy proteins, he says. "The terminology we use is that the Hsp90 machinery is hijacked by cancer," says Dr. Chadli. Proteins that ...
American Chemical Society weekly presspac -- June 10, 2009
... white LEDs that are suitable for practical use. Existing technologies produce tinted shades of white light, require complex components, and become unstable
The researchers describe development of a new, simpler white LED that is the first to achieve stable white light emissions using a ...
Cantabrian cornice has experienced seven cooling and warming phases over past 41,000 years
... deposited by glaciers backs this up this result.
The water rat was king of the Late Pleistocene
According to the study, there were four unstable
cold periods, two more stable ones, and a temperate climatic period at the El Mirn cave. The scientists are unsure about dating the seventh and last ...
Trading energy for safety, bees extend legs to stay stable in wind
... increased with flight speed until the bees were rolled to one side or the other roughly 80 percent of the time, at which point the bees would become unstable
and either crash to the ground or be blown from the airstream. Bees were able to reach higher speeds when flying in lower levels of turbulence, ...
Tumor growth and chemo response may be predicted by mathematical model
... causing more aggressive tumor cells to invade the healthy tissue. As cancer cells invade and replicate themselves, they make the tumor shape unstable
and more invasive. The model correctly predicted the different types of invasion under a variety of conditions.
The model further predicted that ...
Scientists urge global action to preserve water supplies for billions worldwide
... Representatives from Nepal reported on the dangerous spread of mountain moraines, masses of debris left by retreating glaciers, which have become unstable
reservoirs created by rapid glacial melt. Himalayan glaciers supply more than 1 billion people in Asia with drinking water.
Participants also ...
Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes
... content. This kind of testing is particularly important when an upper layer of soil is dry and an underlying layer wet. Then the upper layer becomes unstable
and landslides can occur.
Zhiqu Lu of the University of Mississippi will report on a newer, higher-precision device, one employing laser sensing ...
Home tooth bleaching slightly reduces enamel strength
... solutions of various strengths of either hydrogen peroxide or carbamide peroxide, which provide the whitening effect. They bleach teeth by producing unstable
free radicals that attack pigment molecules in the organic parts of enamel. The reduction in pigment means the molecules no longer reflect light, so ...
Weizmann Institute scientists develop a unique approach for splitting water into hydrogen and oxygen
... together to form hydrogen peroxide (H 2 O 2 ), which quickly breaks up into oxygen and water. 'Because hydrogen peroxide is considered a relatively unstable
molecule, scientists have always disregarded this step, deeming it implausible; but we have shown otherwise,' says Milstein. Moreover, the team has ...
Bird feathers produce color through structure similar to beer foam
... form. They compared the nanostructures to examples of materials undergoing phase separation, in which mixtures of different substances become unstable
and separate from one another, such as the carbon-dioxide bubbles that form when the top is popped off a bubbly drink. They found that the ...
Heinz Maier-Leibnitz Prizes 2009: Six young researchers recognized for outstanding achievements
... for handling complex relationships at the start-up of industrial production processes. In her work, she is attempting to simulate and evaluate unstable
production processes as early as the planning stage and during the start-up phase in order to arrive at effective countermeasures that will ...
Microscope reveals how bacteria 'breathe' toxic metals
... these bacteria naturally convert the metals into an insoluble form. Though the metals would remain in place, they would be stable solids instead of unstable
For this study, Lower and his colleagues used an atomic force microscope (AFM) to test how the bacterium responded to the metallic ...
Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols
... studying the activity of a protein of interest in cells. The protein is attached to a destabilization domain, and the resulting fusion proteins are unstable
and degraded, except in the presence of small ligands. The speed of small-molecule binding makes it an attractive alternative to studying gene ...
Research model may one day 'inoculate' elderly against slip-related falls
... BETHESDA, Md. (Feb 4, 2009) - Training people to avoid falls by repeatedly exposing them to unstable
situations in the laboratory helped them to later maintain their balance on a slippery floor, according to new research from the Journal of ...
Promising new drug being evaluated as possible treatment option for fragile X syndrome
... X syndrome include mental impairment such as learning disabilities, attention deficit, hyperactivity, autistic-like behaviors, and anxiety and unstable
Fragile X syndrome is caused by lack of activity of the FMR1 gene, which is responsible for a protein called FMRP. Without FMRP, activation ...
In just 5 years, gene discovery to clinical trial of potential treatment
... generates an abnormal Lamin A protein (also called progerin) that disrupts the cell's nuclear membrane. Because progerin wreaks havoc, cells become unstable
and abnormal. The resulting gross disfigurement of the cell's nucleus is described as "blebbed," or lobular in shape.
(Recent research indicates ...
CSHL researchers map changing epigenetic modifications that enable transposons to run amok
... Cold Spring Harbor, N.Y. Much like cancer cells, plant cells grown for a long time outside of their normal milieu, in culture dishes, have highly unstable
genomes. Changes in gene activity, or how genes are "expressed," help cells cope with challenging culture conditions but inadvertently also leave ...
AGU journal highlights -- Oct. 16, 2008
... water from the Nordic seas to the North Atlantic, the flow is forced to cross depth contours. As a result, the flow becomes conspicuously unstable
with strong eddy motion in the FaroeShetland Channel.
Rigid topographic control of currents in the Nordic Seas
H. Siland: ...
Stabilizing force for good communication between neurons and muscle cells found
... a message, or neurotransmitter, to the muscle cell to tell it what to do. To get the message, the receiving cell must have a receptor. Oddly, the unstable
protein rapsyn is responsible for anchoring the receptor so it's properly positioned to catch the message.
Medical College of Georgia scientists ...
Cross kingdom conflicts on a beetle's back
... for them exist. Here, however, we have an example of an antibiotic successfully disabling a powerful fungi.
"This particular molecule is too unstable
to be a viable candidate," says Clardy. "Still, we need to study how it kills fungi, learn the mechanisms. We can look into other bacterial genomes ...
Cutting calories could limit muscle wasting in later years
... in the mitochondria and react with oxygen. Iron can change the chemical structure of oxygen, triggering its metamorphosis into a free radical, an unstable
atom that can upset the delicate balance inside the mitochondria. The result? Leeuwenburgh describes it sort of like internal rust.
"Not all free ...
Good breeding increases shelf life
... Forest' performed consistently well, ranking in the top 10 in every experiment. 'Alpi', 'Dark Green Romaine', and 'Queen of Hearts' showed clearly unstable
shelf life. Hayes noted, "cultivars that performed well in our MA environments will likely be useful as parents in breeding programs to develop new ...
Findings released from 1 of the largest percutaneous coronary intervention trials ever
... to result in less bleeding and similar rates of composite ischemia compared to heparin plus GPI in patients undergoing angioplasty for stable angina, unstable
angina and non-ST-elevation myocardial infarction (NSTEMI).
Dr. Stone emphasized the importance of reducing the risk of bleeding. In multiple ...
A new idea for how anti-aging products delay ripening of fruit and wilting of flowers
... extends their shelf life, reduces waste and, ultimately, benefits producers and consumers.
Because 1-MCP is an unstable
gas, growers face a challenge in delivering it to fruits and flowers. Commercially, 1-MCP therefore is complexed with alpha-cyclodextrin, a ...
Outstanding German-Polish scientific cooperation
... and cytosine-guanine possess specific mechanisms that enable them to return to a stable ground state very rapidly after being excited into an unstable
state by UV radiation. The basic processes on which this mechanism is based take place within a few femtoseconds the time it takes light to travel ...
Fishing throws targeted species off balance, Scripps study shows
... are based on the restoration of historic biomass levels, even though the swordfish are clearly undersized.
In the extreme case, the danger of such unstable
dynamics for certain populations for management is that harvest targets may lag the population, potentially making things worse, said Sugihara. A ...
Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice
... to help people with too few blood vessels. But when the body grows new blood vessels at the wrong time or place, these blood vessels are often unstable
and weak, which causes them to leak and potentially lead to diseases such as macular degeneration and diabetic retinopathy.
In 2003, Lis ...
Imports from Latin America may help US meet energy goals, study finds
... markets via delivery at coastal ports.
Biofuel imports complement domestic biofuel production and diminish reliance on oil, the price of which is unstable
and strongly influenced by the OPEC cartel, Leiby said. Even if imported, biofuels can improve our energy security by reducing oil imports and ...
Lake Mead could be dry by 2021
... the population of the Southwest through an unusually dry year, or worse, a sustained drought. In such an event, water deliveries would become highly unstable
and variable, said research marine physicist Tim Barnett and climate scientist David Pierce.
Barnett and Pierce concluded that human demand, ...
Particle accelerator may reveal shape of alternate dimensions
... Geneva, Switzerland.
In an accelerator, smashing atomic nuclei head-on at nearly the speed of light can briefly create new high-energy and highly unstable
particles, which quickly decay into a shower of detectable lower energy ones. Characteristic patterns of decay serve as fingerprints of the fleeting ...
Environmental epigenetics has potential for preventing and treating disease
... metastable epialleles in order to characterize all of the genes susceptible to environmental influences.
With the identification of epigenetically unstable
locations in the human genome, it will be possible to screen individuals at an early age for epigenetically susceptible diseases, allowing for closer ...
Fine print: New technique allows fast printing of microscopic electronics
... and are now commonly used in a variety of industrial processes. However, one of the main features of EHD jets is that the stream of liquid becomes unstable
soon after it leaves the nozzle and either whips around uncontrollably or breaks up into fine liquid drops. Engineers have used these effects to ...