The way you eat may affect your risk for breast cancer
... of serum factors that are involved in tumor
development would possibly provide a way to ... provided greater protection from mammary tumor
development than did the same overall degree of ... methods chronic and intermittent and tumor
development beginning in 10-week old female mice ...
La Jolla Institute discovers novel tumor suppressor
... have discovered its previously unknown role as a tumor
suppressor that may be important in ... function that no one knew it had -- as a tumor
suppressor," said the La Jolla Institute's ... disease.
The team determined that tumor
production hinged on the PLC-beta 3's ability to ...
Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth
... ovarian cancer that has promise for targeting tumor
cells and leaving healthy cells healthy," said ... of this technique, the researchers measured tumor
volume before and after treatment. They found ... lifespan by nearly four weeks and suppressed tumor
growth more effectively, and with minimal ...
A crystal ball for brain cancer?
Survival rates drop even lower if the tumor
returns. Conventional therapies produce little ... only 8 to 15 percent of patients survive without tumor
growth six months after treatment.
The UCLA ... the team saw requires an understanding of how the tumor
creates an independent blood supply.
Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
... from Self-Renewing, Proliferating Autologous tumor
Cells as Patient-Specific Anti-Tumor Vaccines in ... the patient's immune system to react against tumor
stem cells or early progenitor cells that can ... observed following vaccination with irradiated tumor
cells in 48 melanoma patients in a previous trial ...
Cancer's distinctive pattern of gene expression could aid early screening and prevention
... variety of cancers and blood disorders. Because tumor
cells that result from aberrant changes shed ... Georgia Cancer Coalition Scholar. "Every single tumor
that anybody has looked at has aberrant change in ... lot of things we don't know," Dr. Shi says.
is not only gaining methylation in certain areas ...
UCLA researchers discover new molecular pathway for targeting cancer, disease
... to the researchers. How LXR was able to inhibit tumor
cell growth by impeding the Hh pathway was ... as to how we might be able to intervene with tumor
formation," said Farhad Parhami, a professor of ... Hh signaling pathway is an important regulator of tumor
formation, and these findings suggest that LXR ...
'Normal' cells far from cancer give nanosignals of trouble
... some distance from a malignant or premalignant tumor
undergo molecular and other kinds of abnormal ... alterations occurred at some distance from the tumor
and, importantly, could be identified by ... only in cancer cells but in cells far from the tumor
site and are the same in at least three different ...
Dogs, humans, put heads together to find cure for brain cancer
... of four adult brain tumors -may not be as key for tumor
formation as previously thought, and they've ... They believed that the deletion of NF2, with its tumor
suppressing abilities, could trigger tumor
In looking at genetic changes across ...
... genes that are disregulated both in the primary tumor
and in its metastases. In the future, their ... when single cells break off from the primary tumor
and spread to other body regions via the blood ... seldom feels pain or shows other symptoms, the tumor
is frequently not discovered until it has already ...
Tumor suppressor gene in flies may provide insights for human brain tumors
... PP2A (protein phosphatase 2A) suppresses brain tumor
formation and controls the balance of ... function. Instead, they effectively grew into a tumor
Dr. Wang's previous work had identified a protein kinase called Polo as a tumor
suppressor. Because phosphatases like PP2A ...
Caltech researchers explore how cells reconcile mixed messages in decisions about growth
... a protein called E-cadherin, which is a tumor
suppressor protein that promotes adhesion of one ... as a sort of switch that, when present, prevents tumor
formation and, when absent, results in cell ... inhibition to promote unbridled cell division and tumor
"This tunability of the threshold ...
Research uncovers clues to virus-cancer link
... herpesvirus (KSHV) is not only present in every tumor
cell, but that the cells also transcribe ... miRNA biomarkers accurately identify stages of tumor
progression. They found that certain miRNAs were ... the cancer's growth. More aggressive tumor
stages expressed higher levels of KSHV miRNA.
UCLA cancer researchers develop model that may help identify cancer stem cells
... for decades. In one theory, all the cells of a tumor
are the same, with an equal capacity to divide ... theory holds that only a few, select cells from a tumor
have the ability to initiate a new tumor
- the cancer stem cells. In the last decade, ...
Tips from the American Journal of Pathology
... patients with poor clinical outcome. In addition, tumor
onset in mice was accelerated in the absence of ... Caveolin-1 may therefore function as a tumor
suppressor in the stromal microenvironment and ... stromal Cav-1 functions to directly suppress tumor
growth, and uncovering the factors which regulate ...
LSUHSC research describes function of key protein in cancer spread
During the transition from a localized tumor
to metastatic disease, cancer cells acquire the ... at distant points in the body.
metastasis leads to a poor prognosis and ... and invasion processes that occur during tumor
The research team focused on the ...
Tumor growth and chemo response may be predicted by mathematical model
... molecular and cellular levels could shed light on tumor
development and lead to better treatments.
... at Houston, demonstrated the predictability of tumor
growth in brain cancer and chemotherapy response ... developed by Cristini's lab works by defining tumor
biologic and molecular properties relating to ...
Computer model predicts brain tumor growth and evolution
... mass, and it has allowed researchers to recreate tumor
growth in a computer. Through subsequent ... brain tumors, or "gliomas," and can now watch tumor
growth on a computer screen.
Creating such a ... a number of equations describing the process of tumor
evolution and growth. The master computational ...
MITs implantable device offers continuous cancer monitoring
... are accurate but only offer a snapshot of the tumor
at a single moment in time.
Monitoring a tumor
for weeks or months after the biopsy, tracking ... reported that their device successfully tracked a tumor
marker in mice for one month. The work is ...
From cars to cancer: UH professor employs auto industry tools for tumor therapy
"We aim to better understand tumor
deformations using geometric and statistical ... is used to collect information with respect to tumor
size, location and volume," he said. "But the CT ... and they may be "too good to be true."
shrinks as it responds to the treatment," Dong ...
Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy
... the researchers analyzed the genetic basis of tumor
formation from human embryonic stem cells and ... of the cells could minimize the chances of tumor
formation, but the researchers caution that a ... to address the major safety concerns regarding tumor
formation by human embryonic stem cells.
Lithium may help radiation target cancer, spare healthy tissue
... DNA repair in healthy cells but not in brain tumor
cells. The findings suggest that lithium ... damage is unclear.
Radiation kills tumor
cells by damaging their DNA, but it can also ... the mechanisms of DNA repair in normal cells and tumor
cells, suspected that lithium might affect how ...
New early detection studies of lung cancer in non-smokers launched today
... non-smokers with lung cancer have different tumor
tissue structure, gene mutations, and demographic ... the EDRN.
The NCI-EDRN will fund most of the tumor
studies, and the Canary Foundation will provide ... Analysis of Lung Cancer Cell Lines (PI: Hanash)
biomarker discovery: Biomarker Discovery for Lung ...
Publication sets guidelines across cancer therapies: Ensuring the best in patient management
... level. In the past, collecting information about tumor
response in a structured and meaningful format ... of the various techniques developed to monitor tumor
response to these drugs have proven to be ... shown to improve response assessment in several tumor
types, such as lymphoma, and a variety of ...
A longer lasting tumor blocker
... studies in mice show that when treatment stops, tumor
growth rapidly resumes. Now, Yoshiaki Kubota and ... a different molecule, called M-CSF, suppressed tumor
growth even after treatment was stopped.
... Three weeks of anti-VEGF treatment suppressed tumor
growth but, similar to other recent reports, the ...
Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer
... showed that MIS416 significantly inhibited tumor
growth and the formation of metastases when ... When administered as an adjunct to localized tumor
irradiation, MIS416 also demonstrated synergistic ... the reintroduction of previously harvested tumor
antigens. This successful induction of adaptive ...
Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies
... selectively destroy the blood vessels supporting tumor
growth and spread and also to reverse the ability ... facilitate an important cytokine shift in the tumor
environment that subsequently encourages multiple ... that in vitro, anti-PS antibodies stimulate the tumor
microenvironment to recruit monocytes and other ...
TGen researchers discover possible way to block the spread of deadly brain tumors
... time to survive.
"Controlling the actions of tumor
cells by regulating NHERF-1 implicates it as a ... as a 'molecular switch' that regulates the GBM tumor
cell's ability to migrate or divide,'' said Dr. ... surgically and ensure that all of the invading tumor
cells are gone, even when surgery is followed by ...
SIRT1 takes down tumors
... protein SIRT1. By speeding the destruction of the tumor
promoter c-Myc, SIRT1 curbs cell division. The ... chops off acetyl groups, which can inactivate the tumor
Yuan et al. determined SIRT1's ... its breakdown. To test SIRT1's effects on tumor
growth, the researchers implanted cancerous cells ...
UNC study: Scientists identify chemical compound that may stop deadly brain tumors
... how a particular gene mutation contributes to tumor
The findings and potential treatment apply to a type of brain tumor
called secondary glioblastoma multiforme (GBM). ... of the journal Science .
In experiments with tumor
cells, the researchers reversed the effects of a ...
How tumor cells move
... which inhibits the movement and spread of tumor
cells in laboratory tests. When the factor's ...
Focus on particularly aggressive cancers
cells are extremely mobile and "adept" at ... Robert Grosse. "If there is too little SCAI in tumor
cells, then b1-integrin is overactive, so to ...
Novel lung cancer vaccine shows promise in fighting early-stage lung cancer
... immune system to identify and attack specific tumor
cells is showing new promise for the treatment of ... ultimately die of lung cancer.
"Adding the tumor
vaccine to surgery has the potential to boost the ... chemotherapy treatment either because of their tumor
stage or other co-morbidities such as their age ...
Fluorescent cancer cells to guide brain surgeons
... normal brain tissue and, in addition, individual tumor
cells can form satellites in surrounding tissue. Therefore, it is almost impossible to remove the tumor
tissue completely by surgery.
Yet, radical surgical removal of the tumor
would substantially improve the prognosis of ...
UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
... release of breast cancer cells from the primary tumor
and then inhibiting their death."
Muc4 is ... now preparing to test metastasizing breast cancer tumor
cells for the overexpression of Muc4.
"If we ... is also expressed in pancreatic, lung and ovarian tumor
"Muc4 is likely a central cellular ...
Skin cancer study uncovers new tumor suppressor gene
... have identified a gene that suppresses tumor
growth in melanoma, the deadliest form of skin ... and other key enzymes play a functional role in tumor
growth and spread of the disease.
suppressor genes encode proteins that normally ...
Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
... new insight into mechanisms that allow invasive tumor
cells to move, researchers at the Mayo Clinic ... kinase D1 (PKD1) is key to the ability of a tumor
cell to "remodel" its structure, enabling it to ... The researchers found that if PKD1 is active, tumor
cells cannot move, a finding they say explains ...
Gorilla gets MRI at Bronx Zoo
... Wildlife Conservation Society thanks The Brain tumor
Foundation and its "Road To Early Detection" ... seek out a neurological diagnosis.
The Brain tumor
Foundation responded to WCS's request for ... signs.
"Thanks to the generosity of The Brain tumor
Foundation, we were able to perform an MRI of ...
New drug agent knocks out multiple enzymes in cancer pathway
... that is about 200 times more active in killing tumor
cells than similar drugs used in recent clinical ... design drugs to inhibit cell survival pathways in tumor
cells, focusing on a protein called Ras since ... that would inhibit multiple enzymes in the tumor
cell survival pathway, rather than just one, an ...
Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
... have the tools in hand to really say that this tumor
will spread to other organs or not." says the ... confidence that what you are stating about the tumor
is true. Our goal is to develop such a panel and ... including sarcosine, linked to increased tumor
progression. A total of 89 metabolites were ...
Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
... they have appeared to primarily work by forcing tumor
related receptors to shut down pro-growth ... that is short-lasting and which directly kills tumor
cells, and a long-lasting "memory" response that ... "This one-two punch would anticipate how the tumor
changes over time and cut off the cancer's escape ...