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Tuberculosis in Biological News

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

... mechanism of iron acquisition by Mycobacterium tuberculosis and Aspergillus fumigatus . Iron is ... infection. The synthesis of siderophores in M. tuberculosis and A. fumigatus requires special enzymes ... from M. smegmatis (a model organism of M. tuberculosis ) and A. fumigatus . "We have been able to ...

TB -- hiding in plain sight

... Current research suggests that Mycobacterium tuberculosis can evade the immune response. The related report ... More than two million people worldwide die from tuberculosis infection every year. Due in part to ... dangerous infections. Immune responses to tuberculosis rarely result in complete eradication of the ...

Alzheimer's, asthma, cancer, malaria and TB focus of new Singapore grants

... to investigate the mechanisms of infection in tuberculosis and malaria, which cause deaths as well as ... In their studies of Mycobacterium tuberculosis (MTB), which infects an estimated two billion ... In Singapore, the incidence rate of tuberculosis has increased for the first time in 10 years, ...

Pitt-led researchers create quick, simple fluorescent detector for TB

... developed an onsite method to quickly diagnose tuberculosis (TB) and expose the deadly drug-resistant strains of Mycobacterium tuberculosis that can mingle undetected with treatable ... said. Hatfull and his colleagues treated M. tuberculosis with antibiotics at the same time the ...

Einstein and Pitt researchers develop new TB test that will dramatically cut diagnosis time

... developed an onsite method to quickly diagnose tuberculosis (TB) and expose the deadly drug-resistant strains ... the DNA of the phage into the Mycobacterium tuberculosis cell, the bacterium that causes TB, causing the ... the authors of the study. "By infecting live M. tuberculosis cells with a flurophage, a quick and highly ...

Long-sought protein structure may help reveal how 'gene switch' works

... can be used to develop new methods for preventing tuberculosis and other pathogenic bacterial diseases. "We ... Robinson substituted the CRP from Mycobacterium tuberculosis [the pathogen that causes tuberculosis] for the ... with X-ray diffraction. "Although the M. tuberculosis protein in the 'off' state consists of two ...

In India: A search for more effective tuberculosis drugs

... created a compound in his lab in India that stops tuberculosis in its tracks. In a test tube, the molecule hits ... the costly cocktail of drugs that people with tuberculosis must currently take to cure their disease. ... pharmaceutical "weapons" that can slow down the tuberculosis (TB) pathogen's relentless assault. According to ...

Texas Medical Center researchers win collaborative grants

... cancer and a way to identify people at risk for tuberculosis are goals of the first recipients of grants from ... fund more projects." Unraveling mysteries of tuberculosis Why does the tuberculosis germ make some people gravely ill and leave ...

Proteomics study yields clues as to how tuberculosis might be thwarting the immune system

... one day yield new weapons in the fight against tuberculosis and other deadly infectious diseases. Scientists ... As Shui explained, "After mycobacterium tuberculosis are phagocytosed into the macrophage cell, they ... new avenues for pharmacologic intervention of tuberculosis as well as other infectious diseases." ...

Research identifies type of vaccine that holds promise in protecting against TB

... TB germ from one of the strains of the current tuberculosis vaccine, which was created more than 75 years ... a secreted protein from a virulent strain of tuberculosis to help focus the immune system on blocking ... critical to find a better vaccine, Hoft said. tuberculosis strikes developing nations hardest, infecting one ...

Scientists discover bacteria that can cause bone infections

... species of bacteria that is related to the tuberculosis pathogen. The discovery may help improve the ... the bacteria that amongst other diseases, cause tuberculosis and leprosy. These patients often suffer from ... avium, which cause a lung disease similar to tuberculosis in people, especially those with weak immune ...

Gene with probable role in human susceptibility to pulmonary tuberculosis identified

... gene that may confer susceptibility to pulmonary tuberculosis has been identified by Genome Institute of ... role in human susceptibility to Mycobacterium tuberculosis infections. The study also found that males ... to current treatment regimes." Pulmonary tuberculosis is a contagious lung disease caused by a ...

Tuberculosis drug shows promise against latent bacteria

... in clinical trials against multi-drug resistant tuberculosis strains) is quite effective at killing latent ... disease. Despite numerous treatment advances, tuberculosis (TB) remains a serious disease fueled by ... strains, and the ability of Mycobacterium tuberculosis to become dormant and linger in the lungs. In ...

Clinical trial for new tuberculosis vaccine

... genetically engineered to prevent infection with tuberculosis bacteria much more effectively than its ... Planck Institute for Infection Biology. "The BCG tuberculosis vaccine, which was developed by French ... chambers and arm the immune system against the tuberculosis pathogens." The scientific studies were ...

Energy-saving bacteria resist antibiotics

... The moonlighting activity of one enzyme from the tuberculosis bacterium makes it partially resistant to a ... in Bangalore, India. "MurI from Mycobacterium tuberculosis also stops the enzyme DNA gyrase from working, ... emergence of multi-drug resistant strains of M. tuberculosis has led to an active search for novel drug ...

ASM and FIND to partner on strengthening infectious disease diagnosis in developing nations

... novel diagnostics and laboratory expertise for tuberculosis and other infectious diseases that are ... and providing rapid, accurate and affordable tuberculosis diagnostic tests that can be effectively deployed ... cause tuberculosis. Africa represents 28% of all tuberculosis cases and has the highest infection rate per ...

Potential new drug target to fight tuberculosis identified

... 2008) -- With antibiotic resistance on the rise, tuberculosis is emerging as a bigger global health threat than ... Medical College suggests that Mycobacterium tuberculosis has an as yet unsuspected weakness -- one that ... protein that's essential to the defense that M. tuberculosis mounts against the acidic environment of immune ...

Excavated Jericho bones may help Israeli-Palestinian-German team combat tuberculosis

... malaria. 'TB still the biggest killer' tuberculosis - or TB - is a deadly infectious bacterial ... close contact. Dating back thousands of years, tuberculosis was well known in antiquity. However, according ... year. Why Jericho? While the origins of tuberculosis and its evolution remain unclear, it is thought ...

Source of drug-tolerant tuberculosis possibly behind TB relapses, intensity of treatment

... discovered that the primary bacteria behind tuberculosis can grow on surfaces and that drug-tolerant ... The findings suggest a possible reason why human tuberculosis (TB) requires months of intensive antibiotic ... are the first to show that Mycobacterium tuberculosis can grow in surface-level bacteria clusters known ...

Vitamin E may increase tuberculosis risk in male smokers with high vitamin C intake

... Six-year vitamin E supplementation increased tuberculosis risk by 72% in male smokers who had high dietary ... smokers aged 50-69 years. There were 174 cases of tuberculosis in 29,023 participants during the 6-year ... mg/day vitamin E. The effect of vitamin E on tuberculosis risk was modified by the intake of vitamin C in ...

New drug targets may fight tuberculosis and other bacterial infections in novel way

... of dangerous, multi-drug resistant strains of tuberculosis and other killer infections means that in the ... of a key small molecule from Mycobacterium tuberculosis and Mycobacterium leprae (which causes leprosy) ... each year. Multi-drug resistant strains of M. tuberculosis -- as well as even more dangerous, ...

Cornell researcher seeks clues to how tuberculosis infects cells

... the relationship between the bacteria that cause tuberculosis and the human immune system defense cells that ... unlike many bacterial pathogens, Mycobacterium tuberculosis does not react when immune system cells called ... the bacteria serves as the trigger for M. tuberculosis genes to express proteins. The study also ...

Scientists decode genomes of diverse TB isolates

... one linked to more than 50 deaths in a recent tuberculosis (TB) outbreak in KwaZulu-Natal, South Africa. As ... TB by researchers around the world. tuberculosis is a major threat to global public health that ... of different strains, we can learn how the tuberculosis microbe outwits current drugs and how new drugs ...

Harvard scientists solve mystery about why HIV patients are more susceptible to TB infection

... of new treatments to help people with HIV battle Mycobacterium tuberculosis (TB) infection. In their report, appearing in the July 2009 print issue ... to further studies and possible new therapies for treating or preventing tuberculosis in HIV disease." Patel and colleagues made their discovery by ...

SRI International receives $100,000 Grand Challenges Explorations grant

... and the need for broad-spectrum antibiotics. Resistant strains of tuberculosis will initially be screened. Based on those results, the project will be ... and lead to diseases that are difficult to cure. Drug resistant strains of tuberculosis pose a grave threat to global health because treatment options are ...

Open access research celebrated

... of the Year Derek Rajakumar, University of Saskatchewan Mycobacterium tuberculosis monoarthritis in a child Rajakumar D, Rosenberg AM Pediatric ... This case demonstrates the unusual ways that tuberculosis can present in our patients and highlights the difficulty in diagnosing ...

New antibiotic candidates from Braunschweig

... their genetic material. In this way, the propagation of bacteria such as tuberculosis pathogens - is inhibited. A working group at Rutgers University in New ... medicine. We owe the antibiotics that diseases such as plague, cholera or tuberculosis are a thing of the past, at least in the industrialised world. ...

New Systems Biology Awards enable detailed study of microbes

... to study diseases that include severe acute respiratory syndrome (SARS), tuberculosis and influenza. Systems biology is the study of the network of key ... Principal Investigator: Gary K. Schoolnik, M.D. Focus: Mycobacterium tuberculosis University of Washington, Seattle, WA Principal Investigator: ...

New way to make malaria medicine also first step in finding new antibiotics

... to be easily curable have become more difficult to treat. For example, tuberculosis has become so resistant to antibiotics that soon "they'll send you to ... or 10 to the 14th." This combination therapy approach is how HIV-AIDS, tuberculosis and other diseases are now treated. In the case of malaria, combination ...

College cocktails lead to science career

... that not long ago were considered wiped from the face of the Earth - tuberculosis and malaria, for instance. Sacchettini saw these maladies firsthand ... Medicine. "And we were awakened to the fact that infectious diseases like tuberculosis really had never left." Einstein is near Rikers Island, a New York ...

BWF awards $7 million to infectious disease investigators

... Hill Identification of in vivo-secreted proteins of Mycobacterium tuberculosis with roles in host-pathogen interactions James Carlyle, Ph.D. ... University of Alabama-Birmingham Carbon monoxide and Mycobacterium tuberculosis persistence Timothy L. Tellinghuisen, Ph.D. The Scripps Research ...

Sequella receives US and EU orphan drug status for SQ109 for the treatment of TB

... use of SQ109 (N-adamantany1-N-Geranyl-ehtylendiamine) for the treatment of tuberculosis (TB), a chronically debilitating and life-threatening infectious pulmonary ... Orphan Medical Product Designation of SQ109 for the treatment of tuberculosis entitles Sequella to incentives such as protocol assistance (scientific ...

Space technology harnessed to search out TB

... to provide a cost-effective, rapid and accurate tool for diagnosing tuberculosis (TB). The Wellcome Trust has awarded scientists at The Open University ... Space 50 celebrations at Jodrell Bank. TB, which is caused by the M. tuberculosis bacterium, is thought to kill two million people every year, primarily in ...

American Chemical Society's Weekly PressPac -- Sept. 19, 2007

... #5 EMBARGOED FOR 9 A.M., EASTERN TIME, Sept. 24, 2007 Drug-resistant tuberculosis rises, but new treatments in the pipeline Chemical & Engineering News ... toward the global battlefield that pits medicine against drug-resistant tuberculosis (TB), which is claiming a terrible toll, particularly in HIV-infected ...

Munich researchers discover new target for tailored antibiotics

... at TUM, the Technische Universitaet Muenchen, have shed light on a metabolic step that appears in many aggressive microorganisms -- such as tuberculosis and malaria pathogens -- and that may provide a promising target for a new class of antibiotics. The researchers present their results in the ...

American Society for Microbiology honors Deborah T. Hung

... directly inhibited dimerization of the virulence transcriptional activator ToxTin 2005 in Science. Currently, Dr. Hung's work focuses on tuberculosis (TB). She has already developed screens to identify small molecules that probe in vitro TB physiology and TB infection of macrophages. Her goal is to ...

Partnership to accelerate Trudeau Institute discoveries to patient care

... discoveries made at the institute to maximize their benefit to public health worldwide. The Trudeau Institute was originally created as a tuberculosis treatment center in 1884. With the advent of antibiotics in the middle of the last century, however, the institute was reorganized as a research ...

MIT student develops new innovations to selectively kill cancer cells

... class of cancer therapeutics and a new paradigm for enhancing drug delivery to tumors. Cancer currently kills more people worldwide than HIV/AIDS, tuberculosis and malaria combined. Despite billions of dollars invested into drug development and decades of research, selectively eradicating cancer cells has ...

Wonderful cheese is all in the culture

... of a large group of bacteria known as the Actinomycetes , many of which are already used in the production of antibiotics to treat diseases such as tuberculosis and diphtheria. Professor Goodfellow says the next step will be to study the potential benefits of these new microbes. "The next stage is to see ...

Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis

... grant from the internationally renowned Foundation for Innovative New Diagnostics (FIND) to continue his work to develop a test to diagnose active tuberculosis (TB), the world's second deadliest infectious disease. Dr. Campos-Neto aims to create a rapid, sensitive, non-invasive and accurate TB diagnostic ...
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