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Transplant in Biological News

First human gets new antibody aimed at hepatitis C virus

... program, which will be a Phase 2 study in liver transplant patients." HCV attacks the liver and can ... designed to be a therapy shortly before and after transplant surgery. By giving a patient the new antibody ... could, theoretically, be given immediately after transplant surgery to continue neutralizing any remaining ...

REGiMMUNE presents enhanced efficacy data in preclinical transplantation models

... with Low-Dose Sirolimus" at the 2009 American transplant Congress being held in Boston. "We are ... prolonged the survival of grafts in the skin transplant model over Sirolimus single treatment. Likewise, ... a pharmacological approach to induce long-term transplant tolerance by promoting the body's intrinsic ...

Novel antibody prevents infection by hepatitis C virus

... designed to be a therapy shortly before and after transplant surgery. By giving a patient the new antibody ... could, theoretically, be given immediately after transplant surgery to continue neutralizing any remaining ... Use of the new antibody for both liver transplant patients and in newly diagnosed HCV patients will ...

World premiere in stem cell research in Montreal

... 4,000 people wait in vain for a bone marrow transplant due to the lack of compatible donors. It is known that a bone marrow stem cell transplant can reconstitute the recipient's bone marrow. The ... effects: the medicine of the future? Currently, transplant recipients are condemned to take medications ...

Shorter wait means longer life for kidney transplant candidates

... Fla. How long a patient survives after a kidney transplant could depend on where he or she signs up to get ... shows. The shorter the waiting time at a transplant center, the longer patients are likely to live. A ... prognosis depends on the center where the transplant was done. Cecka was not involved in the current ...

Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants

... in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children ... mutations and MMF-related side effects in kidney transplant recipients, while others have suggested a greater ... in this study to conclude that pediatric kidney transplant recipients on MMF therapy have a significantly ...

Researchers explore new driver of transplant rejection: Platelets

... responses that play a critical role in organ transplant rejection, according to a new report from Johns ... potentially hold sway over many aspects of transplant biology," says Craig Morrell, D.V.M., Ph.D., an ... and the immune system, so it's time for the transplant world at large to have platelets on its radar." ...

Researchers engineer pancreatic cell transplants to evade immune response

... cell transplantation therapy is limited because transplant recipients are forced to take powerful ... a way to make foreign beta cells invisible to a transplant recipient's immune system, dramatically ... be applied to protect any type of cellular transplant from rejection." However, pancreatic cell ...

UC Davis researchers exploring gene therapy to fight AIDS

... doctors cured a man of AIDS using a bone marrow transplant comes as no surprise to Gerhard Bauer, a UC Davis ... diseases, the physicians gave him a bone marrow transplant from a person with natural immunity to HIV. The patient has now lived for 20 months since the transplant without any detectable traces of HIV. To ...

Children's Hospital researchers identify genetic mutation that may predict organ rejection

... identified a genetic mutation that identifies transplant recipients who experience rejection. Known as ... Rakesh Sindhi, MD, director of Pediatric transplant Research in the Hillman Center for Pediatric ... toward developing personalized diagnostics for transplant recipients, which will improve outcomes and ...

Children's national co-leads nationwide study of landmark sickle cell treatment

... Medical Center immunologist and blood and marrow transplant physician Naynesh Kamani, MD , will serve as ... If successful, the Sickle Cell Unrelated transplant (SCURT) trial has the potential to extend a ... for two years to gauge the effectiveness of the transplant at minimizing the ravages of sickle cell disease. ...

New technology enhances therapeutic potential of cord blood stem cells

... Cord blood is increasingly being used by transplant centers as an alternative source of stem cells ... of Christopherson's research is to increase the transplant efficiency of umbilical cord blood and ultimately make transplant safer and available to all patients who require ...

Immunosuppressant further linked to birth defects

... malformations seen in an infant born to a kidney transplant recipient who had taken mycophenolate mofetil ... . Approximately 14,000 births to organ transplant recipients, primarily kidney transplant patients, have been reported worldwide. Although ...

Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs

... CHICAGO After a transplant surgery, anti-rejection drugs for the organ ... subjects in a new research study that seeks to transplant stem cells from a kidney donors bone marrow into ... in the post-transplant quality of life for the transplant recipient. Northwestern is the only center in ...

Breakthrough research identifies how cells from pigs may cure diabetes

... sections of the Transplantation Society the Cell transplant Society (CTS), the International Pancreas and Islet transplant Association (IPITA) and the International ... issues, researchers are now working to transplant porcine islets in an engineered pre-vascularized, ...

U of M begins nation's first clinical trial using T-reg cells from cord blood in leukemia treatment

... within the donated cells attack the body of the transplant recipient. GVHD causes one-third of deaths after ... in animal models that infusing T-regs after transplant increases the chance of blood and marrow recovery ... finding ways to make this therapy valuable for transplant patients and potentially useful for patients with ...

Device helps patients survive, regain function til transplant

... blood flow. One patient recovered so fully that a transplant was no longer needed. Patients quality of life ... after one year while remaining on the heart transplant list. The same clinical trial also includes ... for Organ Sharing, adults who need a heart transplant wait an average of 170 days, but nearly 30 ...

Story ideas from the Journal of Lipid Research

... No. 9) ARTICLE HIGHLIGHTS Renal transplant recipients genetic makeup does not negatively ... how obese fat cells work * Renal transplant recipients genetic makeup does not negatively ... effects of these genetic variations in 707 renal transplant patients who received fluvastatin and 697 ...

Test helps in fight against lung infections and for treating other life-threatening infections

... free after more than one year. In another case, a patient was on a lung transplant waiting list, and was receiving oral and inhaled antibiotics, but showed a ... consequently a new combination of antibiotics was administered. The lung transplant was conducted successfully and the patient has been symptom free for more ...

Ovarian transplantation: First baby is born after a new technique

... Hospital, Limoges, France, described a new, two-step method of ovarian transplant that has produced excellent results in women whose ovaries have been ... to the ovaries is insufficient, this will not happen, even though the transplant may look as though it has been successful." To overcome this problem ...

Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy

... at the University of Pittsburgh (USA) used biodegradable nerve guides to transplant APCs into the injured peripheral nerves of laboratory rats. "Adipose ... tube, and those receiving an autograft and nerve guide tube but no APC transplant in the guide tube. Researchers noted that the "gold standard" for ...

GARP makes the difference

... new organ as "foreign" and starts fighting it. In the end, the life-saving transplant will be rejected. Until now, only special drugs have managed to keep the ... distinguishing features to aid them in separating T cells that trigger a transplant rejection from those that inhibit such a reaction: they mainly looked at ...

Tree survival skills

... of establishment. Identifying the specific stress factors responsible for transplant shock and when they occur is crucial if the process is to be improved", ... after transport should be minimized in an effort to maximize growth and transplant success", remarked Stewart. The scientists advise that handling should ...

High blood sugar's impact on immune system holds clues to improving islet cell transplants

... infections," Dr. Pacholczyk said. A shot of insulin or an islet cell transplant normalizes blood glucose levels, enabling, among other things, restoration ... not saying hyperglycemia is good; in fact if diabetics were to get a transplant while their blood glucose was high the procedure alone could be lethal. ...

Single adult stem cell can self renew, repair tissue damage in live mammal

... of self-renewal of a single cell." The ability to isolate and then transplant skeletal adult muscle stems cells could have a wide impact in treating not ... animal's lost function, Sacco and Blau recovered new stem cells from the transplant with full stem cell potency, meeting the final "gold standard" test for ...

Studies on imaging and tracking transplanted cells

... In a study conducted by Dr. Mark A. Zern and colleagues at the transplant Research Institute, University of California Davis Medical Center, the use ... transplanted hepatic cells," said Zern. Contact: Dr. Mark A. Zern, transplant Institute, UC Davis Medical Center, (916) 734-8063; mazern@ucdavis.edu ...

Franklin Square to study airway bypass procedure for severe emphysema

... be an excellent option for those who are not suitable candidates for lung transplant surgery or who would possibly spend years on a lung transplant list," states Krimsky. "Given that emphysema, which permanently destroys ...

Multiple disease-related research gets green light from the NIH

... body. The diseases include multiple sclerosis (MS), rheumatoid arthritis, transplant rejection and sepsis, a leading cause of hospital deaths. In particular, ... with a number of debilitating diseases, in addition to those who suffer transplant rejections." Dr. Smiley believes that prior attempts to treat patients ...

Embryonic stem cells might help reduce transplantation rejection

... Zavazava, M.D., Ph.D., professor of internal medicine and director of transplant research at the UI Roy J. and Lucille A. Carver College of Medicine. ... the animal's existing heart and replace it with another. Thus, to test for transplant success, the study approach involved leaving the original heart intact, ...

Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants

... carbon monoxide dose levels when administered as an inhaled gas to kidney transplant patients over the course of one hour in an acute hospital setting. The ... In the United States, approximately 28,000 patients received a solid organ transplant in 2007. Orphan drug designation provides an accelerated FDA review ...

Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants

... carbon monoxide dose levels when administered as an inhaled gas to kidney transplant patients over the course of one hour in an acute hospital setting. The ... In the United States, approximately 28,000 patients received a solid organ transplant in 2007. Orphan drug designation provides an accelerated FDA review ...

Neural cell transplants may help those with Parkinson's disease

... that hNPCs genetically modified to over-express GDNF were able to survive transplant and produced GDNF for three months, and that functional recovery in test animals increased while no obvious negative side effects from the transplant procedure were observed. Contact: emborg@primate.wisc.edu An ...

Publication offers labs consensus recommendations for diagnosing parasitic diseases

... Cumitech 45 was released covering the topic of infections in solid-organ transplant recipients. Cumitech 45 offers a concise and inclusive description of infections in solid organ transplant recipients of liver, kidney, kidney-pancreas, heart, lung, and intestinal ...

Inflammation triggers cell fusions that could protect neurons, Stanford research shows

... British Columbia in Vancouver, used this technique in the current study to transplant a single hematopoietic stem cell and prove that the heterokaryons in the ... was related to inflammation by using the traditional radiation/bone marrow transplant approach in mice with dermatitis. Finally, they counted the fused cells ...

Stem cells offer cartilage repair hope for arthritis sufferers

... is to harvest cartilage cells from neighbouring healthy cartilage and transplant them into the damaged area. Unfortunately, only a limited number of cells ... it could be effectively transplanted. There are limitations in trying to transplant a patients existing cartilage cells but by culturing it from a resident ...

Clinical trial that may help patients breathe easier begins at Central DuPage Hospital

... be an excellent option for those who are not suitable candidates for lung transplant surgery or who would possibly spend years on a lung transplant list, states Dr. Kovitz. Physicians commonly use bronchoscopes to ...

Researchers at Sarasota Memorial Health Care System to study airway bypass treatment for emphysema

... could be an excellent option for those who may be considering lung transplant or who may not be suitable candidates for lung transplant surgery, which is one of the only other treatment options available for ...

NIH stimulus funding supports Emory biomedical scientists

... technique for shutting off SCN8A in mice, with an eye towards developing similar treatments for humans. The role of memory T cells in transplant rejection: Memory T cells allow the immune system to respond to infections faster and stronger upon a second encounter, but they also play a big role ...

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

... immunogenetics researcher Effie Wang Petersdorf, M.D., whose work has helped refine the tissue-typing process, which enables bone-marrow or stem-cell transplant patients to find suitably matched donors. ...

LSUHSC's Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia

... complication in patients with weakened immune systems, such as those with AIDS, cancer, chronic conditions treated with corticosteroids, or organ transplant recipients. Earlier research by Dr. Kolls found that carbohydrate antibodies are part of the natural response to the Pneumocystis fungus. Theses ...
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