Scientists capture the first image of memories being made
... during memory formation. Importantly, this translation
was synapse-specific and it required activation ... meet at the synapse. Thus highly regulated local translation
occurs at synapses during long-term plasticity ... during neuronal plasticity involves regulated translation
of localized mRNA at stimulated synapses. These ...
Researchers discover critical detail of cellular defense against genetic mistakes
... that is capable of driving translation
and consists of mRNA and the completed functional ... does not. Researchers found that the non-eIF3 translation
initiation directed by the cricket virus sequence ... not only inhibits the pioneer round of translation
so that the translational machinery "falls away" ...
USP Convention and Chinese Pharmacopoeia Commission sign Memorandum of Understanding
... for export from China to the United States.
To assure the availability and use of USP ... USP and ChP will explore ways to expedite the translation
of USP compendia into Chinese. Conversely, USP ... ways for USP to review the quality of the English translation
of the Chinese Pharmacopoeia.
Xie Lab uncovers molecular machinery related to stem cell fate
... and competition by interfering with the function of the protein translation
initiation factor eIF4A. EIF4A and BAM antagonize each other to regulate ... Associate in the Xie Lab and lead author on the paper. "Many protein translation
initiation factors have been reported to be unregulated in different human ...
American Chemical Society's weekly PressPac -- April 29, 2009
... in spacing, capitalization, spelling, and other factors. Proper translation
from English to Chinese, for example, often requires the use of specially ... rate.
ARTICLE #2 FOR IMMEDIATE RELEASE
"Foreign language translation
of chemical nomenclature by computer"
DOWNLOAD FULL TEXT ARTICLE: ...
Penn biologists discover how 'silent' mutations influence protein production
... According to their analysis, mRNA folding and associated rates of translation
initiation play a predominant role in shaping expression levels of individual genes, whereas codon bias influences global translation
efficiency and cellular fitness.
Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain
... in BACE1 levels and led to the phosphorylation of the stress-inducible translation
initiation factor, eIF2?. Further, direct phosphorylation of eIF2? ... linking impaired energy metabolism, an AD-relevant stress, with BACE1 translation
mediated by eIF2? phosphorylation," says Dr. Vassar. "Our findings ...
The International Society for Stem Cell Research releases new guidelines
... A Commentary article that summarizes the Guidelines for the Clinical translation
of Stem Cells will be published by Cell Press in the December issue of ... to proven treatments for patients. The new guidelines will accelerate the translation
of stem cell research into practice while addressing associated ...
Researchers observe spontaneous 'ratcheting' of single ribosome molecules
... Various other proteins also participate in the process.
When protein translation
occurs, single tRNAs enter specific sites in the ribosome, read the code ... motion allows the ribosome to advance along the messenger RNA as protein translation
progresses. Without EF-G, the ribosomal subunits move in relation to one ...
Undergraduates develop 'dirt-powered' microbial fuel cells to light Africa
... the Technology and Entrepreneurship Center at Harvard (TECH) and the Idea translation
Lab, based at SEAS. Both Presser and Bottino have been involved with ... to visual artists. Aviva played a lead role as mentor and the Idea translation
Lab and Harvard Initiative for Global Health (HIGH) continued to support ...
Researchers uncover details about how dietary restriction slows down aging
... decreased TOR signaling, and that decreased TOR signaling reduced translation
or protein production, but this was the first direct evidence that all ... that appear to be regulated in a similar way.
"The role of TOR and translation
in aging is known to be conserved across many different species, so its ...
Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
... findings that shed light on the molecular machinery required for the translation
of histone crosstalk, or communication between histones.
Published in ... was able to demonstrate the molecular machinery required for the translation
of this histone crosstalk, said Ali Shilatifard, Ph.D., Investigator and ...
NIH awards nearly $23M to University of Chicago for translational research
... ethical, and respectful of our communitys needs and values."
of biomedical discovery into effective, deliverable, and personalized ... agendas; involve community organizations in that research; accelerate the translation
of health knowledge and expertise into and out of our community; and ...
Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research
... who helped save millions of lives through his contribution to the discovery and development of more than 80 medicines."
Ullrich has pioneered the translation
of genomics-based discoveries into novel approaches for the treatment of major diseases. Working at Genentech, Inc. in the early 1980s, he developed ...
MicroRNAs help control HIV life cycle
... Molecular Cell .
Tariq Rana, Ph.D., director of the Program for RNA Biology at Burnham, and colleagues, found that the microRNA miR29 suppresses translation
of the HIV-1 genome by transporting the HIV mRNA to processing-bodies (P-bodies), where they are stored or destroyed. This results in a reduction of ...
Next-generation software system for flood warning and risk analysis to be developed
... King's College London Business. A recently granted Proof of Concept award from ICUK will take the development work to the next stage, supporting the translation
of the 'Novel Flood Early Warning System' from a research prototype into a commercial system.
Prof. Zhijia Li, who leads the research at Hohai ...
Boston University biomedical engineers teach bacteria to count
The first, the Riboregulated Transcriptional Cascade (RTC) synthetic gene network, counts by starting and stopping transcription and translation
the process by which a gene's instructions are executed of a series of genes every time an event occurs. The researchers programmed the system so ...
UCSF discovers new glucose-regulating protein linked with diabetes
... into diabetes and many other diseases is conducted in mice, the often-unknown differences between mice and men can create obstacles to direct translation
of such research and need to be taken into account in understanding the progression of human disease, according to the researchers.
"Much has been ...
NAU discovery could help feed millions
... such as deer, coyotes, foxes, raccoons, horses, buffalo and elk as well as cats and dogs.
"What we are doing right now is we are preparing the translation
of this technology to dogs and cats. We have already completed six months of study in dogs. This could have a tremendous impact on reducing the ...
Lombardi scientist brings 'dream team' breast cancer research effort to GUMC
... the cancer center in July. "We hear a lot about the need to accelerate cancer research but this is the first effort that could truly speed up the translation
made in the laboratory and impact cancer care."
SU2C is a charitable initiative supporting groundbreaking research aimed at getting new cancer ...
UCI awarded $45 million for infectious disease research
... lab safety.
"While basic research on these infections and immunity to them is at the core of the center, we recognize the importance of the timely translation
of our findings into products and other applications that people can actually use," Barbour said. "We've made considerable progress, and we're ready ...
Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
... fluorescent protein (eGFP) was constructed. Experiments with a human cancer cell, a squamous cell carcinoma of the head and neck, revealed that translation
of OGFr required approximately 5 hours, and transit into the nucleus took 8 hours; OGFr remained in the nucleus for up to 8 days. Transport through ...
ASBMB Annual Meeting to feature talks on the biochemistry of aging
... linking HFD-obesity to diabetes and heart disease, TOR might be a central mediator of lifespan.
Conserved Links Between Nutrient Signaling, translation
Brian Kennedy, University of Washington, Seattle
(Wed, April 22 8:30 AM - 10:50 AM, Room: 356)
While model organisms like fruit flies ...
UC and partners awarded $23 million to transform discoveries into real-world health solutions
... College of Medicine dean and UC vice president for health affairs. "The CTSA program is a clear recognition by the NIH of the need to speed up the translation
of the important work happening at the basic scientific level, and UC's award is indicative of the quality of scientific discovery happening on our ...
A splice of life
... job is to modify the message relayed from our genetic materialDNAby clipping, or splicing, genetic bits in such a manner that they are acceptable for translation
into protein. Importantly, the spliceosome also rearranges the genetic bits of the message in such a way that it can generate multiple and varied ...
Roberta A. Pagon receives lifetime award in genetics from March of Dimes
... Committee of the American College of Medical Genetics (ACMG).
She is the review board coordinator for the Collaboration, Education, and Test translation
(CETT) Program, which promotes the collaborative development of new tests for rare genetic diseases for use by doctors and patients, and supports the ...
UK researcher identifies just 8 patterns as the cause of all humor
... other direction, producing a pattern of symmetry. However, while all the patterns are relatively simple in structure the activity of some forms of translation
and recontextualization can seem counter-intuitive at first sight.
"In instances of humour these patterns may be recognized individually or in any ...
Heinz Maier-Leibnitz Prizes 2009: Six young researchers recognized for outstanding achievements
... (mRNA) from the cell nucleus. Also, she has, for the first time, been able to demonstrate that nuclear export factors play a decisive role in the translation
of mRNA for protein synthesis. Krebber and her research team have identified a factor that is very important for the termination of protein ...
Stem cells replace stroke-damaged tissue in rats
... in industrialised countries. It is reassuring to know that the technology for treating stroke by repairing brain damage is getting ever closer to translation
into the clinic. This crucial groundwork by Dr Modo and his colleagues will surely be a solid foundation of basic research for much better treatments ...
Plants are political hot potatoes
... enough biomass to support all of our environmental, social and economic objectives. We are learning how to optimize the potential of plants, but the translation
of research findings into application is still rate-limiting. Land and water availability are also key limiting factors."
How to balance these ...
Singapore research organisations team up to advance drug discovery using brain tumor stem cells
... neurological disease. This collaboration will enable all parties to benefit from the exchange of multidisciplinary expertise and will expedite the translation
of research findings into clinical practice," said Prof. Lee Wei Ling, Executive Director of NNI.
Bacteria are models of efficiency
... proteins are produced and RNA polymerase an enzyme that copies the genetic code for protein production onto strands of messenger RNA for further translation
into proteins. RNA polymerase is thus a sort of work 'supervisor' that keeps protein production running smoothly, checks the specs and sets the pace. ...
3 new informatics pilot projects to aid clinical and translational scientists nationwide
... is to advance collaborations in clinical and translational research by interdisciplinary teams of investigators. These collaborations help enable the translation
of rapidly evolving information developed in basic biomedical research into treatments and strategies to improve human health.
Informatics support ...
Key to future medical breakthroughs is systems biology, say leading European scientists
... particular we identify and outline the necessary steps of promoting the creation of pivotal biomedical systems biology tools and facilitating their translation
into crucial therapeutic advances.
The report highlights some recent successes where mathematical modelling has played a key role. The conclusions ...
Team finds breast cancer gene linked to disease spread
... "This indicates that new drugs against Metadherin may potentially benefit a large population of breast cancer patients."
Gene expression is the translation
of information encoded in a gene into proteins that determine an organism's characteristics. Since only a fraction of genes in a genome are expressed ...
IRB Barcelona to coordinate two European projects on biomedicine
DISARMING THE PARASITE THAT CAUSES MALARIA
The consortium coordinated by Llus Ribas de Pouplana, ICREA researcher and head of the Gene translation
Laboratory at IRB Barcelona, will explore a promising line of investigation to find new anti-malarial compounds. The project, called Mephitis, is ...
International public-private partnership offers new paradigm for medicinal chemistry
... application in academic research will serve to further stimulate drug development by pharmaceutical companies. Ultimately this is about enabling the translation
of biomedical research discoveries into therapies for the benefit of patients."
Life Sciences Discovery Fund awards health research program grants
... long-term priority is to develop a self-sustaining program that is supported by public and private sector funds to conduct high-quality research for translation
into effective treatment protocols. Through the use, refinement, and delivery of EBTs, this group of clinician-researchers seeks to improve the ...
Elsevier announces winners of 3rd Annual Scopus Young Indian Scientist Award
... interesting and novel way of highlighting the best of research from young scientists in the country. If it stimulates, even if by a small amount, the translation
of quality research into quality publications, it would have served an important cause", says Prof. K. Vijayaraghavan, Director, National Centre for ...
Researchers at UH explore patient preferences for personalized medicine
... to tailor prescriptions.
"Personalized medicine lies at the crossroads of science and technology, and there are a number of barriers to its translation
and implementation into clinical practice," said Issa, associate professor at the UH College of Technology and College of Pharmacy. "As the science ...