Stem cell research: From molecular physiology to therapeutic applications
... to restore malfunctioning or damaged cells and tissues
in patients. Recent studies have shown that ... neural and erythroid cells. They remained in some tissues
and organs during gestation and could give rise ... contribute to self-repair and self-renewal of tissues
and organs. They generated cells not only for the ...
Skin-like tissue developed from human embryonic stem cells
... stem cells (hESC) to generate complex, multilayer tissues
that mimic human skin and the oral mucosa (the ... have been seeking methods to grow skin-like tissues
outside of the body using new sources of stem ... how hESC can be developed into the multilayer tissues
similar to those that line the gums, cheeks, ...
Study shows transfer of heavy metals from water to fish in Huelva estuary
... zinc, cadmium and copper accumulate in the body tissues
of sole and gilthead bream.
"We found positive ... the waters of the Huelva estuary and those in the tissues
of gilthead bream ( Sparus aurata ) and sole ( ... of zinc and cadmium in the water and in the tissues
of the fish, above all in the gilthead bream, a ...
Research yields potential target for cancer, wound healing and fibrosis
... that serve dual roles of anchoring cells within tissues
and controlling cell behavior. Integrins anchor ... proliferation and differentiation in both healthy tissues
and tumors. Integrins are involved in the ... is an anchorage protein present in connective tissues
and it helps wound healing when it is deposited ...
A new way to assemble cells into 3-D microtissues
... communicate via growth factors.
are presently used in medicine for a range of ... engineers try to improve upon or repair natural tissues
by manipulating living cells from one or more ... By this method, it may be possible to assemble tissues
with more sophisticated properties."
New origin found for a critical immune response
... cells were thought to move from peripheral tissues
into lymph nodes to stimulate T cell responses. ... of activated dendritic cells from peripheral tissues
to lymph nodes. The Duke researchers generated a ... responses. "For so long, dendritic cells from tissues
were the obvious answer," Gunn said. "We found ...
New technique for cancer screening
... quality assessment of DNA methylation in archival tissues
from colorectal cancer patients using ... in methylation between normal and cancerous tissues
can be used as a biomarker for early cancer ... and response to therapy.
Archival tissues, or tissues
that are formalin-fixed and paraffin-embedded for ...
Shades of 1918? New study compares avian flu with a notorious killer from the past
... 24 hours, causing severe damage to respiratory tissues
while sending the host's innate immune response ... virulence. The effects of these strains on host tissues
and gene expression was compared with those of a ... replication of the H5N1 virus.
sampled on days 1, 2 4 and 7 post-infection were ...
Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
... more mature cells that can develop into specific tissues
has been discovered by scientists at the Hebrew ... the biggest challenges today is to generate new tissues
for replacing damaged cells in a variety of ... impossible to do this, mainly because normal tissues
are locked in their fixed program and have lost ...
Next generation microscopy: No stain, big gain
... often take hours or even days because cells or tissues
must be subjected to lengthy fixation and ... harsh treatments or conditions that alter the tissues
themselves, making interpretation of results ... small metabolite and drug molecules in cells and tissues
to medical diagnosis of cancer. Neuroimaging is ...
Building better bones and tissue in the lab
"In many instances our ability to help tissues
such as bone to repair, is limited as we don't fully understand how human tissues
respond to the presence of artificial materials. This becomes even more problematic in tissues
that are loaded due to normal human activity," ...
Cold Spring Harbor Protocols features organ and cell culture methods
... organs like the brain, kidney, and reproductive tissues
requires experimental systems that allow for the study and manipulation of developing cells and tissues
in the laboratory. This month's issue of Cold ... to assay migration between any two adjacent tissues
during development. This protocol assays cell ...
UC Davis researchers discover a key to aggressive breast cancer
... but it was not over-expressed in adjacent healthy tissues
that also carried extra copies of the HER2 gene. ... have been over-expressed in both normal and tumor tissues
from these mice," she said.
Given that ... found that Lig-1 was greatly diminished in tumor tissues
when compared to the normal tissues. The ...
Could Dr. House be replaced by a computer?
... know that different normal and diseased tissues
behave differently. But a method that tells them ... Biotechnology .
Between Healthy and Diseased tissues
Lies the Answer
The model integrates ... occurring in living organisms that allows tissues
to grow, maintain their structures, and function ...
Where optics meets medicine
... within all capillaries of the light sensitive tissues
in the retina at the back of the eye. With it, ... tissue transformations and benign changes in tissues
due to different diseases, such as pancreatitis. ... and Fluorescence Spectra of Human Pancreatic tissues
for Cancer Diagnostics," Tuesday, Oct. 21, 11:30 ...
Researchers discover that growing up too fast may mean dying young in honey bees
... damage and antioxidant mechanisms among different tissues
(head vs. thorax), age-matched behavioral groups ... and catalase were measured in head and thorax tissues
using western blot. Total antioxidant capacity of the tissues
was measured as the ability of homogenate to ...
Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
... unlimited potential to differentiate into human tissues
such as bone, cartilage and muscle.
The ... that blood vessels are the one structure that all tissues
in the human body have in common. These cells can ... were able to identify pericytes in all human tissues
they analyzed, including muscle, fat, pancreas, ...
'Buckyballs' have high potential to accumulate in living tissue
... octanol, which has properties similar to fatty tissues
in animals. Jafvert and doctoral student Pradnya ... or distributed into water, soil and fatty tissues
in wildlife such as fish.
Findings indicated ... have a greater chance of partitioning into fatty tissues
than the banned pesticide DDT. However, while DDT ...
Expanding cell girth indicates seriousness of breast cancer
... exactly represent a tissue cell population since tissues
have tens of thousands of cells," Lu said. "Our ... more complicated if you're dealing with patient tissues
rather than cell lines," he said. "Cell lines contain only one type of cell; patient tissues
have different kinds of cells."
Engineers create bone that blends into tendons
... the ability of natural bone to blend into other tissues
such as tendons or ligaments. The artificial ... because anatomically that's how the majority of tissues
appear and there are studies that strongly ... structures, so the ability to engineer tissues
that more closely mimic these natural ...
From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
... lysis of recombinant Salmonella in host tissues
to release protective antigens and confer ... invasion into and colonizing internal lymphoid tissues
in an immunized individual," said Roy Curtiss, ... Salmonella enterica bacterium colonizes the lymph tissues
of the host and manufactures a protein from the ...
European Science Foundation aims to strengthen 'regenerative medicine'
... to restore lost, damaged, or ageing cells and tissues
in the human body.
Stem cells are the body's ... programmed to perform a specific function. Most tissues
have their own supply of stem cells, and it is ... ways of repairing or replacing damaged tissues
or organs. Because the stem cells are taken from ...
Expanded histology methods book covers processing of animal, plant, and microbial tissues
... sciences who need to process normal or diseased tissues
for microscopic analysis. A new edition, just ... includes not only methods for processing animal tissues
but also for microorganisms and plant tissues. ... with methods for fixing, staining, and processing tissues
using the latest reagents and techniques ...
Why juniper trees can live on less water
... for bubbles to form in the water-conducting xylem tissues
Water is sucked through xylem tissues
under a partial vacuum, "so it's almost like a ... the xylem."
The scientists found that xylem tissues
of juniper species tend to be reinforced with ...
Breast cancer cells have to learn to walk before they can run
... cancer that has not yet invaded the surrounding tissues
may already contain highly motile cells, bringing ... cancer cells have not grown into the surrounding tissues
and remain within the borders of a duct, the most ... allows us to watch labeled cells move around in tissues
and learn a lot about their behavior, which ...
MIT works toward engineered blood vessels
... blood vessels could one day be transplanted into tissues
such as the kidneys, liver, heart or any other ... hope will provide a novel way to someday engineer tissues
in the human body.
The work focuses on ... to implant capillary tubes grown in the lab into tissues
of living animals and try to integrate them into ...
Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues
... the presence of these redox proteins in tissues
other than the chloroplast by fusing the ... team that their expression in nonphotosynthetic tissues
is also regulated by light, albeit indirectly, is ... finding that f and m TRXs occur in the vascular tissues
of both leaves and roots, suggests that these TRX ...
Researchers create system to build transplant tissue
... laboratories may grow synthetically engineered tissues
such as muscle or cartilage needed for ... "A significant impediment to building engineered tissues
is that you can't feed the core," said Abraham ... to the physical engineering aspects of growing tissues
synthetically. Still, many biological challenges ...
Scientists link immune system's natural killer cells to infant liver disease
... also report that blocking a gene that helps NK cells attack bile duct tissues
lessens damage and may be a way to treat the most common cause of ... system responding to an infection in the liver and bile ducts. Surface tissues
inside the bile ducts are damaged, which in turn allows inflammatory cells ...
Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging
... tumors than typical mice.
PAPPA controls the availability in tissues
of a hormone known as insulin-like growth factor (IGF) that is a promoter ... PAPPA, the researchers were able to control the availability of IGF in tissues
and dampen its many ill effects. In the thymus, deletion of PAPPA ...
Trio of signals converge to induce liver and pancreas cell development in the embryo
... embryo to develop into different organs provides insight into ways that tissues
regenerate and how stem cells can be used for new therapies. With ... development have focused on individual molecular signals that induce these tissues
to mature from a common precursor cell population. In a new study, ...
Genetically corrected blood cells obtained from skin cells from Fanconi anemia patients
... concept that this new therapeutic strategy has the potential of generating tissues
using the very skin of those affected with these genetic diseases. This ... many other genetic diseases by differentiating iPS cells towards healthy tissues
these patients lack.
The generation of blood cells in this research ...
New center at Georgia Tech aims to improve recovery of soldiers with severe injuries
... the use of technologies on both male and female patients, and on complex tissues
that consist of nerves, a blood supply and multiple cell types.
... assessing tissue viability, preventing the growth of bone in the soft tissues
of the body and improving pre-hospital care of orthopedic injuries. Since ...
Progress toward artificial tissue?
... soft materials -- which are usually very fragile. Because many biological tissues
are regularly subjected to intense mechanical loads, it is also important ... This results in materials that are as elastic as the softest natural tissues
while simultaneously deriving great strength from the robust DNA links.
Nanotechnology holds promise for STD drug delivery
... cervical, and uterine regions. Furthermore, the siRNAs stayed in the tissues
for at least a week and knockdown of gene activity lasted up to 14 days. ... in cell membranes, liposomes are potentially more toxic to the mucosal tissues
and are unable to provide sustained release. In the current work, the ...
Re-awakening old genes to help in the fight against HIV
... the transmission of HIV. He applied aminoglycoside antibiotics to vaginal tissues
and cervical cells in his lab and found the antibiotic appears to stimulate those cells and tissues
to produce retrocyclins on their own.
He said there is a good ...
Building the lymphatic drainage system
... Our bodies' tissues
need continuous irrigation and drainage. Blood vessels feeding the tissues
bring in the fluids, and drainage occurs via the lymphatic system. While ...
Study finds blood cells can be reprogrammed to act as embryonic stem cells
... "Making pluripotent stem cells from blood, which is one of the easiest tissues
to obtain, provides an easy strategy for generating patient-specific stem ... cells expressed genes for all three embryonic germ layers (the tissues
from which all other tissue types in the body develop) and also produced ...
A missing enzyme conveys major heart protection in pre-clinical work
... if you block the major artery to a heart, oxygen tension drops in the tissues
you can't get oxygen to the tissues
and they die," Stamler said. "This appears to be a major step forward in ...
Mount Sinai Hospital researcher makes stem cell breakthrough
... as starting points and could be used to generate cells from many adult tissues
such as a patient's own skin cells."
Dr. Nagy discovered a new method ... repair, replace, restore and regenerate its own damaged or diseased cells, tissues
The research was funded by the Canadian Stem Cell Network ...