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Thymus in Biological News

Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging

... into old age by maintaining the function of the thymus throughout life, according to researchers ... of UPMC, reports that the novel mouse model has a thymus that remains intact throughout its life. In all ... have the ability to restore the function of the thymus in old age, or perhaps by intervening at an early ...

They are young and need the job: A second chance for dangerous T-cells

... 10 June 2009) During their development in the thymus gland, a kind of 'T-cell school', every T-cell is ... is also a constant production of T-cells in the thymus that may recognize and attack the body's own ... been reprogrammed during their development in the thymus so that they can no longer cause any damage. In ...

Genetic study shows direct link between vitamin D and MS susceptibility 'gene'

... immune system, to perform its regular tasks. The thymus produces an army of T cells, which identify ... own cells or proteins. Ordinarily, the thymus will regulate the T cells and delete those that ... during early life might impair the ability of the thymus to delete these T cells, which then go on to ...

Mice stressed in simulated weightlessness show organ atrophy

... Rutgers researchers should look at the spleen and thymus the organs responsible for most of the animals immune cells. If stress affects the spleen and thymus so that they atrophy, the immune system becomes ... had no basis to expect this, but the spleen and thymus of the OPN-deficient animals remained normal ...

Immune police recognize good and bad guys in the body

... in the thymus. They also reported that most Tregs that mature in the thymus retain their regulatory properties and do not later convert to nave T cells as was previously believed. This finding emphasized the role of the thymus as the primary site where Tregs differentiate and acquire their unique ...

Novocell awarded seminal stem cell patent

... is developing for use as a cell therapy for diabetes, but also other endoderm lineage-derived tissues and organs such as lungs, intestine, liver, thymus and thyroid. "This composition patent is a milestone achievement for Novocell and is the culmination of extensive research that opened the door ...

Fireflies and jellyfish help illuminate quest for cause of infertility

... The research, funded by the Wellcome Trust, identified cells producing prolactin throughout the body. This included the pituitary gland, the thymus an organ in the chest which helps protect against autoimmunity the spleen and inflammatory cells in the abdominal cavity. ...

Identification of protein able to stimulate production of T-cells

... determined that elevated levels of Wnt4 led to a marked increase in the number of white blood cell progenitors, and of immature T cells in the thymus in particular. Conversely, they found that deletion of the Wnt4 gene and lack of the corresponding protein was associated with a decrease in the ...

'Nurse cells' make life and death decisions for infection-fighting cells

... in the upper portion of the chest. Loss of the thymus results in severe immunodeficiency and increased ... The function of T cells produced by the thymus is to recognize harmful invaders. Once invaders ... cells are performing a much bigger role in the thymus than we thought." Thymic nurse cells were ...

Thymus transplants gives hope to babies with fatal immune disease

... three in September, thanks in large part to a thymus transplant she received at Duke University ... show that 75 percent of the babies who received a thymus transplant were alive after one year. The ... However, about 1 percent of these babies have no thymus at all, a situation that ends in death, usually ...

Proteins anchor memories in our brain

... where autoimmune disease is active, but also the thymus -- the organ where T cells and self-proteins, or ... autoimmune disease in the retina. "The thymus is like a filter," said Mark Anderson, MD, PhD, ... demonstrated that insulin is expressed in the thymus ?not just in the pancreas. Studies have shown ...

Autoimmune disease triggered if T cells miss a single protein early on

... where autoimmune disease is active, but also the thymus -- the organ where T cells and self-proteins, or ... autoimmune disease in the retina. "The thymus is like a filter," said Mark Anderson, MD, PhD, ... demonstrated that insulin is expressed in the thymus ?not just in the pancreas. Studies have shown ...

UCLA researchers develop T-cells from human embryonic stem cells

... Those cells were then injected into a human thymus gland that had been implanted in a mouse, and the thymus then changed those blood-forming cells into T-cells. Located just above the heart in humans, the thymus is the organ where T-cells develop. It gradually ...

Immune system police learn early and sometimes badly

... followed T cells as they spent time in the thymus then moved to the body. They found regulatory T cells learn what to protect while in the thymus and that everything the cells learn may not be ... autoimmune disease. T cell schooling in the thymus peaks in the first six weeks of life in the ...

New pathways for autoimmune treatment identified

... cells come out of the bone marrow and go to the thymus where all T cells go for a process of positive ... expression in the thymus, Dr. Mi says. The thymus is supposed to express most body proteins so any ... have learned medullary epithelial cells in the thymus are critical to proper i NKT cell development. A ...

New tool reveals secrets of migrating cells

... two-photon imaging, Witt and Robey identified thymus cells they dubbed beeliners moving nearly two ... focuses on the lives of T cells produced in the thymus and distributed via the bloodstream to the lymph ... continue their two-photon imaging studies of thymus cells and lymph cells, Witt is trying to ...

Genetic defects give the immune system the green light to attack the pancreas

... specifically to each new invader. Formed in the thymus gland, T-cells begin as “precursor?cells and ... of cutting-edge technologies, using cultures of thymus cells from transgenic mice, together with DNA ... The T-cells were alive and able to leave the thymus and attack beta cells. Now that the ...

Discovery Could Lead To Novel Approaches In HIV Treatment

... of a new method to assess how well the thymus (an organ located at the base of the neck) works ... first developed a method to assess how well the thymus functions. The thymus is involved in the development of T-lymphocytes, ...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

... blood, the more likely it is that the patient's thymus gland can act as an efficient factory where stem cells become T cells. The thymus is an immune system organ behind the breastbone ... that's a good sign. It means the patient's thymus is a good T-cell factory." Handgretinger is ...

Infant transplant patients resist infections that kill adult AIDS patients

... 20 patients who as infants underwent heart transplantation and had their thymus removed. As a result the infants were deficient in T cells, the cells ... that when a heart transplant is carried out in very young infants, the thymus that produces T cells is removed and a drug is given that depletes T ...

Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

... in the bone marrow, but B cells mature there while T cells migrate to the thymus gland, which governs their development. "The recognition and ... by foreign invaders (killer T cells). Gamma-delta T cells migrate from the thymus to epithelial tissues such as skin and the linings of the lung. While ...

T for two: Scientists show how immune system chooses best way to fight infection

... response. Now, a team of researchers has discovered a novel mechanism determining whether a maturing T cell is likely to emerge from the thymus as an effector cell or a regulatory cell. The research suggests that new treatments could be developed to deliberately affect the type of T cells ...

Front-line immune cells mature in four stages, study shows

... made decades ago in animals and humans showed that the other two major types of immune cells in the body, T cells and B cells, developed in the thymus and bone marrow, respectively. However, the site and stages of human NK cell development have eluded investigators until now. The findings ...

Scientists identify new model Of NK cell development

... For example, cells destined to become T cells, sophisticated and highly focused killer cells, are released into the bloodstream and migrate to the thymus where they learn their role. In contrast, B cells, which make antibodies, remain and mature in the bone marrow. Until now, scientists thought NK ...

Fox Chase Cancer Center scientists identify immune-system mutation

... to be useful for exploring the pathways of lymphocyte development, according to Kappes. Helper T cells, so called because they arise from the thymus gland, are essential for combating intracellular viral and bacterial infections (cell-mediated immunity) and also for helping other white blood cells ...
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