Baylor researchers unravel mystery of DNA conformation
They found that when DNA is underwound in the same manner that you might underwind a spring, the forces induce one of two bases adenine or thymine
to "flip out" of the sequence, thus relieving the stress that the molecule experiences.
"It always happens in the underwound state," said ...
Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications
... between them. Base pairing rules for DNA dictate that the hydrogen bonds work to join up appropriate nucleotide pairs like jigsaw piecesadenine with thymine
and cytosine with guanine.
The scanning tunneling microscope used in the present study features a delicate electrode tip held very close to the ...
A new way to assemble cells into 3-D microtissues
... from a simple repeat of two bases such as cytosine and adenine ... on one strand, which binds to a complementary repeating sequence of thymine
and guanine ... on the other, up to sequences whose base order varies over the full length of the 20-base strand of synthetic DNA. The more ...
New computational technique allows comparison of whole genomes as easily as whole books
... genome sequences using a reduced, two-letter alphabet - R for the purine nucleic acids, adenine and guanine, and Y for the pyrimidine nucleic acids, thymine
and cytosine - to reduce the complexity of calculation. Using an optimal feature length of 18 base pairs, this test created a family tree identical ...
Finding that 1-in-a-billion that could lead to disease
After studying DNA breathing by itself, the researchers then added UDG into the mix. They saw that UDG holds onto the normal DNA building block thymine
(T) after it pops out of the DNA on its own. However, because T is not identical to U, UDG then lets it fall back into DNA helix.
When the DNA ...
Scientists see DNA get 'sunburned' for the first time
... that form where they shouldn't -- between two thymine
bases stacked together among the billions of ... designed strands of DNA -- ones made solely of thymine
bases, in order to boost the chance of observing ... Then they timed the reactions that caused the new thymine
bonds to form.
Kohler stressed that he and ...
'Pinball protons' created by ultraviolet rays and other causes can lead to DNA damage
... replication and growth. DNA is made of four "bases," Adenine, Guanine, thymine
and Cytosine, and each one pairs with its opposite to form bonds where the "information" of life is stored. Thus, Guanine pairs with Cytosine, and thymine
The team at the University of Georgia studied how the ...
New study sheds light on 'dark states' in DNA
... hinted at its existence, but this is the first time it has been shown to exist in three of the five bases of the genetic code -- cytosine, thymine
The detection of this dark state in single bases in solution increases the chances that it may be found in the DNA double helix, said ...
Uncovering DNA's 'sweet' secret
... the ladder) bind. The bases in normal DNA adhere to a somewhat strict binding scheme - guanine (G) binds with cytosine (C) and adenine (A) binds with thymine
(T). In this "Watson-Crick" basepairing, the G:C bonds are much stronger than A:T or any other bonds.
"In homo-DNA, the Watson-Crick base pairing ...
Study finds 60 new genes controlled by DNA snippet
... sequence under examination was the CArG box. The nucleotide building blocks of DNA chains may contain any one of four nucleobases: adenine (A), thymine
(T), guanine (G) and cytosine (C). Any sequence of code starting with 2 Cs, followed by any combination of 6 As or Ts, and ending in 2 Gs is a CArG ...
Common enzyme is a key player in DNA repair
... the damage, even though it doesn't get rid of it," Walker explained.
The molecular building blocks of DNA are adenine, cytosine, guanine, thymine
?A, C, G, and T in the shorthand of molecular biology. In different combinations, they make up the genes that code for the proteins that carry out ...
DNA size a crucial factor in genetic mutations, study finds
... a double helix. It's like a long, twisted ladder where each rung consists of two molecules that form a base pair. DNA has four bases: adenosine (A), thymine
(T), guanine (G) and cytosine (C). A always pairs with T, and G with C. To copy itself, the DNA molecule unwinds and splits. Either strand is now a ...
Purdue researchers use enzyme to clip 'DNA wires'
... to snip DNA so that scientists can alter the genetic structures of organisms like bacteria.
DNA molecules contain "bases" called guanine, adenine, thymine
and cytosine, represented as G, A, T and C. The bases combine in numerous sequences, and various restriction enzymes attach to and cut specific ...
An HIV Protein Plays a Surprising Role in Gene Activation
... join with so-called general transcription factors to form a pre-initiation complex (PIC) on the gene's promoter, where it binds to region rich in thymine
(T) and adenine (A) named the TATA box. The first transcription factor to associate with the TATA box is called TFIID, a large protein complex ...