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Therapeutic in Biological News

New DNA and RNA aptamers offer unique therapeutic advantages

... a thorough review of aptamers and aptamer-based therapeutic strategies that have the highest likelihood of ... that have been made to aptamers to enhance their therapeutic potential, and the different types of aptamers ... and timely review of aptamer development and therapeutic applications that our readers should enjoy," says ...

Stem cell research: From molecular physiology to therapeutic applications

... small intestine. MSCs have emerged as a promising therapeutic modality for tissue regeneration and autoimmune ... for future drug target candidate screening and therapeutic applications. Professor Qi Zhou has written a ... significant progress in the past decade. Some therapeutic applications are coming closer to being on the ...

Experimental treatment halts hypoxic-ischemic brain injury in newborns

... study also shows this system may be a promising therapeutic target in infants suffering hypoxic-ischemic ... brain injury. This makes it a better target for therapeutic intervention to shut down the injury process ... activator in HIE, the research team examined the therapeutic effect of injecting PAI-1 into newborn rats ...

Researchers team up to provide new hope for childhood hunger

... innovation; his peanut butter-based ready-to-use therapeutic food (RUTF) for the treatment of severe acute ... malnutrition. Develop a more cost-effective therapeutic feeding regimen for home-based therapy for severe ... moderate malnutrition and a more cost-effective therapeutic feeding regimen for home-based therapy for severe ...

Nanodiamonds deliver insulin for wound healing

... or suture materials. Localized release of a therapeutic is a major challenge in biomedicine. The ... the concept of nanodiamond-mediated release of therapeutic proteins," said Dean Ho, assistant professor of ... The large surface area allows a large amount of therapeutic to be loaded onto the particles. They can be ...

UC Davis grant zeroes in on novel asthma diagnosis and treatment

... of California, Davis who discovered a novel therapeutic target for treating inflammation, has received ... which has recently been demonstrated as a novel therapeutic treatment for treating inflammation," Hammock ... grant, "Soluble Epoxide Hydrolase Is a Novel therapeutic Target in Asthma" was one of 12 successful ...

Amarna Therapeutics B.V. and TNO announce SVac research and development partnership

... Amarna Therapeutics acts at the forefront of the therapeutic vaccination and gene therapy markets. Both ... development services into the extremely important therapeutic area of viral vector and gene delivery ... B.V. is a Biotechnology company that develops therapeutic vaccinations to treat immunity-associated ...

Moving gene therapy forward with mobile DNA

... into a patient's cells resulting in a cure or a therapeutic effect. In recent years, it has been shown that ... from virusses that can be tailor-made to deliver therapeutic genes into the patients' cells. However, some of ... transposons in such a way that they can carry the therapeutic gene into the target cell DNA. Doing so, they ...

Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes

... in human gene therapy -- the insertion of therapeutic DNA into tissues and cells in the human body -- ... may be particularly important for delivering therapeutic DNA to the walls of blood vessels. For example, ... gene for vascular endothelial growth factor. This therapeutic use could be important for treating ischemia in ...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... combinations in each patient and influence therapeutic outcomes in different ways. Some gene ... previously has been associated with a favorable therapeutic outcome in people, while fusion oncogenes ... "These patients should be offered alternative therapeutic approaches at diagnosis." ...

Tips from the American Journal of Pathology

... pathogenesis. Future studies will address the therapeutic opportunities of this pathway for the treatment ... galectin-3 may serve as a diagnostic marker and therapeutic target for prostate cancer progression. Dr. ... a marker for prognosis of prostate cancer and a therapeutic target for the treatment of prostate cancer." ...

Therapeutic hypothermia is promising strategy to minimize tissue damage

... al. focus on "Perioperative Hypothermia: Use and therapeutic Implications," and Kim et al. describe "The Use ... Kochanek et al. collaborate on two articles on therapeutic hypothermia in pediatric populations, one ... an overview of "Current and Future Role of therapeutic Hypothermia." ...

Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment

... by ActiveSite Pharmaceuticals, may provide a new therapeutic approach for treatment of diabetic retinopathy, ... further studies are needed to determine the therapeutic potential of ASP-440, the research underscores ... identified plasma kallikrein as a potential therapeutic target in people with diabetic retinopathy. "This ...

VCU survey: US public supports genetic research, testing and government spending on research

... while 36 percent oppose. Cloning and therapeutic cloning. Opinion about therapeutic cloning is more divided. Fifty-two percent of ... treatments. When cloning is not restricted to therapeutic purposes, about eight in 10, 78 percent, oppose ...

Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants

... of the scarce protein available for research and therapeutic development, a team of scientists at Worcester ... available for biomedical research, let alone for therapeutic development. Our study shows that we can use plants to produce interleukin-12, and other therapeutic proteins, in a cost-effective controlled ...

3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions

... indolones are thus novel and promising candidate therapeutic agents for pre-clinical testing against human ... that might be suitable for development as therapeutic agents. The structure-activity relationship ... disorders. These drugs provide promising new therapeutic approaches to deal with the underlying cause of ...

Sirtris' review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery

... and heart disease. Entitled "SIRTUINS Novel therapeutic Targets to Treat Age-Associated Diseases," the ... towards diseases where SIRT1 activation shows therapeutic promise. Such diseases of aging include Type 2 ... indicates a role for other sirtuins in multiple therapeutic areas," continued Dr. Westphal. ...

Previous claims of siRNA therapeutic effects called into question by report in human gene therapy

... 2, 2008The many recent reports documenting the therapeutic efficacy of short interfering RNAs (siRNAs) in ... disease may actually be describing non-specific therapeutic effects related to the ability of siRNA to ... in a paper entitled, "Misinterpreting the therapeutic Effects of siRNA Caused by Immune Stimulation," ...

Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body

... for understanding the cells' role in disease and therapeutic mechanisms, and for developing effective ... damaged tissues. Non-invasively visualizing these therapeutic cells in patients after transfer can be a vexing ... be extremely useful. "Ideally we would label therapeutic cells with our cellular MRI agents before they ...

Structural biology spin-out tackles major diseases

... to new technology that provides a way of creating therapeutic proteins to tackle major diseases such as cancer, ... Ross continued: "Our patented and versatile therapeutic platform technology ProFuse TM, could also tackle ... by Asterion Ltd. into a patented and versatile therapeutic platform technology called ProFuse. Using this ...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

... worldwide. "The discovery of a new potential therapeutic target generates great excitement among patients ... at various targets for possible relevance to therapeutic strategies for PD. Danny G. Winder, PhD, and ... University School of Medicine "CaMKII as a therapeutic Target in Parkinson's Disease" Ann M. ...

UF researchers develop improved gene therapy agent

... enough of the gene-toting virus to yield a therapeutic benefit without triggering an attack from the ... degraded and it goes into the nucleus, and we get therapeutic levels of proteins. We can generate therapeutic levels of Factor IX. The researchers are ...

Neural cell transplants may help those with Parkinson's disease

... Localized delivery is essential for aiming therapeutic molecules when treating neurodegenerative ... motor and dopaminergic function suggest potential therapeutic uses. Contact: rcgron0@uky.edu ... in models of PD. The ability to reliably monitor therapeutic effects would provide valuable information in ...

Sangamo BioSciences to Present at the Bank of America 2008 Healthcare Conference

... and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most ... 1 clinical trials are ongoing to evaluate a ZFP therapeutic for peripheral artery disease. Other therapeutic ... partnerships with companies outside of the human therapeutic space including Dow AgroSciences, Sigma-Aldrich ...

Biomarkers allow doctors to match therapy to patient

... genes, some of which are novel, could provide therapeutic targets for personalized treatment of breast ... neuroblastoma and represents an important therapeutic target: Abstract 5832 Australian researchers ... of this gene may lead to an important new therapeutic avenue for this disease. Researchers observed ...

Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimer's disease

... CD40-CD40L activity, suggesting that this therapeutic approach offers the potential to target the ... study is the first to report that the potential therapeutic mechanism of umbilical cord blood cells is more ... reported phenomena suggesting the non-hematologic therapeutic potential of blood stem cells, said Graham C. ...

Is hybridoma production about to take a quantum leap forward?

... antibodies as a complementary or primary therapeutic agent against a variety of diseases. The most ... fully human mAbs. Many promising biomed and therapeutic concepts that have been shelved, blocked by the ... Neowater® technology and find realization in therapeutic applications. ...

Methadone even at therapeutic levels can kill

... death even when it isnt overdosed but is taken at therapeutic levels primarily for relief of chronic pain or ... up 1 milligram or less of methadone defined as a therapeutic level. These cases were compared with a second ... of otherwise unexplained sudden deaths in the therapeutic methadone group points to a significant ...

International scientists tackle obstacles to treating brain disorders

... treats medications as the enemy, preventing the therapeutic agents from doing their job. In order to develop ... are studying a Trojan horse approach in which therapeutic agents are attached to parts of proteins, such as ... Researchers estimate that very little of therapeutic drugs make it beyond the blood-brain barrier and ...

It is important to demonstrate the influence of the microenvironment in the process of metastasis

... this expression, as well as a simple form of the therapeutic evaluation for new pharmaceutical drugs that ... being able to develop new pharmaceutical drugs or therapeutic targets to combat it. To this end, liver cells ... will have achieved the possibility of developing therapeutic targets in order to try and avoid, as it were, ...

Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal

... were made, no one envisaged their ultimate therapeutic potential." As licensor of the technology, ... enough or in large enough quantities to produce a therapeutic effect. Then one day, looking at the slide he ... for a long time." 1,000-Fold Increase in therapeutic Effect In the lab, Barbas, Lerner, and ...

Widespread support for nonembryonic stem cell research, VCU Life Sciences Survey shows

... say it has a negative affect. Cloning and therapeutic cloning. Opinion about therapeutic cloning is evenly divided with 47 percent in ... treatments. When cloning is not restricted to therapeutic purposes, about eight in 10, or 81 percent, ...

New approach for attacking lupus identified

... side effects. The study identifies very good therapeutic targets, and what needs to be done is identify ... of the interferons, that would lead to new therapeutic approaches where you could block specifically ... say that their work has identified a new therapeutic approach for attacking lupus. What the companies ...

Oosight microscope enables embryonic stem cell breakthrough

... this method (somatic cell nuclear transfer, or therapeutic cloning). Mitalipovs stem-cell derivation ... rhesus monkey eggs. This is the first step in therapeutic cloning, called enucleation. Next, they inserted ... embryos created; and to improve the efficiency of therapeutic cloning in animals. When I was training as an ...

Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery

... genes from the virus and inserting therapeutic genes. The vector then discharges the therapeutic genes into the target cell. The new grant will ... marker genes and begin testing his findings using therapeutic genes in sheep with heart failure. Dr. ...

Human clones: New U.N. analysis lays out world's choices

... freedom for nations to permit strictly controlled therapeutic research, has the greatest political viability of ... disagreement over research cloning (also called therapeutic cloning). "Human reproductive cloning could ... cloning but authorizes strictly controlled therapeutic cloning to prevent the uncontrolled production ...

Carnegie Mellon researchers to develop new drug delivery system

... the brain. To support their therapeutic goals, Zappe and his team have developed ... that has been very difficult to penetrate with therapeutic enzymes that are usually injected into the ... over capsule degradation and the amount of therapeutic enzyme released into the brain by engineered ...

Yale receives $8.4 million to study DNA repair in cancer cells

... the lead researcher, Peter Glazer, M.D., chair of therapeutic radiology and leader of the radiobiology research ... breast cancer. Joann Sweasy, professor of therapeutic radiology, will study how DNA repair occurs in ... cancer therapies. Patrick Sung, professor of therapeutic radiology and of molecular biophysics and ...

The endocannabinoids: Functional roles and therapeutic opportunities

... since appeared on THC. Today it is even used as a therapeutic drug against nausea and for enhancing appetite, ... also by antagonists to the CB1 receptors may have therapeutic potential. The endocannabinoid system generally ... disease. Thus, there is hope for novel therapeutic opportunities. Numerous additional ...

How does the opioid system control pain, reward and addictive behavior?

... demonstrated that mu-receptors mediate both the therapeutic and the adverse activities of this compound ... on the field of opioid research und uncover the therapeutic potential for delta-agonists in the treatment of ... dependence. This receptor therefore mediates therapeutic (analgesia) and adverse (addiction) activities of ...
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(Date:7/31/2014)... photovoltaic effect in 1839, humankind has sought to further ... own purposes. In a new research report published in ... Journal , scientists may have uncovered a new ... on a naturally occurring combination of lipids that have ... time and across speciessuggests that this specific natural combination ...
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