New DNA and RNA aptamers offer unique therapeutic advantages
... a thorough review of aptamers and aptamer-based therapeutic
strategies that have the highest likelihood of ... that have been made to aptamers to enhance their therapeutic
potential, and the different types of aptamers ... and timely review of aptamer development and therapeutic
applications that our readers should enjoy," says ...
Stem cell research: From molecular physiology to therapeutic applications
... small intestine. MSCs have emerged as a promising therapeutic
modality for tissue regeneration and autoimmune ... for future drug target candidate screening and therapeutic
applications. Professor Qi Zhou has written a ... significant progress in the past decade. Some therapeutic
applications are coming closer to being on the ...
Experimental treatment halts hypoxic-ischemic brain injury in newborns
... study also shows this system may be a promising therapeutic
target in infants suffering hypoxic-ischemic ... brain injury. This makes it a better target for therapeutic
intervention to shut down the injury process ... activator in HIE, the research team examined the therapeutic
effect of injecting PAI-1 into newborn rats ...
Researchers team up to provide new hope for childhood hunger
... innovation; his peanut butter-based ready-to-use therapeutic
food (RUTF) for the treatment of severe acute ... malnutrition.
Develop a more cost-effective therapeutic
feeding regimen for home-based therapy for severe ... moderate malnutrition and a more cost-effective therapeutic
feeding regimen for home-based therapy for severe ...
Nanodiamonds deliver insulin for wound healing
... or suture materials.
Localized release of a therapeutic
is a major challenge in biomedicine. The ... the concept of nanodiamond-mediated release of therapeutic
proteins," said Dean Ho, assistant professor of ... The large surface area allows a large amount of therapeutic
to be loaded onto the particles. They can be ...
UC Davis grant zeroes in on novel asthma diagnosis and treatment
... of California, Davis
who discovered a novel therapeutic
target for treating inflammation,
has received ... which has recently been demonstrated as a novel therapeutic
treatment for treating inflammation," Hammock ... grant, "Soluble Epoxide Hydrolase Is a Novel therapeutic
Target in Asthma" was one of 12 successful ...
Amarna Therapeutics B.V. and TNO announce SVac research and development partnership
... Amarna Therapeutics acts at the forefront of the therapeutic
vaccination and gene therapy markets. Both ... development services into the extremely important therapeutic
area of viral vector and gene delivery ... B.V. is a Biotechnology company that develops therapeutic
vaccinations to treat immunity-associated ...
Moving gene therapy forward with mobile DNA
... into a patient's cells resulting in a cure or a therapeutic
effect. In recent years, it has been shown that ... from virusses that can be tailor-made to deliver therapeutic
genes into the patients' cells. However, some of ... transposons in such a way that they can carry the therapeutic
gene into the target cell DNA. Doing so, they ...
Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes
... in human gene therapy -- the insertion of therapeutic
DNA into tissues and cells in the human body -- ... may be particularly important for delivering therapeutic
DNA to the walls of blood vessels. For example, ... gene for vascular endothelial growth factor. This therapeutic
use could be important for treating ischemia in ...
CSHL team develops mouse models of leukemia that predict response to chemotherapy
... combinations in each patient and influence therapeutic
outcomes in different ways.
Some gene ... previously has been associated with a favorable therapeutic
outcome in people, while fusion oncogenes ... "These patients should be offered alternative therapeutic
approaches at diagnosis."
Tips from the American Journal of Pathology
... pathogenesis. Future studies will address the therapeutic
opportunities of this pathway for the treatment ... galectin-3 may serve as a diagnostic marker and therapeutic
target for prostate cancer progression.
Dr. ... a marker for prognosis of prostate cancer and a therapeutic
target for the treatment of prostate cancer."
Therapeutic hypothermia is promising strategy to minimize tissue damage
... al. focus on "Perioperative Hypothermia: Use and therapeutic
Implications," and Kim et al. describe "The Use ... Kochanek et al. collaborate on two articles on therapeutic
hypothermia in pediatric populations, one ... an overview of "Current and Future Role of therapeutic
Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
... by ActiveSite Pharmaceuticals, may provide a new therapeutic
approach for treatment of diabetic retinopathy, ... further studies are needed to determine the therapeutic
potential of ASP-440, the research underscores ... identified plasma kallikrein as a potential therapeutic
target in people with diabetic retinopathy. "This ...
VCU survey: US public supports genetic research, testing and government spending on research
... while 36 percent oppose.
Cloning and therapeutic
cloning. Opinion about therapeutic
cloning is more divided. Fifty-two percent of ... treatments. When cloning is not restricted to therapeutic
purposes, about eight in 10, 78 percent, oppose ...
Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants
... of the scarce protein available for research and therapeutic
development, a team of scientists at Worcester ... available for biomedical research, let alone for therapeutic
development. Our study shows that we can use plants to produce interleukin-12, and other therapeutic
proteins, in a cost-effective controlled ...
3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
... indolones are thus novel and promising candidate therapeutic
agents for pre-clinical testing against human ... that might be suitable for development as therapeutic
agents. The structure-activity relationship ... disorders. These drugs provide promising new therapeutic
approaches to deal with the underlying cause of ...
Sirtris' review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
... and heart disease. Entitled "SIRTUINS Novel therapeutic
Targets to Treat Age-Associated Diseases," the ... towards diseases where SIRT1 activation shows therapeutic
promise. Such diseases of aging include Type 2 ... indicates a role for other sirtuins in multiple therapeutic
areas," continued Dr. Westphal.
Previous claims of siRNA therapeutic effects called into question by report in human gene therapy
... 2, 2008The many recent reports documenting the therapeutic
efficacy of short interfering RNAs (siRNAs) in ... disease may actually be describing non-specific therapeutic
effects related to the ability of siRNA to ... in a paper entitled, "Misinterpreting the therapeutic
Effects of siRNA Caused by Immune Stimulation," ...
Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body
... for understanding the cells' role in disease and therapeutic
mechanisms, and for developing effective ... damaged tissues. Non-invasively visualizing these therapeutic
cells in patients after transfer can be a vexing ... be extremely useful.
"Ideally we would label therapeutic
cells with our cellular MRI agents before they ...
Structural biology spin-out tackles major diseases
... to new technology that provides a way of creating therapeutic
proteins to tackle major diseases such as cancer, ... Ross continued: "Our patented and versatile therapeutic
platform technology ProFuse TM, could also tackle ... by Asterion Ltd. into a patented and versatile therapeutic
platform technology called ProFuse. Using this ...
Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's
"The discovery of a new potential therapeutic
target generates great excitement among patients ... at various targets for possible relevance to therapeutic
strategies for PD. Danny G. Winder, PhD, and ... University School of Medicine
"CaMKII as a therapeutic
Target in Parkinson's Disease"
Ann M. ...
UF researchers develop improved gene therapy agent
... enough of the gene-toting virus to yield a therapeutic
benefit without triggering an attack from the ... degraded and it goes into the nucleus, and we get therapeutic
levels of proteins. We can generate therapeutic
levels of Factor IX.
The researchers are ...
Neural cell transplants may help those with Parkinson's disease
Localized delivery is essential for aiming therapeutic
molecules when treating neurodegenerative ... motor and dopaminergic function suggest potential therapeutic
... in models of PD. The ability to reliably monitor therapeutic
effects would provide valuable information in ...
Sangamo BioSciences to Present at the Bank of America 2008 Healthcare Conference
... and development of
novel DNA-binding proteins for therapeutic
gene regulation and
modification. The most ... 1 clinical trials are
ongoing to evaluate a ZFP therapeutic
for peripheral artery disease. Other
therapeutic ... partnerships with companies
outside of the human therapeutic
space including Dow AgroSciences,
Biomarkers allow doctors to match therapy to patient
... genes, some of which are novel, could provide therapeutic
targets for personalized treatment of breast ... neuroblastoma and represents an important therapeutic
target: Abstract 5832
Australian researchers ... of this gene may lead to an important new therapeutic
avenue for this disease.
Researchers observed ...
Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimer's disease
... CD40-CD40L activity, suggesting that this therapeutic
approach offers the potential to target the ... study is the first to report that the potential therapeutic
mechanism of umbilical cord blood cells is more ... reported phenomena suggesting the non-hematologic therapeutic
potential of blood stem cells, said Graham C. ...
Is hybridoma production about to take a quantum leap forward?
... antibodies as a complementary or primary therapeutic
agent against a variety of diseases. The most ... fully human mAbs.
Many promising biomed and therapeutic
concepts that have been shelved, blocked by the ... Neowater® technology and find realization in therapeutic
Methadone even at therapeutic levels can kill
... death even when it isnt overdosed but is taken at therapeutic
levels primarily for relief of chronic pain or ... up 1 milligram or less of methadone defined as a therapeutic
level. These cases were compared with a second ... of otherwise unexplained sudden deaths in the therapeutic
methadone group points to a significant ...
International scientists tackle obstacles to treating brain disorders
... treats medications as the enemy, preventing the therapeutic
agents from doing their job.
In order to develop ... are studying a Trojan horse approach in which therapeutic
agents are attached to parts of proteins, such as ... Researchers estimate that very little of therapeutic
drugs make it beyond the blood-brain barrier and ...
It is important to demonstrate the influence of the microenvironment in the process of metastasis
... this expression, as well as a simple form of the therapeutic
evaluation for new pharmaceutical drugs that ... being able to develop new pharmaceutical drugs or therapeutic
targets to combat it.
To this end, liver cells ... will have achieved the possibility of developing therapeutic
targets in order to try and avoid, as it were, ...
Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
... were made, no one envisaged their ultimate therapeutic
As licensor of the technology, ... enough or in large enough quantities to produce a therapeutic
Then one day, looking at the slide he ... for a long time."
1,000-Fold Increase in therapeutic
In the lab, Barbas, Lerner, and ...
Widespread support for nonembryonic stem cell research, VCU Life Sciences Survey shows
... say it has a negative affect.
Cloning and therapeutic
cloning. Opinion about therapeutic
cloning is evenly divided with 47 percent in ... treatments. When cloning is not restricted to therapeutic
purposes, about eight in 10, or 81 percent, ...
New approach for attacking lupus identified
... side effects.
The study identifies very good therapeutic
targets, and what needs to be done is identify ... of the interferons, that would lead to new therapeutic
approaches where you could block specifically ... say that their work has identified a new therapeutic
approach for attacking lupus. What the companies ...
Oosight microscope enables embryonic stem cell breakthrough
... this method (somatic cell nuclear transfer, or therapeutic
Mitalipovs stem-cell derivation ... rhesus monkey eggs. This is the first step in therapeutic
cloning, called enucleation. Next, they inserted ... embryos created; and to improve the efficiency of therapeutic
cloning in animals.
When I was training as an ...
Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery
... genes from the virus and inserting therapeutic
genes. The vector then discharges the therapeutic
genes into the target cell. The new grant will ... marker genes and begin testing his findings using therapeutic
genes in sheep with heart failure.
Human clones: New U.N. analysis lays out world's choices
... freedom for nations to permit strictly controlled therapeutic
research, has the greatest political viability of ... disagreement over research cloning (also called therapeutic
"Human reproductive cloning could ... cloning but authorizes strictly controlled therapeutic
cloning to prevent the uncontrolled production ...
Carnegie Mellon researchers to develop new drug delivery system
... the brain.
To support their therapeutic
goals, Zappe and his team have developed ... that has been very difficult to penetrate with therapeutic
enzymes that are usually injected into the ... over capsule degradation and the amount of therapeutic
enzyme released into the brain by engineered ...
Yale receives $8.4 million to study DNA repair in cancer cells
... the lead researcher, Peter Glazer, M.D., chair of therapeutic
radiology and leader of the radiobiology research ... breast cancer.
Joann Sweasy, professor of therapeutic
radiology, will study how DNA repair occurs in ... cancer therapies.
Patrick Sung, professor of therapeutic
radiology and of molecular biophysics and ...
The endocannabinoids: Functional roles and therapeutic opportunities
... since appeared on THC. Today it is even used as a therapeutic
drug against nausea and for enhancing appetite, ... also by antagonists to the CB1 receptors may have therapeutic
potential. The endocannabinoid system generally ... disease. Thus, there is hope for novel therapeutic
Numerous additional ...
How does the opioid system control pain, reward and addictive behavior?
... demonstrated that mu-receptors mediate both the therapeutic
and the adverse activities of this compound ... on the field of opioid research und uncover the therapeutic
potential for delta-agonists in the treatment of ... dependence. This receptor therefore mediates therapeutic
(analgesia) and adverse (addiction) activities of ...