Playing it safe

... in culturing a clearly defined cell type from the testis of adult mice and converting these cells into ... process. ( Cell Stem Cell , July 2, 2009) The testis is a sensitive organ and an astonishing one at ... researchers have long assumed that cells from the testis have a similar potential as in embryonic stem ...

Stem cell chicken and egg debate moves to unlikely arena: the testes

... cells that comprise a specialized niche in the testis of fruit flies actually emerge from adult stem ... thought that a fruit fly's allotment of testis niche cells was handed out at birth and meant to ... by first author Justin Voog, actually caught a testis stem cell population in the act of turning into ...

Female embryonic sexual development driven by universal factor

... led the study. "They have a common primordium, the foundation for both testis and ovary," he said. "Only at a certain stage of development does this ... cast of molecules known to be involved in transforming the primordium into testis or ovary. This molecule, beta-catenin, is an important regulator of cell ...

Human adult testes cells can become embryonic-like

... are among the first scientists to show that human testes stem cells can become embryonic stem-like cells, and they have done this work using testis tissue from organ donors, which they say has provided enough valuable tissue to allow them to make their discoveries. While they have published their ...

6th ESOU Meeting

... such as prostate cancer (PCa), renal cell carcinoma and bladder cancer were the focus of last year's meeting in Berlin. Apart from these conditions, testis cancer will be another highlight of the forthcoming meeting in Istanbul. Prof. Levent Trkeri (Istanbul, Turkey), ESOU board member and local ...

ACS PressPac -- Sept. 17, 2008

... for new male contraceptives as well as medications for treating infertility. JS ARTICLE #4 FOR IMMEDIATE RELEASE "Proteomic Analysis of testis Biopsies in Men Treated with Injectable Testosterone Undecanoate Alone or in Combination with Oral Levonorgestrel as Potential Male Contraceptive" ...

Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality

... compounds responsible for cell growth that help stabilise the structure of DNA. We also found that spermatogenesis 20, a factor unique to the testis and whose function remains unknown, was greatly increased. Taken together, these factors indicate clearly that having diabetes has a direct influence ...

Veterinary college researcher studying brain tumors in people and animals

... that when astrocytomas spontaneously arise in people, they over-express three proteins: interleukin 13 receptor alpha2 (IL-13R), which is a cancer testis tumor like agent; EphA2, a tyrosine kinase receptor; and fos-related antigen 1, an AP-1 transcription factor. Rossmeisl and colleagues working in ...

Human testis harbors HIV-1 in resident immune cells

... report by Roulet et al., “Susceptibility of human testis to human immunodeficiency virus-1 infection in ... led by Dr. Nathalie Dejucq-Rainsford examined testis tissue for the presence of HIV receptors. They ... by using explanted organ cultures in which human testis tissue was grown in culture. ...

Genetic tug of war determines sexual differentiation

... gonad before it commits to either a male testis or a female ovary. If this equilibrium is tipped ... gonad has the ability to transform either into a testis or an ovary. During the earliest stages of ... Fgf9 become active and the process of becoming a testis begins. "The expression of these three genes ...

Study hints at role of stem cell genes in testicular, breast cancers

... seminomas arise in sperm-producing germ cells, which are located in the testis and produce sperm in boys following puberty. Germ cells, like all cells of ... in the nine seminoma samples examined, when compared with normal testis tissue. GDF3 was elevated in 90 percent of cases, OCT4 was elevated in 56 ...

'Jumping genes' contribute to the uniqueness of individual brains

... past. It has been known for a long time that L1 elements are active in testis and ovaries, which explains how they potentially play a role in evolution ... other than germ line cells," says Gage. Apart from their activity in testis and ovaries, jumping L1 elements are not only unique to the adult brain ...

Researchers discover that sheep need retroviruses for reproduction

... genetic material into the DNA of host cells, he said. During evolution of mammals, some retroviruses infected the germline (cells of the ovary and testis that have genetic material that are passed to their offspring) of the host, which is then inherited by their children. These retroviruses, known as ...

Injection may prevent infertility in men receiving cancer chemotherapy

... Ramat Gan, Israel, said that his work showed for the first time that the injection of a drug that enhances the immune system could protect the testis from the effects of paclitaxel (Taxol), a widely used chemotherapy drug. "The effects of chemotherapy treatment on fertility are an important issue ...

Housecat-sized Siberian tiger cubs get collared

... genomic regions lies on the X chromosome. This X chromosomal region spans a cluster of five SPANX genes that are predominantly expressed in the testis and in certain tumors. In this month's issue of Genome Research , Dr. Vladimir Larionov and his colleagues examined the genetic architecture of the ...

Studies on human genome variation provide insight into disease

... genomic regions lies on the X chromosome. This X chromosomal region spans a cluster of five SPANX genes that are predominantly expressed in the testis and in certain tumors. In this month's issue of Genome Research , Dr. Vladimir Larionov and his colleagues examined the genetic architecture of the ...

Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory

... difficult, because we have to recreate for the cultured cells the environment of the developing follicle for egg development or the tissue of the testis for sperm. We want to test whether HESCs can differentiate to cells that produce the hormones for sperm and egg development and isolate these as ....

Environmental chemical cocktail may sabotage sperm

... compounds might contribute to a decrease in human fertility. Other scientists have investigated the negative impact of environmental chemicals on testis function, resulting in reduced numbers of sperm being produced, but these effects require much larger doses than we have used. As far as I am aware, ...