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Telomere in Biological News

Researchers use chemical from medicinal plants to fight HIV

... because a part of their chromosomes known as a telomere becomes progressively shorter with cell division. ... therapy, can prevent or slow this progressive telomere shortening, which could make it a key weapon in ... . A telomere is a region at the end of every cell chromosome ...

When cells go bad

... the first to show in animals that losing just one telomere the end of a chromosome can lead to many ... "The essential point is that loss of a single telomere may be a primary event that puts a cell on the ... biology, found how fruit fly cells with a missing telomere sometimes avoid suicide and instead continue to ...

Baumann lab identifies elusive telomere RNA subunit in single cell model

... for new anti-cancer drugs. A correlation between telomere length and a variety of diseases has further ... on the sometimes surprising correlations between telomere shortening and stress, smoking, obesity, and a ... in a variety of simple model organisms, but telomere maintenance turned out to be quite different in ...

Could vitamin D, a key milk nutrient, affect how you age?

... stress. Using a genetic marker called leukocyte telomere length (LTL), they found those with the highest ... lower levels of inflammation and body stress. The telomere difference between those with the highest and ... there are several lifestyle factors that affect telomere length (obesity, smoking and lack of physical ...

Peter Baumann named Howard Hughes Medical Institute Early Career Scientist

... degenerative diseases. On the other hand, telomerase, a protein central to telomere elongation, is activated in most cancer cells and is considered a promising target for anticancer drugs. By understanding how telomere lengthening is regulated and how telomeres are prevented from becoming too ...

UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

... almost 15 percent of those with familial IPF. Up to 40 percent have short telomere lengths and evidence of telomerase dysfunction. "But we were still left ... Dr. Garcia said. "What about the rest of the families that have normal telomere lengths? What was causing their lung disease?" In the current study, ....

Landmark study opens door to new cancer, aging treatments

... "It's extremely exciting," Skordalakes says. "For the first time, we can see how telomerase assembles at the end of chromosomes to initiate telomere replication." Looking ahead Skordalakes plans to further study TERT and search for new telomerase inhibitors that could become cancer ...

UCLA study identifies mechanism behind mind-body connection

... heart disease and aging. Previous studies show that an enzyme within the cell, called telomerase, keeps immune cells young by preserving their telomere length and ability to continue dividing. FINDINGS: UCLA scientists found that the stress hormone cortisol suppresses immune cells' ability to ...

Osteoarthritis may be sign of faster 'biological ageing'

... the findings showed that white cell telomere lengths were associated with chronological age. ... the 160 people with hand osteoarthritis, the telomere length was significantly shorter than among those ... osteoarthritis were over 50, and the amount of telomere shortening was equivalent to that accrued over 11 ...

A little telomerase isn't enough

... animals turns out to be the animal's inherited telomere length, not the status of the telomerase gene, ... "We know it only takes one critically short telomere to make a cell die, so it's clear that the more ... lab reported the role of the critically short telomere in 2001. The usual treatment for people with ...

Tiny roundworm's telomeres help scientists to tease apart different types of aging

... available online now. In the past, preventing telomere shortening has often been portrayed as the key to ... C. elegans is the perfect model organism to study telomere biology since their regulation is similar to ... In humans and, as we know now, in worms, telomere length is certainly not a limiting factor for ...

DNA end caps may lead to cancer treatments, UT Southwestern researchers report

... professor of cell biology. In human cells, every chromosome has a telomere at each end, and each telomere ends in a single-stranded overhang. (DNA is normally double-stranded.) The ...

GATA: a graphic alignment tool for comparative sequence analysis

... of telomerase inhibitors. Importantly, tankyrase inhibition enhanced telomere shortening upon treatment with a telomerase inhibitor and accelerated ... the time period of drug treatment that is required for the onset of telomere crisis and reduce the potential risk of acquired drug resistance, " writes ...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

... of telomerase inhibitors. Importantly, tankyrase inhibition enhanced telomere shortening upon treatment with a telomerase inhibitor and accelerated ... the time period of drug treatment that is required for the onset of telomere crisis and reduce the potential risk of acquired drug resistance, " writes ...

Exploring the dark matter of the genome

... that we don't understand the genome yet." Celniker agrees. "What we would like to see is a complete sequence of the fruit fly from telomere to telomere" -- that is, from one end of the chromosomes to the other -- including the centromere in the middle." Obtaining a more complete picture ...

Aging cells, aging body: Fresh evidence for a connection

... the presence of six biomarkers, or biological "red flags," that signal cellular aging. For replicative senescence, the most important biomarker is telomere dysfunction-induced foci, or TIFs. Presence of these structures signals that the protective chromosome caps called telomeres have dwindled enough to ...
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(Date:4/20/2014)... lung, breast and pancreatic cancers also promote drug-resistance and ... California, San Diego School of Medicine have discovered a ... drug-resistant tumors that appears responsible for inducing tumor metastasis ... , The findings, published in the April 20, ... may point to new therapeutic opportunities for reversing drug ...
(Date:4/18/2014)... contraceptive pills in Peru found that 28 percent ... quality or falsified. Many pills released the active ... ingredient. One batch had no active ingredient at ... researchers at the Georgia Institute of Technology developed ... assess suspected counterfeit drugs and then characterize their ...
(Date:4/18/2014)... NC Ancient DNA adds a twist to the story ... to be published April 21 in the journal Proceedings ... from the bones of chickens that lived 200-2300 years ago ... ago domestic chickens may have looked far different from the ... of the traits we associate with modern domestic chickens -- ...
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(Date:4/17/2014)... in PLOS Pathogens , children who live in ... mount an immune response to infection with malaria parasites ... high fever and illness and partially control the growth ... help researchers develop future interventions that prevent or mitigate ... year, approximately 200 million cases of malaria occur worldwide, ...
(Date:4/17/2014)... Diego School of Medicine report that older women, plucky ... loss are more likely to be compassionate toward strangers ... in this month,s issue of the International Journal ... associated with better health and well-being as we age, ... the outcomes of individuals whose deficits in compassion put ...
(Date:4/17/2014)... review published in the April issue of Immunity ... Institute for Medical Research, says it,s time to take ... to treating sepsis, which kills millions worldwide every ... when molecules released into the bloodstream to fight an ... is necessary for maintaining good health without inflammation, ...
(Date:4/17/2014)... synthetic biology team has created a new technology ... that could travel the body and selectively target ... cell-based, biological devices that monitor and modify human ... biology. However, no existing technology enabled bioengineers to ... state and respond in a customized fashion. , ...
(Date:4/17/2014)... Il. (April 17, 2014) Doctors who treat ... called lymphangioleiomyomatosis (LAM) can face an agonizing treatment ... of the disease and help relieve shortness of ... transplants, and sirolimus can cause potentially fatal complications ... pulmonologist Dr. Daniel Dilling, medical director of Loyola ...
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