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Targeting in Biological News

New cancer drug delivery system is effective and reversible

... such folate, a vitamin, also work as cancer cell targeting agents, but those now in use are not as good as ... Cheng, who helped pioneer the use of aptamers as targeting molecules for drug delivery. "This is the first ... Another advantage of using aptamers as targeting agents is that they are easily disabled. They ...

Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine

... in a concentration camp. His achievements in gene targeting were recognized with the 2001 Albert Lasker Award ... Mario Capecchis groundbreaking work in gene targeting will have an incalculable impact on generations ... is one of ours. Capecchis development of gene targeting in mouse embryo-derived stem cells allows ...

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

... de Lyon ( http://hvd.ens-lyon.fr/human_virology_dpt ) present a method for targeting hematopoietic stem cells using engineered viral vectors. The article, "Hematopoietic Stem Cell targeting with Surface-Engineered Lentiviral Vectors," is freely available on the ...

Targeting children effective use of limited supplies of flu vaccine and could help control flu spread

... targeting children may be an effective use of limited supplies of flu vaccine, ... might help control a potential pandemic." The researchers argue that targeting children for vaccination would not only help protect those at greatest ...

La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery

... and inflammatory diseases, and currently has multiple programs underway targeting asthma treatment. The company will use its expertise within this arena for the development of a potential drug candidate targeting OX40 ligand. Dr. Croft began studying OX40 in the 1990s because of ...

LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug

... Trust, aims to develop new antimalarial drug candidates which work by targeting a novel enzyme in the respiratory chain of Plasmodium falciparum the ... prerequisite of a target for a 'magic bullet' - a drug capable of targeting an organism without affecting its host. Having identified this enzyme, ...

Engineers create intelligent molecules that seek-and-destroy diseased cells

... therapy seem limitless. Researchers and doctors can use this approach by targeting a specific cellular function or behavior they want to control in a ... consequences for patients. The designer molecules provide a whole new targeting accuracy that should mitigate these side effects. "This is all very ...

Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008

... per share for the first half of 2009. For the full year 2009, Entrust is targeting a net income, in accordance with GAAP, of approximately $0.11 per share. ... charges for the full year by more than $15.0 million. The Company is also targeting bookings from subscription-based products of more than $20.0 million. See ...

JCI online early table of contents: Jan. 19, 2009

... https://www.the-jci.org/article.php?id=32661 ONCOLOGY: Antibodies targeting the protein Pim-1 inhibit cancer cell growth In a number of human ... they propose that future studies should determine whether current drugs targeting PKC-alpha (e.g., aprinocarsen) are of benefit in the setting of ...

Researchers recreate SARS virus, open door for potential defenses against future strains

... They also studied the pathogenesis and the ability of therapeutics targeting epidemic strains to cure bat SARS-CoV infection. SARS (severe acute ... he said. "The key problem is that many of the vaccines and therapeutics targeting the 2002-2003 epidemic strains may not work against future emergent ...

Study may explain exercise-induced fatigue in muscular dystrophies

... the signaling defect and relieve the fatigue. The findings suggest that targeting the signaling pathway may lead to therapies for this type of fatigue. ... many different neuromuscular conditions where fatigue could be treated by targeting this newly discovered pathway," said Kevin Campbell, Ph.D., UI professor ...

The structure of the Mre11 protein bound to DNA

... is important not only for error-free repair of DSBs but also for targeting genes to specific sites in the genome, a valuable technique in cell ... is a key target for both new cancer therapeutics and for controlled gene targeting to treat inherited disorders in humans as well, plus having numerous other ...

Breast cancer cells recycle to escape death by hormonal therapy

... only for relatively short periods. Antiestrogen therapy is more specific, targeting breast cancer cells that express estrogen receptors. In the ... a macroautophagy inhibitor promoted robust cell death. "We believe targeting the autophagosome function will significantly improve the efficacy of ...

Research exposes new target for malaria drugs

... health problems such as anemia, low birth-weight, fever and more. targeting these sticky proteins with drugs is difficult, however, as plasmodia ... after multiple pregnancies by developing an immune response for PfEMP1. targeting this conserved binding domain of the protein with pharmaceuticals that ...

Cancer drug delivery research at Case Western Reserve University cuts time from days to hours

... needed for effective interaction with cancer cells; optimizing potential targeting systems on the PEG ligands for faster, even more specific placement in ... of the PEG ligands. This should lead to optimization of the drug targeting and therapy. If our research is successful, other researchers might adapt ...

New paradigm for cell-specific gene delivery

... of a smooth muscle cell-specific promoter that was able to mediate nuclear targeting of any plasmid carrying this sequence uniquely in cultured smooth muscle ... but as yet their low efficiency in gene transfer and lack of cell-specific targeting and expression are major limitations. According to Dr. David Dean, "The ...

Scientists discover a molecular scaffold that guides connections between brain cells

... a team that has identified molecules guiding this highly specific neuronal targeting in the developing brains of mice. The researchers report in PLoS Biology ... in their newly published paper, Dr. Huangs team traced the sub-cellular targeting of a different set of cerebellar neurons called stellate cells, which make ...

New type of drug shrinks primary breast cancer tumors significantly in just 6 weeks

... than the broad brush approach, in which cells are killed indiscriminately, targeting the stem cells may be more effective and also prevent some of the ... it. We will also look into its applicability in testing novel agents targeting tumour-initiating cells. This finding should also apply to other types of ...

Less can be more, for plant breeders too

... indica varieties by several years of breeding. With an artificial miRNA targeting the Eui1 messenger RNA, the researchers at the International Rice Research ... in rice breeding are manifold and they dont stop at rice genes. By targeting pathogen-derived genes, for example, it should be possible to enhance ...

Yale scientists create artificial 'cells' that boost the immune response to cancer

... First, the universal surface adaptors allow us to add a span of targeting antigen and co-stimulatory molecules. We can also create a sustained ... According to the NSF, devices as such these offer ease and flexibility in targeting different types of T-cells, and is expected to lead to state of the art ...

CSHL scientists identify cells that promote formation of lethal lung metastases

... the prospect of a novel therapeutic target, and suggests that selective targeting of EPCs, perhaps in combination with chemotherapy, may prove to be a ... resistance to chemotherapeutic agents. We feel that approaches based on targeting the genetically stable components of the tumor microenvironment, such as ...

Yale chemist receives NIH Young Investigator Award for antibody targeting

... antibodies that recognize a single small molecule as a universal agent for targeting and destroying many different pathogens and various types of diseased ... synthetic compounds, we already have cell-specific and pathogen-specific targeting molecules we can use or modify. As a synthetic chemist, Spiegel will ...

Massive microRNA scan uncovers leads to treating muscle degeneration

... The findings raise the possibility of slowing muscle loss by targeting the microRNAs that control these cascades of damaging events. This approach is more efficient than targeting individual genes. The team also defined the abnormal microRNA ...

Nanoengineers mine tiny diamonds for drug delivery

... of Medicine. We anticipate they will allow for more sophisticated means of targeting cancer cells while sparing healthy cells from a drugs toxicity. To make ... do a lot of chemistry on the surface, to further functionalize them for targeting purposes. In addition to functionality, they also offer safety -- the ...

New class of drug offers hope to treatment-resistant AIDS patients

... by a University of Georgia researcher may offer a new treatment option by targeting a previously elusive enzyme in the complex retrovirus responsible for the ... and approval is expected this month. Drug developers have been targeting HIV integrase for years, but without much success. Nairs own discovery had ...

A new radiation therapy treatment developed for head and neck cancer patients

... the tumour tissue, which destroys cancer cells. The technique allows targeting of a high dosage of radiation to the tumour while allowing sparing of the adjacent normal tissues from the highest doses of radiation. Boron-mediated targeting of radiation allows treatment of patients who can no longer be treated ...

JCI table of contents: Aug. 16, 2007

... II and EP1-specific agonists. The authors therefore suggest that targeting the PGE2 receptor EP1 might be a viable approach to treating hypertension. ... Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting AUTHOR CONTACT: Matthew D. Breyer Vanderbilt University Medical Center, ...

ComCam Selected by ePortation on New Maritime Domain Awareness Project

... The two companies have teamed to assist additional Ports under the American Recovery and Reinvestment Act of 2009 stimulus specifically targeting the $150m Port Security Grant Program (PSGP) http://www.fema.gov/government/grant/psgp/index.shtm ePortation, Inc. http://www.eportation.com ...

Animal and plant communication at the ESA Annual Meeting

... to natural areas. The number of specialists, however, only increased slightly. These results suggest that the bird predators were preferentially targeting generalists. The difference is likely due to the specialists' ability to take better advantage of their host plants, says Singer. Many ...

Martin Hensen, head of e-strategies, UCB Germany: Making e-marketing more than just an add-on

... But successful e-CRM strategies are the basic starting point for all e-activities, he told eyeforpharma. For the sales force, CRM strategies build targeting and steering, as well as customer classification to personalize and individualize marketing efforts. And such personalization and individualization, ...

Aware, Inc. Reports Second Quarter 2009 Financial Results

... chief executive officer, said, "We are encouraged by the modest growth in our revenues this quarter. Our goal is to generate shareholder value by targeting growing portions of the biometrics, DSL test and home networking markets with a collection of technology, products and services." Note: ...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

... "This report is definitely a reason to hope. We now have a potential new therapy for the treatment of advanced ovarian cancer that has promise for targeting tumor cells and leaving healthy cells healthy," said lead researcher Janet Sawicki, Ph.D., a professor at the Lankenau Institute for Medical ....

Scientists track impact of DNA damage in the developing brain

... cre recombinase, in just the nervous system. St. Jude researchers then developed a mouse that carried an Xrcc1 gene outfitted with biochemical tags targeting the gene for inactivation by the enzyme. The result was a mouse whose nervous system lacked Xrcc1 and so was unable to efficiently repair the ...

Scientists link immune system's natural killer cells to infant liver disease

... system's role in causing injury to bile ducts soon after birth, and they have implications for developing new therapies to block the disease by targeting certain cells or pro-inflammatory circuits," said Jorge A. Bezerra, M.D., the study's senior investigator and research director of the Division of ...

UCLA researchers discover new molecular pathway for targeting cancer, disease

... was previously unknown. "Our finding shows that activation of LXR signaling is a novel strategy for inhibiting Hh pathway activity and for targeting various cell types, including cancer cells, which may provide important clues as to how we might be able to intervene with tumor formation," said ...

Flexible neck in cell-receptor DC-SIGN targets more pathogens

... of Illinois chemist Deborah Leckband show that flexibility in the region near the binding sites of DC-SIGN plays a significant role in pathogen targeting and binding. "Our work focuses on how DC-SIGN recognizes HIV and other pathogens, and on what structural features enable it to bind very tightly to ...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

... next step, the development of receptor subtype-specific drugs is currently encouraged. So-called hyperselective drugs are thought to allow the direct targeting of specific sites of relevant neural activity, thereby maximising the efficacy of the drug within the clinical target and minimising adverse events. ...

Investing wisely to save the Great Barrier Reef

... project leader Dr Stefan Hajkowicz, said. "However, if spread evenly over the entire GBR catchment, these funds will achieve very little. Careful targeting of the investment is crucial. "Scientists estimate that 70 per cent of sediment pollution comes from just 20 per cent of the total catchment ....

MS study offers theory for why repair of brain's wiring fails

... might manipulate the Wnt pathway to improve myelin repair. Given the pathway's role in so many different processes, however, Rowitch cautioned that targeting Wnt could cause unintended side effects. The new work may also have implications for another neurological disease, periventricular leukomalacia, ...

CWRU receives $5 million from Ohio Third Frontier Commission

... Rich (CC) will establish a Pluripotent Stem Cell Facility within CWRU and CC which will be the first of its kind in the State of Ohio. Cell targeting will apply its cell "painting" technology to direct umbilical cord blood stem cells to specific locations in the body to increase cell dosage and ...
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