Researchers discover primer to plant defense system
... research and this paper, titled "Priming in systemic
Among key findings was that ... found to be essential for the increased systemic
Azelaic acid moves throughout ... authors note that, "The identification of novel systemic
acquired resistance components may be useful for ...
Dartmouth researchers discover gene signatures for scleroderma
... conditions, from mild, localized to the skin, to systemic
and life threatening.
Patient complications ... first time that we can classify patients with a systemic
autoimmune disease into different groups by gene ... genes, demonstrating the disease was truly systemic
when the biopsies were taken.
The new research ...
DNA variations signal lupus risk
... is the work of the International Consortium for systemic
Lupus Erythematosus (SLEGEN), of which UAB is a member. SLE is the medical term for systemic
lupus erythematosus, a common form of the ... than in women of other races and ethnicities.
lupus is a chronic inflammatory disease that can ...
Agent that triggers immune response in plants is uncovered
... shift into high gear.
This phenomenon is called systemic
acquired resistance and is known to require ... acid-binding protein 2 (SABP2), is required for systemic
acquired resistance and converts methyl ... be active in the upper, uninfected leaves for systemic
acquired resistance to develop properly. By ...
UT Southwestern researchers probe kidney damage, protection in lupus
... renal disease.
The researchers also studied 340 German patients with systemic
lupus, matched with 400 healthy control subjects. The patients with lupus ... show that some of us have a particular version that increases our risk for systemic
lupus," Dr. Wakeland said.
Future research will examine the mechanisms ...
Long-lasting nerve block could change pain management
... conditions like chronic pain where, rather than use narcotics, which are systemic
and pose a risk of addiction, you could just put that piece of the body to ... the formulation to make it last even longer, while avoiding local and systemic
toxicity. "It is conceivable we could have a formulation that is suitable ...
Tips from the American Journal of Pathology
... Am J Pathol 2009, 174: 1241-1251
Bacterial Toxin Leads to systemic
A group led by Dr. Michael Klapproth at Emory University, ... breach the intestinal epithelial barrier, entering the blood and causing systemic
Lymphostatin, a toxin produced by gram negative bacteria ...
Vitamin E shows possible promise in easing chronic inflammation
... with a low dose of E. coli lipopolysaccharide (LPS) to induce acute systemic
inflammation. The effects were compared with those found in placebo ... Vitamin E for three days prior to giving them what amounts to a minor systemic
bacterial infection," Huey said. "One thing we did in addition to ...
Scientists suspect omega-3 fatty acids could slow acute wound healing
... The researchers had expected those proteins to be lowered by the increased systemic
presence of omega-3 fatty acids in the blood.
"That finding was hard ... other molecular substances that control inflammation locally. Fish oil's systemic
anti-inflammatory power, which has been illustrated in previous studies, ...
Steps toward Stopping Autoimmune Disease
... 20, 2008A landmark genetic study has identified multiple genes linked to systemic
lupus erythematosus (SLE), or lupus, a debilitating autoimmune disease ... Alliance for Lupus Research (ALR) formed and supported the International systemic
Lupus Erythematosus Genetics (SLEGEN) Consortium, charging scientists ...
Best treatment identified to reduce deadly Staph infections
... and are now attacking younger, healthier individuals. Since many of these systemic
infections begin with cuts, minor wounds or skin infections, proper first ... but sometimes through skin infections or other processes it can cause a systemic
infection, and death from such causes as pneumonia, meningitis, or blood ...
Scientists uncork a potential secret of red wine's health benefits
... inflammation, but also show how itor a derivativecan be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis, and systemic
"Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of treatment," said ...
Experimental treatment halts hypoxic-ischemic brain injury in newborns
... in HIE, the research team examined the therapeutic effect of injecting PAI-1 into newborn rats suffering from the brain blood flow reduction and systemic
hypoxia. The enzyme inhibitor was injected into the intracerebroventricular region of the brain, which includes a system of canals that distribute ...
Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
... interest in developing new therapies for melanoma patients with recurrent or distant metastatic disease at the time of diagnosis because there are no systemic
therapies that can be relied upon to cure them," said Robert O. Dillman, M.D., F.A.C.P., executive medical and scientific director at the Hoag Cancer ...
Comprehensive look at rare leukemia finds relatively few genetic changes launch disease
... genome of childhood AML and take a more detailed look at particular AML subtypes.
Added Ina Radtke, Ph.D., the paper's lead author: "This rigorous systemic
genome-wide study was an important step to direct our future efforts to the most effective strategies to pinpoint lesions in AML." She is a ...
Gene expression findings a step toward better classification and treatment of juvenile arthritis
... with one of four major subtypes of JIA persistent oligoarthritis (affecting four or fewer joints), polyarthritis (affecting five or more joints), systemic
arthritis (with fever and rash and inflammation throughout the body) and enthesitis-related arthritis (affecting the junctions between tendons and ...
Tips from the journals of the American Society for Microbiology
... mice lost significantly more weight and were faster to succumb to death than wild-type mice. Both the HK/483 and H/K 486 virus caused a similar systemic
infection in INF-a/β receptor-deficient mice, however, pretreatment with IFN-a/β significantly reduced replication of both viruses.
Potential for non-invasive brain tumor treatment
... that it should be technically possible to treat brain tumors without the side effects associated with the traditional approaches of surgery, systemic
chemotherapy or radiation.
The bioengineers designed and built an ultrasound catheter that can fit into large blood vessels of the brain and ...
Scientists discover new genetic immune disorder in children
... as the inflammatory protein interleukin-1, and acts as a brake on this inflammatory protein. Without IL-1Ra, the children's bodies cannot control systemic
inflammation that can be caused by interleukin-1.
The scientists identified nine patients from six families with DIRA in the Canadian province of ...
Omega fatty acid balance can alter immunity and gene expression
... molecules, this dietary change is believed to also disrupt the proper balance of pro- and anti- inflammatory agents, resulting in increased systemic
inflammation and a higher incidence of problems including asthma, allergies, diabetes, and arthritis.
Floyd Chilton and colleagues wanted to ...
Yeast missing sex genes undergo unexpected sexual reproduction
... the other. Humans are susceptible to three types of yeast infection: thrush (in the mouth and throat), vaginal infection, and a sometimes fatal systemic
infection of bloodstream and organs, such as the kidney.
In a paper published online May 24 in Nature , Heitman's team reports that eight ...
Strong immune response to new siRNA drugs in development may cause toxic side effects
... that through the judicious application of well-informed siRNA design and the use of increasingly effective delivery systems, demonstrations of systemic
siRNA in human subjects will soon be realized."
"This is perhaps the most comprehensive review on siRNAs and innate immunity to date and a must ...
Genetic factors may predict depression in heart disease patients
... have been suggested to account for the greater prevalence of depression among cardiac patients, including the stress of a poor prognosis and systemic
inflammation, although little attention has been paid to date about the possibility of a genetic cause. According to previous studies, approximately ...
Bowman Global Change says public engagement critical to solving climate crisis
... the public to action. For example, connecting car mileage ratings to carbon emission rates fuels public demand for cars with better mileage, a systemic
improvement with significant impact on reducing greenhouse gas emission rates.
Calling on communication experts to bridge the gap between the ...
Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic
... general anesthetics which spread widely throughout the body. Ideally, clinical anesthetics would have a very focused target area in order to minimize systemic
The Penn team will now collaborate with the National Chemical Genomics Center in Rockville, Md., to screen rapidly for novel anesthetic ...
Ocera Therapeutics licenses novel treatment for acute hepatic encephalopathy from UCLB
... at the Institute of Hepatology, UCL (University College London). The research includes a study which demonstrated an acute and sustained reduction of systemic
ammonia levels as well as decreased intracranial pressure in models of AHE in acute liver failure and cirrhosis. The data was published online in ...
Gene linked to lupus might explain gender difference in disease risk
... in human lupus raises the possibility that the gender difference in rates may in part be attributed to sex chromosome genes," Dr. Mohan said.
lupus erythematosus, or lupus for short, causes a wide range of symptoms such as rashes, fever or fatigue that make it difficult to diagnose.
Stopping autoimmunity before it strikes
... and Bjarne Bogen in collaboration with Rune Blomhoff engineered NF-κB such that it would emit light when activated. Using a mouse model of systemic
autoimmunity with features of lupus, they found that NF-κB activation signals were present in affected organs several weeks before the clinical ...
Novel electric signals in plants
... however, can carry different information at the same time: The strength of the inducing stimulus (wound signal) can influence the amplitude of the systemic
signal as well as the effect of different ions. "We may be on the trail of an important signal transmission system that is induced by insect ...
Crib-side studies help struggling newborns go home without feeding tubes
... failure to coordinate sucking and swallowing with breathing, and irritability during feeds. These feeding difficulties can be seen in patients with systemic
illness and may relate to gastrointestinal, esophageal, behavioral, neurological, structural, and cardiorespiratory origins.
Despite the range of ...
Jefferson scientists discover a key protein regulator of inflammation and cell death
... Alnemri said. "Such therapeutics may be useful for the treatment of nucleic aciddependent pathogenic and autoimmune diseases, such as arthritis and systemic
lupus erythematosus," Dr. Alnemri said.
Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
... in the Section on Vascular Cell Biology at the Joslin Diabetes Center and Associate Professor of Medicine at Harvard Medical School, continuous systemic
administration of ASP-440 proved effective in decreasing hypertension-induced increased retinal vascular permeability in rodents, by as much as 70%. ...
In lung cancer, silencing one crucial gene disrupts normal functioning of genome
... reinforce tobacco's link to lung cancer development, but show that deactivating one specific gene through a process known as hypermethylation causes systemic
dysfunction, or hypomethylation, in many genes, said the study's senior investigator, Zdenko Herceg, Ph.D., head of the Epigenetics Group at the ...
UC Davis researchers find molecule that targets brain tumors
... brain tumors are currently treated with surgery to remove as much of the tumor as possible followed by radiation to kill cancer cells left behind and systemic
chemotherapy to prevent spread to nearby tissues," said Kit Lam, senior author of the study and UC Davis chief of hematology and oncology. "It is ...
Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
... research offers a tremendous opportunity to address a critical worldwide public health problem, and extends the Institute's mission to study systemic
disease. This would be an important breakthrough in the diagnosis and treatment of TB."
Recent studies show that an improved TB diagnostic test ...
Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections
... The MCE population was the same as the PP population, but adding back clinically evaluable patients whose protocol violation was use of additional systemic
or topical prohibited antibiotics or high-dose steroids registered as clinical failures.
The causative pathogen distribution in the study ...
Closing the gap: Journal launch brings together wound-healing knowledge
... world are caused by chronic inflammatory and fibrogenic disorders such as cardiovascular disease, pulmonary fibrosis, progressive kidney disease, systemic
sclerosis, liver cirrhosis and inflammatory bowel disease. Fibrogenesis and Tissue Repair features high-quality studies providing novel insights into ...
A new journal where molecular biology meets clinical research
... biology and clinical research. The new journal, launching in 2009, will publish original research offering molecular insights into cellular and systemic
processes underlying defined human diseases as well as potential clinical applications for diagnosis, prevention and therapy.
In line with EMBO's ...
LSUHSC awarded patent for compound inhibiting cancer and other diseases
... eye, infections of the retina, hyperparathyroidism, carotid obstructive disease, chronic uveitis/vitritis, mycobacterial infections, Lyme disease, systemic
lupus erythematosis, psoriasis, myopia, optic pits, Stargarts disease, chronic retinal detachment, hyperviscosity syndrome, toxoplasmosis, trauma, ...
Nanodiamond drug device could transform cancer treatment
... strategies where implanted, long-term drug release is needed.
Ho and his research group previously pioneered the application of nanodiamonds for systemic
drug-carrying applications. This new work successfully transitions the nanodiamonds from basic materials to serving as a foundation for device ...