Joint research into an enzyme that causes genetic diseases
... published in the prestigious scientific journal structure
, to gain in-depth knowledge of the structure
of pyruvate carboxylase when it is in solution ... treatments.
The paper presents the enzyme's structure
under physiological conditions for the first ...
UC San Diego engineer provides insights to decades-old DNA squabble
... used innovative approaches to deduce the internal structure
of chromatin, a key player in DNA regulation, to ... and New York University.
The internal structure
of chromatin is not knowna mystery that has ... to abnormal regulation of chromatin.
of chromatin has been a subject of many ...
All-in-1 nanoparticle: A Swiss Army knife for nanomedicine
... in one tiny package.
The result is the first structure
that creates a multipurpose nanotechnology tool for medical imaging and therapy. The structure
is described in a paper published online this ... charged gold atoms.
Gao compares the completed structure
to a golden egg, where the quantum dot is the ...
What scientists know about jewel beetle shimmer
... colors we see result from the beetle's physical structure
rather than its biology."
When light hits a ... hits them from different angles.
The beetle's structure
also forms helices similar to a cholesteric ... cells sit on or are used to form the curved structure
of its external skeleton. Research shows that ...
Munich researchers discover new target for tailored antibiotics
... steps of the new metabolic pathway. Yet the structure
of the terminal step catalyzed by the IspH enzyme ... the results, and for many years the crystal structure
of the enzyme that would provide the proof could ... very quickly in air, thus losing both its structure
and its function. Only recently a group from the ...
Singapore nanotechnology combats fatal brain infections
... conventional antibiotics because the molecular structure
of most drugs is too big to enter the membrane.
"Our treatment damages the structure
of the pathogen and literally breaks it apart," ...
"Our oligopeptide has a unique chemical structure
that forms nanoparticles with membranepenetrating ...
Structural biology scores with protein snapshot
... magnetic resonance (NMR) methods to determine the structure
of the largest membrane-spanning protein to date. ... of Biochemistry, and colleagues report the NMR structure
of the large bacterial protein diacylglycerol ...
The group's ability to determine the NMR structure
of DAGK suggests that similar methods can now be ...
New nanoparticles could revolutionize therapeutic drug discovery
... in drug discovery.
Understanding the structure
of proteins is a vital first step in developing ... intact, enabling detailed analysis of their structure
and molecular functions.
These new findings, ... Finding a gentle solution that preserves their structure
and activity, yet is robust enough for ...
Researchers observe single protein dimers wavering between two symmetrically opposed structures
... to exist in one "natural" three-dimensional structure
(shape), can actually twist itself into a second ... contrasting with a single preferred folded structure
that is determined by the energy balance between ... been used as a model system to study protein structure
The protein has been found in ...
The SIB recognizes the next generation of bioinformaticians
... residues that are distant in the 3-dimensional structure
of the protein.
The introduced methodology ... of contacting amino acids in the 3-dimensional structure
of proteins and is thus expected to be of help in protein structure
prediction. In an extended form, the same ...
Discovery of the cell's water gate may lead to new cancer drugs
... Gothenburg have determined the three-dimensional structure
of the yeast aquaporin. The results will be ... PLoS Biology .
has been determined using X-ray crystallography and is the highest resolution structure
that has been determined for a membrane protein. ...
Caribbean coral reefs flattened
... of East Anglia (UEA).
The collapse of reef structure
has serious implications for biodiversity and ... vast majority of reefs have lost their complex structure
and become significantly flatter and more ... University in Canada, analysed changes in the structure
of reefs using 500 surveys across 200 reefs ...
LSUHSC research describes function of key protein in cancer spread
... states. The researchers determined the atomic structure
of this region of IQGAP1 and furthermore, built a model of their IQGAP1 structure
bound to the previously determined structure
of Cdc42 in order to understand why IQGAP1 does ...
Researchers gain genome-wide insights into patterns of the world's human population structures
... about the genomic patterns of human population structure
around the world.
Revealing such patterns ...
"Studying genomic patterns of human population structure
also has practical applications in disease-gene ... genomic research findings about the fine-scale structure
of diverse human populations. The results will be ...
Center to investigate plant cells for better biomass fuels
... in the newly funded Center for Lignocellulose structure
and Formation, a Department of Energy, Energy ... efforts to increase our knowledge of the physical structure
of the biopolymers in plant cell walls and ... Nanoscale investigations into the physical structure
of lignocellulose -- the part of plants composed ...
Findings uncover new details about mysterious virus
... also confirmed the existence of a starfish-shaped structure
that covers a "special vertex," an opening in the ... previously been unable to determine the virus's structure
because they had assumed that, like many other ... icosahedral symmetry.
Xiao discovered the true structure
when he decided to try reconstructing the virus ...
Details of bacterial 'injection' system revealed
... UPTON, NY New details of the composition and structure
of a needlelike protein complex on the surface of ... The secretion system is a complex protein structure
that traverses the bacterial cell membrane and ... poisoning, and plague.
"Understanding the 3D structure
of these secretion proteins is important for the ...
Sugar on bacteria surface serves as base for a web of resistance
... sugars on the germs' surface to start building a structure
that helps the microbes resist efforts to kill ... surface of the bacterium as a helix, providing a structure
that encourages cell-to-cell interaction. When ... extracellular DNA that helps maintain the biofilm structure
during this release of seed cells.
"We all ...
Genetic switch potential key to new class of antibiotics
... Researchers have determined the structure
of a key genetic mechanism at work in bacteria, ... study clarified for the first time the exact structure
of nature's smallest known riboswitch, and ... study, Wedekind and colleagues solved the crystal structure
of a preQ1 riboswitch in complex with its ...
Red pandas reveal an unexpected (artificial) sweet tooth
... preferences to genetic analyses of sweet receptor structure
in six related species. Like the cat, each of ... eat bamboo leaves and shoots.
By studying the structure
and function of the sweet receptor gene across ... individual, is unique, defined in part by the structure
of their taste receptors," said Li. "We need to ...
First tri-continuous mesoporous Silica complex structure developed in Singapore
... surfactant template. This completely new porous structure
previously been predicted only mathematically ... Therefore, the ability to tailor the pore structure
of mesoporous material is of fundamental ... synthesized the first tri-continuous mesoporous structure
using a specially designed surfactant ...
University of Kansas graduate student researcher takes aim at deadly brain tumors
... her work involves trying to better understand the structure
of ATF5 and develop ways to target the protein. ... cancer.
Ciaccio studies the ATF5 molecule's structure
using KU's Nuclear Magnetic Resonance Laboratory ... protein and helps Ciaccio better analyze the bZIP structure
of the ATF5 protein. Someday, with a better grasp ...
Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
... to chemotherapy drugs. Understanding its structure
may help scientists design more effective drugs. ... 2009, issue of the journal Science .
is an important advance and we hope it is just ... an associate professor at Scripps Research. "The structure
is a nice tool for understanding how drugs are ...
Researchers develop flow sensors based on hair structures of blind cavefish
... a tall hydrogel structure. Once the entire cupula structure
dried, McConney exposed it to ultraviolet light ... the best flow measurements when the cupula structure
started halfway up the hair and extended past the ... above the hair, giving the total hair-cupula structure
a height of 825 millimeters.
To date, the ...
New technique used to profile anthrax genome
"With traditional methods, transcript structure
and abundance really have to be determined one ... Bergman, because bacterial mRNAs have a different structure
and cannot be easily separated from the other ... were together, it was very easy to see transcript structure
across the genome," said Bergman. "We could see ...
Fossil fragments reveal 500-million-year-old monster predator
... a pair of spinous claws and a circular jaw structure
with many teeth. But it differs from ... from the front of the animal's head.
is unlike anything seen in other fossil or living ... as you would see in a crab or lobster, but this structure
in Hurdia is empty and does not cover or ...
Protein structure determined in living cells
... function of a protein is determined both by its structure
and by its interaction partners in the cell. ... (FIAS) has, for the first time, determined the structure
of a protein in its natural environment, the ... (NMR) spectroscopy, the researchers solved the structure
of a protein within the bacterium Escherichia ...
CSHL researchers pinpoint structure-building role for 2 non-coding RNAs
... MENε and MENβ organize and maintain the structure
of paraspeckles, a compartment within the cell's ... in their stem-cell precursors a sign that their structure
might depend on ncRNAs, whose levels are also ... this interaction is related to paraspeckle structure
remains to be worked out.
The function of ...
Story tips from the Departments of Energy's Oak Ridge National Lab -- March 2009
... previously inaccessible insight to the atomic structure
of a new multicomponent bulk metallic glass. The ... Oak Ridge National Laboratory has revealed the structure
of the complex alloy comprising zirconium, ... methods to gain a better understanding of the structure
behind the material's unique properties, which ...
Scientists unlock the secrets of C. difficile's protective shell
... The detailed structure
of a protective 'jacket' that surrounds cells of ... the secrets of this protective layer's molecular structure
might reveal possible targets for new drugs to ... the first ever high-resolution images of the structure
of LMW-SLP, one of the two proteins that make up ...
Life secret exposed: Scientists unlock mystery of molecular machine
... on Earth.
"While the ribosome is a complex structure
it features a clear hierarchy that emerged based ... jet. Having spent years gazing at the detailed structure
of the ribosome, Prof. Steinberg pondered how such an immense and complex structure
could have assembled itself from smaller building ...
Scripps scientists create first crystal structure of an intermediate particle in virus assembly
... viral proteins perform to create the infectious structure
that causes all manner of misery and disease, say ... HIV are also known to assemble an "intermediary" structure
before morphing into its final assault-proof, ... team have long studied HK97, and had "solved" the structure
of the virus's mature outer coat. It is made up ...
Long-sought protein structure may help reveal how 'gene switch' works
... reports that it has definedfor the first timethe structure
of a "metabolic switch" found inside most types ... researchers set out 25 years ago to study the structure
of CRP in both its active state (with cAMP bound ... in its active ("on") state and examine the structure
using a technique called X-ray diffraction. ...
The Burnham Buzz, February 2009
... Riedl, Ph.D., got the first look at the molecular structure
of the protein complex that controls apoptosis ... death. Dr. Riedl determined the X-ray crystal structure
of the DISC to 2.7 Angstroms resolution and found ... FADD mechanistically control DISC formation. The structure
showed that Fas undergoes a conformational ...
Scattered light rapidly detects tumor response to chemotherapy
... able to provide representations of sub-cellular structure
without disrupting the cells, and can be used to ... of treatment.
"The fact that the changes in structure
appear over two distinct time scales suggests ... in the mitochondria, while the changes in the structure
of the nucleus were responsible for the later ...
A crystal clear view of chalk formation
... Previously, it was also an unknown fact that the structure
of crystallized calcium carbonate depends on the ... as well as help to explain the sophisticated structure
of biominerals - and to better understand the ... and building materials technology. The ingenious structure
of their crystals at nanoscopic level makes them ...
Biologists discover link between CGG repeats in DNA and neurological disorders
... molecule from a double helix into a hairpin-like structure
and, as a result, stall replication. When this ... to the formation of a stable, hairpin-like DNA structure
formed by long CGG repeats.
Abnormal ... phase of the cell cycle. Apparently, the unusual structure
of CGG repeats acts to escape the cellular ...
HWI scientist first in world to unravel structure of key breast cancer target enzyme
... Ghosh's solution of the three-dimensional structure
of aromatase is the first time that scientists ... journal Nature will be publishing the structure
of aromatase at 2.90 angstrom resolution in an ... inhibit aromatase specifically. But because the structure
was not known, nor the mechanism of androgen to ...
Burnham researchers discover 'on switch' for cell death signaling mechanism
... Medical Research (Burnham) have determined the structure
of the interactions between proteins that form ... control DISC formation. The X-ray crystal structure
of the Fas-FADD death domain complex revealed a ... domains bound to four Fas death domains. The structure
showed that Fas undergoes a conformational ...
Biologists learn structure, mechanism of powerful 'molecular motor' in virus
... Ind. - Researchers have discovered the atomic structure
of a powerful "molecular motor" that packages DNA ... product 17. The researchers determined the atomic structure
of these protein segments using a procedure ... materials, and the Purdue researchers studied the structure
of the materials.
"By combining the structural ...