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UCSF researchers identify new drug target for Kaposi's sarcoma

... section of the " Nature Chemical Biology " web site and can be found at ... development in the 1980s, by blocking the active site on the surface of the dimer, but the herpes virus ... Chemical Biology " paper validates this new site as a viable option for small-molecule drugs to ...

Seals quickly respond to gain and loss of habitat under climate change

... and habitat change and established a new breeding site thousands of kilometres from existing breeding ... patterns of seals from this Antarctic breeding site would have been unlikely to take them near other ... breeding sites, and so when their breeding site was lost, their numbers crashed. "The seals ...

Structural biology scores with protein snapshot

... for its substrate diacylglycerol and the active site at the top of the porch. "The active site looks nothing like any other kinase active site it's a unique architecture," Sanders said. The ...

American Chemical Society's Weekly Presspac -- June 17, 2009

... New CAS Web site on everyday chemicals Whether you want to ... CAS Common Chemistry can help. The new Web site provides non-chemists and others with useful ... name or a corresponding CAS Registry Number. The site currently contains approximately 7,800 chemicals ...

UNH researcher receives presidential environmental award

... the project utilized an eelgrass restoration site selection model Short developed with funding from ... and time-consuming process," says Short. "This site selection model helps coastal managers find ... eelgrass growth." In this project, Short notes, site selection was successful; in the 40 acres of ...

American Chemical Society's Weekly PressPac -- June 3, 2009

... New CAS Web site on everyday chemicals Whether you want to ... CAS Common Chemistry can help. The new Web site provides non-chemists and others with useful ... name or a corresponding CAS Registry Number. The site currently contains approximately 7,800 chemicals ...

Sweden to host 1.3 billion Euro research center

... start-up companies. Lund's bid for the site was one of three discussed by research ministers. ... forward very credible bids. On balance, the Lund site has been chosen because it is best suited to ... and the world's, premier neutron facility. This site decision is welcomed as the first major step on ...

New center at Georgia Tech aims to improve recovery of soldiers with severe injuries

... do not yet exist for delivering them to an injury site and of ensuring that they survive and remain at that site long enough to impact the regeneration process. ... is very small and those that arrive at the site do not remain to engraft with the host tissue," ...

American Chemical Society's Weekly PressPac -- May 20, 2009

... New CAS Web site on everyday chemicals Whether you want to ... CAS Common Chemistry can help. The new Web site provides non-chemists and others with useful ... name or a corresponding CAS Registry Number. The site currently contains approximately 7,800 chemicals ...

Google Earth aids discovery of early African mammal fossils

... by the discovery, Gingerich wanted to visit the site where the limestone was quarried, but the exact ... reported that the countertop whale came from a site near the Egyptian city of Sheikh Fadl, but a ... Ahmed El-Barkooky of Cairo University visited the site to collect more of the fossils, which may have an ...

Genetic switch potential key to new class of antibiotics

... for protein building. The mRNA's ribosome binding site is instead locked up by the preQ1 riboswitch, ... how the first base of the mRNA's ribosome binding site binds to a loop of the riboswitch, the "lever" by which the ribosome-binding site is sequestered. Every riboswitch is made of an ...

New drug shows promise in treating drug-resistant prostate cancer

... designs on a drug that tightly attaches to the site on the androgen receptor that binds with testosterone. If that site is blocked, the hormone cannot bind to prostate ... tightly enough to the natural hormone-binding site on androgen receptors to prevent most of them ...

New medications show promise in treating drug-resistant prostate cancer

... designs on a drug that tightly attaches to the site on the androgen receptor that binds testosterone. If that site is blocked, the hormone cannot bind to prostate ... tightly enough to the natural hormone-binding site on androgen receptors to prevent most of them ...

Stanford scientists find new solutions for the arsenic-poisoning crisis in Asia

... the chemistry and biology." Finding a study site Arsenic-laden rocks in the Himalayas feed ... The researchers needed a less-developed site that was chemically, biologically and ... as well." More importantly, the Cambodia site was mostly undeveloped. "Cambodia had been under ...

Young dinosaurs roamed together, died together

... and American paleontologists that excavated the site in the Gobi Desert in western Inner Mongolia. ... all direct evidence of the cause of death. The site provides some of the best evidence to date of the ... In addition to herd composition and behavior, the site also provides encyclopedic knowledge of even the ...

Antioxidants in Midwestern black raspberries influenced by production site

... among black raspberry samples suggested that site differences may be partially attributable to ... vary among locally grown cultivars from harvest site to harvest site and, as a consequence, of how they are handled ...

Little Salt Spring underwater archeological site in Florida receives new funding

... in North Port, Sarasota County, Florida. The site is of enormous archeological and anthropological ... the University's exploration of the preserve. The site is a national archeological treasure, said Teri ... preserve will allow the University to increase site research and excavation. It provides UM the ...

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

... of the final version. An 'atypical' splice site The new discovery stems from a program of ... machinery is correctly guided to the splice site at the beginning of an intron by one of its ... RNA called U1. U1 recognizes this splice site by lining up against the target RNA and pairing a ...

Research elucidates way lungs fight bacteria and prevent infection

... the white blood cells to get through to the site of the infection. The opening of these junctions ... & Microbe . Getting white blood cells to the site of an infection, however, is often a double-edged ... as many white blood cells as possible at the site of an infection is beneficial, but on the other ...

Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA

... splicing by silencers that modulate 5' splice site competition" is published in the December 24 ... the molecular mechanisms responsible for splice site choice remain poorly understood, Nilsen and his ... containing two alternative splice sites, a weak site and a much ...

Damage inflicted during cardiac attacks more widespread, MSU researchers find

... damage artery linings much further away from the site of the attack, leaving survivors at greater risk ... to dilate properly at intervals far away from the site of the attack." Abela compared the process to a tree, with the trunk as the site of the cardiac event and the branches ...

Paleontologists doubt 'dinosaur dance floor'

... visited the northern Arizona wilderness site nicknamed a "dinosaur dance floor" and concluded ... that concluded the pockmarked, three-quarter-acre site in Vermilion Cliffs National Monument was a ... of the St. George (Utah) Dinosaur Discovery site at Johnson Farm. They saw dinosaur tracks en ...

'A dinosaur dance floor'

... 190 million years ago. The three-quarter-acre site which includes rare dinosaur tail-drag marks ... thought to be potholes formed by erosion. The site is so dense with dinosaur tracks that it reminds ... A study identifying the dinosaur track site was published in the October issue of the ...

Researchers develop new self-training gene prediction program for fungi

... pattern is not deterministic. Locating the branch site which is nine nucleotides in length, almost ... is located 20-50 bases upstream of the acceptor site helps to accurately identify an intron. An ... gene. The results showed that by including branch site information in the model, the researchers could ...

Promptu and OAG Team to Deliver Flight Schedule and Status Information on Mobile Devices

... first public product, a WAP site (an internet site formatted specifically for mobile devices) is ... when on the move." The current premium WAP site is also being targeted to airline employees who ... to help them manage their travel needs. The WAP site is being demonstrated today and tomorrow at the ...

A little nitrogen can go a long way

... the order of historical yield zones, though at site 1 in 2003 average grain yields were not different ... management resulted in high yields for all four site years, and site-specific management strategies resulted in no or small yield increases. Only at site 1 in 2003 were there small but statistically ...

New study points to agriculture in frog sexual abnormalities

... calculated the amount of farmland in each site using Google Earth images. Each site was 2.1 square miles, with the toads collected at ... researchers collected at least 20 toads from each site in 2005 and 2006. Examination of the ...

UC San Diego researchers identify potential new drug candidates to combat 'bird flu'

... Generally, compounds that most easily bind to the site are considered to be top hits for validation and ... said, since they bound to both the regular active site and an additional side pocket that opened during ... the strategic targeting of multiple active site pockets," said Amaro. Added Cheng, former ...

Oak Ridge pegged for national ecological network

... have one. "Being selected as a candidate core site to represent the Southern Appalachians and ... comprises a 240-acre forest and has been the site of short- and long-term studies of the ecological ... and metabolism. With this new project, each site will include an intensively instrumented area as ...

Air monitoring helps anticipate possible ecosystem changes

... ago when his research team set up a monitoring site southeast of Canyon with wet and dry deposition ... away, in Big Bend National Park. The Canonceta site sits about midway between the sites at Muleshoe ... so we have to take a longer-term view." The site located along the rim of Ceta Canyon is free from ...

Britain's last Neanderthals were more sophisticated than we thought

... An archaeological excavation at a site near Pulborough, West Sussex, has thrown ... of extinction. "The tools we've found at the site are technologically advanced and potentially ... the first modern, scientific investigation of the site since its original discovery in 1900. During the ...

Yale Environment 360 magazine launches online

... and policy makers from around the world. The site will also provide a forum for discussing global ... of Forestry & Environmental Studies, the new Web site is coming online "at a moment of unprecedented ... noted, has created an opportunity to publish a site that will appeal to a wide international audience ...

Phoenix mission to Mars will search for climate clues

... half across. Green is the color that that landing site selection team used to represent the fewest ... past four years, first helping select the landing site for the 2004 Mars Exploration Rover (MER) ... Accordingly, Arvidson is NASA's Phoenix landing site working group chair. He also is the ...

Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme

... a process known as phosphorylation. The active site where the phosphorylation reaction occurs is an ... for drug development, since blocking the active site would deactivate the enzyme. Unfortunately, the active site of PAK1 shares a molecular architecture similar ...

Sudden Oak Death pathogen is evolving, says new study that reconstructs the epidemic

... Oak Death infestation, and the Bolinas Ridge site in Marin County's Golden Gate National Recreation Area on Mt. Tamalpais, only 5 kilometers from the site where the disease was first observed in ... parts of California, the close proximity of the site in Santa Cruz to a nursery makes it highly ...

Science expands Science Signaling, featuring research related to medical advances, and more

... Knowledge Environment (STKE). Since then, the site has featured an array of Perspective, Review, and ... context for signal transduction research. The site also includes a Database of Cell Signaling, ... a protein called CARD11 that serves as a docking site for signaling molecules. Lenz et al. discovered ...

Promising new nanotechnology for spinal cord injury

... paralysis and loss of sensation below the site of the injury because the damaged nerve fibers ... the formation of scar tissue at the injury site and enables the severed spinal cord fibers to ... grow up and down the spinal cord, penetrating the site of the injury. When the gel was injected into ...

Some migratory birds can't find success in urban areas, study finds

... The researchers determined how urban a nest site was by measuring the percentage of land within a ... While many rural birds returned to the same nest site year after year, nest site turnover in urban areas was about two times ...

First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills

... investigation, the e8 project team found that the site first proposed for the turbines, San Joaquin, had ... petrel nests as well as Miconia. The turbine site was changed to the hill known as El Tropezn, an ... petrels had been observed flying over the project site during the five month study. It was also believed ...

U. of I. librarian launches comprehensive Web database of field guides

... to date. The International Field Guides Web site merges Schmidts own book, A Guide to Field ... the associated International Field Guides Web site got thousands of hits a month, so going Web-only ... cost, plus the region the book focuses on. The site offers more than 5,000 records to date. The ...
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