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Silencing in Biological News

To fight drug addiction, UB researchers target the brain with nanoparticles

... the brain that facilitates addictive behaviors. silencing of the DARPP-32 gene with certain kinds of ... to therapeutic concepts directed at silencing a gene in the brain, using RNA techniques," said ... The nanorods delivered 40 percent of the silencing RNA molecules across the blood-brain barrier ...

Malaria immunity trigger found for multiple mosquito species

... parasite that causes malaria in humans. By silencing the gene, caspar, the researchers were able to ... Rel 2 is activated. The researchers found that silencing of the caspar gene through the manipulation of ... of Plasmodium falciparum in the gut tissue. silencing the gene known as cactus, which is part of ...

A new gene silencing platform -- silence is golden

... Samuel Gunderson has developed a novel gene silencing platform with very significant improvements over ... of New Jersey, has created highly efficient gene silencing agents that function via a novel mechanism of ... gene function and to validate gene targets. Gene silencing molecules also have potential prophylactic and ...

In lung cancer, silencing one crucial gene disrupts normal functioning of genome

... of MTHFR, and consequent partial or complete silencing of the gene, may trigger global hypomethylation ... reveals the novel and surprising role that silencing of normal genes plays in development of lung ... in methylation levels of the other two genes. silencing of the RASSF1A and CDKN2A genes makes sense, said ...

Researchers solve piece of large-scale gene silencing mystery

... the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes ... to Pikaard, if researchers could harness the silencing machinery involved in nucleolar dominance to ... that is the disease's trademark. Completely silencing all ribosomal genes would not be a viable ...

Plants display 'molecular amnesia'

... time the reversal of what is called epigenetic silencing in plants. The findings are important to ... Science Foundation at UC Berkeley, epigenetic silencing was triggered in maize. Once triggered, the maize ... thought, with the ability to remember epigenetic silencing varying depending on position. "This may ...

New gene-silencing pathway found in plants

... a lot of interest in harnessing this sort of silencing on purpose to be able to silence the genes that ... the cellular machinery responsible for gene silencing has major implications for gene therapy, where ... and it's probably the same sort of RNA-directed silencing mechanism." he explains. " If you could prevent ...

Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome

... present study shows for the first time how this silencing of several genes on a chromosome is accomplished. ... give rise to any protein, instead it mediates the silencing of eight to ten genes in a much larger area on ... a long RNA molecule can establish and maintain silencing of multiple genes in a large domain on the ...

Genome communication

... is absolutely required for paramutation silencing at the b1 locus as well as for several other ... interfering RNAs (siRNA) that function in gene silencing in other contexts. The siRNA could thus act as ... for some time as a cell defense mechanism for silencing foreign DNA but is also functional in other ...

Less can be more, for plant breeders too

... successfully demonstrated highly specific gene silencing using so-called artificial miRNAs in rice (Oryza ... With artificial miRNAs (amiRNAs), this natural silencing pathway can be harnessed to inactivate genes of ... Similarly, the researchers also report successful silencing of two other genes, Pds and SPl11. Besides ...

Researchers identify how to switch off cancer cell genes

... to turn them back on." The study showed that silencing of transcription start sites in some cancer cells ... and silenced promoter, suggesting that epigenetic silencing may be accomplished by the stable placement of ... can lock or silence a gene'may ultimately lead to silencing by enabling the stable presence of nucleosomes at ...

Protecting cells from their neighbors

... mutations in a period marked by considerable activity in the milieu. The silencing is governed by a repression mechanism previously described in earlier work ... cells that abut germ cells are protected by a mechanism that blocks the silencing signal emitted by the latter. Casanova explains the context of the study, ...

American Chemical Society's weekly PressPac -- May 27, 2009

... liver inflammation, by almost 50 percent. The results suggest that gene silencing may be "an efficient and more specific approach for therapy of liver ... the report states. ARTICLE #3 FOR IMMEDIATE RELEASE "TGF-#1 Gene silencing for Treating Liver Fibrosis" DOWNLOAD FULL TEXT ARTICLE: ...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

... By adding an siRNA against one of two other common SNPs, Zamore says gene silencing could be effective in 75 percent of patients with Huntington's disease in ... and his colleagues changed one more nucleotide base on the siRNA. Now, the silencing RNA was different from the healthy mRNA by two nucleotides, making it less ...

Small RNAs can play critical roles in male infertility/contraception

... and also in sperm formation. "The sex chromosome silencing in meiotic male germ cells is a well-known phenomenon, which has been ... data confirm that these X chromosome-derived microRNAs indeed escape the silencing effects and mange to be expressed. "This finding opens a ...

Cold Spring Harbor Protocols features stem cell differentiation, plant RNAi methods

... of genes in plants. The most effective means of accomplishing this gene silencing is through the use of viral vectors, with the Tobacco Rattle Virus (TRV) providing the most robust results. "Virus-Induced Gene silencing as a Tool for Delivery of dsRNA into Plants" outlines a simple procedure ...

Michael J. Fox Foundation Funds $1.1 Million for Cutting-edge Approaches to Parkinson's Disease

... Gene silencing techniques and induced pluripotent stem cell technology are among the ... MD, PhD, of Columbia University is working to determine whether a gene silencing technique using microRNAs short, noncoding molecules of RNA can be ...

Class of antibiotics can enhance gene-silencing tool

... introduced RNA hijacks machinery inside the cell called the RNA-induced silencing complex or RISC. To probe how RISC works, Jin and his co-workers ... silences the inserted gene. That way, if a potential drug tweaked the silencing process, the researchers could see it quickly. They found that enoxacin ...

TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer

... we observed on a molecular level," said Sood. "We then focused on whether silencing TG2 would block these effects." Researchers shut off TG2 with a small ... of cell death called autophagy. In a separate paper, they showed that silencing TG2 with the siRNA liposome reduced tumor size, slowed metastasis and ...

Plant biologists discover unexpected proteins affecting small RNAs

... before in any organismplant or animal. Ecker thinks this type of mRNA silencing is not an aberration of ein5/abh1 mutant plants. What we are seeing is in ... Runyon fellowship for cancer research to make. What we learn about RNA silencing pathways in plants could be applied to cancer chemotherapy, Gregory ...

Linchpin gene may be useful target for new breast cancer therapies

... respond to estrogen by any normal pathway." The researchers found that silencing expression of TFAP2C in hormone-responsive breast cancer cells ... of other "downstream" genes involved in cancer growth. In addition, silencing the TFAP2C also knocked out expression of another estrogen receptor called ...

Pushmi-pullyu of B-cell development discovered

... in a different direction. "The complexes help control both the unspooling of DNA to make genes accessible and the demethylation of DNA that removes silencing markers." Although DNA in every cell contains the genes necessary to become B cells, two factors help keep them silent. One is the fact that the ...

MicroRNAs grease the cell's circadian clockwork

... must therefore be fine-tuned and synchronised with precision to ensure cohesion between diverse metabolic processes. MicroRNAs induce gene silencing Ueli Schibler, from the Molecular Biology Department of the University of Geneva, focuses on the mechanisms controlling the tiny oscillators in ...

200,000 rice mutants available worldwide for scientific investigation

... sequenced in 2002 and researchers have come a long way since. Advances in technologies such as high-throughput sequencing and RNA interference gene silencing methods should help to accelerate the process of identifying the functions of the remaining genes in the rice genome." He added: "The availability of ...

200,000 rice mutants available worldwide for scientific investigation

... sequenced in 2002 and researchers have come a long way since. Advances in technologies such as high-throughput sequencing and RNA interference gene silencing methods should help to accelerate the process of identifying the functions of the remaining genes in the rice genome." He added: "The availability of ...

RNA research strategy for Europe takes shape

... in 2006, revolutionised the way scientists think about how genetic information is controlled in cells, and has opened the possibility of using gene silencing as a therapy where rogue genes cause disease. "Research into RNA has great promise for both basic science and biotechnology and medicine," said ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

... online this week and in the February 10, 2009 print edition of the Proceedings of the National Academy of Sciences ( PNAS ), suggest that miRNA silencing to counteract or attack this mechanism may be an effective therapeutic strategy for metastatic melanoma, according to Eva Hernando, Ph.D., assistant ...

CSHL scientists discover how 'companion' cells to sperm protect them from genetic damage

... Portugal. "It allows its own transposons to get activated and suffers DNA damage to essentially just enforce epigenetic reprogramming and transposon silencing in the next generation." Other organisms, such as insects and lower living forms such as ciliates, also carry sperm cells adjacent to larger ...

Discovery could lead to a new animal model for hepatitis C

... establish occludin's role as a required entry factor, the group showed that human liver cells naturally express high levels of occludin, and that by silencing its expression, they could give these once highly susceptible liver cells the ability to completely block infection. "You know, you sort of have ...

JCI online early table of contents: Jan. 19, 2009

... mice lacking the Fak gene in breast tissue were protected in a model of breast cancer caused by excessive activation of Ras and PI3K. Further, silencing the FAK gene arrested the growth of human breast cancer cells with excessive activation of either Ras or PI3K signaling pathways. The authors ...

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

... cell cycle. They checked this finding by using an agent that inhibited JNK, and found that the extract was ineffective. Using a genetic approach silencing the JNK gene also disarmed grape seed extract's lethal attack in leukemia cells. "This is a natural compound that appears to have relatively ...

New research shows how gene function drives natural selection in important class of genetic elements

... the pattern of selection on these elementsa pattern that could derive from the effect of the elements on the host genome, or the effect of host silencing mechanisms on the elements," Baucom said. "Our expectation was that if the elements are adapting to the host genome, we should see evidence of ...

Stowers Institute's Workman Lab discovers novel histone demethylase protein complex

... and lead author on the paper. "Surprisingly, we found that dKDM4a associates with Heterochromatin Protein 1a (HP1a), a classic transcriptional silencing factor. The binding of HP1a stimulates the histone demethylation activity of dKDM4A. In fruit fly larvae without HP1a, we found a significantly ...

Cell movements totally modular, Stanford study shows

... simple modules to generate efficient movements." Vitorino also made some curious, though not immediately useful, observations about the impact of silencing genes for individual cells: "Some inactivations made them spiky, some made them long, some made them so they wouldn't stick together, some made them ...

CSHL scientists discover a new way in which epigenetic information is inherited

... in developing fruit fly oocytes, or egg cells, also includes piRNAs. And these maternally deposited piRNAs prove to be essential for mounting a silencing response against transposons. Inheritance via small RNAs Hannon likens this protection to that afforded by the adaptive immune system which ...

American Chemical Society's Weekly PressPac -- Nov. 19, 2008

... confirming that the transplanted cells were functional and effective, the researchers say. MTS ARTICLE #4 FOR IMMEDIATE RELEASE "Caspase-3 Gene silencing for Inhibiting Apoptosis in Insulinoma Cells and Human Islets" DOWNLOAD FULL TEXT ARTICLE CONTACT: Ram I. Mahato, Ph.D. University of ...

Corn researchers discover novel gene shut-off mechanisms

... thaliana, a small flowering plant of the mustard family that is easy to grow in the lab, have provided a lot of what scientists know about gene silencing in plants. An important key to the process is short sequences of ribonucleic acids known as "small RNAs" which act like biochemical switches that ...

Racial disparities in cardiovascular health linked to birth weight, slavery

... her child will later develop cardiovascular disease as an adult. Nutrients and hormones present in the womb shape a fetus's development, in part by silencing certain genes in the body. These influences can persist into later life to impact adult health. Researchers from Northwestern University argue that ...

RNA molecules, delivery system improve vaccine responses, effectiveness

... against the disease," Roy says. The team worked with what are called "silencing RNA," which shut down specific proteins in the body. "By silencing certain proteins in the cells that process your vaccine, we can direct the immune response one way or the other," says Roy, who holds the General ...

Mount Sinai researchers discover technology that silences genes

... Mount Sinai researchers have developed a new gene silencing technology that could be used to target genes that can lead to the development of certain diseases. This technology could pave the way for preventing ...
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