Protein handlers should be effective treatment target for cancer and Alzheimer's
... that disabling molecular chaperones or the heat shock
factors that control some of them, disables tumor ... the activity of molecular chaperones and heat shock
factors. She theorizes these drugs would be used ... the first to study molecular chaperones and heat shock
factors in animals to better understand their ...
Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
... AUGUSTA, Ga. Dissecting how heat shock
protein 90 gets steroid receptors into shape to ... is a good thing."
While every cell needs heat shock
proteins, cancer cells need them even more to ... is one of the most common of the ubiquitous heat shock
proteins. These proteins are essential in the ...
NYU scientists discover dangerous new method for bacterial toxin transfer
... aureus, a notorious bacterium that causes toxic shock
syndrome and many other types of infections and ... that Staph could transfer genes for deadly toxic shock
to Listeria monocytogenes, which is already known ...
"We happened to be looking at the nasty toxic shock
toxin. As far as we know, this toxin is produced ...
Immune system protein accurate predictor of survival in pediatric septic shock
... of being admitted to the hospital for septic shock
can predict survival in children, yielding a ... for diagnostics and clinical trials of new septic shock
therapies, according to a research team led by ... with more severe cases of pediatric septic shock
and a greater chance of death. That research also ...
Research sheds light on the mechanics of gene transcription
... sets in conventional cells.
They activated heat shock
genes, which protect cells from sudden rises in ... Looking at the location of co-regulated heat shock
genes (genes that are transcribed ... pairs that occupied distinct sites before heat shock
were no closer together after heat shock. As in ...
Research reveals secrets of alcohol's effect on brain cells
... biochemical cascade -- called the heat shock
pathway -- to send a molecule called heat shock
factor 1 (HSF1) into the neuron's nucleus. HSF1 ... bit of DNA to trigger activity in the heat shock
pathway, finding the same piece of DNA in the ...
Komodo even more deadly than thought: Research
... to bleed to death from their wounds: the victims are reported to go into shock
before the dragons kill and eat them.
Some researchers believe that ... by preventing blood clotting and widening blood vessels, thus inducing shock
in a victim.
The researchers also examined fossils of the giant extinct ...
Tree survival skills
... each stage of the transplanting process, trees are exposed to mechanical shock
and vibration that can further disrupt the root system and cause ... Identifying the specific stress factors responsible for transplant shock
and when they occur is crucial if the process is to be improved", Stewart ...
Crabs' memory of pain confirmed by Queen's academic
The main aim of the experiment, however, was to deliver a shock
just under the threshold that causes crabs to move out of the shell, to ... but had remained in their shell appeared to remember the experience of the shock
because they quickly moved towards the new shell, investigated it briefly ...
Oh, my aching back: Give me a shot of ozone
... by small, spongy disks. When these disks are healthy, they act as shock
absorbers for the spine and keep the spine flexible. But when a disk is ... be left with too little disk. Taking out a protruding disk may lose the shock
absorption that naturally resides between them in the spine," said Murphy, ...
Tiny details in three dimensions
... gain new insights into the various clinical symptoms of the disease.
freezing maintains original condition / Resolution up to 5 nanometers
In cryo-electron tomography the organism is shock
frozen so that its original condition is retained. Chemical pretreatment, ...
Battling bacteria in the blood: Researchers tackle deadly infections
In a research paper published in the November issue of the journal shock
, and recent papers in the journals Bulletin of Mathematical Biology and ... of the bloodstream and into these areas.
In the paper published in shock
, Younger and his team describe their new model of bacterial infection of ...
GN Netcom Introduces Innovative Noise Blackout Technology
... sound quality. Used together with advanced DSP
technology and Audio shock
Protection that monitors incoming audio volume,
sound is balanced to ... -- Multipoint technology -- A2DP & DSP technology -- Acoustic shock
Protection -- Up to 5.5 hours of talk time -- 250 hours standby time -- ...
Hyperviscous fluids: Better treatment for severe blood loss
... pressure plummets, and patients exhibit mental confusion. Hypovolemic shock
can progress within a matter of one or two hours to organ failure and ... saline in treating those patients and in advancing our knowledge about shock
Research team says extraterrestrial impact to blame for Ice Age extinctions
The detonation either fried them or compressed them because of the shock
wave, said Ted Bunch, NAU adjunct professor of geology and former NASA ... spherical carbon cages resembling a soccer ball, which are formed in shock
events outside the Earths atmosphere. Trapped inside the fullerenes is a ...
Structure of protective protein in the eye lens revealed
... form after their production. If this folding process fails, the protein thread becomes an inextricable, useless tangle.
Small heat shock
proteins (sHsps) are a particularly important group of chaperones. They prevent the clumping of proteins under stress conditions. αB-crystallin ...
DOE-funded research projects win 46 R&D 100 Awards for 2009
... UV Holography Lens - The lens will help scientists measure the size and velocity of particles ejected off a metal after it is hit by a shock
wave. The physics of these particles will be used to develop a theoretical model for nonnuclear experiments that safely simulate atomic experiments. ...
High-tech vehicle design boosts emergency rescue capacity
... vehicle needed for rapid access to disaster zones. "Our four-stretcher carrier is adjustable at the front and rear end to cope with the state of shock
of the patient," adds Strobel. "For easy maintenance all our loaded components are made of stainless steel. And all profiles are rounded for safety ...
The sound of light: Innovative technology shatters the barriers of modern light microscopy
... that causes slight local increases temperature, which in turn result in tiny local volume expansions. This happens very quickly and creates small shock
waves. In effect, the short laser pulse gives rise to an ultrasound wave that the researchers pick up with an ultrasound microphone.
The real ...
Resilin springs simplify the control of crustacean limb movements
... He said, "The exquisite rubbery properties of resilin are known to be put to use as energy storage mechanisms in jumping insects and as biological shock
absorbers in many animals. I have now shown that it is used to simplify the sensory and motor control systems at a limb joint."
The limbs studied, ...
A combined tooth-venom arsenal revealed as key to Komodo dragon's hunting strategy
... to be similar to that of the gila monster and many snakes which cause a severe loss in blood pressure by widening blood vessels, thereby inducing shock
in a victim. These findings may explain the observations by Dr Fry and others that Komodo Dragon prey become still and unusually quiet soon after ...
Key protein regulating inflammation may prove relevant to controlling sepsis
... Vinay Tergaonkar, Ph.D., who headed the research team. "In doing so, WIP1 minimizes the extent of inflammatory response that could lead to septic shock
and subsequent death of patients."
Dr. Tergaonkar and his colleagues compared the inflammatory response in mice lacking in WIP1 and in a control ...
American Chemical Society's Weekly PressPac -- April 22, 2009
... monocytogenes , the deadliest of the species, the researchers say.
The scientists describe development of the biosensor using so-called heat shock
proteins which the body produces in response to stress instead of the antibodies used in other tests. They showed that their new sensor was faster ...
Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes
... pulses of ultrasound. These pulses create tiny bubbles out of dissolved gas in prostate tissue. As the bubbles violently collapse, they release tiny shock
waves, a phenomena called acoustic cavitation. Over tens of thousands of pulses, the combined force of these cavitations liquefies nearby tissue into ...
Discovering the secret code behind photosynthesis
... bacterial-type on/off switches in chloroplasts suggests a new model for gene regulation in plants."
Professor Allen adds: "To many, it will be shock
to learn that some messages are sent within plant cells - and, probably, animal cells - using the same telegraph system as the one found in ...
Darwin's seminal impact on biology, anthropology, philosophy and psychology
"In 300 years from now, there is a greater chance that Darwin will be taught in a philosophy class than Immanuel Kant. He produced a shock
wave that transformed every aspect of our perception of the world and ourselves. It's a revolution greater than the Copernican revolution," says ...
Engineering technology pinpoints earliest signs of animal life
... on the correct date for the divergence of complex multicellular animal life, between 635 and 750 million years ago. It appears that the climatic shock
of the two major glacial episodes of the Neoproterozoic caused a major reorganisation of marine ecosystems including the evolution of animal feeders ...
Molecular mechanism of anaphylactic shock decoded
... Frankfurt University and the Max Planck Institute in Bad Nauheim was published online in "The Journal of Experimental Medicine ".
is an acute, life-threatening allergic reaction, usually brought on by medication, insect stings, or other allergens, which has become more frequent ...
Global warming linked to European viral epidemic
... problems, needing Intensive Care treatment, such as acute dialysis and/or mechanical ventilation. In some rare cases it can, moreover, cause the shock
with internal haemorrhaging and death for which these infections are infamous. Clement said, "In 1997, more than 9,000 people in the Russian republic ...
'Fly guy' makes memory breakthrough
... synthesis. Fragile X flies that were fed drugs that reduced the production of protein in the brain remembered to avoid the smell associated with a shock
almost as much as the normal flies.
The next step, he said, is to translate the findings into the creation of drugs to treat the condition in ...
'World Energy Outlook' to be presented at Rice University Dec. 9
... of Simmons & Company International, a specialized energy investment banking firm, and author of "Twilight in the Desert: The Coming Saudi Oil shock
and the World Economy."
For more on the event, go to www.bakerinstitute.org .
The event will be held at Baker Hall on the Rice University ...
The physics of star-forming clouds and the urban environment
... which an initially small, laminar flame, as might be caused by a spark, can evolve into a turbulent flame that produces high compression and strong shock
waves. The shocks, in turn, may couple with the flame to form unsteady, propagating shock-flame complexes that may transition to a detonation.
GSA congratulates 2008 award winners
... in, and had a major impact on, the field by virtue of their mentoring, and whose inspiration is sought by students and colleagues.
New Investigator Award
Presented to Ilhem Messaoudi, PhD , Oregon Health & Science University
This award is given annually for innovative and ...
Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
... lower norepi-quinone, higher NADH and lower NAD+. This will cause the built-in logic structure to output the signal "1,0,1,0" which points to shock
and will trigger a pre-determined treatment response.
"This is biocomputing in action," said Wang.
"We are just at the beginning of this ...
Why binge drinking is bad for your bones
... Frederick Wezeman, PhD, professor in the Department of Orthopaedic Surgery and Rehabilitation and Ryan Himes, a research assistant in the Burn and shock
The National Osteoporosis Foundation says that many people who abuse alcohol do not get enough calcium. Alcohol also can affect ...
Stabilizing force for good communication between neurons and muscle cells found
... positioned to catch the message.
Medical College of Georgia scientists have found what keeps rapsyn in proper conformation.
It is a heat shock
protein, one of a large family of molecular chaperones that make sure proteins get where they are needed and do what they should, says Dr. Lin Mei, ...
Deep biosphere research points to new methods for recovering petroleum
... that don't have to use environmentally unfriendly, toxic solvents.
Funded through NSF's Emerging Topics in Biogeochemical Cycles program, shock
and his team will be the first to link organic geochemical reactions deep in the Earth's crust to the support of microbes in the deep biosphere. In ...
Ceramic material revs up microwaving
... Chemistry of Materials.
Petalite is a commonly occurring mineral that contains lithium, aluminum and silicon and is often used to make thermal shock
resistant ceramics because it expands very little when heated. Ceramic sintering uses powdered minerals pressed together hard to form green bodies. ...
Pesticide build-up could lead to poor honey bee health
... in the wax because the wax is reprocessed to form the structure of the hives," says Maryann Frazier, senior extension associate. "It was a bit of a shock
to see the levels and the widespread presence of these pesticides."
While the researchers expected the presence of the chemicals available to ...
Tips from the Journals of the American Society for Microbiology
... regions are at especially high risk where illness may range from mild symptoms to potentially fatal forms of dengue hemorrhagic fever and dengue shock
syndrome. With all four strains of the virus sharing similar clinical presentation, epidemiology, and distribution, development of a vaccine ...