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Sepsis in Biological News

Older men more likely than women to die after pneumonia

... multicenter Genetic and Inflammatory Markers of sepsis (GenIMS) study. Participants were enrolled upon ... such as cardiac disease or cancer. Severe sepsis occurred in 588 (31 percent) subjects. Of these, about half had severe sepsis on their first day of hospitalization. Men ...

Children's National research links platelets to sepsis-related organ failure

... over the last few decades, mortality rates for sepsis have not really improved," said Robert ... of dying and to design new interventions." sepsis is the tenth leading cause of death in the United States. More than 40 percent of sepsis cases are fatal, and in most, the resulting organ ...

In the laboratory, green tea proves a powerful medicine against severe sepsis

... ingredient in green tea rescued mice from lethal sepsis and the findings could pave the way to clinical ... Wang had previously discovered a late mediator of sepsis called HMGB1, a substance expressed in the late ... which they felt would prevent the lethal sepsis process from moving forward. And it worked. ...

Study begins to reveal clues to the cause and progression of sepsis

... PITTSBURGH, Aug. 13 Not all patients with sepsis mount the same immune response, even when they ... and death. More than 30 percent will die, making sepsis the 10th leading cause of death. While incidence rates of sepsis have been steadily increasing over the years, ...

Scientists uncork a potential secret of red wine's health benefits

... and systemic sepsis. "Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of ... one of the researchers involved in the work. "Moreover, many survivors of sepsis develop a very low quality of life due to the damage that inflammation ...

Nature study demonstrates that bacterial clotting depends on clustering

... to new clinical methods for treating serious medical conditions such as sepsis and anthrax. It has long been known that blood often coagulates during sepsis or bacterial infections, but this has generally been regarded as a host's ...

Key to out-of-control immune response in lung injury found

... and auto-immunity through regulation of T- and B-cells. When sepsis was induced in mice with and without the Cblb gene, there was a marked ... of inflammatory cytokines, called NF-kB, is induced in lung tissue after sepsis by that receptor to a much greater extent from the Cblb-deficient mice ...

Sugar on bacteria surface serves as base for a web of resistance

... can foster creation of the biofilm. Some critically ill hospitalized patients also are susceptible to infection by Pseudomonas, which can lead to sepsis or bacteremia, common causes of death in very sick intensive-care patients. With Psl clearly identified as the foundation of the matrix, or the ...

Research could lead to new non-antibiotic drugs to counter hospital infections

... Once the host is weakened by an illness, surgical procedure or immunosuppressive drugs, however, P. aeruginosa can cause infection, inflammation, sepsis and death. Why P. aeruginosa can suddenly turn on its host has eluded researchersuntil now. Scientists have long known that after an operation ...

Lung airway cells activate vitamin D and increase immune response

... dampen inflammation," Hansdottir said. "Controlling inflammation through vitamin D is good because too much inflammation can cause problems such as sepsis and seems to contribute to autoimmune disease." Hansdottir noted that vitamin D insufficiencies and deficiencies (which are more severe) are ...

Multiple disease-related research gets green light from the NIH

... diseases, in addition to those who suffer transplant rejections." Dr. Smiley believes that prior attempts to treat patients suffering from sepsis by removing fibrin failed because those treatments most likely removed both unhealthy and healthy fibrin. With this infusion of research funds, Dr. ...

Immune system protein accurate predictor of survival in pediatric septic shock

... septic shock. Despite today's potent antibiotics and pediatric intensive care units, septic shock remains a serious public health challenge. sepsis sets off a chain reaction of events that can ultimately lead to uncontrolled inflammation in the body and puts a person's entire immune system into ...

Pitt receives $2.5 million to simulate and analyze brain, immune system activity

... the project. The immune system models will plot the various chemical and physical changes that occur as the body battles influenza, inflammation, sepsis and necrosis, and wounds. Ultimately, Rubin explained, the researchers want to pinpoint the origin of such conditions as multiple organ dysfunction ...

CAPHOSOL relieves oral mucositis and improves quality-of-life in cancer patients

... mucosa, which can then become susceptible to oral opportunistic infections, possibly resulting in bacteremia (the presence of bacteria in the blood), sepsis (the presence of pathogenic microorganisms in the blood) or other potentially fatal complications. The economic impact of mucositis can be ...

Solving an avian scourge could also provide benefits to human health

... called ExPEC (extra-intestinal pathogenic E. coli, which includes APEC), which have been associated with illnesses such as urethral infections, sepsis and meningitis. Another human health ramification comes from work done by several research groups that have demonstrated that the poultry disease ...

Gene chips used to distinguish ventilator-associated pneumonia from underlying critical illness

... way to diagnose ventilator associated-pneumonia in intensive care units and predict patients' recovery," says Sarah Dunsmore, Ph.D., who oversees sepsis grants at the National Institute of General Medical Sciences, which partially funded the study. "This innovative approach has the potential to ...

Bacterial infections in premature babies more common than previously realized

... of genital mycoplasmas is not part of routine clinical practice in obstetrics and neonatology. Similarly, standard treatment for suspected neonatal sepsis does not include antibiotics effective against these microorganisms. Romero and Garite further state that, The initial uncertainties of whether ...

First high-res 3D structures of mammalian HSP90 protein solved

... allow for the long-term development of a family of drugs that could be narrowly targeted for individual proteins, for example specifically treating sepsis only. Economic Impact Just as companies have been founded to develop HSP90 inhibitors, the same potential exists here. This will spur a new ...

New study aims to stop sepsis in its tracks

... interventions can halt the progression to severe sepsis and septic shock. Key to the project is ... set of standard procedures to diagnose and treat sepsis in emergency departments. The National ... Director Elias A. Zerhouni, M.D. Every year, sepsis affects more than 700,000 Americans. About 30 ...

Researchers identify new weapon to fight deadly bacterial sepsis

... the Centers for Disease Control and Prevention, sepsis killed 120,491 hospitalized people in 2000. The same study found cases of sepsis in the U.S. have risen dramatically in recent ... protecting heart function and greatly reducing sepsis deaths. Moreover, the scientists have ...

Gene chip technology shows potential for identifying life-threatening blood infection

... halting its lethal spread, doctors who suspect sepsis typically rush to prescribe powerful antibiotics, ... that doctors one day could quickly distinguish sepsis from widespread non-infectious inflammation based ... in patterns of gene expression that are unique to sepsis vs. non-infectious inflammation. "Our ...

Researches discover gene critical for protection against septic-shock-induced death

... regulating the body's innate immune response to sepsis and septic shock, according to a study by a ... for the treatment of life-threatening sepsis. sepsis is a complex disease characterized by an ... as potential targets for the next generation of sepsis therapies. The incidence ...

Mayo Clinic researchers challenge sepsis theory

... challenged the accepted theory on the cause of sepsis -- a condition in which the body's cells generate fever, shock and often death. sepsis is thought to occur when poisons from bacterial ... . Their findings suggest that sepsis begins with a change in certain cellular ...

Lack of a key enzyme dramatically increases resistance to sepsis

... could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders. ... individuals are far more susceptible to severe sepsis and have a significantly increased risk of dying ... School of Medicine showed that the incidence of sepsis in the United States has increased almost nine ...

Protein prevents detrimental immune effects of bacterial sepsis

... The importance of this work is underscored by the fact that bacterial sepsis ranked among the top ten causes of death in both adults and neonates in ... Vital Stat Rep 2005, 53:1-89). The patients at greatest risk of developing sepsis and SIRS are those with impaired immune systems. When such patients are ...

New Estimates For The Causes Of Child Deaths Worldwide

... to six causes: pneumonia (19%), diarrhoea (18%), malaria (8%), neonatal sepsis or pneumonia (10%), preterm delivery (10%), and asphyxia at birth (8%). ... regions, deaths in the neonatal period, primarily due to preterm delivery, sepsis or pneumonia, and birth asphyxia should also be addressed. The new ...

Cell wall of pneumonia bacteria can cause brain and heart damage

... according to Elaine Tuomanen, M.D., chair of the St. Jude Department of Infectious Diseases. S. pneumoniae is a leading cause of pneumonia, sepsis (a potentially life-threatening bloodstream infection) and meningitis (inflammation of the membranes surrounding the brain and spinal cord). The ...

Stanford snake venom study shows that certain cells may eliminate poison

... cells released proteins that broke down a molecule called endothelin-1, one of the major toxins produced by the body during bacterial peritonitis or sepsis (bacterial infection in the blood). In perusing the scientific literature, Metz noticed that endothelin-1 bore a striking similarity to ...

Less is more, gene study shows

... percentage of Africans and African Americans have a functional copy of the gene. Interestingly, people who lack the gene are better able to resist sepsis than those who have a working copy. "This is another indication that loss of the gene would be good for the individual, but it doesn't show that ...

HIV accessory protein disables host immunity via receptor-protein intermediary

... in the host cell. To verify their idea, the researchers used a mouse model in which PARP-1 was knocked out and found that their cells were immune to sepsis (pathogens and their toxins in the blood), because the NF-kB molecules did not go into overdrive, kicking up inflammatory molecules called cytokines. ...

Community MRSA is re-emergence of 1950s pandemic, study suggests

... the bacteria. First isolated in Australia and Canada in 1953, type 80/81 penicillin-resistant Staphylococcus aureus bacteria caused skin lesions, sepsis and pneumonia in children and young adults around the world. This pandemic of both hospital and community acquired infections waned throughout the ...

Substance protects resilient staph bacteria

... be present for S. epidermidis to survive on medical implants. S. epidermidis infections are rarely fatal but can lead to serious conditions such as sepsis (widespread toxic infection) and endocarditis (inflammation of the lining of the heart and its valves). Because of the ability of PGA to promote ...
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(Date:10/15/2014)... awarded the 44th Rosenstiel Award for Distinguished Work in ... exploring the mechanisms of genomic instability and its implications ... the second alumnus to win the Rosenstiel Award; the ... , Alt is the Charles A. Janeway Professor of ... and an investigator at the Howard Hughes Medical Institute ...
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